http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Guarana Water Eextraction Thing of The Comparison with Acute Toxic and Learning Ability Effects
Suzuki, Ikukatsu,Gu, Yeun-Hwa,Hayashi, Ikuo,Takeuchi, Tetsuo,Takagi, Yasuyuki,Mizumoto, Norihite INSTITUTE OF ORIENTAL MEDICINE KYUNG-HEE UNIVERSIT 2002 JOURNAL OF ORIENTAL MEDICINE Vol.7 No.1
Central excited material is contained in Guarana water extraction thing, and the central excited material is thought to be caffeine, teopiline, and teobulomine by this experiment. And, the LD50 value of Guarana water extraction thing without a shell is calculated 2900mg/kg with though the LD50 value of Guarana warter extraction thing with the shell was calculated 1350mg/kg with by the Behrens-Karber method. An acute toxic examination due to the existence of the shell was done again and more than the above result as a future subject. The computation of the LD50 value and the analysis of the element of the shell could get it further again in fraction chromatography. It is examined where strong toxic material is contained, and it thinks that it is necessary to do specifying of the toxic material.
Akira Furuta,Yasuyuki Suzuki,Taro Igarashi,Takahiro Kimura,Shin Egawa,Naoki Yoshimura 대한배뇨장애요실금학회 2022 International Neurourology Journal Vol.26 No.1
Purpose: To investigate the influence of multiple recurrences and repeated surgeries of Hunner lesions on bladder capacity under general anesthesia in patients with interstitial cystitis (IC). Methods: We retrospectively reviewed the clinical records of Hunner-type IC (HIC) patients who underwent transurethral fulguration or resection of Hunner lesions combined with hydrodistension by a single surgeon between 2011 and 2020. Recurrence was defined as reappearance of uncontrolled urinary symptoms in association with new Hunner lesions identified by cystoscopy. Recurrent Hunner lesions were then treated by transurethral surgeries. The recurrence-free rate, potential predictive factors of recurrence, and changes in bladder capacity under anesthesia were examined at each surgical procedure. Results: A total of 92 surgeries were performed in 47 HIC patients, 23 (49%) of whom required multiple procedures (range, 1–5 times). The mean recurrence-free time after the first surgery was 21.7 months. The recurrence-free rate was 53% at 24 months, and decreased to 32% at 48 months. There were no significant differences in age, sex, bladder capacity under anesthesia at the first surgery, duration from symptom onset to the first surgery, O’Leary-Sant questionnaire including symptom and problem indexes, visual analogue scale pain score, and the number of comorbidities between the cases with or without recurrence. Bladder capacity under anesthesia was gradually decreased as the number of surgeries was increased, and bladder capacity at the fourth procedure was significantly decreased to 80% of the capacity at the first surgery. Conclusions: These results suggest that multiple recurrences and repeated surgeries of Hunner lesions result in a reduction of bladder capacity under anesthesia in HIC patients although no predictive factors for recurrence of Hunner lesions were detected
( Seongjin Oh ),( Yasuyuki Suzuki ),( Shusuke Hayashi ),( Yutaka Suzuki ),( Satoshi Koike ),( Yasuo Kobayashi ) 한국축산학회(구 한국동물자원과학회) 2017 한국축산학회지 Vol.59 No.11
Background: Cashew nut shell liquid (CNSL) is an agricultural byproduct containing alkylphenols that has been shown to favorably change the rumen fermentation pattern only under experimentally fixed feeding conditions. Investigation of CNSL potency in rumen modulation under a variety of feeding regimens, and evidence leading to the understanding of CNSL action are obviously necessary for further CNSL applications. The objective of this study was to evaluate the potency of CNSL for rumen modulation under different dietary conditions, and to visually demonstrate its surfactant action against selected rumen bacteria. Methods: Batch culture studies were carried out using various diets with 5 different forage to concentrate (F:C) ratios (9:1, 7:3, 5:5. 3:7 and 1:9). Strained rumen fluid was diluted with a buffer and incubated with each diet. Gas and short chain fatty acid (SCFA) profiles were characterized after 18 h incubation at 39 °C. Monensin was also evaluated as a reference additive under the same conditions. Four species of rumen bacteria were grown in pure culture and exposed to CNSL to determine their morphological sensitivity to the surfactant action of CNSL. Results: CNSL supplementation decreased total gas production in diets with 5:5 and 3:7 F:C ratios, whereas the F:C ratio alone did not affect any gas production. Methane decrease by CNSL addition was more apparent in diets with 5:5, 3:7, and 1:9 F:C ratios. An interactive effect of CNSL and the F:C ratio was also observed for methane production. CNSL supplementation enhanced propionate production, while total SCFA production was not affected. Monensin decreased methane production but only in a diet with a 1:9 F:C ratio with increased propionate. Studies of pure cultures indicated that CNSL damaged the cell surface of hydrogen- and formate-producing bacteria, but did not change that of propionate-producing bacteria. Conclusion: CNSL can selectively inhibit rumen bacteria through its surfactant action to lead fermentation toward less methane and more propionate production. As CNSL is effective over a wider range of dietary conditions for such modulation of rumen fermentation in comparison with monensin, this new additive candidate might be applied to ruminant animals for various production purposes and at various stages.
Enhancement of Radioprotection and Anti-Tumor Immunity by Yeast-Derived β-Glucan in Mice
Yoshimi Niwano,Yasuyuki Takagi,Takashi Nakamura,Takeo Hasegawa,Ikukatsu Suzuki,Masami Oshima,Hitoshi Tawaraya,Yeun-hwa Gu 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.2
Intraperitoneal injection of .-glucan was shown to greatly delay mortality in mice exposed to whole-bodyX-ray radiation and tumor growth in tumor-bearing mice. Since the leukocyte and lymphocyte numbers were increased by asingle dose of .-glucan, the radioprotective effect of .-glucan is probably mediated, at least in part, by a hemopoietic actionin irradiated mice. In addition, both natural killer (NK) and lymphokine-activated killer (LAK) activities were significantlyincreased by repeated doses of .-glucan. Augmented immunological activity as seen in increased NK and LAK activity by .-glucan seems to play a role in preventing secondary infections associated with irradiation, and probably contributes to theattenuated tumor growth in tumor-bearing mice through enhanced anti-tumor immunity. These results suggest that .-glucanmay be a promising adjunct treatment for cancer patients receiving radiotherapy.
Monitoring Water Quality of Environmental Waters by Bioassays
Akiyoshi, Sakoda,Ryo, Shoji,Yasuyuki, Sakai,Motoyuki, Suzuki 영남대학교 환경문제연구소 2000 環境硏究 Vol.19 No.2
Environmental waters such as river and lake waters in Japan are often deteriorated by various kinds of trace and unidentified chemicals despite of the recent development of sewage systems and wastewater treatment technologies. This situation appears to become worse and worse. In addition to the contamination by particular toxicants, complex toxicity due to multi-component chemicals could be much more serious. Bioassays are toxicity tests of chemicals and pharmaceuticals by using living animal bodies, organs, cells and so on, and have been intensively utilized in pharmacology so far. The situation mentioned above have led us to apply bioassays far monitoring water quality of environmental waters by expressing the direct and potential toxicity to human beings and ecosystems instead of concentrations of particular chemicals. However, the problems encountered involve the fact that bioassays for pharmaceutical purposes in general need complicated, time-consuming and expert procedures. Also, a methodology to feed back the resultant toxicity data to water environment management is not establishcd yet. For this purpose, we have developed a novel bioassay methodology based on the fluorescein isothiocyanate-labelled low-density lipopntein (FITC-LDL) uptaking activity of human hepatoblastoma Hep G2 cells. The new method enabled us to detect the toxicity of environmental waters such as river water directly within 2 hours of exposure without concentrating water samples. This is significantly quick and easy as compared to conventional cell survival bioassays. The toxicity data for 255 selected chemicals sod environmental waters obtained by this method were organized by a mathematical equation in order to make use of those data much more effectively and practically to the management of environmental waters. The mathematical description of complex toxicity found for mixtures was proposed and demonstrated. As model cases of our methodology, some approaches to reduce the toxicity actually delected in a river water were proposed. Our methodology would be one of the promising examples of applying bioassays for monitoring environmental water quality and of suggesting a solution of toxicity problem encountered.