Laparoscopic vs Open Distal Pancreatectomy: Technical Evaluation from Dalin Tzu Chi Experience

( Wen Yao Yin ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: This study emphasized on the postoperative complications following resection solely on normal pancreatic tissue by laparoscopic technique or open method. Methods: We collected a total of 47 cases of cases who underwent distal pancreatectomy. The prospective group: 9 cases of laparoscopic distal pancreatectomy(LDP) and 13 cases of open distal pancreatectomy who were operated in recent 3 consecutive years, were compared with the other retrospective group of 25 cases operated before laparoscopic era. The postoperative mortality and morbidity were compared and statistically evaluated. Results: The overall complication between laparoscopic and open group was quite similar (6/9, 66.6% vs 14/38,,32.4%, p=0.142). However severe complications occurred higher in patients with open method in both groups (8/13 61.5% vs 3/9 33.3%, p=0.387) though no significant difference probably due to small number of cases. In contrast, patients in retrospective group (all open) showed surprisingly low severe complication (3/25, 12%). If we look at the severe complications in three subgroups (two laparoscopic and open in prospective group and one retrospective open group), a significant difference with p value 0.002 only between the two open groups (prospective open 69.2% vs retrospective open 3/25 12%, p=0.001). Regarding the transaction site, no difference seen between neck and tail but taken together with closure method, closure with TA (mostly at neck) was much better than GIA. Severe complication for LDP was lower than open group for soft pancreas with good p value (3/9 33.3% vs 8/11 72.7% p -0.07). Conclusions: Closure technique with TA55 resected at neck is a reliable technique. LDP was associated with early recovery with less overall complications. Fistula rate was comparable but less severe in LDP. Double Clamping technique (developed by our team) with slowly flattening method may be helpful for favorable outcome

Thorough Pre-Transplant Evaluation and Appropriate Case Selection Is the Mainstay for Better Survival in Recipients with Malignancy

( Wen Yao Yin ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Death from cardiovascular disease and infection are decreasing proper screening, prophylaxis, aggressive risk factor management, and interventional therapies. Cancer, on the other hand, is poorly screened both in recipient and donor to prevent post-transplant malignancy. Methods: We review the cases of liver and kidney transplant patients taken care in Dalin Tzu Chi General hospital in the past twelve years. We reviewed the issues on cancer before transplant, any cancer transmission from the donor, cancer after transplantation, outcomes of transplant recipients with cancer, and the role of screening and therapy in reducing the impact of cancer in transplant recipients. Results: There were 40 liver transplant and 46 kidney transplant patients with a total of 86 cases in this study. Sixteen cases (19.28 %) were associated with malignancy.A total of 16 cases (19.28%) died in this study. Among the kidney transplant patients, a total of 5 cases had malignancy: one renal cell carcinoma (RCC), three Transitional cell carcinoma (TCC) and one colon cancer. Two TCC cases were de novo malignancy.A case of TCC died of recurrence Among the liver transplant patients, 5 cases of living donor liver transplant (LDLT) and 4 cases of deceased donor liver transplant (DDLT) patients were associated with malignancy. No recurrence after follow up of 6 months to 8 years except a patient with an occult cecal cancer died one year after LDLT. Four cases of malignancy in DDLT: two HCC, one prostate cancer, and one nasopharyngeal cancer were noted. Both of the HCC patients died 3 months after DDLT and about 3 years after transplantation respectively. Conclusions: No significant difference in survival between cancer and non-cancer patients. We considered thorough preoperative screening is fundamental to prevent poor prognosis.

Cadaveric Study of Pancreatic Duct Leak after Distal Pancreatectomy with Laparoscopic Stapler Based on Critical Findings in Clinical Study at Dalin Tzu Chi General Hospital

( Bradley Yin ),( Chun Ming Chang ),( Wen Yao Yin ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Our clinical study showed that transection site (body) and staple sizes (>2.5mm) were key factors contributing to the occurrence of postoperative pancreatic fistua( POPF). If we can create a neck (thin pancreas) on the body of the pancreas by slowly compressing before cutting using another clamp (double clamping) to allow optimal situation for 2.5mm staples, then the occurrence of POPF and leakage can be significantly reduced. Such a study is the first study in literature done on a well preserved cadaver Methods: Three adult cadavers were used, with each pancreas exposed for convenience but with equipment of laparoscopy to showcase assure that the technique can be done laparoscopically. Each pancreas was cut at multiple sites: one cut at each neck and tail, and three cuts each on the body of the pancreas. Each cut different staple size ( 2.5 mm and 3.8 mm) and the clamping method (single or double). The leakage was checked by three steps: gross observation, probing with catheter, and methylene blue. Results: Cuts performed with 2.5 mm staple and/or double clamping showed no leakage on both neck and body region. Cuts with both 3.8mm staple and single clamping technique show leakage on body region but no leakage at the neck and tail. Conclusions: The result had supported the hypothesis of double clamping method and smaller staple can reduce the chance of leakage and therefore reduce the chance of fistula after the operation.

Study on the Simulation and Experiment of Cantilever Beam Piezoelectric Energy Harvester

Yao Fenglin,Meng Wengjun,Zhao Jie,Yin hang 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.9

Owing great to the widespread application of wireless sensor networks, supply energy for these wireless sensors proves to be a significant issue. Moreover, for the ambient vibration lies everywhere, the vibration can supply energy for the wireless sensor via energy harvester. The single cantilever beam piezoelectric energy harvester becomes the research focus for the simple structure and higher energy conversion efficiency. Due to the transcendental equation in distributed parameter model, the numerical method is become powerful complement for theoretical and experimental method. Static analysis, model analysis, harmonic response analysis and mechanical-electrical coupling analysis are simulated in ANSYS. Four aspects of the harvester has been studied in detail. Test and measurement show that Geometry and shape parameters have great affect to piezoelectric single cantilever energy harvester. In addition, the inherent characteristics of piezoelectric patch will affect enormously on the electrical characteristics

Concentration-Controlled and Phytic Acid-Assisted Synthesis of Self-Assembled LiFePO4 as Cathode Materials for Lithium-Ion Battery

Yin Li,Keyu Zhang,Zhengjie Chen,Yunke Wang,Li Wang,Feng Liang,Yaochun Yao 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2020 NANO Vol.15 No.02

The olivine LiFePO4 with various morphologies and different growth lattice planes was prepared by a controllable hydrothermal method with changing precursor concentration and using phytic acid as phosphorus source. The microstructure, crystal orientation and electrochemical performance of the prepared samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM) and charge–discharge tests. The results show that the morphologies of all samples change from spindle-like to hierarchical plate-like and then to long plate-like shape, and the main exposed facets transform from (100) to (001). This indicates that the precursor concentration and phytic acid play important roles in exposing facets and controlling the morphology of LiFePO4. In order to illustrate these phenomena, a reasonable assembly process is provided and the formation is explained. Li ion diffusion coefficient along [100] and [001] directions was calculated by using electrochemical impedance spectroscopy (EIS). The results show that the diffusion coefficient of (100) facet is higher than that of (001) facet, indicating a good electrochemical performance for (100) facet. In addition, the capacity test is carried out, which also confirms the above results. With the precursor concentration of 0.5 M, the obtained LiFePO4 with self-assembled hierarchical structure, smaller size and (100) facet shows the best electrochemical performance: 162.1 mAh/g at 0.1C and 112.4 mAh/g at 10 C. Using phytic acid as phosphorus source and controlling precursor concentration to prepare high performance LiFePO4 open up a new prospect for the production of cathode materials for lithium ion batteries.

Effect of Hybridization on Carcass Traits and Meat Quality of Erlang Mountainous Chickens

Yin, H.D.,Gilbert, E.R.,Chen, S.Y.,Wang, Y.,Zhang, Z.C.,Zhao, X.L.,Zhang, Yao,Zhu, Q. Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.10

Native chickens hold a significant share of the market in China. In response to the huge demand from the market, the productivity of Chinese native chickens needs to be improved. Cross breeding is an effective method to increase productivity, although it might affect meat quality. In this study, two pure lines (SD02 and SD03) of Erlang mountainous chickens were hybridized with a yellow feather and faster growing line (SD01). The effect of hybridization on carcass and meat quality (physiochemical and textural traits) was measured in the $F_1$ population at d 91 of age. The hybrids exhibited higher body weight and dressed weight, and amount of semi-eviscerated, eviscerated, breast muscle and abdominal fat (p<0.05). Abdominal fat yield also increased (p<0.05) compared to the offspring of the two pure-lines. Meanwhile, there was no significant difference in meat quality traits except for the myofiber diameter and density and the shear force of the breast muscle. Overall, the offspring of cross-lines were similar to pure lines in meat color, pH value, inosinic acid, crude protein, crude fat, dry matter, moisture content and amino acid composition in the breast muscle. These results suggest that productivity can be improved via cross-breeding while maintaining meat quality of the Erlang mountainous chicken.

Different segregation effects for Sc and Ce in an Al/δ´ interface

Yao Jian-Gang,Jiang Yong,Yin Deng-Feng 한국물리학회 2021 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.78 No.8

The behaviors of Sc and Ce segregation at Al (100)/δ´(100), Al (110)/δ´(110), and Al (111)/δ´(111) interfaces were theoretically predicted to explore the differences in the segregation effects in Al–Li alloys. The results show that Sc exhibits an evident trend to segregation to the Al/δ´ interface whereas this effect for Ce seems to be weak. The variation of the segregation energy is associated with the different orientation of the corresponding interface. The preferable segregated site is on the Al matrix side where the solutes tend to substitute the Al atom at the Li site for the first layer of the corresponding interface.

A biothiols and H 2 O 2 responsive fluorescence probe for selective cancer imaging

Yin Nan,Qin Guixin,Wang Yuting,Tang Jiali,Yao Xin,Xu Qingling 대한화학회 2024 Bulletin of the Korean Chemical Society Vol.45 No.3

Identification of cancer from normal tissues is important for early diagnosis of cancer. Combined detection of multiple tumor markers is important for accurate diagnosis. It is urgent to develop fluorescent probes that are responsive to multiple cancer characterizations for selective cancer imaging. Herein, we designed a novel near‐infrared (NIR) fluorescent probe ( IRAPA ) using a hemi‐cyanine skeleton as fluorophore and 3‐acrylamidopropanoic ester as recognizing unit that is responsive to both oxidative and reductive molecules. IRAPA has faint fluorescence emission as the intramolecular charge transfer (ICT) process is blocked. H 2 O 2 , glutathione (GSH) and cysteine (Cys) can individually induce the hydrolysis of ester bond and give fluorescent NIR IROH . IRAPA shows low cytotoxicity and produces strong fluorescence specifically in cancer cells/tissues. While the normal cells/tissues showed very weak fluorescence. Moreover, IRAPA shows higher differences between cancer and normal cells compared to probes that only response to biothiols or ROS. Identification of cancer from normal tissues is important for early diagnosis of cancer. Combined detection of multiple tumor markers is important for accurate diagnosis. It is urgent to develop fluorescent probes that are responsive to multiple cancer characterizations for selective cancer imaging. Herein, we designed a novel near-infrared (NIR) fluorescent probe (IRAPA) using a hemicyanine skeleton as fluorophore and 3-acrylamidopropanoic ester as recognizing unit that is responsive to both oxidative and reductive molecules. IRAPA has faint fluorescence emission as the intramolecular charge transfer (ICT) process is blocked. H2O2, glutathione (GSH) and cysteine (Cys) can individually induce the hydrolysis of ester bond and give fluorescent NIR IROH. IRAPA shows low cytotoxicity and produces strong fluorescence specifically in cancer cells/tissues. While the normal cells/tissues showed very weak fluorescence. Moreover, IRAPA shows higher differences between cancer and normal cells compared to probes that only response to biothiols or ROS.

Helicobacter pylori and Pancreatic Cancer Risk: a Meta-analysis Based on 2,049 Cases and 2,861 Controls

Wang, Yin,Zhang, Fu-Cheng,Wang, Yao-Jun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11

Aim: Helicobacter pylori (H. pylori) have been considered as a risk factor for many cancers. We conducted this meta-analysis to clarify the association between H. pylori infection and the risk of pancreatic cancer. Methods: We searched the Medicine/Pubmed and Embase databases, studies about the association between H. pylori infection and pancreatic cancer published up to Jan.2014 were included. Finally, a total of 9 studies were used for this a meta-analysis. The odds ratios (ORs) and 95% confidence interval (95%CI) of H. pylori infection on pancreatic cancer with respect to control groups were evaluated. Two authors independently assessed the methodological quality and extracted data. This meta-analysis was conducted using software, state (version 12.0) to investigate heterogeneity among individual studies and to summarize the studies. Using the fixed-effects or random-effects model, depending on the absence or presence of significant heterogeneity. Sensitivity analysis was performed to assess the influence of each individual study on the pooled ORs by omitting a single study each time. Publication bias was evaluated by funnel plot, using Egger's and Begg's tests. Results: There was no significant association between H. pylori infection and pancreatic cancer risk in the summary ORs,(OR=1.06, 95%CI: 0.74-1.37) through the random-effect method, but heterogeneity among studies was significant ($I^2$=58.9%), so we put the studies into two subgraphs (eastern and western). The results about western (OR=1.14 95%CI:0.89, 1.40) showed heterogeneity among the western countries of $I^2$=6.6%, with no significant association between Hp+ and pancreatic cancer, but the eastern countries (OR=0.62, 95%CI:0.49, 0.76), $I^2$=0, suggested that decreasing pancreas-cancer risk in subjects with Hp+ infection. Simultaneously, 7 studies examined CagA+ strains was (OR=0.84 95%CI:0.63, 1.04), $I^2$=36% with the random-effect method, subgraphs indicated that CagA+ could decrease the risk of pancreatic cancer in the eastern subjects (OR=0.66, 95%CI:0.52-0.80), but the association was not statistically significant in the western subjects (OR=0.95, 95%CI:0.73, 1.16). Conclusion: Hp+ and CagA+ infection are associated with a decreased risk of pancreatic cancer in eastern populations but have no significant associations in western countries.

Simulation of in-situ preheating of ni-based multi-layer and multi-pass coatings on H13 steel

Honggang Yin,Jinhua LI,Liwei Zhao,Fangping Yao 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.9

COMSOL was used to simulate the temperature field of the preheating and nonpreheating processes of the laser cladding multi-layer and multi-pass coating, and experimental verification was carried out. The results show that the temperature gradient value of the coating at the Z-axis is much larger than the value at the X and Y-axis, respectively. It indicates that the coating is sensitive to cracks at the Z-axis. After preheating, the quality of the coating is improved, and the results of the geometric morphology in experiments are basically consistent with the results of simulation. With increase in coating temperature, the cladding efficiency increased. The difference of temperature between the first and second layer was significantly reduced. The temperature gradient value at the Z-axis decreased. The coating grain structure presents as refined and well-distributed. The temperature gradient size in each layer decreased with the number of coatings increasing.