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Min, Sun-Hong,Cho, Ilsung,Park, Chawon,Jung, Wongyun,Hwang, Won Taek,Kim, Minho,Lee, Kyo Chul,Lee, Yong Jin,Lim, Sang Moo,Hong, Bong Hwan 대한방사성의약품학회 2019 Journal of radiopharmaceuticals and molecular prob Vol.5 No.2
Radiopharmaceuticals include therapeutic radiopharmaceuticals and diagnostic radiopharmaceuticals. Therapeutic radiopharmaceuticals are administered to the body and ingested at specific organs to detect radiation emitted from the site and to construct an image to diagnose the disease. Diagnostic radiopharmaceuticals are used to treat diseases by killing cells with radiation emitted from radiopharmaceuticals, such as cancer cells, vascular endothelial cells, arthritis, and Alzheimer's disease. The application possibilities of terahertz imaging technology for the combination of radiopharmaceuticals and molecular imaging medicine are discussed and experimental methods are presented. Terahertz imaging is expected to be a powerful technique because of the effective piercing feasibility, which enables to perform safe and high resolutive imaging. To investigate the response of cell to the terahertz wave, both the pulsed and CW THz wave systems are employed. THz imaging of a rat's paraffin-embedded epithelial cell with tumor is studied in advance.
송용근(Song yongkeun),조성호(Cho sungho),정원균(Jung wongyun) 한국방사선학회 2014 한국방사선학회 학술대회 논문집 Vol.2014 No.추계
탄소 빔을 환자의 치료를 위해 Spread out bragg peak (SOBP)로 변조하려면 Active 및 Passive 변조방식 등 두 가지 방법을 사용하고 있다. Active 변조 방식은 Bragg peak의 중첩으로 구현되고, Passive 변조 방식은 Ridge filter를 사용한다. Ridge filter 하나의 groove의 Height 및 Width는 SOBP의 형상을 결정한다. Ridge filter는 일반적으로 탄소치료 시설에서 사용되지만, 또한 양성자에도 사용된다. 현재 부산 기장군에 건설 중인 중비자치료시설은 Passive 변조 방식을 이용해서 SOBP를 구현 할 계획이다. Passive 변조방식의 주요 Component인 Ridge filter를 설계하기 위해, 전산모사를 수행하는 것이 필수적이다. 본 연구에서는 SOBP을 만드는 Ridge filter를 구현하고, FLUKA 2011코드를 사용하여 Water phatom 내 흡수되는 선량을 계산하였다. To create Spread Out Bragg Peak (SOBP) for the treatment of patient with carbon beam is two kinds of methods. There are active modulation and passive modulation, respectively. Active modulation method is implemented as superposition of Bragg Peak, and passive modulation method is using ridge filter. The ridge filter is a static component positioned in the beam line. The beam is spread to a monoenergetic, homogeneous field of carbon ions before entering the ridge filter. The shape of each of the groove determines the shape of the SOBP. Ridge filters are commonly used in carbon therapy facilities, but are also used for protons. At the carbon ion therapy center by Korea Institute of Radiological and Medical Sciences (KIRAMS) in Busan, Korea, we are planning to adopt the passive modulation. To design ridge filter of passive modulation key components, it is essential to carry out the Monte Carlo Simulation. In this study, we implemented ridge filter to create SOBP, and calculated absorbed dose in water phantom using FLUKA 2011 code.
Estimation of the medical need for carbon-ion radiotherapy in Korea
Cho, Ilsung,Seo, Young Seok,Jung, WonGyun,Kim, Mi-sook JAPAN RADIATION RESEACH SOCIETY 2018 JOURNAL OF RADIATION RESEARCH Vol.59 No.5
<P><B>Abstract</B></P><P>The Korea Heavy Ion Medical Accelerator project focuses on the development of medical accelerator facilities for delivering carbon-ion beams to cancer patients. The purpose of the present study was to estimate the clinical need for carbon-ion therapy in Korea. Seven tumor sites, namely head and neck, liver, lung, colon and rectum, prostate, bone and soft tissue, and pancreas were selected as eligible sites for receiving carbon-ion radiotherapy (RT) by radiation oncologists of the Korea Institute of Radiological and Medical Sciences. Cancer incidence data for the selected tumor sites were obtained from the Korea National Cancer Incidence Database in order to estimate the potential medical need for carbon-ion RT. The carbon-ion RT adaption rate was assessed based on the clinical experience of other carbon-ion therapy facilities. An estimation model was constructed for estimating the medical need for carbon-ion RT, and from this, 25 606 patients were deemed to be potential candidates for carbon-ion RT. This estimated potential need corresponded to 10% of newly diagnosed cancer patients in Korea. The realistic estimation was calculated as ranging between 4000 and 6300 patients, depending on the carbon-ion RT adaptation rate. This estimated medical need corresponded to 2–3% of newly diagnosed cancer patients in Korea. Taken together, our findings suggest that there is a clear medical need for carbon-ion RT in Korea, with at least 4000 potential patients per year.</P>
A Comparison Study of the Ridge Filter Parameter by Using FLUKA and GEANT4 Simulation Codes
Yongkeun Song,Jaeik Shin,Sungho Cho,Seunghoon Yoo,Ilsung Cho,Eunho Kim,Wongyun Jung,Sanghyoun Choi,오경민 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.67 No.1
We investigated the parameter optimization of the ridge filter’s thickness for carbon-ion therapy by using a Monte Carlo simulation. For this study, a ridge filter was designed for the spreadout Bragg peak (SOBP) by considering the relative biological effectiveness (RBE). The thickness, height, and width of the ridge filter were designed by using the FLUKA and the GEANT4 codes, and we analyzed and compared the results of the physical dose distributions for the FLUKA and the GEANT4 codes. The results showed that the minimum width of the groove for the ridge filter should be at least 0.5 cm for an appropriate biological dose. The SOBP sections were 8 cm, 9 cm, and 10 cm, respectively, when the heights were 3.5 cm, 4.0 cm, and 4.5 cm. The height of the ridge filter was designed to be associated with the SOBP width. Also, the results for the FLUKA and the GEANT4 codes showed that the average value of the difference was 3% and that the maximum error was 5%; however, the trends were similar. Therefore, the height and the width of the groove for the ridge filter are important parameters for deciding the length and the plateau of the SOBP.
Sun-Hong Min,Bong Hwan Hong,Ilsung Cho,Chawon Park,Wongyun Jung,Won Taek Hwang,Minho Kim,Kyo Chul Lee,Yong Jin Lee,Sang Moo Lim 대한방사성의약품학회 2019 Journal of radiopharmaceuticals and molecular prob Vol.5 No.2
Radiopharmaceuticals include therapeutic radiopharmaceuticals and diagnostic radiopharmaceuticals. Therapeutic radiopharmaceuticals are administered to the body and ingested at specific organs to detect radiationemitted from the site and to construct an image to diagnose the disease. Diagnostic radiopharmaceuticals areused to treat diseases by killing cells with radiation emitted from radiopharmaceuticals, such as cancer cells,vascular endothelial cells, arthritis, and Alzheimer's disease. The application possibilities of terahertz imagingtechnology for the combination of radiopharmaceuticals and molecular imaging medicine are discussed andexperimental methods are presented. Terahertz imaging is expected to be a powerful technique because ofthe effective piercing feasibility, which enables to perform safe and high resolutive imaging. To investigate theresponse of cell to the terahertz wave, both the pulsed and CW THz wave systems are employed. THz imagingof a rat’s paraffin-embedded epithelial cell with tumor is studied in advance.
간암에 대한 양성자 치료계획에서 셋업 오차와 문지름 인자에 따른 불확실성의 대한 평가
조성호(SungHo Cho),유승훈(SeungHoon Yoo),조일성(IlSung Cho),송용근(YongKeun Song),신재익(JaeIk Shin),김은호(EunHo Kim),정원균(WonGyun Jung) 한국방사선학회 2015 한국방사선학회 학술대회 논문집 Vol.2015 No.춘계
We investigated the effect of set-up error and smearing factor in proton therapy for liver cancer under the artificial movement of isocenter of target volume and adjustment of smearing factor using treatment planning system. The plans were the clinically designed passive scattered treatment plans in Eclipse v9.8 (Varian Medical Systems, Palo Alto, CA) according to RTOG protocol. The artificial movement of isocenter in target volume is from -1 cm to 1cm along to x, y, z axis based on the position of original target volume. Also, smearing factor is adjusted from 0.3 to 1.2. To compare the dose conformity evaluation by set-up error and smearing factor, we used Dmax, Dmin, Dmean and conformity index(CI) and inhomogeneity coefficient(IC). The conformity index and inhomogeneity coefficient of the dose in the target volumes was respectively calculated using the formula (Dmax-Dmin)/Dmean and VDP/Vtarget, where VDPis the volume enclosed by the prescribed isodose surface, i.e., prescription dose and Vtarget is the volume of normalization target. As a results, for the X-axis setup error, there is no difference in value of Dmax and Dmin within ± 0.5cm setup errors, however it was rapidly increased beyond the ±0.5cm setup errors. Y axis and Z axis setup errors also showed a similar trend as X-axis. In the case of smearing factor, there is little difference in Dmax and Dmin when smearing factor has high value, inhomogeneity under no setup errors was 14.05, 11.5 and 8.8 in 0.3, 0.7 and 1.2 smearing factor, respectively. Therefore, smearing factor is very important parameter in particle therapy because it can adjust the dose distribution. 양성자를 이용한 간암치료 시 환자 위치 에러와 문지름 인자에 따른 영향을 분석하기 위해서 치료계획 시스템을 이용하 여 인공적인 타켓볼륨의 중심점 이동과 문지름 인자의 조절에 대한 영향을 분헉하였다. 치료계획은 이클립스 9.8을 이용 하여 스캐터링 방식의 치료 방식으로 설계하였다. 타켓 볼륨의 중심점이동은 X, Y, Z 세 방향으로 -1에서 1cm 까지 이동하였으며, 문지름 인자는 0.3에서 1.2로 이용하였다. 환자위치 에러와 문지름 팩터에 따른 선량 분포를 비교하기 위하여 우리는 Dmax, Dmin, Dmean, Conformity index(CI)와 비균질상수를 사용하였다. 그 결과 X축 환자위치에 따라서 ± 0.5cm 이내에서는 Dmax, Dmin 차이가 나타나지 않았으나 이후에는 큰 차이를 보였다. Y, Z축 에러도 비슷한 분포를 보였다. 문지름 인자의 경우 높은 값을 사용할 때는 Dmax, Dmin 의 차이가 나타나지 않았으나 낮은 값을 사용할 때는 큰 차이를 보였다. 따라서 환자위치 와차와 문지름 인자는 입자치료에서 선량 분포를 조절할 수 있기 때문에 매우 중요한 파라미터이다.