대장에 발생한 샘암종에서 MUC1과 MUC2 점소 발현의 의의

이윤경,이주호,이용,심재영,박정훈,오수섭,박진실,기근홍 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

Background : Mucins possess the unique function of protecting and lubricating the epithelial surface and other important functions such as call growth, direct implication in the fetal development, the epithelial renewal and differentiation, the epithelial integrity, carcinogenesis, immune regulation, cellular adhesion and metastasis. Purpose : This study was done to provide the significance of alteration of MUC1 and MUC2 expression in colorectal adenocarcinoma, A series of 131 colorectal adenocarcinomas including 11 mucinous carcinomas were screened immunohistochemically for their expression of MUCI and MUC2, Materials and mehtods : Of 131 carcinomas, 76 (58,5%) were MUCI positive and 91 (68, 9%) were MUC2 positive, In normal colonic goblet cells, MUCl was not expressed but MUC2 was expressed in cytoplasm, Conclusion There were up-regulation of MUCI and down-regulation of MUC2 in colorectal carcinomas, The frequency of MUC2 positivity according to differentiation was statistically reliable. (p=0.0001)

On the “Dualism” of Civil Procedure Defects and the Way to Cure

Zhu, Fu-Yong 한중법학회 2020 中國法硏究 Vol.41 No.-

민사절차하자는 민사소송절차 정의의 형평성에 대한 일종의 파괴이다. 재판 권과 소권이 함께 작용하는 영역에서 당사자 절차하자 구제 권리의 충분성은 재판권을 보장하는 권리 해결 절차의 결함, 민사소송활동규범의 효과적인 작동 을 촉진하는데 중요하고 필요하다. 많은 요인들에 기초하여, 중국은 '중대한 절 차상의 하자'에 대해 일원화된 입법 규정과 이론 연구로 인해 다수의 법원이 경미한 절차상의 하자에 대해 간단한 처리를 하거나 묵살함으로써 당사자들의 절차적 이익을 크게 감소시킴으로써 당사자들의 의구심과 우려를 해소하기 어 렵다. 이를 위해서는, 절차 하자의 유형을 경미한 절차하자와 중대한 절차하자 로 유형화하고, 서로 다른 구제 경로를 설계하는 것이 필요하다. 대화 교류 체 계를 확립하고, 논쟁범위와 권리구제절차의 운영을 명확히 하여, 그에 따라 절 차무효, 절차유효, 절차자동조정효과를 발생하였다. 중대한 절차하자에 대해서 는 당사자의 의지를 나타내고 법원의 감독을 핵심으로 하는 구제 체계를 확립 하고, 재심사유를 세분화하며, 당사자에게 절차적 선택권을 부여하고, 쌍방향 구속 체계를 확립하고, 절차하자를 강화할 수 있도록 하였다. The defect of civil procedure is a kind of destruction to the balance of justice in civil procedure. In the field of the joint effect of judicial power and litigation right, the adequacy of the party’s procedural defect remedy right is particularly necessary to protect the judicial power to heal procedural defects and promote the effective operation of civil litigation activities. Due to the unitary tendency of the theoretical and practical circles on the types of procedural defects, the “dualization” of procedural defects has only formal significance, it is difficult to resolve the parties’ doubts and dissatisfaction, and it really affects judicial justice and legal authority. Based on whether procedural flaws have a substantial impact on the judgment results, the procedural flaws are classified as “dual” of minor procedural flaws and major procedural flaws, and different treatment paths are designed: For minor procedural flaws, the right of party opposition is established Centered relief mechanism: Establish a dialogue mechanism, clarify the scope of dissent, and the operation of the procedure of right relief, resulting in the effects of invalid procedures, effective procedures, and self-healing procedures. For major procedural defects, the establishment of the party’s will be established and the court will review. The level of supervision is the core relief mechanism, detailing the reasons for returning to retrial, giving the parties the right to choose a procedure, establishing a two-way restraint mechanism, and strengthening supervision and management, so that procedural defects can be cured.

Scanning Tunneling Microscopy Study on the Ultrastable Si(3 3 7)-4×1 Terrace Formed by Annealing Si(5 5 12)-2×1 at an Elevated Temperature

Yong-Zhe Zhu,Hidong Kim,서재명 한국물리학회 2010 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.57 No.1

Selection of templates is important for the study of nanodevice fabrication. In the present study, we show that a wide, flat, and ultrastable Si(3 3 7)-4×1 terrace, combined with the Si(1 1 3)-4×2 facet, is converted from the Si(5 5 12)-2 × 1 surface through accumulated annealing at an elevated temperature. Scanning tunneling microscopy reveals that, in this irreversible surface structural phase transition, the surface has been gradually changed in two steps, step-roughening and atomic diffusion along a one-dimensional row. This (3 3 7)-4×1 surface is expected to be a good template for the growth of one- or two-dimensional nanostructures.

Ancient Chinese Fangzhongshu (Sexual Skills and Methods) Therapy for Premature Ejaculation

Yong Zhu,Qiang Chen,Yuexing Gu,Jin Yue,Qingqi Zeng 대한남성과학회 2016 The World Journal of Men's Health Vol.34 No.3

Premature ejaculation (PE) is a common male sexual dysfunction that can have significant effects on a couple’s relationship. Behavioral therapy and psychotherapy are both safe and effective methods of treating PE. Ancient Chinese fangzhongshu (sexual skills and methods), which reflects a summary of expert experiences in sexology, contains many therapies for sexual dysfunction that are similar to those used in behavioral therapy or psychotherapy. A brief introduction dealing with the latest definitions of PE and treatment strategies drawn from behavioral therapy and psychotherapy is provided. Typical therapies for PE from ancient Chinese fangzhongshu are listed and briefly analyzed in order to define their domain of applicability and instructions for use. Ancient Chinese fangzhongshu contains many effective and safe therapies for PE. It should be incorporated into modern medical practice after critical analysis, and its scientific aspects should be promoted as a way of improving reproductive health, both to benefit individuals affected by PE and to promote traditional Chinese culture. Based on an analysis of the condition of the individual patient, one or multiple therapies guided by fangzhongshu can be expected to have an effect on the patient. Ancient Chinese fangzhongshu is of great value and should to be popularized and applied as a remedy for PE.

论医疗纠纷仲裁困境之化解

Zhu Fu Yong(朱福勇),Yang Wen Wu(杨,文午) 원광대학교 법학연구소(의생명과학법센터) 2018 의생명과학과 법 Vol.19 No.-

중국의 학계에서 의료분쟁에 대하여 중재가 가능한 분쟁으로 인식하고 있지만, 의료분쟁을 강제중재로 할 것인지 임의중재로 할 것인지에 대하여는 여전히 이론연구가 비교적 부족하다. 실무에 있어서, 심천의료분쟁중재원의 임의중재를 보면, 의료분쟁을 중재함에 있어 편리성 면에서는 높은 점수를 줄 수 있지만, 의료분쟁에의 중재적용율 면에 있어서는 여전히 많은 문제점이 나타나고 있다. 즉, 심첨의료분쟁중재원의 임의중재방식의 주요 문제점은 중재해결의 적용율에 있다고 할 수 있다. 이러한 이유로 심천의료분쟁중재원은 임의중재방식을 취하면서 극소수의 의료분쟁에 대하여 당사자간 중재협의를 달성한다. 이처럼 의료분쟁중재방식은 의료분쟁중재의 적용율에 지대한 영향을 준다. 본 연구에서는 임의중재와 강제중재의 장단점을 분석하여 의료기관과 환자간의 중재에 있어 적용율 제고 및 의료기관과 환자 쌍방당사자의 의사자치 등 모든 요소를 종합적으로 고려하여 의료분쟁중재에 있어 임의와 강제의 상호결합된 중재방식을 제안한다. 이러한 연구를 통하여, 오늘날 중국의 다원화된 분쟁해결방식에 있어, 특히 의료분쟁중재제도에 대한 법률적 완비를 위한 문제점과 그 해결방법을 제시하고자 한다. Medical disputes have arbitrability. Most of the academic circles have reached consensus. However, there are big differences in theoretical research on whether medical dispute arbitration should adopt compulsory arbitration or arbitrary arbitration. In practice, the Shenzhen Medical Dispute Arbitration Institute’s trial of medical dispute arbitration under the Arbitrary Arbitration Model confirms that arbitration is an efficient and convenient solution to medical disputes, but it also exposes the shortcomings of the low rate of arbitration for medical disputes in the Shenzhen Medical Disputes Court. The reason for this is Shenzhen. Under the arbitrary arbitration model adopted for arbitration of medical disputes, very few parties to the dispute can reach an arbitration agreement and submit it to arbitration. The arbitration model of medical disputes has a great influence on the application rate of medical dispute arbitration. Therefore, this paper analyzes the advantages and disadvantages of arbitrary arbitration and compulsory arbitration, comprehensively considers increasing the application rate of arbitration in doctor-patient disputes, and taking into account the autonomy of both doctors and patients. It is believed that arbitration of medical disputes should adopt arbitrary and compulsory arbitration models. At present, under the background of the establishment of a diversified dispute resolution mechanism in China, it is advisable to improve the system rules and regulations on medical dispute arbitration as soon as possible, properly handle the connection between medical dispute arbitration and judicial litigation, and improve the supporting measures related to medical dispute arbitration. 医疗纠纷具备可仲裁性在学界大多已取得共识,但在医疗纠纷仲裁应采取强制仲裁还是任意仲裁论题上,理论研究存在较大分歧。实务中,深圳医疗纠纷仲裁院的任意仲裁模式下的医疗纠纷仲裁试点证实仲裁解决医疗纠纷高效便捷,但也暴露了深圳医疗纠纷仲裁院医疗纠纷仲裁适用率低的缺陷,究其原因,在于深圳医疗纠纷仲裁所采取的任意仲裁模式下,极少纠纷主体能够达成仲裁协议并提交仲裁。医疗纠纷仲裁模式对医疗纠纷仲裁适用率的影响至巨,故本文在分析任意仲裁和强制仲裁优缺点,综合考虑提高仲裁在医患纠纷中的适用率以及兼顾医患双方意思自治的基础上,认为医疗纠纷仲裁宜采取任意与强制相结的仲裁模式。当前,在我国构建多元化纠纷解决机制的大背景下,应当顺势尽快完善有关医疗纠纷仲裁的制度规章,妥善处理医疗纠纷仲裁与司法诉讼的衔接,完善与医疗纠纷仲裁相关的配套措施。

뿌리혹선충 방제를 위한 Pasteuria penetrans의 대량증식

Zhu Yong-Zhe,조명래,임춘근,허장현 한국농약과학회 2004 한국농약과학회 학술발표대회 논문집 Vol.- No.-

Growth Mechanism of Isolated Indium Nanowires Formed on Si(5 5 12)-2×1 Templates

Yong-Zhe Zhu,김희동,Jae M. Seo 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.61 No.3

Through self-assembly of In atoms on a reconstructed Si(5 5 12)-2×1 surface, nanowires of a width less than 5 nm have been formed. One specific site of the one-dimensional structure of the substrate turns out to be inert to arriving In atoms so that the self-assembled nanowires are well-isolated from each other, resulting in a high aspect ratio. In addition to such an isolation, keeping the same periodicity as the substrate (<i>i.e.</i>, 5.35 nm) during such self-assembly is another interesting point of the present system. In the present study, the detailed growth mechanism has been disclosed by using scanning tunneling microscopy.

Influence of differential leadership on teachers' professional ethics: an empirical study from Chinese universities

Zhu, Yong-yue,Guo, Min-yu 서울대학교 교육연구소 2021 Asia Pacific Education Review Vol.22 No.3

In Chinese society, the teachers’ professional ethics have been considered important since ancient times and have been widely discussed. This paper aims to explore the mechanism of the infuence of diferential leadership with local cultural adapt‑ ability on college teachers’ professional ethics. A total of 403 valid responses were collected from a questionnaire survey of university teachers in many regions of China, and the data were statistically analysed by SPSS17.0 and AMOS22.0. The results showed that diferential leadership positively infuences college teachers’ professional ethics, and college teachers’ professional identity plays a mediating role between diferential leadership and teachers’ professional ethics. The efect of diferential leadership on college teachers’ professional identity and professional ethics is negatively moderated by the tendency towards collectivism, and it seems to be contrary to the national culture of Chinese, which is high in collectivism, but consistent with the strong will of college teachers and the current workplace characteristics embodied in the sample investigated. It is expected that the research results of this paper can provide theoretical guidance for the construction of teachers’ professional ethics in relevant governments and colleges.

Synthesis and Antitumor Activity of Novel Diaryl Ether Hydroxamic Acids Derivatives as Potential HDAC Inhibitors

Yong Zhu,Tao Lu,Xin Chen,Zeng Wu,Yixuan Zheng,Yadong Chen,Weifang Tang 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.10

A series of diaryl ether hydroxamic acids were synthesized for the first time and evaluated for the HDAC biology and antiproliferative activity. The structures of these new hydroxamic acids derivatives were confirmed by IR, 1H-NMR and mass spectrum. Some of these compounds showed micro molar activity in the HDAC inhibitory assay and against four cancer cell lines.

Synthesis, Characterization and Biological Activities of Novel (E)-3-(1-(Alkyloxyamino)ethylidene)-1-alkylpyrrolidine-2,4-dione Derivatives

Zhu, Zhao-Yong,Shi, Qing-Ming,Han, Bao-Feng,Wang, Xian-Feng,Qiang, Sheng,Yang, Chun-Long Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.9

Twenty novel tetramic acid derivatives (E)-3-(1-(alkyloxyamino)ethylidene)-1-alkylpyrrolidine-2,4-diones were synthesized by the reaction of 3-(1-hydroxyethylidene)pyrrolidine-2,4-diones with O-alkyl hydroxylamines. The title compounds were confirmed by IR, $^1H$ NMR, MS and elemental analysis. The structure of compound 6r was further verified by X-ray diffraction crystallography. The bioassays showed that most of the title compounds exhibited noticeable herbicidal and fungicidal activities.