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Lilin Gong,Rong Li,Wei Ren,Zengchan Wang,Zhihong Wang,Maosheng Yang,Suhua Zhang 대한의학회 2017 Journal of Korean medical science Vol.32 No.2
Here, we aimed to study the effect of the forkhead box O1-insulin receptor substrate 2 (FOXO1-IRS2) gene interaction and the FOXO1 and IRS2 genes-environment interaction for the risk of type 2 diabetes mellitus (T2DM) in a Chinese Han population. We genotyped 7 polymorphism sites of FOXO1 gene and IRS2 gene in 780 unrelated Chinese Han people (474 cases of T2DM, 306 cases of healthy control). The risk of T2DM in individuals with AA genotype for rs7986407 and CC genotype for rs4581585 in FOXO1 gene was 2.092 and 2.57 times higher than that with GG genotype (odds ratio [OR] = 2.092; 95% confidence interval [CI] = 1.178–3.731; P = 0.011) and TT genotype (OR = 2.571; 95% CI = 1.404–4.695; P = 0.002), respectively. The risk of T2DM in individuals with GG genotype for Gly1057Asp in IRS2 gene was 1.42 times higher than that with AA genotype (OR = 1.422; 95% CI = 1.037–1.949; P = 0.029). The other 4 single nucleotide polymorphisms (SNPs) had no significant association with T2DM (P > 0.05). Multifactor dimensionality reduction (MDR) analysis showed that the interaction between SNPs rs7986407 and rs4325426 in FOXO1 gene and waist was the best model confirmed by interaction analysis, closely associating with T2DM. There was an increased risk for T2DM in the case of non-obesity with genotype combined AA/CC, AA/AC or AG/AA for rs7986407 and rs4325426, and obesity with genotype AA for rs7986407 or AA for rs4325426 (OR = 3.976; 95% CI = 1.156–13.675; P value from sign test [Psign] = 0.025; P value from permutation test [Pperm] = 0.000–0.001). Together, this study indicates an association of FOXO1 and IRS2 gene polymorphisms with T2DM in Chinese Han population, supporting FOXO1-obesity interaction as a key factor for the risk of T2DM.
MiR-601 inhibited small cell lung cancer progression by modulating SIRT1
Ding Hao,Gong Chenhu,Zhang Zhihong,Xu Hui,Ma Chunping 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.3
Background Dysfunction of microRNAs (miRNAs) contribute to small cell lung cancer (SCLC) progression. Accumulating evidence indicated miR-601, acted as a tumor suppressor gene, has shown an altered expression pattern in multiple cancers. However, little was known about in terms of the function of miR-601 during SCLC progression. Objective Our project intended to illustrate the functions of miR-601 during the development and metastasis of SCLC. Results We found a decreased expression of miR-601 in SCLC tumor tissues and cell lines. Moreover, functional studies suggested that miR-601 overexpression resulted in a reduced cell growth and induced apoptosis of SCLC cells. Notably, sirtuin 1 (SIRT1) was identifi ed as a putative target of miR-601. MiR-601 suppressed SIRT1 expression via interacting with the 3′-untranslated region (UTR) of SIRT1 in SCLC cells. Also, SIRT1 expression was negatively associated with that of miR-601 in SCLC tissues. The restoration of SIRT1 alleviated the inhibitory eff ect of miR-601 on SCLC progression. Conclusion Our data documented the tumor-suppressive function of miR-601 in SCLC via targeting SIRT1, suggesting miR-601 as a new potential therapeutic approach for SCLC treatment.