비부비동 반정성 유두종의 전산화 단층촬영상과 자기공명영상의 분석

배창훈,서영중,이석춘,천승민,백운희,정은채,송시연,김용대 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Background: Computed tomography (CT) is commonly used to evaluate the degree of sinus involvement in case of inverted papilloma (IP). However, CT cannot differentiate tumor from adjacent inflammatory mucosa or retained secretions. By contrast, magnetic resonance imaging (MRI) has been reported to be useful in distinguishing IP from paranasal sinusitis. This study investigated whether preoperative assessment with MRI and CT accurately predict the extent of IP. Materials and methods: CT and MRI were retrospectively reviewed in 9 case of IP. Patients were categorized into staged based on CT and MRI findings according to the staging system proposed by Krouse. The involvement of IP in each sinus was also assessed. Results: Differentiation of IP from inflammatory disease may be more successful in routine case where the inflammatory mucosa has low signal intensity on T1-weighted images and very high signal intensity on T2-weighted images. CT imaging could not differentiate tumor from adjacent inflammatory mucosa or retained secretions. Conclusion: Preoperative MRI of IP can predict the location and extent of the tumor involvement in the paranasal sinuses and sometimes predicts malignant changes.

生物學的 燐除去機轉 및 內部返送率과 SRT가 除去率에 미치는 影響

신응배,이영대,최용수,이정욱 漢陽大學校 環境科學硏究所 1995 環境科學論文集 Vol.16 No.-

본 연구에서는 생물학적 인 제거공정의 혐기-호기-무산소 조건을 단일 반응조내에서 발생토록 고안하여 인제거 실험을 수행하였으며, 고안된 반응기내에서의 인 제거기전을 규명하고 제거효율을 평가하였으며 또한 내부반송율과 SRT 변화에 따른 유기물과 인제거 효율을 평가하였다. 고안된 공정의 종합적 인제거효율 평가를 통해 최적 운전조건을 평가·분석하였다. 실험 결과 유기물 제거율은 Aerobic recycle rate 100%, 200%에서 TOC 95% 이상, BOD와 COD 90% 이상으로 우수하였으며, 인은 Aerobic recycle rate 100%에서 폐수유입 지점 0.2일 때가 최적조건으로 분석·평가되었다. SRT 변화와 T-P, PO₄-P 제거율과의 관계는 SRT 10일에서 94%, 92% 이상으로 높은 제거효율을 나타내었다. In this investigation, phosphorus removal experiment was conducted in a single reactor combining anaerobic-aerobic-anoxic zone. Attempts have been made to delineate phosphorus removal mechanisms and to evaluate the removal efficiency. Also performed in this experiment are the removal characteristics of organic and phosphorus with different internal recycle ratios and varying SRT conditions. In addition, this study evaluates the best operation conditions in terms of phosphorus removal efficiency. The removal efficiencies of TOC, BOD and COD were observed to be higher than 95%, 90% and 90%, respectively with aerobic recycle ratios of 100% and 200%. If is further estimated that the optimal operational conditions for phosphorus removal are observed when the aerobic internal recycle rate is 100% with the wastewater inlet point being 0.2 from the bottom. The percent removal efficiencies are 92% for T-P and 90% for PO₄-P. In case of SRT, higher removal efficiencies are observed with the solid retention time of 10 days than with SRT's of 5 and 20 days. The removal rates observed are 94% for T-P and 92% for PO₄-P with the solid retention time of 10 days.

Phenyl ester계열 강유전성 액정혼합물의 전기광학과 유전적 성질에 관한 연구

김용배,최진욱 건국대학교 기초과학연구소 2000 理學論集 Vol.25 No.-

Phenyl ester계열 강유전성 액정혼합물의 카이랄 스멕틱 C상(SmC* phase), 카이랄 스멕틱 A상(SmA* phase) 그리고 카이랄 네마틱상(N* phase)들에서의 전기광학과 유전적 성질을 연구하였다. 강유전성 액정혼합물(KU-1001)의 SmA* 상 범위에서 장 유도효과에 의한 경전효과 때문에 작은 경사각이 관찰되었다. KU-1001 혼합물의 전기광학 응답시간은 상온에서 약 50㎲이고, SmC*-SmA* 상전이 근처에서는 높은 전장에서 2㎲보다 빠르게 나타내었다. 또한 N* 상에서는 인가 전기장에 무관하며 10㎲의 응답시간을 나타내었다. 유전율 이방성은 주파수와 온도에 크게 의존하며, SmC* 상과 SmA* 상에서는 음의 값을 나타내었고, N* 상에서는 0에 접근하였다. 이 현상은 N* 상에서의 변전효과 때문에 일어난다. KU-1002 혼합물은 유전 이방성의 값이 음인 강유전성 액정물질이 높은 인가 전장영역에서 관찰되는 변칙적인 스위칭 거동을 하였다. A phenyl ester type of ferroelectric liquid crystal mixtures have discussed dielectric and electro-optic properties for chiral smectic C(SmC*), chiral smectic A(SmA*) and chiral nematic (N*) phases. The tilt angle exhibits a small tail in the SmA* phase due to field induced effect, which is an electroclinic effect. KU-1001 mixture shows a optical response time of about 50㎲ at room temperature and low electric field down to 2㎲ for high electric field close to the SmC*_SmA* phase transition. In the N* phase, the value of the optical response time is order of 10㎲ and almost independent of the applied field. The dielectric anisotropy Δε has been negative value in the SmC* and SmA* phases which strongly depends on frequency and temperature. It approaches zero in the N* phase. This is the favorable condition sought in order to exploit flexoelectric effect in the N* phase. Anomalous switching behaviour of FLC materials with negative dielectric anisotropy have been reported. KU-1002 mixture shows a minimum in response time at a sufficiently high field.

의료보험 구강요양급여비에 관한 조사연구

장용형,백대일,김종배,문혁수 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.1

The government of our country has started Medical insurance policy, one of the social security systems. However, statistical date of medical insurance benefits is not much. Especially dental data is insufficient and irrational. In order to get reliable data which offer a valuable suggestion to direction of health care insurance system, the author studied the amount of total care benefits at 1998 which revealed by the survey and analysis of medical statistic index. And it divided into medical insurance, dental insurance, korean-medicine insurance benefits. The dental insurance benefits divided into dental survey and dental disease care benefits again. The dental disease care expenses is composed of dental caries and its advanced disease care expenses, periodontal disease care expenses, other dental disease care expenses. Its date is revealed by the survey and investigation of the demands of 12 dental clinic in 1998. The major findings of the analysis are summarized as follows; 1. In Medical insurance system, the total insurance benefits(include pharmaceutical expenses) was ￦10,115,324,330,000 and the total medical insurance benefits was ￦9,730,793,383,000. The Total dental insurance benefits was ￦647,033,656,600. The ratio of total medical insurance benefits to the total insurance benefit was the 96.20%, and the ratio of dental insurance benefits to the total medical insurance benefits was the 6.65% 2. The individual dental insurance benefits was ￦13,935.7. Among the individual dental insurance benefits, the proportion of the individual dental surveying expenses was 34.62% and individual dental disease care expenses was 46.04% 3. The most part of the dental insurance benefits was dental caries and its advanced disease care expenses and periodontal disease care expenses. 4. Among the dental caries its advanced disease care benefits, the percentage of tertiary preventive expenses was 40.52%. 5. To reduce the expenditure of finance of the health care insurance system and to poromote national oral health, it is necessary to increase the primary and the secondary preventive expenses. 6. Oral diagnostic expenses, oral health care planning expenses and preventive expenses for oral disease, prosthetic expenses in medical insurance benefits didn's supplied. 7. It should be make the legal basis of supply for oral diagnostic expenses and oral health care expenses. 8. Statistic data of the dental insurance should be more rationalize.

부비강미분화암종 3예

김용대,곽동석,이형중,신재흔,배창훈,송시연 영남대학교 의과대학 2004 Yeungnam University Journal of Medicine Vol.21 No.1

Sinonasal Undifferentiated Carcinoma (SNUC) is a very rare, highly aggressive malignant tumor of the nasal cavity and paranasal sinuses. SNUC tends to present with advanced-stage disease, often with intracranial invasion. It requires an aggressive multimodality therapy that includes surgical resection. A cure rate of less than 20% is generally reported in the literature, with most patients dying within 1 year of onset of the disease. Three patients diagnosed as SNUC were treated at the Yeungnam University Medical Center between the years 2000 and 2003 were analyzed retrospectively. All patients presented with the disease very advanced. The three cases were given chemotherapy or chemotherapy with radiotherapy. Two patients died of the disease, surviving only 6 and 11 months following treatment, respectively. We did a follow-up on just the one remaining case with incomplete controlled disease for 27 months. The overall prognosis of SNUC is very poor. We consider that more intensive multimodality therapies are recommended for all patients with SNUC.

무전해 Ni-Cu-P 폐 도금액의 재사용에 관한 연구(Ⅱ)

오이식,배영한 釜慶大學校 2002 釜慶大學校 論文集 Vol.7 No.-

Reusing of electroless Ni-Cu-P waste solution was investigated in the plating time, plating rate and deposit. It is difficult for initial solution with 55% waste solution additive at batch type to reuse the waste solution. Initial solution with 60% waste solution additive at continuous type is a task of great difficulty to reuse of waste solution. Component change of nickel-copper for electroless deposition was increased by deposited inferiority and with decrease of plating time.

전자충돌이 Mo/Pd(100)계의 저에너지 전자회절 pattern에 미치는 영향

김홍직,신용상,노창완,진원배 東亞大學校附設基礎科學硏究所 1999 基礎科學硏究論文集 Vol.16 No.1

Mo 재질의 평판 위에 Pd(100) 결정시료를 놓고 3 keV의 Ar 이온선으로 동시에 bombardment 시킬때, Mo 원자들이 Pd(100)상에 증착 되는 현상을 발견하였다. 이렇게 증착된 Mo 원자들의 덮임율과 흡착구조, 그리고 이들 흡착구조들이 전자선 충격에 의해 받는 영향을 LEED와 AES를 이용하여 조사하였다. 흡착된 Mo 원자의 덮임율이 0.1일 때, Mo/Pd(100)로부터 어닐링(annealing) 온도 300℃와 500℃이상에서 각각 c(4×2)와 c(4×2)3+(√5×√5)R arctan 1/2 pattern이 관측되었다. 이들 pattern중 안정된 흡착구조인 (√5×√5)R arctan 1/2 는 3 keV의 전자선 충격에 의한 영향이 매우 적으나 불안정한 흡착구조인 c(4×2)는 민감하게 영향을 받고 있음을 알 수 있었다. Pd(100) sample was mounted on Mo plate in ultra high vacuum chamber, and both of Pd(100) sample and Mo plate were bombarded by 3 keV Ar ion beam. It was found that this bombardment gave rise to deposition of Mo atoms on Pd(100). The coverage and overlayer structure of Mo adatom, and an effect of the electron impact on this Mo/Pd(100) system were investigated by LEED and AES. When the coverage of Mo was 0.1, c(4×2) and c(4×2)+(√5×√5)R arctan 1/2 pattern were observed from this system at annealing temperature of 300℃ and above 500℃, respectively. When irradiating 3 keV electron beam on these surface structures, the c(4×2) corresponding to unstable overlayer structure from both LEED patterns was sensitively influenced but the (√5×√5)R arctan 1/2 not sensitively by 3 keV electron impact.

P型 α-多孔 SiC. 的光致發光光潽硏究

이기환,김영유,두영뢰,우배매 公州大學校 基礎科學硏究所 1998 自然科學硏究 Vol.7 No.-

The photoluminescence (PL) spectra from p-type a-porous silicon carbides prepared under UV photo-assisted process and under dark-current condition are investigated in detail. Emission bands with peak energies of 2.35, 2.50, 2.70, and 3.43 are resolved. The PL stability in tune and the PL difference arising from different tuning excitation energies are studied. It is found that the PL spectra of the a-porous silicon carbide depend strongly on the preparation conditions for electrochemical etching. The PL spectrum of the sample prepared under photo-assisted process has an enhancement on the lower-energy side of the emission; on the contray, another one under dark-current condition has an enhancement at the higher energy side, and the former stability is better than the latter one, and the latter PL intensity decreases with the increase of the time in the air. The reasons about these differences are discussed.

주의력 결핍-과잉행동장애아동의 주의력 수준이 CPT와 WCST수행에 미치는 효과

이현아,박형배,배대석,백용매 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 본 연구는 주의력 결핍-과잉행동장애 아동과 정상아동의 주의력 수준이 CPT와 WCST수행에 미치는 영향을 검토하여 ADHD아동의 특징적인 인지결함을 알아보고자 하였다. 방 법 : 1999년 12월부터 2000년 4월까지 Y대학 의료원 소아정신과를 방문하여 ADHD로 진단된 아동들을 K-ABC의 하위검사인 수회생검사를 실시하여 주의력 낮은 집단(N=18),중간집단(N=18), 높은 집단 (N=18)로 분류하였고 주의력 수준에 따라 분류된 ADHD집단에게 지능검사와 CPT및 WCST를 실시하였다. 또한 정상아동에게도 수회생 검사를 통해 ADHD아동중 주의력 수준이 높은 집단과 동일한 주의력을 가진 아동을 선정한 후 이들에게도 ADHD아동과 동일한 검사를 실시하여 수행을 비교하였다. 결 과 : 본 연구의 결과를 요약하면 다음과 같다. CPT하위검사중 누락오류와 오경보 오류에서 ADHD집단과 정상집단간에는 의미있는 차이가 나타나지 않았고, ADHD집단내에서도 주의력의 수준에 따른 차이는 없었다. 그러나 WCST수행의 경우 ADHD의 각 하위집단간에 주의력 수준에 따른 차이는 없었으나, 정상집단에 비해서는 ADHD집단의 수행이 저조한 것으로 나타났다. 결 론 : ADHD아동의 특징적인 인지결함은 단순한 주의력의 결함이 아니라 자극이 선택되어 실행에 이르기까지의 과정인 정보처리과정 중 주의력의 감독, 자기조절, 억제과정과 같은 보다 고차적인 인지기능인실행기능에 문제가 있음을 확인할 수 있었다. 따라서 ADHD아동의 치료를 위해서도 단순한 주의력 결핍의 개선보다는 문제해결능력과 계획력, 충동성 같은 인지행동을 변화시키기 위한 치료전략이 필요한 것으로 생각된다. Objectives : The purpose of this study was to investigate the effects of attention level in normal children and Attention Deficit Hyperactivity Disorder(ADHD) children on Continuous Performance Test(CPT) and Wisconsin Card Sorting Test(WCST) performances. Methods : For this survey, the ADHD children were classified into low, medium, and high attention groups according to the attention level. Normal Group of Children, Chosen for their same attention level as that of high attention level group among ADHD groups, was compared in their CPT and WCST performances with ADHD groups. Results : The findings of the study were as follows. 1) the ADHD groups distinguished by their attention level ; in other words, the low, medium, and high attention level groups ; showed no differences in CPT performances. This means the unique cognitive deficit of ADHD group is not the character of attention capacity limit. 2) the ADHD group showed lower performances on WCST than the normal group, regardless of attention level. Conclusion : ADHD group have a deficit in the ability or regulation stategy, adaptability of attention, and non appropriate response, which are needed for efficient division of prescribed information processing. These results imply that the cognitive deficit of ADHD is a character which shows that the execution deficit, which is a higher cognitive function, is a cognitive deficit of ADHD group, rather than simple attention deficit.

두경부 편팡상피세포암 세포주에서 세포주기 조절인자의 활성 및 이상:후두편평상피세포암에서 종양억제 유전자 CDKN2 유전자 발현이상

송시연,한태희,배창훈,김용대,송계원 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Background: Cyclin-dependent kinase (CDK) inhibitors are family of molecules that regulate the cell cycle. The CDKN2, a CDK4 inhibitor, also called p16, has been implicated in human tumorigenesis. The CDKN2, inhibits the cyclin/CDK complexes which regulate the transition from G1 to S phase of cell cycle. There is a previous repot that homozygous deletion of CDKN2 region on chromosome 9p21 was detected frequently in astrocytoma, glioma and osteosarcoma, less frequently in lung cancer, leukemia and ovarian cancer, but not detected in colon cancer and neuroblastoma. However, little is known about the relationship between CDKN2 and laryngeal cancer. Therefore this study was initiated to investigate the role of CDKN2 in human laryngeal squamous cell carcinoma development. Materials and methods: We used 5 human laryngeal carcinoma cell lines whether they have deletion or losses of CDKN2 gene expression by DNA-PCR or RT-PCR, respectively. We examined 8 fresh frozen human laryngeal cancer tissues to detect the loss of heterozygosity(LOH) of CDKN2 PCR was performed by using micosatellite markers of short arm of human chromosome 9 (D9S126, D9S144, D9S156, D9S161, D9S162,D9S166, D9S166, D9S171,D9S200 and D9SIFNA).For informative cases, allelic loss was scored of the signal of one allele was significantly decreased in tumor DNA when compared to eh same allele in normal DNA. Results: the CDKN2 DNA deletion was observed in 3 cell lines. The CDKN2 mRNA expression was observed in only one cell line, which was very weak. LOH was detected in 7 cases(87.5%) Conclusion: These results suggest that CDKN2 plays a role in the carcinogenesis of human laryngeal squamous cell carcinoma