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GRADED w-NOETHERIAN MODULES OVER GRADED RINGS
Wu, Xiaoying Korean Mathematical Society 2020 대한수학회보 Vol.57 No.5
In this paper, we study the basic theory of the category of graded w-Noetherian modules over a graded ring R. Some elementary concepts, such as w-envelope of graded modules, graded w-Noetherian rings and so on, are introduced. It is shown that: (1) A graded domain R is graded w-Noetherian if and only if R<sup>g</sup><sub>𝔪</sub> is a graded Noetherian ring for any gr-maximal w-ideal m of R, and there are only finite numbers of gr-maximal w-ideals including a for any nonzero homogeneous element a. (2) Let R be a strongly graded ring. Then R is a graded w-Noetherian ring if and only if R<sub>e</sub> is a w-Noetherian ring. (3) Let R be a graded w-Noetherian domain and let a ∈ R be a homogeneous element. Suppose 𝖕 is a minimal graded prime ideal of (a). Then the graded height of the graded prime ideal 𝖕 is at most 1.
A GENERALIZATION OF ω-LINKED EXTENSIONS
Wu, Xiaoying Korean Mathematical Society 2022 대한수학회보 Vol.59 No.3
In this paper, the concepts of ω-linked homomorphisms, the ω<sub>𝜙</sub>-operation, and DW<sub>𝜙</sub> rings are introduced. Also the relationships between ω<sub>𝜙</sub>-ideals and ω-ideals over a ω-linked homomorphism 𝜙 : R → T are discussed. More precisely, it is shown that every ω<sub>𝜙</sub>-ideal of T is a ω-ideal of T. Besides, it is shown that if T is not a DW<sub>𝜙</sub> ring, then T must have an infinite number of maximal ω<sub>𝜙</sub>-ideals. Finally we give an application of Cohen's Theorem over ω-factor rings, namely it is shown that an integral domain R is an SM-domain with ω-dim(R) ≤ 1, if and only if for any nonzero ω-ideal I of R, (R/I)<sub>ω</sub> is an Artinian ring, if and only if for any nonzero element α ∈ R, (R/(a))<sub>ω</sub> is an Artinian ring, if and only if for any nonzero element α ∈ R, R satisfies the descending chain condition on ω-ideals of R containing a.
Xiaoying Chang,Jikang Jian,Gemei Cai,Rong Wu,Jin Li 대한금속·재료학회 2016 ELECTRONIC MATERIALS LETTERS Vol.12 No.2
Three-dimensional FeSe2 microflowers were synthesized for the firsttime by a facile solvothermal method, using FeCl2·4H2O and seleniumpowder as raw materials, along with ethanolamine as solvent. Theproducts were characterized by X-ray diffraction (XRD), scanningelectron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS),transmission electron microscopy (TEM), and X-ray photoelectronspectroscopy (XPS). The results show that the FeSe2 microflowersconsist of nanosheets with a thickness of about 50 - 80 nm. The Ramanspectrum shows the characteristic peaks of Se-Se vibration modes. Theoptical band gap of the sample was determined to be 1.48 eV by UVvisibleabsorption spectroscopy. The photoluminescence properties ofthe FeSe2 microflowers and their catalytic activity for the hydrogenevolution reaction were also assessed. Finally, a possible growthmechanism of the FeSe2 microflowers is proposed.
Spinosin Inhibits Aβ<sub>1-42</sub> Production and Aggregation via Activating Nrf2/HO-1 Pathway
( Xiaoying Zhang ),( Jinyu Wang ),( Guowei Gong ),( Ruixin Ma ),( Fanxing Xu ),( Tingxu Yan ),( Bo Wu ),( Ying Jia ) 한국응용약물학회 2020 Biomolecules & Therapeutics(구 응용약물학회지) Vol.28 No.3
The present research work primarily investigated whether spinosin has the potential of improving the pathogenesis of Alzheimer’s disease (AD) driven by β-amyloid (Aβ) overproduction through impacting the procession of amyloid precursor protein (APP). Wild type mouse Neuro-2a cells (N2a/WT) and N2a stably expressing human APP695 (N2a/APP695) cells were treated with spinosin for 24 h. The levels of APP protein and secreted enzymes closely related to APP procession were examined by western blot analysis. Oxidative stress related proteins, such as nuclear factor-erythroid 2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) were detected by immunofluorescence assay and western blot analysis, respectively. The intracellular reactive oxygen species (ROS) level was analyzed by flow cytometry, the levels of Aβ<sub>1-42 </sub>were determined by ELISA kit, and Thioflavin T (ThT) assay was used to detect the effect of spinosin on Aβ<sub>1-42 </sub>aggregation. The results showed that ROS induced the expression of ADAM10 and reduced the expression of BACE1, while spinosin inhibited ROS production by activating Nrf2 and up-regulating the expression of HO-1. Additionally, spinosin reduced Aβ<sub>1-42 </sub>production by impacting the procession of APP. In addition, spinosin inhibited the aggregation of Aβ<sub>1-42</sub>. In conclusion, spinosin reduced Aβ<sub>1-42</sub> production by activating the Nrf2/HO-1 pathway in N2a/WT and N2a/ APP695 cells. Therefore, spinosin is expected to be a promising treatment of AD.
Overexpressing osa-miR171c decreases salt stress tolerance in rice
Wu Yang,Tian Fan,Xiaoying Hu,Taihui Cheng,Mingyong Zhang 한국식물학회 2017 Journal of Plant Biology Vol.60 No.5
The miRNA171 family is one of the well-conservedmiRNA families, and its role under stresses is not knownexcept its expression on genome-wide expression analyses. osa-miR171c was induced by high concentration of salt (150mM NaCl). A rice dh mutant with osa-miR171c overexpressiontriggered by a T-DNA insertion, significantly decreased salttolerance at the stages of germination and seedling. Thisphenotype was confirmed by osa-miR171c overexpressiontransgenic rice. Compared with wild-type (WT), dh mutantreduced amounts of free proline and increased the water lossrate after salt treatment. Stomatal density in the leafepidermis of dh mutant also increased. Moreover, dh mutantincreased sensitivity to ABA treatment. Several stressresponsivegenes were down-regulated in dh mutant than inWT under salty stress. These results indicate that osamiR171cis involved in modulating physiological changes,stomatal development, ABA-dependent pathways and expressionof stress-related genes; thereby, it possibly contributes tosalty tolerance.
Han Peipei,Wu Shu,Li Limei,Li Danping,Zhao Jun,Zhang Haishan,Wang Yifang,Zhong Xuemin,Zhang Zhe,Li Ping,Matskova Liudmila,Zhou Xiaoying 한국유전학회 2022 Genes & Genomics Vol.44 No.4
Background: Acetyl-CoA acyltransferase 1 (ACAT1) is a key enzyme catalyzing the production of mitochondrial ketone bodies. We have shown that ACAT1 is down-regulated in kidney renal clear cell carcinoma (KIRC) previously. Objective: To investigate the reasons for downregulation of ACAT1 in KIRC and explore the underlying mechanisms involved in metastatic inhibition regulated by ACAT1. Methods: The Gene Expression Omnibus (GEO) database was queried for meta-analysis of ACAT1 mRNA expression in KIRC. The UALCAN website was used to compare the methylation levels of the ACAT1 promoter region in KIRC and normal tissues. RT-qPCR was used to quantitate ACAT1 transcription levels. The GCBI and Tarbase V.8 databases were used to predict miRNAs that may target the mRNA of ACAT1. The correlation between mRNA expression of ACAT1, MMP7 (matrix metallopeptidase 7), CDH1 (E-cadherin), EpCAM (epithelial cell adhesion molecule), and VIM (vimentin) was analyzed. Extracellular MMP7 protein was quantitated using an ELISA assay. Results: The methylation level of the ACAT1 promoter region in KIRC was significantly higher than that in the normal kidney tissues. The ACAT1 mRNA expression in the KIRC cell lines was restored after treatment with 5-aza-dC (p < 0.05). MiR-21-5p is a conserved microRNA targeting ACAT1. It is expressed at a significantly higher level in KIRC than in normal tissues (p < 0.001). MiR-21-5p miRNA expression negatively correlates with ACAT1 mRNA expression. The expression of miR-21-5p is higher at the T3-T4 stages and in the histologic grades G3-G4. Patients with high miR-21-5p expression tended to have lower overall survival, suggesting that miR-21-5p could serve as a potentially valuable diagnostic biomarker for KIRC (AUC = 0.957; p < 0.001). A mimetic of miR-21-5p inhibited the expression of ACAT1 mRNA and protein. In addition, ACAT1 mRNA expression positively correlates with CDH1 and EpCAM but is negatively correlated with VIM. Overexpression of ACAT1 suppresses the secretion of MMP7 in KIRC cells. Conclusion: Expression of ACAT1 in KIRC is controlled at two levels, firstly by the hypermethylation of the ACAT1 promoter region and secondly by overexpression of miR-21-5p. Downregulation of ACAT1 expression correlates with epithelial-mesenchymal transition (EMT).
Georgenia faecalis sp. nov. isolated from the faeces of Tibetan antelope
Wang Xiaoxia,Yang Jing,Huang Yuyuan,Wu Xiaomin,Wang Licheng,Han Limei,Li Sha,Li Huan,Fu Xiaoying,Chen Hai,Zhu Xiong 한국미생물학회 2020 The journal of microbiology Vol.58 No.9
Two aerobic, Gram-stain-positive, non-motile, non-sporulating coccoid strains, designated ZLJ0423T and ZLJ0321, were isolated from the faeces of Tibetan antelope (Pantholops hodgsonii). Their optimal temperature, NaCl concentration and pH for growth were 28°C, 0.5% (w/v) NaCl and pH 7.5, respectively. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strains ZLJ0423T and ZLJ0321 were very similar to each other (99.8%) and had a sequence similarity of 97.0% with Georgenia satyanarayanai NBRC 107612T and Georgenia subflava CGMCC 1.12782T. Phylogenomic analysis based on 688 core genes indicated that these strains formed a clade with G. satyanarayanai NBRC 107612T and Georgenia wutianyii Z294T. The predominant cellular fatty acids were anteiso-C15:0, anteiso-C15:1 A and C16:0. The major menaquinone was MK-8(H4). The cell-wall amino acids consisted of alanine, lysine, glycine and aspartic acid, with lysine as the diagnostic diamino acid. Diphosphatidylglycerol, phosphatidylglycerol, phosphatidylinositol, phosphatidylinositol mannosides and two unidentified lipids formed the polar lipid profile. The DNA G + C content of both isolates was 73.9 mol%. The digital DNA–DNA hybridization value between strains ZLJ0423T and ZLJ0321 was 91.2%, but their values with closely related species and other available type strains of the genus Georgenia were lower than the 70% threshold. On the basis of polyphasic taxonomic data, strains ZLJ0423T and ZLJ0321 represent a novel species within the genus Georgenia, for which the name Georgenia faecalis sp. nov. is proposed. The type strain is ZLJ0423T (= CGMCC 1.13681T = JCM 33470T).