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RISS 인기검색어
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- 저자 : Yifei Mao (검색결과 3 건)
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Yifei Mao,Zhongtang Xiong,Songxin Wu,Zhiqing Huang,Ruoxian Zhang,Yuqin He,Yuling Peng,Yang Ye,Tianfa Dong,Hui Mai 한국유방암학회 2022 Journal of breast cancer Vol.25 No.2
Purpose: Knowing the distinction between benign and borderline/malignant phyllodes tumors (PTs) can help in the surgical treatment course. Herein, we investigated the value of magnetic resonance imaging-based texture analysis (MRI-TA) in differentiating between benign and borderline/malignant PTs. Methods: Forty-three women with 44 histologically proven PTs underwent breast MRI before surgery and were classified into benign (n = 26) and borderline/malignant groups (n = 18 [15 borderline, 3 malignant]). Clinical and routine MRI parameters (CRMP) and MRI-TA were used to distinguish benign from borderline/malignant PT. In total, 298 texture parameters were extracted from fat-suppression (FS) T2-weighted, FS unenhanced T1-weighted, and FS first-enhanced T1-weighted sequences. To evaluate the diagnostic performance, receiver operating characteristic curve analysis was performed for the K-nearest neighbor classifier trained with significantly different parameters of CRMP, MRI sequence-based TA, and the combination strategy. Results: Compared with benign PTs, borderline/malignant ones presented a higher local recurrence (p = 0.045); larger size (p < 0.001); different time-intensity curve pattern (p = 0.010); and higher frequency of strong lobulation (p = 0.024), septation enhancement (p = 0.048), cystic component (p = 0.023), and irregular cystic wall (p = 0.045). TA of FS T2- weighted images (0.86) showed a significantly higher area under the curve (AUC) than that of FS unenhanced T1-weighted (0.65, p = 0.010) or first-enhanced phase (0.72, p = 0.049) images. The texture parameters of FS T2-weighted sequences tended to have a higher AUC than CRMP (0.79, p = 0.404). Additionally, the combination strategy exhibited a similar AUC (0.89, p = 0.622) in comparison with the texture parameters of FS T2-weighted sequences. Conclusion: MRI-TA demonstrated good predictive performance for breast PT pathological grading and could provide surgical planning guidance. Clinical data and routine MRI features were also valuable for grading PTs.
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Fault Detection for a Class of Nonlinear Networked Control Systems with Communication Constraints
Zehui Mao,Yifei Pan,Bin Jiang,Wen Chen 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.1
This paper is concerned with fault detection for a class of nonlinear networked control systems with stochastic transfer delays and data drops. A modified T-S fuzzy model is used to represent the considered system. The infinitely distributed time delays are introduced to describe the delays in the controllers. In the fault detection filter, a sequence of stochastic variables is introduced to govern the random occurrence of the stochastic transfer delays and data drops in the measurements, and all of the stochastic variables are mutually independent. Sufficient conditions using regular and piecewise Lyapunov functions are derived for the existence of the designed filter. An example is employed to show the effectiveness and applicability of the proposed fault-detection method.
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Circular RNA expression profiles in the porcine liver of two distinct phenotype pig breeds
Huang, Minjie,Shen, Yifei,Mao, Haiguang,Chen, Lixing,Chen, Jiucheng,Guo, Xiaoling,Xu, Ningying Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.6
Objective: An experiment was conducted to identify and characterize the circular RNA expression and metabolic characteristics in the liver of Jinhua pigs and Landrace pigs. Methods: Three Jinhua pigs and three Landrace pigs respectively at 70-day were slaughtered to collect the liver tissue samples. Immediately after slaughter, blood samples were taken to detect serum biochemical indicators. Total RNA extracted from liver tissue samples were used to prepare the library and then sequence on HiSeq 2500. Bioinformatic methods were employed to analyze sequence data to identify the circRNAs and predict the potential roles of differentially expressed circRNAs between the two breeds. Results: Significant differences in physiological and biochemical traits were observed between growing Jinhua and Landrace pigs. We identified 84,864 circRNA candidates in two breeds and 366 circRNAs were detected as significantly differentially expressed. Their host genes are involved in lipid biosynthetic and metabolic processes according to the gene ontology analysis and associated with metabolic pathways. Conclusion: Our research represents the first description of circRNA profiles in the porcine liver from two divergent phenotype pigs. The predicted miRNA-circRNA interaction provides important basis for miRNA-circRNA relationships in the porcine liver. These data expand the repertories of porcine circRNA and are conducive to understanding the possible molecular mechanisms involved in miRNA and circRNA. Our study provides basic data for further research of the biological functions of circRNAs in the porcine liver.
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