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SHIROZU, Takahiro,IWANO, Hiroki,OGISO, Takatoshi,SUZUKI, Toshiyuki,BALBOULA, Ahmed Z.,BAI, Hanako,KAWAHARA, Manabu,KIMURA, Koji,TAKAHASHI, Hitomi,RULAN, Bai,KIM, Sung-Woo,YANAGAWA, Yojiro,NAGANO, Masa 家畜繁殖硏究所 2017 Journal of Reproduction and Development Vol.63 No.3
<P> Interferon tau (IFN-τ) is a ruminant-specific type I IFN secreted by a conceptus before its attachment to the uterus. IFN-τ induces the expression of IFN-stimulated genes (ISGs) via the type I IFN receptor (IFNAR), which is composed of IFNAR1 and IFNAR2 subunits in the endometrium. However, expression patterns of IFNARs during the estrous cycle have not been reported. We hypothesized that the response to a type I IFN changes along with IFNARs and the IFN-regulatory factors (IRFs) driving transcription of IFN signal-related genes and modulating a type I IFN signal during the estrous cycle. We investigated the estrous cycle stage-dependent type I IFN induction of ISGs and expression patterns of IFN signal-related genes in bovine endometrial tissues. Endometrial tissue pieces collected from bovine uteri at each estrous stage (early, mid, and late) were cultured with or without recombinant bovine IFN-α or concentrated pregnant uterine flushing (PUF) on day 18 after confirming the presence of a conceptus. IFN-α and PUF each significantly increased the expression of ISGs in endometrial tissues. The induction levels of the typical ISGs (<I>MX1-a</I> and <I>ISG15</I>) were significantly higher at the mid stage and correlated with high expression of <I>IRFs</I> at the mid stage. The immunostaining of IFNARs showed strong fluorescence intensities in luminal and glandular epithelia at the early and mid stages. Collectively, these results suggest that the endometrium exhibits estrous cycle stage-dependent responsiveness to type I IFN that may be associated with the expression of IFNARs and IRFs for pregnancy recognition.</P>
Complex Epidemiology of Prostate Cancer in Asian Countries
Kagenori Ito,Takahiro Kimura 대한비뇨기종양학회 2023 대한비뇨기종양학회지 Vol.21 No.1
The incidence of prostate cancer (PCa) has increased worldwide in recent years along with the recommendation for prostate-specific antigen testing, and mortality has been declining owing to advances in fragmented and simplified access to treatment care. However, GLOBOCAN (Global Cancer Observatory) data show that this result is not true for all countries. It has been reported that the degree of PCa progression at diagnosis and survival rates differ among racial groups. Based on various comparisons between Caucasians and Asians, it was inferred that survival rates were higher in Asians despite the higher degree of progression at diagnosis, suggesting a better prognosis for life compared with Caucasians. The survey among Asian countries did not reveal any obvious differences among Asian subregions; rather, it inferred that the impact of the level of development among the countries was significant. The development of healthcare systems and medical care could improve PCa survival in developing countries.
Akira Furuta,Yasuyuki Suzuki,Taro Igarashi,Takahiro Kimura,Shin Egawa,Naoki Yoshimura 대한배뇨장애요실금학회 2022 International Neurourology Journal Vol.26 No.1
Purpose: To investigate the influence of multiple recurrences and repeated surgeries of Hunner lesions on bladder capacity under general anesthesia in patients with interstitial cystitis (IC). Methods: We retrospectively reviewed the clinical records of Hunner-type IC (HIC) patients who underwent transurethral fulguration or resection of Hunner lesions combined with hydrodistension by a single surgeon between 2011 and 2020. Recurrence was defined as reappearance of uncontrolled urinary symptoms in association with new Hunner lesions identified by cystoscopy. Recurrent Hunner lesions were then treated by transurethral surgeries. The recurrence-free rate, potential predictive factors of recurrence, and changes in bladder capacity under anesthesia were examined at each surgical procedure. Results: A total of 92 surgeries were performed in 47 HIC patients, 23 (49%) of whom required multiple procedures (range, 1–5 times). The mean recurrence-free time after the first surgery was 21.7 months. The recurrence-free rate was 53% at 24 months, and decreased to 32% at 48 months. There were no significant differences in age, sex, bladder capacity under anesthesia at the first surgery, duration from symptom onset to the first surgery, O’Leary-Sant questionnaire including symptom and problem indexes, visual analogue scale pain score, and the number of comorbidities between the cases with or without recurrence. Bladder capacity under anesthesia was gradually decreased as the number of surgeries was increased, and bladder capacity at the fourth procedure was significantly decreased to 80% of the capacity at the first surgery. Conclusions: These results suggest that multiple recurrences and repeated surgeries of Hunner lesions result in a reduction of bladder capacity under anesthesia in HIC patients although no predictive factors for recurrence of Hunner lesions were detected
Pulmonary Metastases After Low-Dose-Rate Brachytherapy for Localized Prostate Cancer
Masahito Kido,Hidetoshi Kuruma,Hiroshi Sasaki,Kenta Miki,Manabu Aoki,Takahiro Kimura,Hiroyuki Takahash,Chihiro Kanehira,Shin Egawa 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.5
Purpose: To analyze unusual events and focus discussion on pulmonary metastasis in particular after low-dose-rate brachytherapy (LDR-BT) for prostate cancer (PCa). Materials and Methods: A total of 616 consecutive patients who had undergone LDR-BT for clinically localized PCa at Jikei University Hospital between October 2003 and April 2010 were enrolled in this study. Follow-up information was summarized, and patterns of biochemical recurrence and clinical outcome were investigated. Results: Disease risk was stratified as low-risk in 231 patients, intermediate-risk in 365, and high-risk in 20, respectively. Of these patients, 269 (43.7%) had received hormonal therapy (HT) in combination with LDR-BT, and 80 (13.0%) had received external beam radiotherapy (EBRT). Average dosimetric parameter values with and without EBRT were 95.3% and 94.2% for V100, 132.8 Gy and 164.2 Gy for D90, and 180.6 Gy2 and 173.7 Gy2 for the biologically effective dose. Biochemical recurrence was noted in 14 patients (6.1%) in the low-risk group, 25 patients (6.8%) in the intermediate-risk group, and 6 patients (30.0%) in the high-risk group, respectively. In these cases of biochemical recurrence, 9 (64.3%), 13 (52.0%), and 4 patients (66.7%) in each respective risk group showed signs of clinical recurrence. Five patients (19.2%) with clinical recurrence developed pulmonary metastases, of which 4 were isolated lesions. All tumors responded favorably to subsequent HT. Conclusions: LDR-BT for biologically aggressive PCa may be linked to possible pulmonary metastasis owing to tumor dissemination during seed implantation. This information is important in planning adequate treatment for these patients.
Angle-Resolved Photoemission Spectroscopy on Mixed-Valent Sm1−xYxS
Keiichiro Imura,Tetsuya Hajiri,Masaharu Matsunami,Shin-ichi Kimura,Masaki Kaneko,Takahiro Ito,Yusuke Nishi,Noriaki K. Sato,Hiroyuki S. Suzuki 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12
We report the results of angle-resolved photoemission spectroscopy (ARPES) on the Sm1−xYxSsystem, which exhibits a black-to-golden phase transition induced by yttrium substitution and by anapplied external pressure, in order to investigate the mechanism of this transition and the electronicstructure of both phases. The obtained ARPES spectrum of pure SmS (x = 0) indicates a bandinsulator, in which the shallowest electronic state is the Sm2+ 4f state at a binding energy of about0.4 eV. With increasing x, the top of the Sm2+ 4f band shifts to the lower binding energy side andtouches the Fermi level for x = 0.33. Because of the discontinuous reduction of the lattice constantin the vicinity of the black-to-golden phase transition (x 0.17), the golden phase induced byyttrium substitution is concluded to be an intermediate valence state.
SUZUKI, Toshiyuki,SAKUMOTO, Ryosuke,HAYASHI, Ken-Go,OGISO, Takatoshi,KUNII, Hiroki,SHIROZU, Takahiro,KIM, Sung-Woo,BAI, Hanako,KAWAHARA, Manabu,KIMURA, Koji,TAKAHASHI, Masashi 家畜繁殖硏究所 2018 Journal of Reproduction and Development Vol.64 No.6
<P>Interferon-tau (IFNT), a type I interferon (IFN), is known as pregnancy recognition signaling molecule secreted from the ruminant conceptus during the preimplantation period. Type I IFNs, such as IFN-alpha and IFN-beta, are known to activate cell-death pathways as well as induce apoptosis. In cows, induction of apoptosis with DNA fragmentation is induced by IFNT in cultured bovine endometrial epithelial cells. However, the status of cell-death pathways in the bovine endometrium during the preimplantation period still remains unclear. In the present study, we investigated the different cell-death pathways, including apoptosis, pyroptosis, and autophagy, in uterine tissue obtained from pregnant cows and <I>in vitro</I> cultured endometrial epithelial cells with IFNT stimulation. The expression of <I>CASP7</I>, <I>8,</I> and <I>FADD</I> (apoptosis-related genes) was significantly higher in pregnant day 18 uterine tissue in comparison to non-pregnant day 18 tissue. The expression of <I>CASP4</I>, <I>11,</I> and <I>NLRP3</I> (pyroptosis-related genes) was significantly higher in the pregnant uterus in comparison to non-pregnant uterus. In contrast, autophagy-related genes were not affected by pregnancy. We also investigated the effect of IFNT on the expression of cell-death pathway-related genes, as well as DNA fragmentation in cultured endometrial epithelial cells. Similar to its effects in pregnant uterine tissue, IFNT affected the increase of apoptosis-related (<I>CASP8</I>) and pyroptosis-related genes (<I>CASP11</I>), but did not affect autophagy-related gene expression. IFNT also increased γH2AX-positive cells, which is a marker of DNA fragmentation. These results suggest that apoptosis- and pyroptosis-related genes are induced by IFNT in the pregnant bovine endometrial epithelial cells.</P>
Yuhei Mori,Itaru Miura,Michinari Nozaki,Yusuke Osakabe,Ryuta Izumi,Takahiro Akama,So Kimura,Hirooki Yabe 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.3
Parkinson’s disease is often complicated by psychiatric symptoms. Psychiatrists are caught in a dilemma between such symptoms and physical treatment since Parkinson’s disease sometimes shows treatment resistance based on pharmacological treatment-induced dopamine dysfunction. Here, we report on a 64-year-old woman with a 15-year history of Parkinson’s disease with stage IV severity based on the Hoehn and Yahr scale. She was admitted to our hospital with a diagnosis of major depressive disorder with psychotic features. Unfortunately, her treatment course for depression was complicated by neuroleptic malignant syndrome. Because we were concerned about the persistence of her depressive symptoms, the risk of psychotropic drugs causing adverse effects, and progressive disuse syndrome, we administered modified electroconvulsive therapy. Her symptoms of neuroleptic malignant syndrome and depression sufficiently improved after five sessions of modified electroconvulsive therapy. Additionally, the primary motor symptoms of her Parkinson’s disease also markedly improved. The improvement of neuroleptic malignant syndrome and her motor symptoms based on dopamine dysfunction can be explained by electroconvulsive therapy’s effectiveness in activating dopamine neurotransmission. Besides, the marked improvement of her depressive episode with psychotic features was presumed to involve dopamine receptor activation and regulation. Because advanced Parkinson’s disease can sometimes be refractory to treatment based on pharmacological treatment-induced dopamine dysfunction, psychiatrists often have difficulty treating psychiatric symptoms; electroconvulsive therapy may stabilize the dopaminergic system in such cases, presenting a possible non-pharmacologic treatment option for Parkinson’s disease.