ESTABLISHMENT AND CHARACTERIZATION OF FIN CELL LINES FROM DIPLOID, TRIPLOID, AND TETRAPLOID Misgurnus anguillicaudatus

Xia Li,Chen Ma,Yanjie Qin,Yajuan Li,Di Wu,Liwen Bai,Aijun Pei 한국수산과학회 양식분과 2015 한국수산과학회 양식분과 학술대회 Vol.2015 No.5

New insight into the microstructure–thermal stability relationships in ceria-zirconia solid solution and the application in Pd-only three-way catalyst

Yajuan Cui,Li Lan,Zhonghua Shi,Shandong Yuan,Yaoqiang Chen,Yi Dan 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.60 No.-

Three ceria-zirconia solid solutions were prepared by different synthesis routes. The results showed that CZ3 exhibited incompact structure with heterogeneous particle size distribution, accompanied by a bimodal pore size distribution. After aging treatment, the specific surface area and cumulative pore volume of CZ3-a were 37 m2/g and 0.22 cm3/g, which decreased by only 51% and 4% respectively from the fresh state. And the particle volume increased by only 4 times. Among the three samples, the textural/structural properties of CZ3 showed the smallest degradation, indicating the highest thermal stability, which was attributed to the incompact structure and special texture.

Light-Chain Cardiac Amyloidosis: Cardiac Magnetic Resonance for Assessing Response to Chemotherapy

Guo Yubo,Li Xiao,Gao Yajuan,Shen Kaini,Lin Lu,Wang Jian,Cao Jian,Zhang Zhuoli,Wan Ke,Zhou Xi Yang,Chen Yucheng,Zhang Long Jiang,Li Jian,Wang Yining 대한영상의학회 2024 Korean Journal of Radiology Vol.25 No.5

Objective: Cardiac magnetic resonance (CMR) is a diagnostic tool that provides precise and reproducible information about cardiac structure, function, and tissue characterization, aiding in the monitoring of chemotherapy response in patients with lightchain cardiac amyloidosis (AL-CA). This study aimed to evaluate the feasibility of CMR in monitoring responses to chemotherapy in patients with AL-CA. Materials and Methods: In this prospective study, we enrolled 111 patients with AL-CA (50.5% male; median age, 54 [interquartile range, 49–63] years). Patients underwent longitudinal monitoring using biomarkers and CMR imaging. At followup after chemotherapy, patients were categorized into superior and inferior response groups based on their hematological and cardiac laboratory responses to chemotherapy. Changes in CMR findings across therapies and differences between response groups were analyzed. Results: Following chemotherapy (before vs. after), there were significant increases in myocardial T2 (43.6 ± 3.5 ms vs. 44.6 ± 4.1 ms; P = 0.008), recovery in right ventricular (RV) longitudinal strain (median of -9.6% vs. -11.7%; P = 0.031), and decrease in RV extracellular volume fraction (ECV) (median of 53.9% vs. 51.6%; P = 0.048). These changes were more pronounced in the superior-response group. Patients with superior cardiac laboratory response showed significantly greater reductions in RV ECV (-2.9% [interquartile range, -8.7%–1.1%] vs. 1.7% [-5.5%–7.1%]; P = 0.017) and left ventricular ECV (-2.0% [-6.0%–1.3%] vs. 2.0% [-3.0%–5.0%]; P = 0.01) compared with those with inferior response. Conclusion: Cardiac amyloid deposition can regress following chemotherapy in patients with AL-CA, particularly showing more prominent regression, possibly earlier, in the RV. CMR emerges as an effective tool for monitoring associated tissue characteristics and ventricular functional recovery in patients with AL-CA undergoing chemotherapy, thereby supporting its utility in treatment response assessment.

Pharmacokinetics and Biodistribution of Paclitaxel-loaded Pluronic P105 Polymeric Micelles

Yongzhong Wang,Yajuan Li,Lijun Zhang,Xiaoling Fang 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.4

A novel polymeric micelle formulation of paclitaxel (PTX) has been prepared with the purpose of improving in vitro release as well as prolonging the blood circulation time of PTX in comparison to a current PTX formulation, Taxol injection. This work was designed to investigate the preparation, in vitro release, in vivo pharmacokinetics and tissue distribution of PTX-loaded Pluronic P105 micellar system. The micelles were prepared by thin-film method using a nonionic surfactant Pluronic P105 and a hydrophobic anticancer drug, PTX. With a dynamic light scattering sizer and a transmission electron microscopy, it was shown that the PTX-loaded micelles had a mean size of approximately 24 nm with narrow size distribution and a spherical shape. The in vitro release profiles indicated that the release of PTX from the micelles exhibited a sustained release behavior. A similar phenomenon was also observed in a pharmacokinetic study in rats, in which t1/2β and AUC of the micelle formulation were 4.9 and 5.3-fold higher than that of Taxol injection. The biodistribution study in mice showed that the PTXloaded micelles not only decreased drug uptake by liver, but also prolonged drug retention in blood and increased distribution of drug in lung, spleen and kidney. These results suggested that the P105 polymeric micelles may efficiently load, protect and retain PTX in both in vitro and in vivo environments, and could be a useful drug carrier for i.v. administration of PTX.

Pharmacokinetics and Biodistribution of Paclitaxel-Ioaded Pluronic P105 Polymeric Micelles

Wang, Yongzhong,Li, Yajuan,Zhang, Lijun,Fang, Xiaoling 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.4

A novel polymeric micelle formulation of paclitaxel (PTX) has been prepared with the purpose of improving in vitro release as well as prolonging the blood circulation time of PTX in comparison to a current PTX formulation, Taxol injection. This work was designed to investigate the preparation, in vitro release, in vivo pharmacokinetics and tissue distribution of PTX-loaded Pluronic P105 micellar system. The micelles were prepared by thin-film method using a nonionic surfactant Pluronic P105 and a hydrophobic anticancer drug, PTX. With a dynamic light scattering sizer and a transmission electron microscopy, it was shown that the PTX-loaded micelles had a mean size of approximately 24 nm with narrow size distribution and a spherical shape. The in vitro release profiles indicated that the release of PTX from the micelles exhibited a sustained release behavior. A similar phenomenon was also observed in a pharmacokinetic study in rats, in which $t_{1/2{\beta}}$ and AUC of the micelle formulation were 4.9 and 5.3-fold higher than that of Taxol injection. The biodistribution study in mice showed that the PTX-loaded micelles not only decreased drug uptake by liver, but also prolonged drug retention in blood and increased distribution of drug in lung, spleen and kidney. These results suggested that the P105 polymeric micelles may efficiently load, protect and retain PTX in both in vitro and in vivo environments, and could be a useful drug carrier for i.v. administration of PTX.

Preeclampsia serum-induced collagen I expression and intracellular calcium levels in arterial smooth muscle cells are mediated by the PLC-γ1 pathway

Rongzhen Jiang,Yincheng Teng,Yajuan Huang,Jinghong Gu,Li Ma,Minglin Shi,Yuedi Zhou 생화학분자생물학회 2014 Experimental and molecular medicine Vol.46 No.-

In women with preeclampsia (PE), endothelial cell (EC) dysfunction can lead to altered secretion of paracrine factors that induce peripheral vasoconstriction and proteinuria. This study examined the hypothesis that PE sera may directly or indirectly, through human umbilical vein ECs (HUVECs), stimulate phospholipase C-γ1-1,4,5-trisphosphate (PLC-γ1-IP3) signaling, thereby increasing protein kinase C-α (PKC-α) activity, collagen I expression and intracellular Ca2+ concentrations ([Ca2+]i) in human umbilical artery smooth muscle cells (HUASMCs). HUASMCs and HUVECs were cocultured with normal or PE sera before PLC-γ1 silencing. Increased PLC-γ1 and IP3 receptor (IP3R) phosphorylation was observed in cocultured HUASMCs stimulatedwith PE sera (Po0.05). In addition, PE serum significantly increased HUASMC viability and reduced their apoptosis (Po0.05); these effects were abrogated with PLC-γ1 silencing. Compared with normal sera, PE sera increased [Ca2+]i in cocultured HUASMCs (Po0.05), which was inhibited by PLC-γ1 and IP3R silencing. Finally, PE sera-induced PKC-α activity and collagen I expression was inhibited by PLC-γ1 small interfering RNA (siRNA) (Po0.05). These results suggest that vasoactive substances in the PE serum may induce deposition in the extracellular matrix through the activation of PLC-γ1, which may in turn result in thickening and hardening of the placental vascular wall, placental blood supply shortage, fetal hypoxia–ischemia and intrauterine growth retardation or intrauterine fetal death. PE sera increased [Ca2+]i and induced PKC-α activation and collagen I expression in cocultured HUASMCs via the PLC-γ1 pathway.

Characterization of the fluoridating process of hydroxyapatite

Xiao-liang Guo,Qun-li Rao,Ling-ling Li,Yajuan Zou,Chengchei Wu 한양대학교 세라믹연구소 2016 Journal of Ceramic Processing Research Vol.17 No.8

F-substituted hydroxyapatites were synthesized by chemical precipitation method using Ca(CH3COO)2·H2O and KH2PO4 asreactants and KF·2H2O as fluorination agent. Fourier transform infrared spectrometer (FTIR), X-ray diffraction (XRD) andX-ray fluorescence spectrometer (XRF) were used to characterize samples. The results showed that the more fluorine wasadded the more OH ions replaced by F. Moreover, OH-F bond was formed between crystalline, and the bond was strongerthan that of original OH-OH, so the grains of hydroxyapatite grew larger and the crystallinity increased as F content increased.

H∞ Synchronization of Uncertain Chaotic Lur’e Systems with Timevarying Delay via Stochastic Sampling

Hanxiao Zhao,Wei Li,Jiayong Zhang,Chao Ge,Yajuan Liu 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.4

In this article, the problem of H∞ synchronization for uncertain chaotic systems with time-varying delay controlled by random sampling is considered. The variable sampling period is assumed to switch stochastically between different values with given probability. In addition, the disturbance and the parameter uncertainty that may occur in many actual system are taken into account. With the help of input delay method, the chaotic Lur’e systems (CLSs) with probability sampling is converted to a continuous system. Then, based on the Lyapunov-Krasovskii functional (LKF) theory, a novel LKF is proposed. By using the reciprocal convex method, sufficient conditions are obtained to guarantee the stability of the error system and to reduce the influence of external disturbances under the condition of bounded H∞ norm. By solving a series of linear matrix inequalities (LMIs) which are obtained, the corresponding sampled data controller can be obtained. Finally, a numerical example is used to illustrate the superiority and effectiveness of proposed method.

Mesocarbon microbead densified matrix graphite A3-3 for fuel elements in molten salt reactors

Wang, Haoran,Xu, Liujun,Zhong, Yajuan,Li, Xiaoyun,Tang, Hui,Zhang, Feng,Yang, Xu,Lin, Jun,Zhu, Zhiyong,You, Yan,Lu, Junqiang,Zhu, Libing Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.5

This study aims to provide microstructural characterization for the matrix graphite which molten salt reactors (MSRs) use, and improve resistance to molten salt infiltration of the matrix graphite for fuel elements. Mesocarbon microbeads (MCMB) densified matrix graphite A3-3 (MDG) was prepared by a quasi-isostatic pressure process. After densification by MCMBs with average particle sizes of 2, 10, and 16 ㎛, the pore diameter of A3-3 decreased from 924 nm to 484 nm, 532 nm, and 778 nm, respectively. Through scanning electron microscopy, the cross-section energy spectrum and time-of-flight secondary ion mass spectrometry, resistance levels of the matrix graphite to molten salt infiltration were analyzed. The results demonstrate that adding a certain proportion of MCMB powders can improve the anti-infiltration ability of A3-3. Meanwhile, the closer the particle size of MCMB is to the pore diameter of A3-3, the smaller the average pore diameter of MDG and the greater the densification. As a matrix graphite of fuel elements in MSR was involved, the thermal and mechanical properties of matrix graphite MDG were also studied. When densified by the MCMB matrix graphite, MDGs can meet the molten salt anti-infiltration requirements for MSR operation.

Exponential Synchronization of Delayed Neural Networks with Actuator Failure Using Stochastic Sampled-data Control

Ganlei Zhang,Jiayong Zhang,Wei Li,Chao Ge,Yajuan Liu 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.2

This paper investigates the exponential synchronization issue for delayed neural networks with stochastic sampling. The variable sampling period of controller is assumed to switch stochastically between different values with given probability. In addition, the actuator failure phenomenon may occur in many actual systems which is taken into account. By using input delay method, the sampling system is converted to the continuous system. Then, a neoteric time-delay Lyapunov-Krasovskii functional (LKF) that contains delay bounds information is constructed and by using reciprocally convex approach, the sufficient conditions are derived to guarantee the exponentially mean-square stable of the delayed neural networks. The corresponding sampled-data controller can be obtained in terms of the solution to linear matrix inequalities (LMIs). Finally, one numerical example is used to illustrate the effectiveness of proposed method.