International Young Doctors` Session : Session 3 ; Low serum LH level during ovarian stimulation is associated with early pregnancy loss in IVF/ICSI cycles with GnRH antagonist protocol

( Yi Ting Chiang ),( Yu Chieh Yang ),( Chi Hsien Chung ),( Mei Jou Chen ),( Shee Uan Chen ),( Yu-shih Yang ) 대한산부인과학회 2013 서울심포지움 Vol.18 No.-

User Identification Design by Fusion of Face Recognition and Speaker Recognition

Chao-Yu Lin,Kai-Tai Song,Yi-Wen Chen,Shuo-Cheng Chien,Sin-Horng Chen,Chen-Yu Chiang,Jyh-Her Yang,Yi-Chiao Wu,Tzu-Jui Liu 제어로봇시스템학회 2012 제어로봇시스템학회 국제학술대회 논문집 Vol.2012 No.10

Intelligent human-robot interface helps a mobile robot to extract external information and interact with a user. User identification information allows a robot to generate appropriate behaviors and make personalized human-robot interaction (PHRI) more natural and safe. Most of service robots move around in various application settings, and biometric features always change during relative movements. In this work, a fusion recognition system based on face and speaker classifiers is designed to achieve the user recognition in various environments. We propose a method to fuse face and speech recognition results based on the concept of confidence indices. Through the derived confidence indices, the system combines the two classifiers and gives improved recognition results. Experiments on a laboratory home service robot show that person recognition rates in 15 environmental situations all outperform those of using single modality.

Treatment outcomes of patients with stage II pure endometrioid-type endometrial cancer: a Taiwanese Gynecologic Oncology Group (TGOG-2006) retrospective cohort study

Hung-Chun Fu,Jen-Ruei Chen,Min-Yu Chen,Keng-Fu Hsu,Wen-Fang Cheng,An Jen Chiang,Yu-Min Ke,Yu-Chieh Chen,Yin-Yi Chang,Chia-Yen Huang,Chieh-Yi Kang,Yuan-Yee Kan,Sheng-Mou Hsiao,Ming-Shyen Yen 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.5

Objective: Choice of hysterectomy and adjuvant treatment for International Federation of Gynecology and Obstetrics (FIGO) 2009 stage II endometrioid endometrial cancer (EEC) is still controversial. Aims of this study were to evaluate survival benefits and adverse effects of different hysterectomies with or without adjuvant radiotherapy (RT), and to identify prognostic factors. Methods: The patients at 14 member hospitals of the Taiwanese Gynecologic Oncology Group from 1992 to 2013 were retrospectively investigated. Patients were divided into simple hysterectomy (SH) alone, SH with RT, radical hysterectomy (RH) alone, and RH with RT groups. Endpoints were recurrence-free survival (RFS), overall survival (OS), disease-specific survival (DSS), adverse effects and prognostic factors for survival. Results: Total of 246 patients were enrolled. The 5-year RFS, OS, DSS and recurrence rates for the entire cohort were 89.5%, 94.3%, 96.2% and 10.2%, respectively. Patients receiving RH had more adverse effects including blood loss (p<0.001), recurrent urinary tract infections (p=0.013), and leg lymphedema (p=0.038). Age over 50-year (HR=9.2; 95% confidence interval [CI], 1.2–70.9) and grade 3 histology (HR=7.28; 95% CI, 1.45–36.6) were independent predictors of OS. Grade 3 histology was an independent predictor of RFS (HR=5.13; 95% CI, 1.38–19.1) and DSS (HR=5.97; 95% CI, 1.06–58.7). Patients receiving adjuvant RT had lower locoregional recurrence (p=0.046), but no impact on survival. Conclusion: Different treatment modalities yield similar survival outcomes. Patients receiving SH with RT had lower locoregional recurrent with acceptable morbidity. Age and tumor grading remained significant predictors for survival among patients with FIGO 2009 stage II EEC.

Allogeneic Serum Eye Drops for the Treatment of Severe Dry Eye in Patients With Chronic Graft-Versus-Host Disease

Chiang, Chun-Chi,Lin, Jane-Ming,Chen, Wen-Lu,Tsai, Yi-Yu Masson Pub. USA 2007 Cornea Vol.26 No.7

PURPOSE:: To describe the use of allogeneic serum eye drops to treat 2 patients with chronic graft-versus-host disease (GVHD)-induced severe ocular surface disease. METHODS:: Small case series. RESULTS:: Conventional therapy failed to control the ocular symptoms of 2 patients with GVHD who presented with severe dry eye syndrome. Because autologous serum was unavailable in these cases, we used allogeneic serum eye drops as an alternate option for treating their ocular surface disease. Both donors had serologic tests performed before donation. Use of the allogeneic serum eye drops had a beneficial clinical effect, with marked attenuation of the patients’ symptoms. This therapy proved to be safe during 10 months of treatment. CONCLUSIONS:: Allogeneic serum eye drops may be a good alternative treatment for patients with severe dry eyes caused by GVHD.

Pull-Through Buddy Wire Technique for Endovascular Thrombectomy in Patients with Acute Ischemic Stroke: Technical Note

Chiang Pin-Yi,Lin Yen-Heng,Huang Yu-Cheng,Lee Chung-Wei 대한신경중재치료의학회 2021 Neurointervention Vol.16 No.1

Excessive tortuosity is a notable cause of failed endovascular thrombectomy for acute large-vessel occlusion stroke. Transcervical access (TCA) is a commonly proposed solution for overcoming this difficulty. However, the large-bore catheter usually used in TCA increases the risk of serious local complications. This paper presents a modified technique for TCA that uses a pull-through buddy wire (PTBW) to track a large-bore femoral guiding sheath (GS) into the carotid artery via a small carotid puncture site. The carotid puncture site can be easily managed through gentle manual compression. Two illustrative cases using this technique to deal with a large aortic arch and tortuous left common carotid artery are reported. In both cases, recanalization was achieved after successful GS placement. Using a PTBW is feasible in TCA.

Enhanced Performance of Pseudo-Bilayer Organic Photovoltaic Devices via Small Molecule Doping

Syu, Yu-Wei,Huang, Peng-Yi,Li, Husan-De,Hsu, Ching-Ling,Chiu, Kuan-Cheng,Kim, Choongik,Chen, Ming-Chou,Chao, Yu-Chiang American Chemical Society 2014 The Journal of Physical Chemistry Part C Vol.118 No.19

<P>Controlling both the film crystallinity of the active layer for better charge transport and the interdiffusion between donor and acceptor materials for optimal bicontinuous networks is essential in producing pseudo-bilayer polymer solar cells. In this work, we investigated the influence of a doping solution-processable small molecule with high carrier mobility, 5,11-bis(triethylsilylethynyl) anthradithiophene (TES-ADT), on the performance of pseudo-bilayer polymer solar cells made of an underlayer of poly(3-hexylthiophene) (P3HT) and an upper layer of [6,6]-phenyl-C61-butyric acid methyl ester (PCBM). By analysis of the X-ray diffraction and UV–vis absorbance spectra of P3HT:TES-ADT blend films it was demonstrated that the film crystallinity was enhanced by TES-ADT doping in the P3HT underlayer. The hole mobility extracted from the current density–voltage curves of hole-only devices based on P3HT:TES-ADT demonstrated an optimized value with proper TES-ADT doping and thermal annealing. An intermixed photoactive layer was observed for the annealed device, indicating the occurrence of interdiffusion with a large interfacial area. With improved film crystallinity and interdiffusion, the optimal device performance was obtained when 5% TES-ADT was blended with P3HT and a thermal annealing treatment at 150 °C for 1 min was conducted. At that optimal condition, the mean crystallite size was increased by 35%, and hence the enhancement of 8% and 14% in power conversion efficiency and short-circuit current density was observed, respectively.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2014/jpccck.2014.118.issue-19/jp502331x/production/images/medium/jp-2014-02331x_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp502331x'>ACS Electronic Supporting Info</A></P>

Mycorrhiza 처리가 Ardisia pusilla의 생육 및 내건성에 미치는 영향

백이화(Yi Hwa Baek),백정애(Jung Ae Baik),이윤정(Yun Jeong Lee),남유경(Yu Kyeong Nam),손보균(Bo Kyoon Sohn),이재선(Jae Sun Lee),장매희(Mae Hee Chiang) (사)한국생물환경조절학회 2009 생물환경조절학회지 Vol.18 No.2

균근을 이용한 Ardisia pusilla의 내건성 증진효과를 알아보기 위하여 내생균근 Glomus spp.을 접종하여 생육상에서 30일 동안 재배한 후 수분스트레스처리를 실시하였다. 수분스트레스처리는 5일간 무관수 상태로 두었다가 관수하는 방법으로 60일 동안 반복 처리하였다. 식물생육은 균근처리시 대조구에 비해 증가하였으며, 관수시 스분스트레스의 회복력도 빨랐다. 식물체내 양부함량은 지하부의 Fe, Mn, 및 Cu의 함량의 경우 균근 접종 식물이 대조구에 비해 현저히 높았으나 이에 반하여 프롤린 함량은 대조구에서 균근 접종식물에 비해 높게 나타났다. To investigate the effect of mycorrhiza on drought resistance and plant growth, Ardisia pusilla were colonized with arbuscular mycorrhiza (AM), Glomus spp. Host plants were cultured in a growth chamber for 30 days after colonization with AM. Water stress treatment was carried out by repeating five days off-watering and re-watering for 60 days. The growth of A. pusilla was enhanced by AM colonization compared to that of control, while the proline contents was significantly reduced in AM colonized plants compared to that of non-mycorrhizal plants. The inorganic nutrient contents i.e. Fe, Mn, Zn, and Cu in arbuscular mycorrhizal plants were higher than those of control.

Novel Biomarkers of Alzheimer’s Disease: Based Upon N-methyl-D-aspartate Receptor Hypoactivation and Oxidative Stress

Ting-I Chiang,Yi-Hsiang Yu,Chieh-Hsin Lin,Hsien-Yuan Lane 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.3

Early detection and prevention of Alzheimer’s disease (AD) is important. The current treatment for early AD is acetylcholine esterase inhibitors (AChEIs); however, the efficacy is poor. Besides, AChEI did not show efficacy in mild cognitive impairment (MCI). Beta-amyloid (A) deposits have been regarded to be highly related to the pathogenesis of AD. However, many clinical trials aiming at the clearance of A deposits failed to improve the cognitive decline of AD, even at its early phase. There should be other important mechanisms unproven in the course of AD and MCI. Feasible biomarkers for the diagnosis and treatment response of AD are lacking to date. The N-methyl-D-aspartate receptor (NMDAR) activation plays an important role in learning and memory. On the other hand, oxidative stress has been regarded to contribute to aging with the assumption that free radicals damage cell constituents and connective tissues. Our recent study found that an NMDAR enhancer, sodium benzoate (the pivotal inhibitor of D-amino acid oxidase [DAAO]), improved the cognitive and global function of patients with early-phase AD. Further, we found that peripheral DAAO levels were higher in patients with MCI and AD than healthy controls. We also found that sodium benzoate was able to change the activity of antioxidant. These pieces of evidence suggest that the NMDAR function is associated with anti-oxidation, and have potential to be biomarkers for the diagnosis and treatment response of AD.

Blind QR Code Steganographic Approach Based upon Error Correction Capability

( Yin-jen Chiang ),( Pei-yu Lin ),( Ran-zan Wang ),( Yi-hui Chen ) 한국인터넷정보학회 2013 KSII Transactions on Internet and Information Syst Vol.7 No.10

A novel steganographic QR code algorithm, which not only coveys the secret into the widely-used QR barcode but also preserves the readability of QR content and the capability of error correction, is presented in this article. Different from the conventional applications for QR barcode, the designed algorithm conceals the secret into the QR modules directly by exploiting the error correction capability. General browsers can read the QR content from the QR code via barcode readers; however, only the authorized receiver can further reveal the secret from the QR code directly. The new mechanism can convey a larger secret payload along with adjustment of the QR version and error correction level. Moreover, the blind property allows the receiver to reveal the secret without the knowledge of the embedded position of modules. Experimental results demonstrate that the new algorithm is secure, efficient and feasible for the low-power QR readers and mobile devices.

Ovarian cancer risk score predicts chemo-response and outcome in epithelial ovarian carcinoma patients

Hsiao-Yun Lu,Yi-Jou Tai,Yu-Li Chen,Ying-Cheng Chiang,Heng-Cheng Hsu,Wen-Fang Cheng 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.2

Objective: Cytoreductive surgery followed by adjuvant chemotherapy is a standard frontlinetreatment for epithelial ovarian cancer (EOC). We aimed to develop an ovarian cancer riskscore (OVRS) based on the expression of 10 ovarian-cancer-related genes to predict thechemoresistance, and outcomes of EOC patients. Methods: We designed a case-control study with total 149 EOC women including 75chemosensitives and 74 chemoresistants. Gene expression was measured using thequantitative real-time polymerase chain reaction. We tested for correlation between theOVRS and chemosensitivity or chemoresistance, disease-free survival (DFS), and overallsurvival (OS), and validated the OVRS by analyzing patients from the TCGA database. Results: The chemosensitive group had lower OVRS than the chemoresistant group (5 vs. 15, p≤0.001, Mann-Whitney U test). Patients with disease relapse (13 vs. 5, p<0.001, Mann Whitney U test) or disease-related death (13.5 vs. 6, p<0.001) had higher OVRS than thosewithout. OVRS ≥10 (hazard ratio=3.29; 95% confidence interval=1.94–5.58; p<0.001) was theonly predictor for chemoresistance in multivariate analysis. The median DFS (5 months vs. 24 months) and OS (39 months vs. >60 months) of patients with OVRS ≥10 were significantlyshorter than those of patients with OVRS <9). The high OVRS group also had significantlyshorter median OS than the low OVRS group in 255 patients in the TCGA database (39 vs. 49months, p=0.046). Conclusions: Specific genes panel can be clinically applied in predicting the chemoresistanceand outcome, and decision-making of epithelial ovarian cancer.