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Effect of Feed Restriction in Modeling of Dietary Obesity
Yeoung Mi Cho,Sunhee Shin,Dongsun Park,Jeong Hee Jeon,Min-Jung Jang,Jwa Jin Kim,Jae Wook Kim,Hyeong-Jin Ji,Chang Hwan Kim,Seongjin Baek,Seok-Yeon Hwang,Gonhyung Kim,Yun-Bae Kim 한국실험동물학회 2007 Laboratory Animal Research Vol.23 No.4
Ad libitum feeding of normal diet to rats usually leads to overweight, showing higher body-mass index than 25, while the supplementation of high (20-40%) content of lard or beef tallow in the diet to make a high-fat diet (HFD)-induced obesity rather decreases body weights partially due to decrease in feed intake of HFD or occurrence of diarrhea. In our study, for modeling dietary obesity, rats were subjected to feed restriction by 20 and 40% with normal diet or HFD supplemented with 25% of lard for 6 weeks. Ad libitum (100%) feeding of HFD decreased body weight gain and body fat in rats, resulting from a lower feed intake and transient diarrhea, compared to that of animals fed normal diet. In comparison with ad libitum-feeding groups, HFD restricted to 60 and 80% resulted in higher body weight gain and body fat compared with the normal diet with corresponding restriction to 60% or 80%. The changes in body and fat weights exhibited a good relationship with blood lipids profiles and leptin level in feed restricted groups. In addition, body fat and lipid profiles were confirmed to be parallel with the lipid accumulation in the liver and blood parameters associated with liver function. Based on the results, it is suggested that an appropriate degree (80%) of dietary restriction could be a candidate of modeling HFD-induced obesity for the screening of antiobesity substances.
mtDNA D-loop 변이로 확인된 한국재래닭의 다양한 모계기원
조창연(Chang-Yeon Cho),이풍연(Pung-Yeon Lee),고응규(Yeoung-Gyu Ko),김학규(Hak Kyu Kim),박미나(Mi-Na Park),연성흠(Seung-Hum Yeon) 韓國家禽學會 2011 韓國家禽學會誌 Vol.38 No.1
우리나라 재래닭의 기원을 구명하기 위해서 mtDNA Dloop 영역을 분석한 결과, 1,231~1,232개의 염기구성되어 있으며, 35개소에서 변이가 관찰되었다. 변이 부위를 이용하여 Haplotype을 분류한 결과, 21종으로 분류되었으며 이중 9개인 GenBank에 미등록된 것으로 밝혀졌다. Hplotype 다양성으로 추정한 한국 재래닭의 유전적 변이성은 중국의 재래닭과 유사한 것으로 추정되었다. Haplotype에 대한 Network 분석 결과, 재래닭은 5개의 Clade로 분류되었다. 이들 Clade에 대한 각 집단의 분포 현황으로 한국 재래닭은 운남성 및 중국 재래닭이 보인 결과와 유사하나, 일본의 재래닭과는 약간 상이한 것으로 밝혀졌다. 이상의 결과로 우리나라 재래닭은 공통선조가 다른 5개 이상의 모계가 중국을 통하여 유래되었으며, 일본에도 전파된 것이 확인되었다. 한편, 일본은 한반도를 유래하지 않은 닭의 유입이 있었던 것으로 추정된다. In this study, we analyzed the mitochondrial DNA D-loop region of Korean native chicken to clarify their phylogenetic relationships, possible maternal origin and routes of introduction into Korea. A 1231-1232 bp DNA fragment from the mtDNA D-loop region was sequenced in 315 chickens from 11 populations, Thirty-five variable sites that defined 21 haplotyes were observed. In Korean native chicken, diversity accounted for 90% of the variation, little differentiation among the strains. The 21 haplotypes clustered into 5 clades which were A, B, C, D and E. These results indicate that Korean chickens were derived from China with multiple origins.