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Xuejin Fan,Qi Peng,Yanhua Chen,Zeke Ma,Xiaoguang He,Biying Deng,Hui Huang,Juan Zeng,Chuyun Cheng,Shaoji Liu,Xiaomei Lu 한국유전학회 2015 Genes & Genomics Vol.37 No.12
The aim of this study was to test the impact of variants rs900400 (located near LEKR1 and CCNL1) and rs9883204 (located in ADCY5) on birth weight in a Chinese population. We conducted a case–control study including 156 low-birth- weight infants as the case group and 100 normal-birth-weight infants as the control group. The rs900400 and rs9883204 variants were analyzed by gene sequencing in all the participants. Our results revealed a significant difference in the genotype distribution (v2 = 10.449, p = 0.005) and allele distribution (v2 = 9.277, p = 0.002) of rs900400 between the case group and the control group. The C allele of rs900400 was associated with lower birth weight (OR 1.771 [95 % CI 1.237–2.535]) in the Chinese population. However, the rs9883204 polymorphism was not informative in the Chinese population. Our study shows that the ‘‘birth weightlowering’’ variant rs900400 located near LEKR1 and CCNL1, which is strongly associated with birth weight in European cohorts, appears to have a similar association in Chinese cohorts. However, the rs9883204 variant located in ADCY5 does not appear to be correlated with low birth weight in the same population. Moreover, we found that the variant rs900400 may also be associated with premature birth, thereby supporting the need for further research in this area.
Effect of molecular weight of regenerated silk fibroin on silk-based spheres for drug delivery
Zengkai Wang,Xiangming Li,Yanhua Cui,Kai Cheng,Mingdong Dong,Lei Liu 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.10
Silk fibroin presents a good advantage as a drug carrier for drug delivery, due to the excellent biocompatibility, biodegradability and tunable drug loading and release properties. In this work, we constructed silk spheres by phase separation of the regenerated silk fibroin (RSF) solutions with different MW and polyvinyl alcohol; and it was revealed that MW of RSF can affect the structure, size, surface potential and drug loading and release efficiency of silk spheres. Silk spheres prepared from high MW of RSF were found to load more macromolecular drug with negative charge compared to middle and low MW of RSF. However, for the positive charge and low MW drug, the silk spheres prepared from low MW of RSF could present a high loading efficiency compared to other carriers. Finally, a positive drug with low MW, streptomycin was encapsulated in silk spheres prepared from low MW of RSF, and displayed a long bactericidal and bacteriostatic effect compared to bared streptomycin solution. The results obtained provide guidelines for the modification and options of drug transport vehicles for more efficient drug delivery and utilization through a simple, rapidly constructed, applicable and low-cost drug carrier.