Clinical Significance of BCR-ABL Fusion Gene Subtypes in Chronic Myelogenous and Acute Lymphoblastic Leukemias

Ye, Yuan-Xin,Zhou, Juan,Zhou, Yan-Hong,Zhou, Yi,Song, Xing-Bo,Wang, Jun,Lin, Li,Ying, Bin-Wu,Lu, Xiao-Jun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22

Background: Some reports have suggested that chronic myeloid leukemia (CML) patients have a higher prevalence of M-bcr than acute lymphoblastic leukemia (ALL) patients, which show a higher prevalence of m-bcr. However, the relationship between BCR-ABL subtypes and progression of CML and ALL remains unclear. Materials and Methods: 354 CML chronic phase (CML-CP) patients, 26 CML blastic phase (CML-BP) patients and 72 ALL patients before treatment with BCR-ABL positive were recruited for blood routine examination and bone marrow smear cytology. Some 80 CML-CP and 32 ALL patients after imatinib (IM) treatment were followed-up for BCR-ABL relative concentrations detected after treatment for 3, 6 and 9 months and 1 year. Results: Before treatment, CML-CP patients showed lower BCR-ABL relative concentrations with a higher proportion of M-bcr (42.7%) compared to CML-BP and ALL patients while ALL patients had a higher BCR-ABL relative concentration with high expression of m-bcr (51.4%). Patients with M-bcr demonstrated higher WBC counts than those with m-bcr and the mixed group and higher PLT counts were noted in the CML-CP and ALL groups. After imatinib (IM) treatment, patients with m-bcr showed higher BCR-ABL relative concentrations in both CML-CP and ALL groups. Conclusions: This study identified the BCR-ABL gene as an important factor in CML and ALL cases. The M-bcr subtype was associated more with CML while the m-bcr subtype was associated more with ALL. Patients with m-bcr seem to have a poorer response to IM in either CML or ALL patients compared to M-bcr patients.

王羲之新體書風研究

YE XIN 한국동양예술학회 2022 동양예술 Vol.54 No.-

왕희지는 중국서예사에서 이른바 서성으로 일컬어질 정도로 위대한 서예가로 평가받고 있다. 문제는 서예미학과 서예사적 측면에서 볼 때 어떤 점에서 왕희지를 이처럼 추숭하는가 하는 점에 대해서는 구체적으로 밝힌 연구는 별로 없다. 본 논문에서는 이런 점을 王羲之의 서풍을 이른바 新體書風이란 관점에 초점을 맞추어 규명하고자 한 것이다. 구체적으로는 왕희지 신체서풍의 형성 배경과 신체서풍의 특징, 신체서풍의 심미의식에 초점을 맞추어 논한 것이다. 먼저 왕희지 신체서풍의 형성 배경을 왕희지가 살았던 시대 정황 및 서풍 변모에 초점을 맞추어 살펴보았다. 왕희지 서풍을 신체서풍이라고 할 수 있다면 그 신체서풍과 상대적인 구체서풍이 있었다고 할 수 있다. “구체서풍(古體書風)”의 작품들은 한 가지 공동적인 특징이 있다. 즉 용필은 소박하고 무게가 있으며 예서 파임의 필의가 있고 결구는 대부분 납작하고 횡세를 취하며 글자마다 다 독립적이다. 본 논문에서는 이 같은 구체서풍에서 탈피한 왕희지 신체 서풍의 특징이 무엇인지를 규명하였다. 구체적으로 왕희지가 기존의 각체를 精研하였고, 기존 서풍이 갖는 여러 가지 장점을 博採하였고, 漢魏古風을 벗어나고자 한 점에서 규명하였다. 다음 구체서풍과 상대화된 新軆書風의 審美意識을 살펴보고자 하였다. 이런 점을 왕희지 신체서풍은 陰柔之美를 강조하였고, 아울러 中和之美를 존숭했다는 점에서 규명하였다. 이같은 연구와 규명을 통해 왕희지 신체 서풍이 갖는 서예사적인 의미와 미학을 규명하고자 하였다.

Research on Improved Collaborative Filtering Recommendation Algorithm

Xin Ye 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.9

This paper has improved the accuracy of recommendation by an improved collaborative filtering algorithm based on conventional computing method. By considering the preferences of different user and the similarity of their respective preferences, it proposed a similarity formula based on logarithm. Experimental results show that compared to traditional collaborative filtering algorithms, the new recommendation algorithm dramatically increased the recommendation accuracy, with better personalized recommendation effect.

Characterization of gene expression in watermelon ripening fruit by random cDNA sequencing

Ye Xin Rong,Choy Yoon Hi(최윤희),Nam Hong Gil(남홍길) 한국원예학회 1999 원예과학기술지 Vol.17 No.2

Laparoscopic Liver Resection: A Journey from Strength to Strength

Ye Xin Koh,Ser Yee Lee,Goh Kim Poh, Brian,Chung Yip Chan Korean Society of Gastrointestinal Cancer 2017 Journal of digestive cancer reports Vol.5 No.1

Risk of Treatment-related Mortality with Sorafenib in Patients with Cancer

Zhang, Xin-Ji,Zhang, Tian-Yi,Yu, Fei-Fei,Wei, Xin,Li, Ye-Sheng,Xu, Feng,Wei, Li-Xin,He, Jia Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Background: Fatal adverse events (FAEs) have been reported with sorafenib, a vascular endothelial growth factor receptor kinase inhibitor (VEGFR TKI). We here performed an up-to-date and detailed meta-analysis to determine the overall risk of FAEs associated with sorafenib. Methods: Databases, including PubMed, Embase and Web of Science, and abstracts presented at the American Society of Clinical Oncology annual meetings were searched to identify relevant studies. Eligible studies included randomized controlled trials evaluating sorafenib effects in patients with all malignancies. Summary incidence rates, relative risks (RRs), and 95% confidence intervals (CIs) were calculated for FAEs. In addition, subgroup analyses were performed according to tumor type and therapy regimen. Results: 13 trials recruiting 5,546 patients were included in our analysis. The overall incidence of FAEs with sorafenib was 1.99% (95%CI, 0.98-4.02%). Patients treated with sorafenib had a significantly increased risk of FAEs compared with patients treated with control medication, with an RR of 1.77 (95%CI 1.25-2.52, P=0.001). Risk varied with tumour type, but appeared independent of therapy regimen. A significantly increased risk of FAEs was observed in patients with lung cancer (RR 2.26; 95% CI 1.03-4.99; P= 0.043) and renal cancer (RR 1.84; 95% CI 1.15-2.94; P= 0.011). The most common causes of FAEs were hemorrhage (8.6%) and thrombus or embolism (4.9%). Conclusions: It is important for health care practitioners to be aware of the risks of FAEs associated with sorafenib, especially in patients with renal and lung cancer.

Association Between MDM2 SNP309 T>G and Risk of Gastric Cancer: A Meta-analysis

Tian, Xin,Tian, Ye,Ma, Ping,Sui, Cheng-Guang,Meng, Fan-Dong,Li, Yan,Fu, Li-Ye,Jiang, Tao,Wang, Yang,Ji, Fu-Jian,Fang, Xue-Dong,Jiang, You-Hong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Background: As a negative regulator of P53, MDM2 plays an important role in carcinogenesis; a polymorphism in its promoter region. SNP309 T>G, is known to increase the expression of MDM2, thus being considered related to higher susceptibility to neoplasia. However, no agreement has been achieved regarding its effects on gastric cancer. Methods: The present systematic meta-analysis was performed based on comprehensive literature search from Pubmed, Web of science and CBM databases. Results: It was suggested from 6 independent studies that the GG genotype is associated with a significantly increased risk of gastric cancer (Recessive: OR = 1.43, 95% CI = 1.08-1.91, P = 0.013), and subgroup analysis also confirmed the relationship (English publications-recessive model: OR = 1.45, 95% CI = 1.10-1.91, P = 0.009; Studies in China-recessive model: OR = 1.58, 95% CI = 1.08-2.30, P = 0.017). No publication bias was detected. Conclusion: The meta-analysis indicated a significant inverse association between GG genotype carriage and elevated risk of gastric cancer. However, more studies and detailed information are needed to fully address the topic.

A Fuzzy C-Means Clustering Algorithm Based on Improved Quantum Genetic Algorithm

An-Xin Ye,Yong-Xian Jin 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.1

Aiming at the problem of traditional fuzzy C-means clustering algorithm that it is sensitive to the initial clustering centers and easy to fall into the local optimization, an improved algorithm that combines Improved Quantum Genetic Optimization with FCM algorithm is proposed. In this study, chromosomes are comprised of quantum bits encoded by real number. Chromosomes are renovated by quantum rotating gates and mutated by quantum hadamard gate. The gradients of object function are utilized in adjusting the value of rotating angle by a dynamic strategy. Each chain of genes represents a optimization result, Therefore, a double searching space is acquired for the same number of chromosomes. Experimental results show that the proposed method improves the stability and the accuracy of classification.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun,Yeting Hong,Yuhan Shu,Caixia Wu,Guiqin Ye,Hanxiao Chen,Hongying Zhou,Ruilan Gao,Jianbin Zhang 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.2

Colon cancer, the third most frequent occurred cancer, has high mortality and extremely poor prognosis. Ginsenoside, the active components of traditional Chinese herbal medicine Panax ginseng, exerts antitumor effect in various cancers, including colon cancer. However, the detailed molecular mechanism of Ginsenoside in the tumor suppression have not been fully elucidated. Here, we chose the representative ginsenoside Rg3 and reported for the first time that Rg3 induces mitophagy in human colon cancer cells, which is responsible for its anticancer effect. Rg3 treatment leads to mitochondria damage and the formation of mitophagosome; when autophagy is inhibited, the clearance of damaged mitochondria can be reversed. Next, our results showed that Rg3 treatment activates the PINK1-Parkin signaling pathway and recruits Parkin and ubiquitin proteins to mitochondria to induce mitophagy. GO analysis of Parkin targets showed that Parkin interacts with a large number of mitochondrial proteins and regulates the molecular function of mitochondria. The cellular energy metabolism enzyme GAPDH is validated as a novel substrate of Parkin, which is ubiquitinated by Parkin. Moreover, GAPDH participates in the Rg3-induced mitophagy and regulates the translocation of Parkin to mitochondria. Functionally, Rg3 exerts the inhibitory effect through regulating the nonglycolytic activity of GAPDH, which could be associated with the cellular oxidative stress. Thus, our results revealed GAPDH ubiquitination by Parkin as a crucial mechanism for mitophagy induction that contributes to the tumor-suppressive function of ginsenoside, which could be a novel treatment strategy for colon cancer.

Association between the severity of hypodontia and the characteristics of craniofacial morphology in a Chinese population: A cross-sectional study

Xin Xiong,Jiaqi Liu,Yange Wu,Chengxinyue Ye,Qinlanhui Zhang,Yufan Zhu,Wenke Yang,Jun Wang 대한치과교정학회 2023 대한치과교정학회지 Vol.53 No.3

Objective: To investigate craniofacial differences in individuals with hypodontia and explore the relationship between craniofacial features and the number of congenitally missing teeth. Methods: A cross-sectional study was conducted among 261 Chinese patients (males, 124; females, 137; age, 7–24 years), divided into four groups (without hypodontia: no teeth missing, mild: one or two missing teeth, moderate: three to five missing teeth, severe: six or more missing teeth) according to the number of congenitally missing teeth. Differences in cephalometric measurements among the groups were analyzed. Further, multivariate linear regression and smooth curve fitting were performed to evaluate the relationship between the number of congenitally missing teeth and the cephalometric measurements. Results: In patients with hypodontia, SNA, NA-AP, FH-NA, ANB, Wits, ANS-Me/N-Me, GoGn-SN, UL-EP, and LL-EP significantly decreased, while Pog-NB, AB-NP, N-ANS, and S-Go/N-Me significantly increased. In multivariate linear regression analysis, SNB, Pog-NB, and S-Go/N-Me were positively related to the number of congenitally missing teeth. In contrast, NA-AP, FH-NA, ANB, Wits, N-Me, ANS-Me, ANS-Me/N-Me, GoGn-SN, SGn-FH (Y-axis), UL-EP, and LL-EP were negatively related, with absolute values of regression coefficients ranging from 0.147 to 0.357. Further, NA-AP, Pog-NB, S-Go/N-Me, and GoGn-SN showed the same tendency in both sexes, whereas UL-EP and LL-EP were different. Conclusions: Compared with controls, patients with hypodontia tend toward a Class III skeletal relationship, reduced lower anterior face height, flatter mandibular plane, and more retrusive lips. The number of congenitally missing teeth had a greater effect on certain characteristics of craniofacial morphology in males than in females.