Non-Arteritic Ischemic Optic Neuropathy Following COVID-19 Vaccination in Korea: A Case Series

Moon Yeji,정재호,신현진,최동규,박경아,Jeon Hyeshin,이병주,김성준,Oh Sei Yeul,Ahn Hyosook,정승아,Kim Ungsoo Samuel,이행진,이주연,Choi Youn Joo 대한의학회 2023 Journal of Korean medical science Vol.38 No.12

Background: To report the clinical manifestations of non-arteritic anterior ischemic optic neuropathy (NAION) cases after coronavirus disease 2019 (COVID-19) vaccination in Korea. Methods: This multicenter retrospective study included patients diagnosed with NAION within 42 days of COVID-19 vaccination. We collected data on vaccinations, demographic features, presence of vascular risk factors, ocular findings, and visual outcomes of patients with NAION. Results: The study included 16 eyes of 14 patients (6 men, 8 women) with a mean age of 63.5 ± 9.1 (range, 43–77) years. The most common underlying disease was hypertension, accounting for 28.6% of patients with NAION. Seven patients (50.0%) had no vascular risk factors for NAION. The mean time from vaccination to onset was 13.8 ± 14.2 (range, 1–41) days. All 16 eyes had disc swelling at initial presentation, and 3 of them (18.8%) had peripapillary intraretinal and/or subretinal fluid with severe disc swelling. Peripapillary hemorrhage was found in 50% of the patients, and one (6.3%) patient had peripapillary cotton-wool spots. In eight fellow eyes for which we were able to review the fundus photographs, the horizontal cup/ disc ratio was less than 0.25 in four eyes (50.0%). The mean visual acuity was logMAR 0.6 ± 0.7 at the initial presentation and logMAR 0.7 ± 0.8 at the final visit. Conclusion: Only 64% of patients with NAION after COVID-19 vaccination have known vascular and ocular risk factors relevant to ischemic optic neuropathy. This suggests that COVID-19 vaccination may increase the risk of NAION. However, overall clinical features and visual outcomes of the NAION patients after COVID-19 vaccination were similar to those of typical NAION.

30대 페미니스트 서사에서 세대의 교차와 분화 읽기 –공지영의 『무소의 뿔처럼 혼자서 가라』(1993)를 중심으로

문예지(Moon, Yeji) 한국현대문학회 2021 한국현대문학연구 Vol.- No.65

이 글은 1993년 발표된 공지영의 소설 『무소의 뿔처럼 혼자서 가라』를 1980년대에 대한 노스탤지어나 남성경험에 기반한 ‘후일담 소설’의 감성구조와 동일화 되지 않는 특유의 페미니스트 세대 서사로 읽어내기를 시도한 것이다. 이는 오랜 시간 공지영의 문학을 수식해온 ‘386 세대’, ‘후일담 소설’, ‘페미니즘 작가’라는 규정이 정작 비평장의 적극적인 작품 분석에 의해서 규명된 것이 아니라는 문제의식에 근거한다. 이에 따라 본고는 1990년대 초 386세대 남성들이 진정성의 에토스를 통해 역설적으로 자기구축에 성공한 반면, 왜 여성들은 자기를 잃어가는 체험 속에서 지속적으로 수치심을 느껴야만 하는지에 대한 질문을 장편 『무소의 뿔처럼 혼자서 가라』를 통해 제기하고자 하였다. 이 소설에서 ‘운동권의 기억’은 배경으로 존재하며, 살아남았다는 부끄러움을 통해 그 자신의 진정성의 윤리를 구축하는 후일담의 정서구조는 중심인물의 몫이 아니다. 후일담 주체의 윤리가 후경화된 자리에 놓인 여성들의 서사에서 중요하게 부각되는 것은 구체화된 일상을 살아가는 여성들의 마음에 시시각각 솟구치는 모욕감, 수치심, 열등감과 같은 감정들이다. 본고는 특히 소설 속 주인공 여성들의 ‘30대 페미니스트’라는 세대-젠더적 특성에 주목하여, 주변 인물들과 여성인물들 간의 관계성 및 감정의 문제를 중점적으로 살펴보았다. 당대의 새로운 결혼문화를 보여주는 대표적 텍스트로서 『무소의 뿔처럼 혼자서 가라』는 ‘남녀평등’ 첫 세대라고 명명된 30대 기혼 남녀들이 겪은 갈등을 적극적으로 문학화하였다. 소설 속 여성들은 결혼생활의 고통과 수치심을 내면화한 채, 공통의 경험을 가지고 있으면서도 쉽게 연대하지 못한다. 그러나 소설은 동세대의 인물들 사이에 남아 있는 차이의 문제를 부정의 대상이었던 어머니 세대와의 닮음과 교차시키면서, 세대 내 동질성과 세대 간 단절성을 해체할 수 있는 가능성을 보여준다. 또한 읽기의 차원에서 『무소의 뿔처럼 혼자서 가라』를 하나의 징후로 독해하는 것이 유효한 이유는, 이 소설이 한 시대의 ‘베스트셀러’로서 많은 여성들의 공감대를 확보했다는 사실 그 자체가 아니라, 텍스트의 안과 밖을 경유해 다양한 세대의 여성들의 목소리가 분화, 교차되는 양상을 포착할 수 있다는 점에 있다. This article attempts to read Gong Jiyoung’s novel Go Alone Like a Rhino’s Horn, published in 1993, as a unique feminist-generation narrative that is not identified with the emotional structure of ‘reminiscence’ based on male experiences or nostalgia for the 1980s. This is based on the awareness of the problem that the definitions of ‘386 generation’, ‘reminiscence’, and ‘feminist writers’, which have been modifying Gong Jiyoung’s literature for a long time, were not given through active analysis of works by the critics. Thus, reading Go Alone Like a Rhino’s Horn, this paper attempted to raise the question of why women had to constantly feel shame in the experience of losing themselves, while 386 generation men paradoxically succeeded in self-construction through the ethos of authenticity in the early 1990s. In this novel, the memory of student movements exists in the background of the story, and the emotional structure of reminiscences, which builds an ethics of authenticity through the shame of surviving, does not belong to the main characters. What stands out important in women"s narratives, where the ethics of reminiscence became secondary, are feelings such as insult, shame, and inferiority that rise up to the hearts of women in daily In particular, this paper focused on the relationship and emotional problems between the main characters and minor characters, paying attention to the generational/gendered characteristics of female protagonists as feminists in their 30s. As a representative work depicting the marriage culture of the time, Go Alone Like a Rhino’s Horn actively discloses the discord and conflict experienced by married men and women in their 30s, who were named the first generation of ‘gender equality’. The women in the novel internalize their shame due to the pain of marriage, and although they have common experiences, they do not easily connect with each other. However, the novel intersects the problem of remaining differences between the characters of the same generation with the resemblance to the mother"s generation, which was the object of denial, showing the possibility of dismantling the homogeneity within and between generations. The reason why it is valid to view Go Alone Like a Rhino’s Horn as a symptomatic example in terms of reading is not in itself that this novel secured consensus among many women of the time, but that we can capture the differentiation and crossing of voices of various generations of women inside and outside this novel.

Antibody–drug conjugates and bispecific antibodies targeting cancers: applications of click chemistry

Yeji Hong,Su‑Min Nam,Aree Moon 대한약학회 2023 Archives of Pharmacal Research Vol.46 No.3

Engineering approaches using antibody drug conjugates (ADCs) and bispecific antibodies (bsAbs) are designed to overcome the limitations of conventional chemotherapies and therapeutic antibodies such as drug resistance and non-specific toxicity. Cancer immunotherapies have been shown to be clinically successful with checkpoint blockade and chimeric antigen receptor T cell therapy; however, overactive immune systems still represent a major problem. Given the complexity of a tumor environment, it would be advantageous to have a strategy targeting two or more molecules. We highlight the necessity and importance of a multi-target platform strategy against cancer. Approximately 400 ADCs and over 200 bsAbs are currently being clinically developed for several indications, with promising signs of therapeutic activity. ADCs include antibodies that recognize tumor antigens, linkers that stably connect drugs, and powerful cytotoxic drugs, also known as payloads. ADCs have direct therapeutic effects by targeting cancers with a strong payload. Another type of drug that uses antibodies are bsAbs, targeting two antigens by linking to antigen recognition sites or bridging cytotoxic immune cells to tumor cells, resulting in cancer immunotherapy. Three bsAbs and one ADC have been approved for use by the FDA and the EMA in 2022. Among these, two of the bsAbs and the one ADC are used for cancers. We introduced that bsADC, a combination of ADC and bsAbs, has yet to be approved and several candidates are in the early stages of clinical development in this review. bsADCs technology helps increase the specificity of ADCs or the internalization and killing ability of bsAbs. We also briefly discuss the application of click chemistry in the efficient development of ADCs and bsAbs as a conjugation strategy. The present review summarizes the ADCs, bsAbs, and bsADCs that have been approved for anti-cancer or currently in development. These strategies selectively deliver drugs to malignant tumor cells and can be used as therapeutic approaches for various types of cancer.

Low-Speed Transportation Mode Detection for People with Mobility Disabilities: A Pilot Study

Yeji Woo(우예지),Sungjin Hwang(황성진),Jiwoong Heo(허지웅),Jucheol Moon(문주철),Hansung Kim(김한성),Jaehyuk Cha(차재혁),Kwanguk (Kenny) Kim(김광욱) 한국컴퓨터그래픽스학회 2022 한국컴퓨터그래픽스학회 학술대회 Vol.2022 No.7

Poster Session : PS 1421 ; Hemato-Oncology(Hematology) : Posterior Reversible Encephalopathy Syndrome As-sociated with FOLFIRI Chemotherapy in Metastatic Colorectal Cacer: A Case Report

( Yeji Han ),( Eunmi Nam ),( Kyungeun Lee ),( Youngchul Moon ),( Joomyung Sung ),( Kyungmin Cho ),( Jungeun Choi ),( Jooyoung Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Posterior reversible encephalopathy syndrome (PRES) is known to have symptoms of headache, visual disturbances, altered consciouseness and seizures, which can be result of acute hypertension, eclampsia, renal failure and the use of immunosuppressive or cytotoxic agents. We report a case of PRES ocurred as a result of FOLfiRI (irinotecan, 5-FU) chemotherapy in metastatic colorectal cacer/ Case Report: A 51-year old male with diagnosed of rectal cancer with liver metastasis, underwent an a low anterior resection on April,19, 2013.After operation, he has XELOX (capecitabine, oxaliplatin) as palliative chemotherapy. After sixth XELOX chemotherapy, chemotherapy as change of disease progression. When FOLfiRI chemotherapy administered, suddenly he appeared to have partial seizure with sudden eyeball deviation . The infusion of chemotherapy was stopped immediately ,he had treatment with anticonvulsants, such as phenytoin, levetiracetam. The brain MRI showed that white matter change in the bilateral occipital lobe, supported the diagnosis of PRES. The conservative treatment was continued for several days. After few days, the patient recovered from symptom and after that, he had chemotherapy XELOX and bevacizumab instead of FOLfiRI. The brain MRI after six months did not show any previous lesion, he is currently well being followed up as an outpatient. Conclusion: There are no known reports of the association between PRES and FOLfiRI chemotherapy.We postulate that FOLfiRI chemotherapy can disrupt the normal endothelial function of the brain leading to the development of PRES.

Identification of distinctive clinical significance in hospitalized patients with endoscopic duodenal mucosal lesions

( Yeji Han ),( Hye-kyung Jung ),( Ji Young Chang ),( Chang Mo Moon ),( Seong-eun Kim ),( Ki-nam Shim ),( Sung-ae Jung ),( Joo-young Kim ),( Ji-yun Bae ),( Sae-in Kim ),( Ji-hyun Lee ),( Sanghui Park ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.5

Background/Aims: Duodenitis is not infrequent finding in patient undergoing endoscopy. However, hospitalized patients have a higher incidence of secondary duodenal mucosal lesions that might be related with inflammatory bowel disease (IBD), cytomegalovirus (CMV) infection, tuberculosis, immunologic disorders, or other rare infections. We aimed to identify clinicopathologic features of duodenal mucosal lesions in hospitalized patients. Methods: All hospitalized patients having duodenal mucosal lesions were identi-fied by endoscopic registration data and pathologic data query from 2011 to 2014. The diagnostic index was designed to be sensitive; however, a detailed review of medical record and endoscopic findings was undertaken to improve specificity. Secondary duodenal lesion was defined as having specific reason to explain the duodenal lesion. Results: Among 6,334 hospitalized patients have undergone upper endoscopy, en-doscopic duodenal mucosal lesions was detected in 475 patients. Secondary duo-denal lesions was 21 patients (4.4%) and the most frequent secondary cause was IBD (n = 7). The mean age of secondary group was significantly lower than that in primary group (42.3 ± 18.9 years vs. 58.5 ± 16.8 years, p = 0.00), and nonsteroidal anti-inflammatory drugs were less frequently used in secondary group, but there was no differences of gender or presence of Helicobacter pylori. The involvement of distal part of duodenum including postbulbitis or panduodenitis was more fre-quently detected in secondary group than in primary group. By multivariate re-gression analysis, younger age of 29 years and the disease extent were significant predictors for the secondary mucosal lesions. Conclusions: Secondary duodenal mucosal lesions with different pathophysiol-ogy, such as IBD or CMV infection, are rare. Disease extent and age seems the most distinctive feature of secondary duodenal mucosal lesions.

Dietary intake of fats and fatty acids in the Korean population

Yeji Baek,Ji-Yun Hwang,Kirang Kim,Hyun-Kyung Moon,Sanghui Kweon,Jieun Yang,Kyungwon Oh,Jae Eun Shim 한국영양학회 2015 Nutrition Research and Practice Vol.9 No.6

BACKGROUND/OBJECTIVES: The aim of this study was to estimate average total fat and fatty acid intakes as well as identify major food sources using data from the Korea National Health and Nutrition Examination Survey (KNHANES) VI-1 (2013). SUBJECTS/METHODS: Total fat and fatty acid intakes were estimated using 24-hour dietary recall data on 7,048 participants aged ≥ 3 years from the KNHANES VI-1 (2013). Data included total fat, saturated fatty acid (SFA), monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), n-3 fatty acid (n-3 FA), and n-6 fatty acid (n-6 FA) levels. Population means and standard errors of the mean were weighted in order to produce national estimates and separated based on sex, age, income, as well as residential region. Major food sources of fat, SFA, MUFA, PUFA, n-3 FA, and n-6 FA were identified based on mean consumption amounts of fat and fatty acids in each food. RESULTS: The mean intake of total fat was 48.0 g while mean intakes of SFA, MUFA, PUFA, n-3 FA, and n-6 FA were 14.4g, 15.3 g, 11.6 g, 1.6 g, and 10.1 g, respectively. Intakes of MUFA and SFA were each higher than that of PUFA in all age groups. Pork was the major source of total fat, SFA, and MUFA, and soybean oil was the major source of PUFA. Milk and pork were major sources of SFA in subjects aged 3-11 years and ≥ 12 years, respectively. Perilla seed oil and soybean oil were main sources of n-3 FA in subjects aged ≥ 50 years and aged < 50 years, respectively. CONCLUSIONS: Estimation of mean fatty acid intakes of this study using nationally represented samples of the Korean population could be useful for developing and evaluating national nutritional policies.

Analysis of components and Structural form of Ishige okamurae Yendo according to the Harvesting Area and Time

Hyeonjoeng Moon,Min-Ju Kim,Ramakrishna Chilakala,Kangho Ko,Jinsol Ra,Seongheon Jeong,Yeji Cheon,Sun Hee Cheong 한국식품영양과학회 2022 한국식품영양과학회 학술대회발표집 Vol.2022 No.10

소수성 처리된 나노다공성 알루미늄 양극산화피막의 제빙

신예지(Yeji Shin),김진휘(Jinhui Kim),신동민(Dongmin Shin),문형석(Hyung-Seok Moon),이정훈(Junghoon Lee) 한국표면공학회 2021 한국표면공학회지 Vol.54 No.5

Icing causes various serious problems, where water vapor or water droplets adhere at cold conditions. Therefore, understanding of ice adhesion on solid surface and technology to reduce de-icing force are essential for surface finishing of metallic materials used in extreme environments and aircrafts. In this study, we controlled wettability of aluminum alloy using anodic oxidation, hydrophobic coating and lubricant-impregnation. In addition, surface porosity of anodized oxide layer was controlled to realize superhydrophilicity and superhydrophobicity. Then, de-icing force on these surfaces with a wide range of wettability and mobility of water was measured. The results show that the enhanced wettability of hydrophilic surface causes strong adhesion of ice. The hydrophobic coating on the nanoporous anodic oxide layer reduces the adhesion of ice, but the volume expansion of water during the freezing diminishes the effect. The lubricant-impregnated surface shows an extremely low adhesion of ice, since the lubricant inhibits the direct contact between ice and solid surface.

복합재 적층 구조물의 면내 파손 해석을 위한 소프트웨어 개발

정예지(Yeji Jung),최수영(Soo Young Choi),안현수(Hyon Su Ahn),하석운(Seok Wun Ha),문용호(Yong Ho Moon) 한국항공우주학회 2016 한국항공우주학회 학술발표회 논문집 Vol.2016 No.11