오감각적 자극과 감성 브랜드 프로모션 공간 연출 디자인에 관한 연구 -마임 건강식품 알로주스 프로모션 연출을 중심으로-

김은애,김예은,정채림,진산,이진민,장미정,이성애 숙명여자대학교 산업디자인연구소 2017 숙명디자인학 연구 Vol.24 No.-

본 연구는 최근 감성중심의 디자인 환경에서 화두되고 있는 ‘오감’을 활용하여 브랜드 프로모션 공간을 연출하는 일련의 프로세스를 제안하는데 목적이 있다. 본 연구 범위는 2017년 3월~6월 15주간 숙명여대 환경디자인학과 <융합연출디자인> 수업에서 진행된 수업의 결과물로서 4개 팀 중 1개 팀의 작업물이다. 연구방법은 오감에 대한 문헌 연구와 융합연출 디자인 조사 정리한 사례 연구로 한다. 그 결과 본 연구는 산업체 <마임>과 연계하여 오감을 융합하는 쇼케이스 프로젝트부터 실제 브랜드 프로모션 공간 연출에 이르기까지 건강식품에 대한 브랜드의 일관성과 감성, 스토리성을 제시하였다. 끝으로 본 연구는 오감 을 활용한 공간 연출 디자인으로, 브랜드와 실질적으로 융합하여 브랜드를 프로모션함에 있어서 감성적인 접근방안을 제시 한 것에 의의가 있다. 또한 향후 본 연구는 이와 관련된 공감각, 오감을 담은 브랜드커뮤니케이션 디자인과 브랜드이미지, 브랜드 공간 연출개발에 있어서 기초 자료로 활용될 것으로 기대된다.

표면근전도와 전자각도기를 이용한 자동차 부품 조립작업 위험요인 평가

강동묵,이철호,,신용철,김은아,우지훈,조병만,이수일 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Objectives: As automobile part manufacturing is characterized by high speed and high repetition, observation methods which are usually utilized for static posture are inappropriate to evaluate musculoskeleatal risk factors. This study quantified the risk factors of musculoskeletal disorders on the forearm and suggested exposure limits by estimating the risk factors using surface electromyography (EMG) and electrogoniometer. Methods: Ten percent of the total workers at 3 automobile part manufacturing factories were randomly selected, and 99 male workers were recruited as study subjects. The study was conducted during May 2003 to September 2004. The workers were equipped with electrogoniometers on the wrist and the elbow, surface EMGs on the skin of the flexor digitorum superficialis (FDS) and extensor carpi radialis (ECR) muscles, and the heart beat recorder during work as indicators of joint movement, local muscle tension and physical work load, respectively. Results: After controlling for age, body mass index and job stress, wrist flexion maximum angle, FDS relative activity (RA) and ECR RA were significantly associated with forearm musculoskeletal symptoms. The odds ratios of the forearm were 5.0(95% CI: 1.1-22.7), 14.0(95% CI: 1.5-128.8) and 7.3(95% CI: 1.1-49.4) for wrist flexion maximum angle more than 76˚, FDS RA more than 2.8%, and ECR RA more than 3.5%, respectively. Conclusions: Joint angle and focal muscle activity were associated with forearm musculoskeletal symptoms. To reduce forearm musculoskeletal symptoms among automobile part manufacturers, the wrist flexion angle, and FDS and ECR activity need to be reduced below the guidelines recommended in this study.

Change of lysophosphatidylcholine 16:0 predict 28-day mortality in sepsis patients admitted to the intensitve care unit : a prospective study using MALDI-TOF MS

( Eun Hye Lee ),( Mi Hwa Shin ),( Jong-min Park ),( Sang-guk Lee ),( Nam Su Ku ),( Ah Young Leem ),( Sang Hoon Lee ),( Joo Han Song ),( Song Yee Kim ),( Kyung Soo Chung ),( Ji Ye Jung ),( Young Ae Kan 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

Purpose: Sepsis remains a critical problem worldwide and one of the main causes of death in intensive care units (ICU). We investigated plasma lysophosphatidylcholine (LPC) 16:0 level using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in ICU sepsis patients. Methods: Patients admitted medical ICU were prospectively enrolled from March 2017 through June 2018 at Severance Hospital. The inclusion criteria for the study were a fulfillment of at least 2 criteria of systemic inflammatory response syndrome (SIRS) or presence of sepsis. The definition of sepsis followed the revised sepsis 3-definition. Results: Of the 120 enrolled patients, 15 patients were non-infectious SIRS, 37 patients were classified as sepsis and 68 were septic shock. Of these 105 patients who meet the sepsis diagnostic criteria, 70 patients survived and 35 patients were dead at 28-day. Mean plasma LPC concentration (μmol/L) of septic shock patients was significantly lower than those of non-infectious SIRS (26.55 vs. 70.65, p<0.001) and sepsis patients (26.55 vs. 48.50, p<0.01). The area under the curve (AUC) predicting 28-day mortality of ΔLPC16:0 (D7-D0) was 0.792 that was higher than APACHE II score (AUC;0.694) and SOFA score (AUC;0.678). In the multivariate analysis, LPC16:0 change less than cut-off value (Δ LPC16:0 (D7-D0) ≤14.859; HR, 5.467) were associated with increased 28-day mortality. Conclusion: Our results indicate that Δ LPC16:0 in sepsis patients using MALDI-TOF MS could help to better predict prognosis and mortality of sepsis patients in ICU.

Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity

Lee, Eun-Young,Lee, Hyun-Cheol,Kim, Hyun-Kwan,Jang, Song Yee,Park, Seong-Jun,Kim, Yong-Hoon,Kim, Jong Hwan,Hwang, Jungwon,Kim, Jae-Hoon,Kim, Tae-Hwan,Arif, Abul,Kim, Seon-Young,Choi, Young-Ki,Lee, Che NATURE AMERICA INC 2016 NATURE IMMUNOLOGY Vol.17 No.11

<P>The mammalian cytoplasmic multi-tRNA synthetase complex (MSC) is a depot system that regulates non-translational cellular functions. Here we found that the MSC component glutamyl-prolyl-tRNA synthetase (EPRS) switched its function following viral infection and exhibited potent antiviral activity. Infection-specific phosphorylation of EPRS at Ser990 induced its dissociation from the MSC, after which it was guided to the antiviral signaling pathway, where it interacted with PCBP2, a negative regulator of mitochondrial antiviral signaling protein (MAVS) that is critical for antiviral immunity. This interaction blocked PCBP2-mediated ubiquitination of MAVS and ultimately suppressed viral replication. EPRS-haploid (Eprs(+/-)) mice showed enhanced viremia and inflammation and delayed viral clearance. This stimulus-inducible activation of MAVS by EPRS suggests an unexpected role for the MSC as a regulator of immune responses to viral infection.</P>

만성 췌장염에 동반된 비장 내 가성낭종 1 예

이은희,안대현,박두호,양동헌,안병민,황성하,이동수,이강문,이영중,장영이 대한소화기학회 2000 대한소화기학회지 Vol.36 No.5

As the pancreas and the spleen lie adjacently, complication in spleen may occur during the course of acute or chronic pancreatitis. Intrasplenic pseudocyst is one of the complications which may occur. These complications are spontaneous rupture, bleeding, secondary infection (abscess) and splenic infarction. Intrasplenic pseudocyst is the most common complication. Diagnosis can be usually made under emergency conditions and is mainly based on ultrasonogram, computed tomography (CT), selective arteriogram, endoscopic retrograde cholangiopancreatography (ERCP) and ultrasono-or computed tomography-guided needle aspiration of fluid collection in the left upper quadrant. We experienced a 48-year-old man complaining of supraumbilical pain. He was diagnosed as having intrasplenic pseudocyst associated with chronic pancreatitis, which was confirmed by ultrasonography of abdomen, abdominal CT, ERCP and ultrasono-guided aspiration. After external catheter drainage was performed intrasplenic pseudocyst was regressed, but still remained. Thus, distal pancreatectomy and splenectomy were performed. We report this case with a review of literature.

Clinical and microbiological features of nontuberculous mycobacteria infection in young adult : experience at a tertiary hospital

( Eun Hye Lee ),( Ah Young Leem ),( Sang Hoon Lee ),( Joo Han Song ),( Song Yee Kim ),( Kyung Soo Chung ),( Ji Ye Jung ),( Moo Suk Park ),( Young Sam Kim ),( Joon Chang ),( Young Ae Kang ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

Background: The prevalence of nontuberculous mycobacteria lung disease (NTM-LD) is increasing worldwide. However, there is limited information about the NTM-LD of young age people. Methods: Patients diagnosed with NTM-LD at severance hospital between January 2006 and December 2016 were retrospectively reviewed. Clinical characteristics and microbiologic features of patients under 40 years were compared with patients over 40 years. Results: Total 906 patients were identified NTM-LD. Of these, 29 patients (3.2%) were under 40 years of age (young age group) and the remaining 877 were over 40 years of age (old age group). Mean age of the two groups were 32 (IQR 24-33) and 64 (IQR 56-72), respectively. Female was predominant in both groups and about half of the patients had a history of tuberculosis (51.7% vs.51.5%, p=0.984). 7 patients (24.1%) of the young age group had malignancy history and among them, 6 patients were hematologic cancer who subsequently received bone marrow transplantation. The proportion of the nodular bronchiectatic form of NTM-LD is significantly higher in old age group (67.5%) compared to young age group (31.0%) (p=<0.001). M.avium complex (MAC) was the most common etiologic organism in both groups, however, it was less common in the young age group (44.8% vs. 65.3%, p=0.023). Identification of M.abscessus complex (MABC) was higher in young age group although statistically insignificant (24.1% vs. 17.0%, p=0.318). Conclusion: This study could help to better understand the characteristics and microbial features of NTM-LD of young age people.

Regional Gray Matter Volume Related to High Occupational Stress in Firefighters

Lee Deokjong,Kim Woojin,Lee Jung Eun,Lee Junghan,Lee Seung-Koo,Chang Sei-Jin,Jeung Da Yee,Hyun Dae-Sung,Ryu Hye-Yoon,Kim Changsoo,Jung Young-Chul 대한의학회 2021 Journal of Korean medical science Vol.36 No.50

Background: Firefighters inevitably encounter emotionally and physically stressful situations at work. Even firefighters without diagnosed post-traumatic stress disorder receive clinical attention because the nature of the profession exposes them to repetitive trauma and high occupational stress. This study investigated gray matter abnormalities related to high occupational stress in firefighters using voxel-based morphometry (VBM) and surface-based morphometry (SBM). Methods: We assessed 115 subjects (112 males and 3 females) using magnetic resonance imaging and evaluated occupational stress by the Korean Occupational Stress Scale-26 (KOSS-26). Subjects were classified into highly or lowly stressed groups based on the median value of the KOSS-26. Results: In VBM analysis, we found that firefighters with high occupational stress had lower gray matter volume (GMV) in both sides of the insula, the left amygdala, the right medial prefrontal cortex (mPFC), and the anterior cingulate cortex than firefighters with low occupational stress. In SBM analysis based on regions of interest, the GMV of the bilateral insula and right mPFC were also lower in the highly stressed group. Within the highly stressed group, low GMV of the insula was significantly correlated with the length of service (left: r = −0.347, P = 0.009; right: r = −0.333, P = 0.012). Conclusion: Our findings suggest that regional GMV abnormalities are related to occupational stress. Regional gray matter abnormalities and related emotional dysregulation may contribute to firefighter susceptibility to burnout.

Novel pendrin inhibitor attenuates lipopolysaccharide-induced acute lung injury in mice

( Eun Hye Lee ),( Jae Young Choi ),( Mi Hwa Shin ),( Wan Namkung ),( Ji Soo Choi ),( Su Hwan Lee ),( Ah Young Leem ),( Sang Hoon Lee ),( Kyung Soo Chung ),( Song Yee Kim ),( Ji Ye Jung ),( Young Ae Ka 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.0

Background: Pendrin is encoded by SLC26A4 and its mutation leads to congenital hearing loss. Additionally, pendrin is up-regulated in inflammatory airway diseases such as chronic obstructive pulmonary disease, allergic rhinitis, and asthma. In this study, the effects of a novel pendrin inhibitor, YS-01, were investigated in an LPS-induced acute lung injury (ALI) mice model, and the mechanism underlying the effect of YS-01 was examined. Methods: LPS (10 mg/kg) was intranasally instilled in wild type (WT) and pendrin-null mice. Lung injury parameters were assessed in the lung tissue and bronchoalveolar lavage fluid (BALF). Pendrin levels in the BALF of 41 pneumonia/ARDS patients and 25 control (solitary pulmonary nodule) patients were also measured. Results: LPS instillation induced lung injury in WT mice but not in pendrin-null mice. YS-01 treatment dramatically attenuated lung injury and reduced BALF cell counts and protein concentration after LPS instillation in WT mice. Proinflammatory cytokines and NF-κB activation were suppressed by YS-01 treatment in LPS-induced ALI mice. However, the protective effects of pendrin inhibitor lost after SCN- instillation. Furthermore, pendrin expression was upregulated in pneumonia/ARDS patient compared to that in control patient BALF (mean, 24.86 vs. 6.83 ng/mL, p < 0.001). Conclusions: A novel Pendrin inhibitor, YS-01, suppressed lung injury in LPS-induced ALI mice and our data provide a new strategy for the treatment of inflammatory airway diseases including sepsis-induced ALI.

Analysis on difference of consumer’s evaluation on visual features of pork cuts

( Yee Eun Lee ),( Hyun Jung Lee ),( Minsu Kim ),( Ji Won Yoon ),( Minkyung Ryu ),( Cheorun Jo ) 한국축산학회(구 한국동물자원과학회) 2021 한국축산학회지 Vol.63 No.3

This study investigates how visual appearance of pork cuts affects consumer preference. Images of pork belly, Boston butt, and loin were chosen on the basis of visible fattiness and used to analyze consumers’ perception of the appearance of each pork cut. Meat color and visible fat proportion of images of pork cuts were analyzed by the researchers before conducting the survey. A total of 211 pork eaters evaluated the pork cuts based on appearance (lightness of color, redness, visible fat proportion, and fat distribution), preferability, and overall acceptability. Also, muscle pieces from different pork cuts were taken and the relative area composition of muscle fibers was measured. Based on survey results, correlation between visual traits and preferences of each pork cut was analyzed. The survey results showed that preferred pork appearance varied as per each individual’s favorite pork cut. Also, the respondents evaluated visual characteristics and preference for each pork cut differently possibly due to the different visual characteristics of each cut. Correlation analysis between visual traits and preference indicated that overall acceptability of pork cuts was mainly influenced by fat preference, followed by color preference. Fat and color preferences for each pork cut were affected by various visual attributes including redness, lightness of color, visible fat proportion, and fat distribution, but their effects were considerably varied among different pork cuts. Thus, Korean consumers perceived and assessed pork appearance using various quality cues but the evaluation depended on which cut was being observed.

The change of serum inflammatory markers and cytokines following anti-tuberculosis drug therapy.

( Eun Hye Lee ),( Ah Young Leem ),( Joo Han Song ),( Song Yee Kim ),( Kyung Soo Chung ),( Eun Young Kim ),( Ji Ye Jung ),( Moo Suk Park ),( Young Sam Kim ),( Se Kyu Kim ),( Joon Chang ),( Young Ae Kan 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Introduction: Active pulmonary tuberculosis (TB) is associated with cell-mediated immunity. Multiple cytokines and inflammatory markers are known to have roles in control TB infection. In this study, we aimed to investigate the change of multiple cytokines and inflammatory markers in active TB patients following anti-TB drug therapy. Methods: Patients with active TB were prospectively recruited between December 2010 and February 2013 at Severance Hospital, in Seoul, South Korea. Treatment was based on the standard regimen of rifampicin (10 mg/kg body weight [BW]/day), isoniazid( 5 mg/kg BW/day), ethambutol (15-25 mg/kg BW/day),and pyrazinamide (15-30 mg/kg BW/day). Blood samples were collected from active TB patients (total n=18) at before (T0), after 2 months (T2), and after 6 months (T6) of anti-TB treatment. We measured the levels of IFN-γ, IL-2, IL-12, IL-10, IL-13, and TNF-αin the supernatant from the QuantiFERON-TB Gold In-Tube assay (QFT-GIT) and WBC count, neutrophil count, lymphocyte count, platelet count, red cell distribution width (RDW), mean platelet volume(MPV), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR). Results: Compared to baseline levels, IL-10, TNF-α in the supernatant from QFT-GIT, WBC count, neutrophil count, platelet count were produced in significantly lower amounts in response to the treatment. As for IFN-γ, IL-2, IL-12, IL-13 responses, the decrease of median values were not statistically significant. Also the results showed that the IL-10/ IFN-γ ratio of supernatant of QFT-GIT and neutrophil to lymphocyte ratio (NLR)after treatment significantly decreased compared to the baseline, whereas the IL-2/ IFN-γ ratio of supernatant of QFT-GIT increased after treatment. Conclusions: In conclusion, IL-10, TNF-αin the supernatant from QFT-GIT, WBC count, neutrophil count, platelet count decreased following anti-TB drug therapy. And also the IL-2/IFN-γ ratio, IL-10/IFN-γ ratio of supernatant of QFT-GIT, neutrophil to lymphocyte ratio (NLR) may be used as biomarkers to evaluate the effectiveness of drug therapy in active TB patients.