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Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?
Yan, Zhen,Kim, Eunjoon,Datta, Dibyadeep,Lewis, David A.,Soderling, Scott H. Society for Neuroscience 2016 The Journal of neuroscience Vol.36 No.45
<P>Actin polymerization governs activity-dependent modulation of excitatory synapses, including their morphology and functionality. It is clear from humangenetics that neuropsychiatric and neurodevelopmental disturbances are multigenetic in nature, highlighting the need to better understand the critical neural pathways associated with these disorders and how they are altered by genetic risk alleles. One such signaling pathway that is heavily implicated by candidate genes for psychiatric and neurodevelopmental disorders are regulators of signaling to the actin cytoskeleton, suggesting that its disruption and the ensuring abnormalities of spine structures and postsynaptic complexes is a commonly affected pathway in brain disorders. This review will discuss recent experimental findings that strongly support genetic evidence linking the synaptic cytoskeleton to mental disorders, such as schizophrenia and autism spectrum disorders.</P>
Yan, Zhen,Ma, Yu Zhen,Liu, Dong jun,Cang, Ming,Wang, Rui,Bao, Shorgan Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.4
RNA interference (RNAi) is an acknowledged useful and effective tool to study gene function in various cells. Here, we suppressed the Connexin 43 (Cx 43) gene expression during in vitro development of ovine pre-implantation embryos using the RNAi method. The 353 bp Cx 43 double-stranded RNA was microinjected into in vitro fertilized ovine zygotes, and the levels of target mRNA and protein were investigated. Control groups included uninjected zygotes or those injected with RNase-free water. The dsRNA injection resulted in the specific reduction of Cx 43 transcripts as analyzed by quantitative real-time RT-PCR and decreased protein levels as shown by Western blot analysis at the blastocyst stage. Microinjection of Cx 43 dsRNA led to 20.3%, 21.7% and 34.5% blastocyst rates and 19.2%, 37.5% and 41.3% hatched blastocyst rates in Cx 43 dsRNA-injected, water-injected and uninjected groups, respectively. Then the RNAi could not significantly affect cell number and cell death rates of blastocysts. Therefore, suppression of Cx 43 dsRNA and proteins did not apparently affect the development potential of ovine pre-implantation embryos but may play a role in embryo quality. RNAi technology is a promising approach to study gene function in early ovine embryogenesis.
Yanzhen, Qiao,Zandi, Yousef,Rahimi, Abouzar,Pourkhorshidi, Sara,Roco-Videla, Angel,Khadimallah, Mohamed Amin,Jameel, Mohammed,Kasehchi, Ehsan,Assilzadeh, Hamid Techno-Press 2021 Advances in nano research Vol.11 No.3
Taking into account the decreased number of available lands, the construction of structures on soft soil leads towards the development of soil stabilizing models. This study is aimed at studying the decrement of land resources available, and the design of civil engineering structures on soft soils that will develop the soil impact of nano-SiO<sub>2</sub> in the use of clay soil with low liquid limit, in particular shear resistance and unconfined compression. A novel nano-soil stabilizer has been created in this investigation by use of nano-SiO<sub>2</sub> activity and ultrafine features that have enabled cement-based stabilizers to increase their characteristics in broad application possibilities. This research aims to examine the influence on soil engineering, particularly the shear strength of clay soil with a low liquid limit to the effect of adding nano-SiO<sub>2</sub>. Nano-SiO<sub>2</sub> has 3 different percentages combined with soil (i.e., 0.5, 0.7 percent by weight of the parent soil), A direct shear test was used to evaluate the shear strength of the specimen, and then the results were analyzed by Artificial Neural Network (ANN) to increase the accuracy of outcomes. Increased nano-SiO<sub>2</sub> concentration was shown to lead to an increased internal friction angle and cohesiveness on clay soil. The optimal content for nano-SiO<sub>2</sub> is 0.7%. ANN could accurately demonstrate the shear strength percentages in nano-SiO<sub>2</sub> content.
Yan Feng,Yanzhen Yu,Liping Qiu,Yawen Yang,Zhigang Li,Miaowan Li,Lisha Fan,Yuzhong Guo 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1
Haydite and sorption functional media (SFM),made of clinoptilolite tailings, were used as filter media forbiological aerated filter (BAF) to treat synthetic wastewater in parallel. The aim of this work was toevaluate impact of SFM on the removal of ammonia nitrogen in a biological aerated filter reactor underammonium nitrogen shock loads. It could be demonstrated that: (1) the BAF with SFMpresented higherammonia nitrogen removal efficiency than that with haydite; (2) during the phase of higher influentconcentrations SFMs were collecting ammonia nitrogen and can buffer ammonia nitrogen loads anddampen the effluent concentration of ammonia nitrogen; (3) when the influent concentration decreasesammonia nitrogen will desorb from the SFM and can be utilized by the nitrifying bacteria growing on theSFM. Therefore, with the SFM application existing BAF unites can be upgraded and the stability of theoperation process of BAF can be improved significantly.
Peng Cao,Di Cui,Yanzhen Ming,Varut Vardhanabhuti,Elaine Lee,Edward Hui 대한자기공명의과학회 2021 Investigative Magnetic Resonance Imaging Vol.25 No.4
Purpose: To accelerate magnetic resonance fingerprinting (MRF) by developing a flexible deep learning reconstruction method. Materials and Methods: Synthetic data were used to train a deep learning model. The trained model was then applied to MRF for different organs and diseases. Iterative reconstruction was performed outside the deep learning model, allowing a changeable encoding matrix, i.e., with flexibility of choice for image resolution, radiofrequency coil, k-space trajectory, and undersampling mask. In vivo experiments were performed on normal brain and prostate cancer volunteers to demonstrate the model performance and generalizability. Results: In 400-dynamics brain MRF, direct nonuniform Fourier transform caused a slight increase of random fluctuations on the T2 map. These fluctuations were reduced with the proposed method. In prostate MRF, the proposed method suppressed fluctuations on both T1 and T2 maps. Conclusion: The deep learning and iterative MRF reconstruction method described in this study was flexible with different acquisition settings such as radiofrequency coils. It is generalizable for different in vivo applications.
Renjie Ji,Yonghong Liu,Yanzhen Zhang,Xin Dong,Zhili Chen,Baoping Cai 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.6
Silicon carbide (SiC) ceramic has been widely used in modern industry. However, the beneficial properties of SiC ceramic make machining difficult and costly by conventional machining methods. This paper proposes a new process of machining SiC ceramic using end electric discharge (ED) milling. The process is able to effectively machine a large surface area on SiC ceramic at low cost and no environmental pollution. The effects of emulsion concentration, emulsion flux, milling depth, copper electrode number, and copper electrode diameter on the process performance such as the material removal rate, electrode wear ratio, and surface roughness have been investigated. In addition, the microstructure of the machined surface is examined with a scanning electron microscope, and the material removal mechanism of SiC ceramic during end ED milling is obtained.
Renjie Ji,Yonghong Liu,Yanzhen Zhang,Baoping Cai,Xiaopeng Li,Chao Zheng 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.1
A novel hybrid process that integrates end electric discharge (ED) milling and mechanical grinding is proposed. The process is able to effectively machine a large surface area on SiC ceramic with good surface quality and fine working environmental practice. The polarity, pulse on-time, and peak current are varied to explore their effects on the surface integrity, such as surface morphology, surface roughness, micro-cracks, and composition on the machined surface. The results show that positive tool polarity, short pulse on-time, and low peak current cause a fine surface finish. During the hybrid machining of SiC ceramic, the material is mainly removed by end ED milling at rough machining mode, whereas it is mainly removed by mechanical grinding at finish machining mode. Moreover, the material from the tool can transfer to the workpiece, and a combination reaction takes place during machining.