항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

구강내 악성흑색종에 대한 임상연구

김욱규,허진호,황대석,김용덕,신상훈,김종렬,정인교 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.23

The prognosis of oral malignant melanoma is poor compared with cutaneous melanoma. It may be related to the difficulty of wide enough resection, the early hematogenous matastases, higher stage at initial diagnosis, tendency to growth vertically. In the view of histological differences between oral mucosa and skin, it is impossible use Clark’s and Breslow’s classifications for prognosis. The great problem is that there is still no consensus on the treatment due to rarity. Because data collection from case reports is considered to be the best source of information and should be pooled to anlalyze key determinants of outcome, We reported on 6 cases of primary malignant melanoma of the oral cavity which were diagnosed and treated in Pusan National University Hospital recently and reviewed the literature. Immunohistochemical study on S100 Protein, GP 100 (HMB-45) with biopsy was usable to confirm the melanoma. Neck dissection including wide excision is recommended if lymph node involvement is suspected. Additionally, adjuvant chemotherapy could be supporting therapy.

Stage II B형 골육종에 대한 술전 항암화학요법 및 수술적 치료 결과

김정만,우영균,김형민,김훈교,이승구,강용구 가톨릭중앙의료원 가톨릭암센터 1997 암심포지움 Vol.- No.1

Recent advances in imaging techniques, surgery and combination anti-cancer chemotherapy have brought high survial rates in osteosarcoma. To investigate the survival rate, local recurrence and complications in treatment, we analysed 25 osteosarcoma cases who had been treated with preoperative neo-adjuvant chemotherapy, surgery and post operative chemotherapy at Department of Orthopedic Surgery, Catholic University. From May 1988 to April 1995, 42 cases of stage IIB osteosarcoma were admitted in Department of Orthopedic surgery. Among them, 17 cases who didn't follow our treatment guidance were excluded in this study. The average age were 19 years. There were 21 males and 4 females. The involved sites were 4 humerus, 10 femur, 10 tibia and 1 talus. Eleven cases had received intra-arterial cisplatin and intravenous adriamycin chemotherapy, and 7 T-10 protocol and 7 intravenous ifosfamide, ADR, methotrexate, cisplatin. Among twenty-three cases were treated with limb salvage surgery, and 2 amputation. The average follow-up was 35 months(3-82). There were 14 cases of continuous disease free, 9 cases of died of desease, 1 case of alive with disease, and 1 case of no evidence of disease at final follow-up. There were three cases of local recurrence at 6,8 and 12 months after operation. The Estimated kaplan-Meier's 5 year survival rates for all, ADR-cisloatin group, T-10 protocol group, and ifosfamide regimen group were 66%, 73%, 44% and 72%, respectively.

Casein micelle의 구조와 성질

김영교 高麗大學校自然資源科學硏究所 1993 自然資源科學硏究 Vol.1 No.-

This review is an attempt to bring what is known about casein micelles together into a coherent sum-mary. The casein micelles of milk are the colloidal particles of casein camplex, and dispersed in milk with forming a colloidal phase. The nature of the casein micelles has been investignated in many labo-ratories, and with good reason, for this colloidal complex is the essence of many problems encoun-tered in dairy technology. The attempt is, therefore, made to summarize the camposition of casein mice-lles, some properties of individual caseins and calloidal-calcium phosphate, and inter-action between casein micelle components which is the forces res-ponsible for the stability of the casein micelles. On the other hand, many models for casein micelles. On the other hand, many models for casein micelle structure are proposed, however, some of the ear-lier models and theories no longer appear workable. In this review, a few models are selectively intro-duced and discussed.

TiN Ion-Plating이 교정용 브라켓의 접착강도에 미치는 영향

김석용,권오원,김교한 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.1

TiN ion-plating이 교정용 브라켓의 접착강도에 미치는 영향을 알아보기 위하여 세 종류의 서로 다른 기저면형태를 가지는 스테인레스 스틸제의 브라켓을 선택하고, TiN ion-plating 된 브라켓과 ion-plating 되지 않은 브라켓을 치아에 접착시켰을 때 초기 및 장기접착강도, 접착계면의 주사전자현미경 관찰, 파단면의 주사전자현미경 관찰을 비교 분석하여 다음과 같은 결론을 얻었다. · TiN ion-plating을 하지 않은 경우 24시간 후의 접착강도는 Micro-Loc형이 5.89±1.77MPa, Foil Mesh형이 4.27±1.12MPa, Undercut형이 2.64±0.58MPa로 Micro-Loc형이 가장 높았고, 그 다음이 Foil Mesh형 그리고 Undercut형의 순으로 나타났다(P<0.05). · TiN ion-plating시 24시간 후의 접착강도는 Micro-Loc형이 6.26±1.51 MPa, Foil Mesh형이 7.45±2.01MPa, Undercut형이 2.93±0.84MPa로 ion-plating 하지 않은 경우와 달리 Foil Mesh형이 Micro-Loc형보다 오히려 높게 나타났고, Undercut형이 역시 가장 낮은 접착강도를 나타내었다(P<0.05). Ion-plating 유무에 따른 24시간 후의 접착강도는 3가지형 모두에서 ion-plating시 증가하였으나 Foil Mesh형에서만 유의한 증가가 있었다(P<0.001). · 장기침적시 ion-plating의 유무에 관계없이 전반적으로 초기(1일)접착강도보다 증가하였으며 접착력의 안정성을 나타내었다. · 접착계면의 주사전자현미경 관찰 결과 브라켓 기저면의 형태나 ion-plating 유무에 관계 없이 레진이 브라켓 기저면으로 잘 퍼져 들어가 브라켓과 치아와의 사이에 견고한 접착면을 나타내었고, 장기침적의 경우도 같은 양상을 나타내었다. · 파단면의 주사전자현미경 관찰에서는 다양한 파괴양상이 나타났다. This study was conducted to see the effect of TiN ion-plating on the bond strength of orthodontic bracket. Three stainless-steel brackets with different base types were chosen; when TiN ion-plated brackets and non ion-plated brackets were bonded to the teeth, initial and long-term bond strength were measures. The observations of bonding surface and failure sites through the scanning electron microscope were analysed and compared. The summary of this study was as follows: · When TiN ion-plating was not applied, the Micro-Loc type was the highest in bond strength after 24 hours as 5.89±1.77MPa, followed by 4.27±1.12MPa for Foil Mesh type and 2.64±0.58MPa for Undercut type(P<0.05). ·Under TiN ion-plating, the bond strength after 24 hours showed: Micro-Loc type 6.26±1.51MPa, Foil Mesh type 7.46±2.01MPa, Undercut type 2.93±0.84MPa. Unlike in the case of non ion-plating, Foil Mesh type showed a higher strength than Micro-Loc type, with Undercut type still showing the lowest bond strength(P<0.05). The bond strength, after 24 hours, increased in case of ion-plated in all 3 types, but a significant increase was shown only in Foil Mesh type(P<0.001). · Under a long-term immersion, regardless of ion or non ion-plating, bond strength in general increased over the initial bond strength(one day), with more stability. · Through scanning electron microscopic observation of bonding surface, it was found that, regardless of the bracket base type or the application of ion-plating, the resin was thoroughly spreaded into bracket base to form a solid bonding surface between the bracket and the tooth. This was also true in case of a long-term immersion. · The scanning electron microscopic observation of failure sites revealed diverse failure patterns.

국내 공공부문 설계시공일괄입찰방식의 낙찰자 선정방법 개선에 관한 연구

김만철,서용철,구교진,현창택 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

Design-Build is considered as the project delivery system to manage construction process more efficiently than design-bid-build. So Korea government has encouraged Design-Build in public sector. But single selection method of weighted criteria doesn't provide the greatest value to owner. Therefore, there is a need to improve selection method to meet owner's needs and project characteristics. This study proposes four types of selection method. Each of selection method is focused on price, qualification, time. The use of these selection methods enable owner to provide the greatest value.

Liver-Fluke의 寄生이 山羊의 繁殖障害와 乳肉生産에 미치는 影響에 관한 硏究

金敎準,田暢淇,金容國,金相根 충남대학교 농업과학연구소 1979 農業技術硏究報告 Vol.6 No.1

These studies were carried out to investigate the effects of liver-fluke infection on the reproductive disorder and milk and meat production in Korea Native Goat. A survey of infected goat in Chungnam district was conducted with 474 head by interdermal reaction and also a clinical observation was founded. A experiment was carried out to determine the effects of liver fluke extract on the reproductive disorder by subcutaneous injection and milk and meat yield were measured from treated goats. The results obtained were summarized as follows. 1. The rate of positive goat was 71.3% among the surveyed goat and the highest rate was appeared at 3∼4 years old goats as 81.4%. 2. The treated goats lost condition and failed to thrive, and became progressive weaker. 3. In hemogram observation, the rate of eosinophil leucocyte was increased significantly by extract treated. 4. It was appeared the pathogenic signs such symptoms poisoning liver function disturbance and reproductive disorder from treated goats with liver fluke extract. 5. In milking goat the milk yield droped significantly and fattening goat did not fatten. 6. The gross income value per capita was lower from infected goat and it was analysed more sensitivly in net income value.

Vital Bleaching이 법랑질 접착에 미치는 영향

김종해,권태엽,권용훈,김교한 大韓齒科器材學會 2003 대한치과재료학회지 Vol.30 No.4

The objective of this in vitro study was to evaluate the effect of bleaching on the composite to enamel bond and surface hardness change. Extracted human premolars were treated with 35% hydrogen peroxide (Sigma Chemical Co, USA) for 1hr/day at 0, 3, 6 and 9 day respectively. For the obsrvation of surface mophology alteration due to the treatment with hydogen peroxide, a SEM (S-4300, Hitachi, Japan) was used. The specimens were ground flat using serial SiC papers and ground ultra-finely using a 0.1㎛ diamond compound paste. To measure the microhardness, five non-carious premolars were ground using SiC papers and ten indentations were made on the surfacd with Vickers hardness tester (FM-7 FUTURE-TEC Inc., Japan). To evaluate shear bond strength, composite was bonded with One Up Bond-F, Prompt L-Pop, AQ Bond to the non-bleached and bleached enamel surface of sixty non-carious premolars. The bonding procedure is postponed for 1 week after bleaching and shear bond strength was measured. All specimens with a SEM. Bleaching created some enamel porosity but the teeth showed nonsignificant morphological chonge as bleaching time increased from SEM analysis. Most microhardness change occured on the first day of bleaching. Bleaching with 35% hydrogen peroxide did not result in significant change in the shear bond strength of composite resin to enamel. In the shear bond strength test, the fractured surfaces of specimens showed mixed adhesive and cohesive failure behavior.

공공 건설공사 중 부도에 따른 공사지연 방지 방안 : Focused on Apartment Houses

김백용,조영준,구교진,현창택 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

The purpose of this study was to reduce the factor of construction delay in the owner's aspect by analyzing the actual condition of field supervision positively such as construction delay sample and process at the distressed company's construction site. As we analyze the examples of construction delay and reopening into various types, to minimize construction delay after the dishonor of a contractor we propose "Cooperation and reliance fixing between the contract parties through the improvement of order method, Contracting system and Construction management system".

약물치료에 순응도가 낮은 마취고위험군의 전립선비대증에서 TUNA의 임상적 경험

성용완,최은용,김덕교 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.10