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시화호 유입 지천의 지표수와 퇴적물 용출수가 수서 지표생물에 미치는 급ㆍ만성 생태 독성 영향
박예나(Yena Park),김선미(Sunmi Kim),한선영(Sunyoung Han),이지연(Jiyoun Lee),박윤석(Yoon Suk Park),윤충식(Chung Sik Yoon),최경호(Kyungho Choi) 환경독성보건학회 2008 환경독성보건학회지 Vol.23 No.4
Acute and chronic toxicities of sediment elutriate and surface water samples collected at Lake Shihwa were evaluated using standard toxicity testing organisms including Vibrio fischeri, Daphnia magna and Moina macrocopa. Acute exposure resulted in toxic effects in all surface water or sediment elutriate samples, except for those collected from the reed swamp and Okgu stream. The rainy season influenced the toxicity of the water samples, presumably either by dilution of point discharge or through introduction of non-point source contaminants through runoff. In the sediment, elutriate and surface water samples, copper was detected above potentially lethal concentration, which may in part explain the observed toxicity, Considering acute toxicities of the surface water streams that direct to the Lake Shihwa, efforts should be warranted to control and reduce discharge of point and non-point sources along Lake Shihwa.
Jin, Yena,Yoon, Yae Jin,Jeon, Yoon Jung,Choi, Jiyeon,Lee, Yu-Jin,Lee, Joonku,Choi, Sangho,Nash, Oyekanmi,Han, Dong Cho,Kwon, Byoung-Mog Pergamon Press 2017 Biochemical pharmacology Vol.142 No.-
<P><B>Abstract</B></P> <P>The roles and significance of signal transducer and activator of transcription 3 (STAT3) in human cancers have been extensively studied and STAT3 is a promising therapeutic target for cancer drug discovery. During the screening of natural products to identify STAT3 inhibitors, we identified geranylnaringenin (CG902), which decreased luciferase activity in a dose-dependent manner. CG902 specifically inhibited STAT3 phosphorylation at Tyr-705 in DU145 prostate cancer cells and decreased the expression levels of STAT3 target genes, such as cyclin D1, cyclin A, and survivin. Notably, the knockdown of the SHP-2 gene by small interfering RNA suppressed the ability of CG902 to inhibit STAT3 activation and CG902 activated the phosphatase activity of SHP-2 through direct interaction with SHP-2 and induced the phosphorylation of SHP-2. The interactions between CG902 and SHP-2 were confirmed by pull-down assay using biotinylated CG902. The interactions were also further validated by the drug affinity responsive target stability (DARTS) and cellular thermal shift assay (CETSA). The inhibitory effect of CG902 on cell growth was confirmed using the DU145 mouse xenograft model. We propose that CG902 inhibits STAT3 activity through a mechanism that involves the interactions between CG902 and SHP-2, and the phosphorylation of SHP-2, which leads to SHP-2 activation in DU145 cells. CG902 is the first compound to regulate STAT3 activity via the modulation of SHP-2 activity, and our results suggest that CG902 is a novel inhibitor of the STAT3 pathway and an activator of SHP-2, and may be a useful lead molecule for the development of a therapeutic STAT3 inhibitor.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Yoon Ji-Hee,Choi Yunha,Lee Yena,Yoo Han-Wook,Choi Jin-Ho 대한소아내분비학회 2021 Annals of Pediatirc Endocrinology & Metabolism Vol.26 No.2
Purpose: Osteoporosis is a skeletal disorder characterized by reduced bone mass that results in increased risk of fractures. Pediatric osteoporosis can be caused by monogenic diseases, chronic diseases, and/or their treatment. This study was performed to investigate the effect of pamidronate infusion on osteoporosis in children and adolescents. Methods: This study included 13 unrelated pediatric patients (10 males and 3 females) whose bone mineral density (BMD) z-score was <-2.0. Pamidronate was administered intravenously at a dosage of 1 mg/kg for 3 consecutive days every 4 months. Clinical and biochemical findings were reviewed retrospectively. The BMD values of the lumbar spine and femoral neck were assessed by dual energy x-ray absorptiometry at baseline and annually. Results: The underlying diseases were immobilization (62%), inflammatory bowel disease (23%), protein-losing enteropathy (8%), and idiopathic juvenile osteoporosis (8%). The mean age at the start of treatment was 12.7±4.3 years. Duration of treatment ranged from 12–50 months. The baseline height-standard deviation score (SDS) and weight-SDS were -2.01±2.08 and -2.60±1.62, respectively. The lumbar spine BMD z-scores improved significantly after 1 year of pamidronate treatment, but the femoral neck BMD z-scores did not. However, both z-scores had significantly increased by the end of treatment. Conclusion: This study demonstrated that pamidronate treatment increased BMD in pediatric patients with osteoporosis with no significant adverse events. Further studies are required to better define the long-term efficacy and safety of pamidronate therapy in a large number of pediatric patients.
Yoon, Yae Jin,Kim, Young-Hwan,Jin, Yena,Chi, Seung-Wook,Moon, Jeong Hee,Han, Dong Cho,Kwon, Byoung-Mog Elsevier 2018 Cancer letters Vol.434 No.-
<P><B>Abstract</B></P> <P>It is reported that 2′-hydroxycinnamaldehyde (HCA), isolated from cinnamon, has anti-tumor effects through the modulation of multi-target molecules. In this study, we identified pyruvate kinase M2 (PKM2) as a direct target of HCA by use of biochemical methods including affinity chromatography, drug affinity responsive target stability, and cellular thermal shift assay. PKM2 is up-regulated in multiple cancer types and is considered as a potential target for cancer therapy. HCA binds directly to PKM2 and selectively decreases the phosphorylation of PKM2 at Tyr105, indicating a potential anti-proliferative effect on prostate cancer cells. As a PKM2 activator, HCA increases pyruvate kinase activity by promoting the tetrameric state of PKM2. However, HCA suppresses protein kinase activity of PKM2 by decreasing the phosphorylation at Tyr105. Moreover, this leads to a decrease of PKM2-mediated STAT3 phosphorylation at Tyr705 and a down-regulation of target genes, including MEK5 and cyclin D1. Furthermore, HCA suppresses tumor growth and the release of tumor extracellular vesicles <I>in vivo</I> by inhibiting the phosphorylation of PKM2. Collectively, our results suggest that HCA may be a potential anticancer agent targeting PKM2 in cancer progression.</P> <P><B>Highlights</B></P> <P> <UL> <LI> HCA inhibits proliferation of DU145 prostate cancer cells and suppresses their growth in a xenograft mouse model. </LI> <LI> HCA directly binds to PKM2 in cancer cells and tumor tissues. </LI> <LI> HCA increases pyruvate kinase activity by promoting the tetrameric state of PKM2. </LI> <LI> HCA suppresses the release of tumor extracellular vesicles (EV) by dephosphorylating PKM2. </LI> </UL> </P>
Kim, Yena,Kim, Hyeongkeun,Kim, Tae Young,Rhyu, Se Hyun,Choi, Dong Soo,Park, Won Kyu,Yang, Cheol-Min,Yoon, Dae Ho,Yang, Woo Seok Elsevier 2015 Carbon Vol.81 No.-
<P><B>Abstract</B></P> <P>It has become critically important to develop reliable method to transfer chemical vapor deposited (CVD) graphene from its growth substrate to the target substrate without leaving undesired polymer residues on the graphene surface. Here, we have found that for the two different transfer method – <I>wet transfer</I> using poly(methyl methacrylate) (PMMA) and <I>dry transfer</I> using polydimethylsiloxane (PDMS) as support layer, the amount of polymer residues and other impurities left on the graphene surface varies depending on the solvent used to remove those polymers. The exposure of the graphenes to different organic solvents such as acetone and chloroform resulted in different amount of polymer residues and impurities present on the graphene surface, which impact the electronic structure of the transferred graphene. It was found that the graphene obtained using the dry transfer method and acetone as solvent with a 2D to G (<I>I</I> <SUB>2D</SUB>/<I>I</I> <SUB>G</SUB>) intensity ratio of 4.58 and a 2D peak full width-half maximum (FWHM) of 24.66, which was higher than that using the wet transfer method and chloroform as solvent. These results showed that graphene was less affected by the polymer residues and impurities or the dry transfer method rather than the wet transfer method. In addition, using acetone rather than chloroform as solvent in the dry transfer method led to less contaminated graphene.</P>
「숲속의 전남」 만들기 정책에 대한 지방산림정책적 의의
윤병선 ( Byungsun Yoon ),김혜린 ( Hyerin Kim ),양천은 ( Cheoneun Yang ),허예나 ( Yena Heo ),김민희 ( Minhee Kim ),안기완 ( Kiwan An ) 한국산림경제학회 2016 산림경제연구 Vol.23 No.2
전라남도는 산림자원 가치를 극대화하고 산림ㆍ임업으로부터 소득과 공원 같은 아름다운 전남을 지향하고자 「숲속의 전남」 만들기 10개년 계획(2015-2024)을 발표하였다. 본 연구는 지방산림정책의 대표적인 사례인 「숲속의 전남」 만들기에 대한 성격을 규명하고 지방산림정책적 의의와 한계점 분석을 통해 지역산림정책 활성화 방안을 마련하고자 수행되었다. 그 결과, 첫째 2015년 「숲속의 전남」 만들기 계획에 의거, 경관ㆍ소득숲 3,215ha, 학교ㆍ마을 숲 등 52개소, 가로수 116km, 주민참여 숲 39개소에 사업비 462억원을 투자하였다. 둘째, 전남 나무심기 지원에 관한 조례 제정, 「숲속의 전남」 도 협의회 및 시ㆍ군 협의회의 구축, 민간차원의 (사) 「숲속의 전남」 발족, 협력(도민, 임업인, NGO, NPO), 재정(기업 사회적 `참여, 재능기부, 출연금) 등의 거버넌스가 구축은 지방산림정책을 실현하는 수단으로 그 의의가 크다. 성공적인 「숲속의 전남」 만들기 사업을 실행하기 위한 (사) 「숲속의 전남」 역할에 대한 중요성을 제안하였다. Jeollanam-do announced the `10-years Jeonnam Forest Project(2015-2024)` to maximize multiple forest values, get income from forests and seek beautiful Jeonnam as parks. This study was carried out to make activation plan of local forest policy through clarifying the character of `Jeonnam Forest Project` and analyzing implication and limitation of local forest policy. As a result, 46.2 billion was invested in scenery-income forest(3,215ha), school · village forest(52 places), street trees(116km) and community participation forests(39 places) based on “Jeonnam Forest Project” in 2015. Second, establishing the governance which were enactment of local ordinance about tree plant in Jeonnam, building a province conference and cities and counties conference of `Jeonnam Forest Project`, starting a `Jeonnam Forest Project` as nongovernmental, cooperation(inhabitant of the Jeonnam, forester, NGO, NPO), budget(social participation, talent donation, contribution), etc was significance as a means to realizing the local forest policy. This study proposed the role of `(Corp.) Jeonnam Forest Project` to run the successful project of `Jeonnam Forest Project`.
Jungkon Kim,Yena Park,Sangwoo Lee,Jihyun Seo,Dongwook Kwon,Jaehong Park,Tae-Hyun Yoon,Kyungho Choi 한국환경보건학회 2013 한국환경보건학회지 Vol.39 No.4
Objectives: This study was conducted to identify factors determining the toxicity of manufactured silver nanoparticles (AgNPs) on aquatic organisms. Methods: For this purpose, we prepared several AgNPs with varied characteristics, including hydrodynamic size (nano-ABCAgCit vs -sized-ABCAgCit), impurities (ABCAg stock vs ABCAg), and citrate capping (ABCAgCit), using a commercially available manufactured AgNP (ABCAg stock). Acute tests were conducted using larval zebrafish (Danio rerioI). In addition, in order to determine the ecotoxicological potentials of various capping agents, toxicity tests were conducted with microbes, waterfleas, and fish for eight different capping agents that are used for NPs. Results: The toxicity of AgNPs in terms of 96 h fish LC50 increased in the following order: ABCAg stock < ABCAg = ABCAgCit = nano-ABCAgCit < μ-sized-ABCAgCit < AgNO3. After removing impurities by dialysis, 96 h LC50 value decreased significantly from 126.6 μg/L (95% confidence intervals [CI]: 107.0-146.2) (ABCAg stock) to 78.6 μg/L (CI: 72.7-84.8) (ABCAg). For μ-sized-ABCAgCit (ranging between 3.9 and 40.6 nm) and ABCAgCit (40.6 nm and 9.1 μm), the 96 h LC50 of the former (43.9 μg/L, CI: 36.0-51.7) was approximately two-fold lower than that of the latter (87.0 μg/L, CI: 73.5-100.3). Conclusions: In this study, we found that for acute lethality, the contribution of impurities and particle size was significant, but that of citrate was negligible.