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      • SCIESCOPUSKCI등재

        Amino acid, fatty acid, and carbohydrate metabolomic profiles with ginsenoside-induced insecticidal efficacy against Ostrinia furnacalis (Guenee)

        Liu, Shuangli,Wang, Xiaohui,Zhang, Rui,Song, Mingjie,Zhang, Nanqi,Li, Wanying,Wang, Yingping,Xu, Yonghua,Zhang, Lianxue The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.4

        Background: Previous studies have shown the insecticidal efficacy of ginsenosides. In the present study, we aimed to investigate the metabolic mechanism related to the inhibitory effect of panaxadiol saponins (PDSs) against the Asian corn borer Ostrinia furnacalis (Guenee). Methods: Third instar larvae of O. furnacalis were fed normal diets with different concentrations of PDSs for 4 days. The consumption index, relative growth rate, approximate digestibility, and conversion of ingested and digested food were recorded. A targeted gas chromatographye-mass spectrometry assay was performed to detect the profiles of amino acids, fatty acids, and carbohydrates in larvae of O. furnacalis. In addition, the activity of detoxification-related enzymes was determined. Results and Conclusions: PDSs decreased the consumption index, relative growth rate, approximate digestibility, and conversion of ingested and digested food in the 3rd instar larvae of O. furnacalis in a dose-dependent manner. PDSs decreased 15 free amino acids, 16 free fatty acids, and 5 carbohydrates and increased the levels of palmitoleic acid, palmitic acid, and 9-octadecenoic acid in the 3rd instar larvae. The activity of detoxification-related enzymes, such as acetylcholinesterase, glutathione S-transferase, cytochrome P450, carboxylesterase, trehalase, acid phosphatase, and alkaline phosphatase, was reduced in a dose-dependent manner in the 3rd instar larvae exposed to PDSs. These data confirmed the inhibitory effect of PDSs against growth, food utilization, and detoxification in the 3rd instar larvae of O. furnacalis and the potential for using PDSs as an efficient tool for insect pest management for O. furnacalis larvae.

      • KCI등재

        Amino acid, fatty acid, and carbohydrate metabolomic profi les with ginsenoside-induced insecticidal effi cacy against Ostrinia furnacalis (Guenee)

        Shuangli Liu,Xiaohui Wang,Rui Zhang,Mingjie Song,Nanqi Zhang,Wanying Li,Yingping Wang,Yonghua Xu,Lianxue Zhang 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.4

        Background: Previous studies have shown the insecticidal efficacy of ginsenosides. In the present study,we aimed to investigate the metabolic mechanism related to the inhibitory effect of panaxadiol saponins(PDSs) against the Asian corn borer Ostrinia furnacalis (Guenee). Methods: Third instar larvae of O. furnacalis were fed normal diets with different concentrations of PDSsfor 4 days. The consumption index, relative growth rate, approximate digestibility, and conversion ofingested and digested food were recorded. A targeted gas chromatographyemass spectrometry assaywas performed to detect the profiles of amino acids, fatty acids, and carbohydrates in larvae ofO. furnacalis. In addition, the activity of detoxification-related enzymes was determined. Results and Conclusions: PDSs decreased the consumption index, relative growth rate, approximate digestibility,and conversion of ingested and digested food in the 3rd instar larvae of O. furnacalis in a dosedependentmanner. PDSs decreased 15 free amino acids, 16 free fatty acids, and 5 carbohydrates andincreased the levels of palmitoleic acid, palmitic acid, and 9-octadecenoic acid in the 3rd instar larvae. The activity of detoxification-related enzymes, such as acetylcholinesterase, glutathione S-transferase,cytochrome P450, carboxylesterase, trehalase, acid phosphatase, and alkaline phosphatase, was reducedin a dose-dependent manner in the 3rd instar larvae exposed to PDSs. These data confirmed theinhibitory effect of PDSs against growth, food utilization, and detoxification in the 3rd instar larvae ofO. furnacalis and the potential for using PDSs as an efficient tool for insect pest management forO. furnacalis larvae.

      • A Study of Leveraging Memory Level Parallelism for DRAM System on Multi-Core Architecture

        Yuxuan Wang,Yingping Zhang,Xiaotian Zhang,Jian Yin,Licheng Chen 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.4

        DRAM system has been more and more critical on modern multi-core architecture where the Moore’s law has been made effect on increasing the number of cores integrated in a processor chip. The performance of DRAM system is usually measured in term of bandwidth and latency, which are regarded as inherently depending on Row Buffer Hit Rate (RBHR) according to previous studies. In this paper, we find that Memory Level Parallelism (MLP) exhibits a stronger correlation with the performance of DRAM system on multi-core/many-core architecture than RBHR, and promoting MLP significantly improves DRAM system performance. In order to exploit the MLP, we have evaluated various approaches including multi-bank, multi-row-buffers, multi-memory-controllers and the obsolete Virtual Channel Memory (VCM). The experimental results show that VCM is a better alternative to traditional DRAM chip on multicore/many-core architecture than the other three approaches because VCM has almost all the advantages of the others: 1) it can improve homogeneous workloads’ IPC by 2.21X on a 16-core system with 32 virtual channels due to leveraging unexploited MLP. 2) It can also promote Quality-of-Service (QoS) of DRAM system by removing unfairness while memory controllers serve memory requests. 3) It can save energy and has low area costs. Unfortunately, VCM, which was proposed in the late 1990s, faded away before multi-core/manycore became dominated. Therefore, we suggest memory chip vendors reconsider the VCM technology for multi-core architecture.

      • KCI등재

        Oxygen Uptake Rate Controlling Strategy Balanced with Oxygen Supply for Improving Coenzyme Q10 Production by Rhodobacter sphaeroides

        Ze-Jian Wang,Xingzi Zhang,Ping Wang,Zhiwei Sui,Meijin Guo,Siliang Zhang,Yingping Zhuang 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.3

        The effects of different oxygen uptake rates (OUR) on the physiological metabolism of Rhodobacter sphaeroides were investigated systematically in 50 L fermenters due to the significant influence on industrial coenzyme Q10 production under oxygen supply limitation. Meanwhile, the seriously decreased oxygen transfer rate caused by the increased broth viscosity was successfully prevented with OUR-directed continuous ammonium sulfate feeding in the late fermentation phase. The statistical analysis results showed that controlling OUR constantly at 45 ± 2.2 mmol/L/h by the oxygen supply level adjustment and the continuous ammonium sulfate feeding could greatly enhance Q10 production. This OUR-Stat controlling strategy successfully achieved the maximal coenzyme Q10 production (2584 ± 82 mg/L), which was 15.4% higher than that of the control. The highest specific CoQ10 content was 25.9 mg/(g DCW)), and the yield of CoQ10 to glucose consumption was up to 19.37 mg/g. These results demonstrated that the optimal OUR-Stat controlling strategy would be effective and economical for improving the industrial CoQ10 production.

      • KCI등재

        Optimization of photocatalytic degradation of Cefradine using a “green” goethite/H2O2 system

        Ruiping Li,Shaoming Hong,Xiaocong Li,Bin Zhang,Hailin Tian,Yingping Huang 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.78 No.-

        An environmental friendly photocatalyst, goethite in the presence of H2O2, was used to remove Cefradinefrom aqueous solution. Four factors were examined using Box–Behnken Design and results wereanalyzed by response surface method. H2O2 concentration had the largest effect on Cefradine removaland the optimal reaction conditions were: H2O2 concentration, 4 mmol/L; solution pH, 5; goethitedosage, 1.2 g/L and illumination time, 9 h. Experimental data on Cefradine removal under optimalconditions closely coincided with model predictions, validating the model. Hydroxyl radicals ( OH) andsuperoxide anion were involved in the Cefradine photodegradation process and that OH makes thelarger contribution.

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