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Association Between the Ku70-1310C/G Promoter Polymorphism and Cancer Risk: a Meta-analysis
Xu, Lu,Ju, Xiao-Bing,Li, Pu,Wang, Jue,Shi, Zhu-Mei,Zheng, Ming-Jie,Xue, Dan-Dan,Xu, Yan-Jie,Yin, Yong-Mei,Wang, Shui,You, Yong-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2
Ku70 plays an important role in DNA double-strand break repair. Studies revealing conflicting results on the role of the Ku70-1310C/G promoter polymorphism on cancer risk led us to perform a meta-analysis to investigate this relationship. Ten case-control studies with 2566 cases and 3058 controls were identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of associations. The overall results suggested no association between the Ku70-1310C/G promoter polymorphism and total cancer risk. However, on stratified analysis, significantly increased risks were observed among the Asian population (GG vs. CC: OR=1.50, 95%CI=1.10-2.06; GG vs. CC/CG: OR=1.47, 95%CI=1.07-2.01) and population-based case-control studies (GG vs. CC: OR=1.57, 95%CI=1.12-2.22; CG vs. CC: OR=1.35, 95%CI=1.11-1.64; CG/GG vs. CC: OR=1.37, 95%CI=1.14-1.65). Additionally, variant genotypes were associated with a significantly increased breast cancer risk (GG vs. CC: OR=1.80, 95%CI=1.26-2.56; GG vs. CC/CG: OR=1.40, 95%CI=1.01-1.95).
Chen, Kang-Yin,Rha, Seung-Woon,Li, Yong-Jian,Poddar, Kanhaiya L,Jin, Zhe,Minami, Yoshiyasu,Wang, Lin,Kim, Eung Ju,Park, Chang Gyu,Seo, Hong Seog,Oh, Dong Joo,Jeong, Myung Ho,Ahn, Young Keun,Hong, Taek American Heart Association, etc.] 2009 CIRCULATION - Vol.119 No.25
<P>BACKGROUND: Whether triple antiplatelet therapy is superior or similar to dual antiplatelet therapy in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention in the era of drug-eluting stents remains unclear. METHODS AND RESULTS: A total of 4203 ST-segment elevation myocardial infarction patients who underwent primary percutaneous coronary intervention with drug-eluting stents were analyzed retrospectively in the Korean Acute Myocardial Infarction Registry (KAMIR). They received either dual (aspirin plus clopidogrel; dual group; n=2569) or triple (aspirin plus clopidogrel plus cilostazol; triple group; n=1634) antiplatelet therapy. The triple group received additional cilostazol at least for 1 month. Various major adverse cardiac events at 8 months were compared between these 2 groups. Compared with the dual group, the triple group had a similar incidence of major bleeding events but a significantly lower incidence of in-hospital mortality. Clinical outcomes at 8 months showed that the triple group had significantly lower incidences of cardiac death (adjusted odds ratio, 0.52; 95% confidence interval, 0.32 to 0.84; P=0.007), total death (adjusted odds ratio, 0.60; 95% confidence interval, 0.41 to 0.89; P=0.010), and total major adverse cardiac events (adjusted odds ratio, 0.74; 95% confidence interval, 0.58 to 0.95; P=0.019) than the dual group. Subgroup analysis showed that older (>65 years old), female, and diabetic patients got more benefits from triple antiplatelet therapy than their counterparts who received dual antiplatelet therapy. CONCLUSIONS: Triple antiplatelet therapy seems to be superior to dual antiplatelet therapy in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention with drug-eluting stents. These results may provide the rationale for the use of triple antiplatelet therapy in these patients.</P>
Methylome-wide Association Study of Patients with Recent-onset Psychosis
Yan-Hong Piao,Yin Cui,Fatima Zahra Rami,Ling Li,Maryam Karamikheirabad,Shi Hyun Kang,Sung-Wan Kim,Jung-Jin Kim,Bong Ju Lee,Young-Chul Chung 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.3
Objective: Dysregulation of gene expression through epigenetic mechanisms may have a vital role in the pathogenesis of schizophrenia (SZ). In this study, we investigated the association of altered methylation patterns with SZ symptoms and early trauma in patients and healthy controls. Methods: The present study was conducted to identify methylation changes in CpG sites in peripheral blood associated with recent-onset (RO) psychosis using methylome-wide analysis. Lifestyle factors, such as smoking, alcohol, exercise, and diet, were controlled. Results: We identified 2,912 differentially methylated CpG sites in patients with RO psychosis compared to controls. Most of the genes associated with the top 20 differentially methylated sites had not been reported in previous methylation studies and were involved in apoptosis, autophagy, axonal growth, neuroinflammation, protein folding, etc. The top 15 significantly enriched Kyoto Encyclopedia of Genes and Genomes pathways included the oxytocin signaling pathway, long-term depression pathway, axon guidance, endometrial cancer, long-term potentiation, mitogen-activated protein kinase signaling pathway, and glutamatergic pathway, among others. In the patient group, significant associations of novel methylated genes with early trauma and psychopathology were observed. Conclusion: Our results suggest an association of differential DNA methylation with the pathophysiology of psychosis and early trauma. Blood DNA methylation signatures show promise as biomarkers of future psychosis.
Oxidation behavior of YAG-ZrB2 ceramics prepared by spark plasma sintering
Jie-Guang Song,Da-Ming Du,Yin-Yan Ju,Yang-Liang Li,Shi-Bin Li,Gang-Chang Ji 한양대학교 세라믹연구소 2010 Journal of Ceramic Processing Research Vol.11 No.4
ZrB2 and YAG are widely applied because of some excellent properties, but ZrB2 is easily oxidized in high-temperature air. To make ZrB2 ceramics have better oxidation resistance, high-density YAG-ZrB2 ceramics were prepared. The oxidation behavior of YAG-ZrB2 ceramics is investigated at different temperatures. The results indicate that the enhanced weight change differs according to the temperature range, slightly in the temperature 900-1000oC, sharply from 1100-1300 and smoothly above 1300oC. The weight change rate of YAG-ZrB2 ceramics is increased by prolonging the oxidation time, but the weight change rate of YAG-ZrB2 ceramics is gradually reduced. The oxidation layer is porous as compared to the YAG-ZrB2 ceramics layer.
Preparation and properties of ZrB2-YAG-Al2O3 ceramics
Jie-Guang Song,Gang-Chang Ji,Shi-Bin Li,Yang-Liang Li,Da-Ming Du,Lian-Meng Zhang,Yin-Yan Ju 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.4
ZrB2, YAG and Al2O3 are widely applied because of some excellent properties, but ZrB2 is easily oxidized in high-temperature air. To achieve better properties in ZrB2 ceramics, high-density ZrB2-YAG-Al2O3 ceramics were prepared. Below 1000℃, the shrinkage of ZrB2-YAG-Al2O3 ceramics is less than that of ZrB2-YAG ceramics. From 1000℃ to 1600℃, the second largest shrinkage occurs. Above 1600℃, the shrinkage of ZrB2-YAG-Al2O3 ceramics is more than that of ZrB2-YAG ceramics. The fracture toughness of sintered ceramics from coated raw materials is higher than that of sintered ceramics with mixed raw materials with the same phases and phase content, the fracture toughness of ZrB2-YAG-Al2O3 ceramics is higher than that of ZrB2-YAG ceramics with the same raw materials. The weight gain of all types of ceramics is increased with all increase in the oxidation temperature, the weight gain of ceramics is reduced with all increase in the YAG-Al2O3 content and Al2O3 proportion, especially above 1500℃. ZrB2, YAG and Al2O3 are widely applied because of some excellent properties, but ZrB2 is easily oxidized in high-temperature air. To achieve better properties in ZrB2 ceramics, high-density ZrB2-YAG-Al2O3 ceramics were prepared. Below 1000℃, the shrinkage of ZrB2-YAG-Al2O3 ceramics is less than that of ZrB2-YAG ceramics. From 1000℃ to 1600℃, the second largest shrinkage occurs. Above 1600℃, the shrinkage of ZrB2-YAG-Al2O3 ceramics is more than that of ZrB2-YAG ceramics. The fracture toughness of sintered ceramics from coated raw materials is higher than that of sintered ceramics with mixed raw materials with the same phases and phase content, the fracture toughness of ZrB2-YAG-Al2O3 ceramics is higher than that of ZrB2-YAG ceramics with the same raw materials. The weight gain of all types of ceramics is increased with all increase in the oxidation temperature, the weight gain of ceramics is reduced with all increase in the YAG-Al2O3 content and Al2O3 proportion, especially above 1500℃.
Effect of synthesis conditions on the particle size and morphology of YAG powder
Jie-Guang Song,Fang Wang,Ming-Han Xu,Yin-Yan Ju,Yang-Liang Li,Shi-Bin Li,Gang-Chang Ji 한양대학교 세라믹연구소 2012 Journal of Ceramic Processing Research Vol.13 No.2
Yttrium aluminum garnet (YAG) is currently a widely applied structural and functional material. To prepare highperformance YAG ceramics we prepared pure YAG powder, after calcining the precursor at 1100 ºC, by co-precipitation with ammonia as the precipitant and aluminum nitrate as well as yttrium nitrate as raw materials. The preparation conditions for the YAG precursor were a pH of 9, a titration rate of 10 ml/ minute and a reaction time of 60 minutes. The mean paricle size of the YAG powder was 11ìm. The mean particle size for the YAG powder increased with an increase in the pH and at a higher pH the YAG particles were more irregular in shape. The mean particle size and particle size distribution range of the YAG powder increased with an increase in the titration rate. For the YAG powder with a higher mean particle size, the particle size distribution range was wider but the size of most YAG particles was still small and the YAG particles were nearly spherical.
Effect of raw materials on the properties of ZrB2-YAG-Al2O3 multi-phase ceramics
Jie-Guang Song,Fang Wang,Da-Ming Du,Yin-Yan Ju,Shi-Bin Li,Gang-Chang Ji,Lian-Meng Zhang 한양대학교 세라믹연구소 2014 Journal of Ceramic Processing Research Vol.15 No.2
ZrB2 belongs to a class of ceramics defined ultra-high-temperature ceramics with extremely high melting temperatures, but ZrB2 ceramics is difficultly sintered and easily oxidized. To make ZrB2 ceramics possess the high relative density and the better oxidation resistance. The effects of raw materials on the properties of ZrB2 composite were investigated. YAG and Al2O3 help for the densification of ZrB2 ceramics. Fracture toughness of sintered ceramics with coated powder is higher than that of sintered ceramics with mixed powder. The mechanical property of ZrB2-YAG-Al2O3 materials is higher than that of ZrB2-YAG materials. Oxidation layer thickness of sintered ceramics with coated powder is thinner than that of sintered ceramics with mixed powder. These results show the sintered ZrB2 based multi-phase ceramics with coated microstructure help to increase the mechanical properties and oxidation resistance. The oxidation resistance of ZrB2-YAG-Al2O3 ceramics is better than that of ZrB2-YAG materials.
Ke Ding,Ke Shang,Zu-Hua Yu,Chuan Yu,Yan-Yan Jia,Lei He,Cheng-Shui Liao,Jing Li,Chun-Jie Zhang,Yin-Ju Li,Ting-Cai Wu,Xiang-chao Cheng 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.2
Newcastle disease virus (NDV) and Salmonella Pullorum have significant damaging effects on the poultry industry, but no previous vaccinecan protect poultry effectively. In this study, a recombinant-attenuated S. Pullorum strain secreting the NDV hemagglutinin-neuraminidase(HN) protein, C79-13ΔcrpΔasd (pYA-HN), was constructed by using the suicide plasmid pREasd-mediated bacteria homologousrecombination method to form a new bivalent vaccine candidate against Newcastle disease (ND) and S. Pullorum disease (PD). The effectof this vaccine candidate was compared with those of the NDV LaSota and C79-13ΔcrpΔasd (pYA) strains. The serum hemagglutinationinhibition antibody titers, serum immunoglobulin G (IgG) antibodies, secretory IgA, and stimulation index in lymphocyte proliferation wereincreased significantly more (p < 0.01) in chickens inoculated with C79-13ΔcrpΔasd (pYA-HN) than with C79-13ΔcrpΔasd (pYA) but werenot significantly increased compared with the chickens immunized with the LaSota live vaccine (p > 0.05). Moreover, the novel strain provides60% and 80% protective efficacy against the NDV virulent strain F48E9 and the S. Pullorum virulent strain C79-13. In summary, in this study,a recombinant-attenuated S. Pullorum strain secreting NDV HN protein was constructed. The generation of the S. Pullorum C79-13ΔcrpΔasd(pYA-HN) strain provides a foundation for the development of an effective living-vector double vaccine against ND and PD.