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- 저자 : Yanqun Wei (검색결과 3 건)
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Dai Wei,Duan Yanqun,Yuan Wenkang,Wang Siyu 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.4
A large number of researches have shown that circular RNA (circRNA) is new hope for the diagnosis or treatment of tumors, including liver cancer (LCa). However, it remains largely unclear the role of circRNA in the progression of LCa and its molecular mechanism. GSE164803 microarray dataset was applied to identify dysregulated circRNAs in LCa and noncancerous tissues. CircTUBGCP5 (hsa_circ_0034049) was selected for further research. Biological functions of circTUBGCP5 were investigated by EdU, colony formation, flow cytometry, glucose consumption and lactate production assay, and in vivo tumorigenesis. RNA pull-down assay and dual-luciferase reporter assay were used to investigate the interaction between circTUBGCP5, miR-144-3p, and ACSL4. We demonstrated that circTUBGCP5 was significantly up-regulated in LCa tissues and cells. CircTUBGCP5 promoted LCa cell proliferation, anti-apoptotic ability, glycolysis, and tumorigenesis at least partially by sponging miR-144-3p to regulate ACSL4 protein level. In conclusion, circTUBGCP5 is a forceful contributor to malignant behaviors and glycolysis of LCa via modulating the circTUBGCP5/miR-144-3p/ACSL4 axis, which has provided a target for the diagnosis and treatment of LCa patients.
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Study on nanosized zircon powder based dual sensitive sensor
Huang Shizhen,Lin Wei,Chen Wei,Chen Wenzhe,Shao Yanqun 한국물리학회 2009 Current Applied Physics Vol.9 No.3
Study on the nanosized ceramic material of ZrO2 which has usually been used as electronic ceramics, function ceramics, structure ceramics and so on. The material of ZrO2 was made by low-temperature super alkaline condition. The powder was detected by XRD, and the result showed that the material was pure ZrO2. According to the Scherer formula computation, the ZrO2 average grain diameter was about 21 nm. The material was sensitive both to the ammonia and to the humidity. Full performance test was carried to the sensor made by the sensitive material. To 20 × 10-6 NH3, the sensitive is 3, and to 1000 × 10-6 NH3, the sensitive is 12.5. The sensor has good selectivity, and has almost no sensitive to else gases, so it is a good gas sensor with excellent selectivity. To 1000 × 10-6 NH3, the response time is 2 s, and recovering time is also only 27 s. The sensitive range of humidity is 25–98%RH under 25 ℃ . Both response and recovered time of humidity are less than 30s. The sensor realized the dual sensitive. Study on the nanosized ceramic material of ZrO2 which has usually been used as electronic ceramics, function ceramics, structure ceramics and so on. The material of ZrO2 was made by low-temperature super alkaline condition. The powder was detected by XRD, and the result showed that the material was pure ZrO2. According to the Scherer formula computation, the ZrO2 average grain diameter was about 21 nm. The material was sensitive both to the ammonia and to the humidity. Full performance test was carried to the sensor made by the sensitive material. To 20 × 10-6 NH3, the sensitive is 3, and to 1000 × 10-6 NH3, the sensitive is 12.5. The sensor has good selectivity, and has almost no sensitive to else gases, so it is a good gas sensor with excellent selectivity. To 1000 × 10-6 NH3, the response time is 2 s, and recovering time is also only 27 s. The sensitive range of humidity is 25–98%RH under 25 ℃ . Both response and recovered time of humidity are less than 30s. The sensor realized the dual sensitive.
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Chao Lin,Yanan Hu,Yanqun Wei,Zhiqin Cai 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.6
As one of the most important components in the micro in-pipe robot, the supporting and locking mechanism determines the working performance of the robot. In this paper, a new supporting and locking mechanism based on the non-circular gear compound transmission (SLM-NGCT) is proposed. According to the advanced mechanisms and differential geometry theory, transmission coordinates of the movement mechanism were established and the movement equations were derived. The influence factors and change rules of the displacement, velocity and acceleration of the movement mechanism were analyzed. Based on gear meshing theory and the cam theory, the mechanical characteristics of the flexible friction block of the movement mechanism were analyzed. A simulation model of SLMNGCT was established and the comparison results between simulation and theoretical model show the correctness of the theoretical analysis and the feasibility of non-circular gear pairs instead of the cam mechanism. The study has guiding significance in the supporting and locking mechanism of micro in-pipe robot.
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