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Astrophysically Important 26Si States Studied with the 28Si(4He,6He)26Si Reaction
Y. K. Kwon,이춘식,J. Y. Moon,J. H. Lee,J. Y. Kim,M. K. Cheoun,S. Kubono,H. Yamaguchi,J. J. He,A. Saito,Y. Wakabayashi,H. Fujikawa,G. Amadio,N. Iwasa,K. Inafuku,L. H. Khiem,M. Tanaka,Y. Fuchi,A. A. Chen,S 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.2
The emission of a 1.809-MeV γ-ray from the first excited state of 26Mg, followed by β-decay of 26Al in its ground state (denoted as 26Alg.s.), has been identied by several gamma-ray telescopes. To resolve the controversy over the possible sources of the observational 1.809-MeV γ-rays, one needs accurate knowledge of the production rate of 26Alg.s.. The 25Al(p,γ)26Si reaction is one of the most important astrophysical reactions to be investigated, but its rate is uncertain due to the lack of level information on 26Si above the proton threshold (Qpγ = 5.518 MeV). Illiadis et al. suggested that the 25Al(p,γ)26Si reaction should be dominated by a 3+ unnatural parity state at Ex = 5970 keV. Recent studies proposed several states as candidates for the 3+ states. However, the spin-parity assignments for these states are still uncertain. In the present work, we measured the 28Si(4He,6He)26Si reaction at 120 MeV to confirm the unnatural parity states just above the proton threshold. The measurement was performed with the high-resolution particle analyzer at the Center for Nuclear Study, University of Tokyo. We observed a total of 22 excited states in 26Si. The 7018-keV level, which was only observed by Bardayan et al. with the 28Si(p; t)26Si reaction, was confirmed in our measurement. Among the candidates of unnatural parity states at Ex = 5678, 5916, and 5945 keV, the 5918-keV state was only observed within the error of the excitation energy. A new state at Ex = 6101 keV was also identified.
R&D Status of High-current Accelerators at IFP
J. J. Deng,J. S. Shi,W. P. Xie,L. W. Zhang,K. Z. Zhang,S. P. Feng,J. Li,M. Wang,Y. He,L. S. Xia,Z. Y. Dai,H. T. Li,L. Wen,S. F. Chen,X. Li,Q. G. Lai,M. H. Xia,Y. C. Guan,S. Y. Song,L. Chen 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.61
High-current accelerators have many important applications in Z-pinches, high-power microwaves, and free electron lasers, imploding liners and radiography and so on. Research activities on Zpinches, imploding liners, radiography at the Institute of Fluid Physics (IFP) are introduced. Several main high-current accelerators developed and being developed at IFP are described, such as the Linear Induction Accelerator X-Ray Facility Upgrade (LIAXFU, 12 MeV, 2.5 kA, 90 ns), the Dragon-I linear induction accelerator (20 MeV, 2.5 kA, 60 ns), and the Primary Test Stand for Z-pinch (PTS, 10 MA, 120 ns). The design of Dragon-II linear induction accelerator (20 MeV, 2.5 kA, 3 × 60 ns) to be built will be presented briefly.
He, W.,Van Ngoc, H.,Qian, Y.T.,Hwang, J.S.,Yan, Y.P.,Choi, H.,Kang, D.J. New York] ; North-Holland 2017 APPLIED SURFACE SCIENCE - Vol.392 No.-
We report that ultra-thin tellurium (Te) nanoflakes were successfully grown on a sample of a gold-coated textile, which then was used as an active piezoelectric material. An output voltage of 4V and a current of 300nA were obtained from the bending test under a driving frequency of 10Hz. To test the practical applications, Te nanoflake nanogenerator (TFNG) device was attached to the subject's arm, and mechanical energy was converted to electrical energy by means of periodic arm-bending motions. The optimized open-circuit voltage and short-circuit current density of approximately 125V and 17μA/cm<SUP>2</SUP>, respectively, were observed when a TFNG device underwent a compression test with a compressive force of 8N and driving frequency of 10Hz. This high-power generation enabled the instantaneous powering of 10 green light-emitting diodes that shone without any assistance from an external power source.
He, Y.,Kim, H.,Ryu, T.,Kang, Y.,Kim, J.A.,Kim, B.H.,Lee, J.H.,Kang, K.,Lu, Q.,Kim, K. North-Holland Pub ; Elsevier Science Ltd 2013 FEBS letters Vol.587 No.2
This study revealed that CWR22Rv-1 cells overexpressing δ-catenin display bigger tumor formation and higher angiogenic potentials than their matched control cells in the CAM assay. In addition, δ-catenin overexpression in CWR22Rv-1 cells results in increased hypoxia-inducible factor 1-alpha (HIF-1α and vascular endothelial growth factor (VEGF) expression. Furthermore, δ-catenin overexpression was found to enhance nuclear distribution of both β-catenin and HIF-1α in hypoxic condition, which is diminished by knockdown of δ-catenin. Our current study adds novel evidence regarding contribution of δ-catenin to the progression of prostate cancer.
He, X.,Bonaparte, N.,Kim, S.,Acharya, B.,Lee, J.Y.,Chi, L.,Lee, H.J.,Paik, Y.K.,Moon, P.G.,Baek, M.C.,Lee, E.K.,Kim, J.H.,Kim, I.S.,Lee, B.H. Elsevier Science Publishers 2012 Journal of controlled release Vol.162 No.3
Chemotherapy-induced apoptosis of tumor cells enhances the antigen presentation and sensitizes tumor cells to T cell-mediated cytotoxicity. Here we harnessed the apoptosis of tumor cells as a homing signal for the delivery of T cells to tumor. Jurkat T cells were anchored with ApoPep-1, an apoptosis-targeted peptide ligand, using the biocompatible anchor for membrane (BAM), an oleyl acid derivative. The ApoPep-1-BAM conjugate was efficiently anchored to cell membrane, while little anchoring was obtained with ApoPep-1 alone. The retention period of the ApoPep-1-BAM conjugate on cell membrane was approximately 80 and 40min in the absence and presence of serum, respectively. ApoPep-1 was resistant to degradation in serum until 2h. The apoptosis-targeted T cells that were anchored with the ApoPep-1-BAM preferentially bound to apoptotic tumor cells over living cells. When intravenously injected into tumor-bearing mice, the number of apoptosis-targeted T cells and in vivo fluorescence signals by the homing of the cells to doxorubicin-treated tumor were higher than those of untargeted T cells. Accumulation of apoptosis-targeted T cells at other organs such as liver was not detected. These results suggest that the chemotherapy-induced apoptosis and subsequent enhancement of T cell delivery to tumor by the membrane anchoring of the apoptosis-targeted peptide could be a novel strategy for cancer immunotherapy.
Du, J.,Chen, H.,Yang, H.,Sang, R.,Qian, Y.,Li, Y.,Zhu, G.,Mao, Y.,He, W.,Kang, D.J. Elsevier 2013 Microporous and mesoporous materials Vol.182 No.-
A porous Nd-doped TiO<SUB>2</SUB> monolith was successfully synthesized with polystyrene spheres as a template using a sol-gel method followed by calcination at high temperature. The porous Nd-doped TiO<SUB>2</SUB> monolith was characterized by X-ray diffractometry, scanning electron microscopy and Brunauer-Emmett-Teller measurements. Nd doping can increase the TiO<SUB>2</SUB> surface area by hindering the growth of large TiO<SUB>2</SUB> particles, and suppressing the recombination of photo-produced hole/electron (h<SUP>+</SUP>/e<SUP>-</SUP>) pairs. Moreover, its porous structure can provide a large surface area, facilitating enhanced adsorption and fast transfer of pollutants. To evaluate the photocatalytic activity of the porous Nd-doped TiO<SUB>2</SUB> monolith, the photo-degradation for methyl orange was investigated under UV-Vis irradiation. The porous 0.5% Nd-doped TiO<SUB>2</SUB> monolith showed better behavior than the other as-prepared samples and Degussa P25 due to its narrow band gap, high efficiency for h<SUP>+</SUP>/e<SUP>-</SUP> pair separation, and large surface area. The synergistic combination of Nd doping and the porous structure is a promising material design strategy for use in the degradation of organic pollutants.
To, J. W.,Ng, J. W.,Siahrostami, S.,Koh, A. L.,Lee, Y.,Chen, Z.,Fong, K. D.,Chen, S.,He, J.,Bae, W. G. Springer Science + Business Media 2017 NANO RESEARCH Vol.10 No.4
<P>The development of high-performance and low-cost oxygen reduction and evolution catalysts that can be easily integrated into existing devices is crucial for the wide deployment of energy storage systems that utilize O-2-H2O chemistries, such as regenerative fuel cells and metal-air batteries. Herein, we report an NH3-activated N-doped hierarchical carbon (NHC) catalyst synthesized via a scalable route, and demonstrate its device integration. The NHC catalyst exhibited good performance for both the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER), as demonstrated by means of electrochemical studies and evaluation when integrated into the oxygen electrode of a regenerative fuel cell. The activities observed for both the ORR and the OER were comparable to those achieved by state-of-the-art Pt and Ir catalysts in alkaline environments. We have further identified the critical role of carbon defects as active sites for electrochemical activity through density functional theory calculations and high-resolution TEM visualization. This work highlights the potential of NHC to replace commercial precious metals in regenerative fuel cells and possibly metal-air batteries for cost-effective storage of intermittent renewable energy.</P>
Yang, Y.,He, S.,Wang, Q.,Li, F.,Kwak, M.J.,Chen, S.,O'Connell, D.,Zhang, T.,Pirooz, S.,Jeon, Y.,Chimge, N.O.,Frenkel, B.,Choi, Y.,Aldrovandi, Grace M.,Oh, B.H.,Yuan, Z.,Liang, C. Cell Press 2016 Molecular cell Vol.62 No.4
<P>UV-induced DNA damage, a major risk factor for skin cancers, is primarily repaired by nucleotide excision repair (NER). UV radiation resistance-associated gene (UVRAG) is a tumor suppressor involved in autophagy. It was initially isolated as a cDNA partially complementing UV sensitivity in xeroderma pigmentosum (XP), but this was not explored further. Here we show that UVRAG plays an integral role in UV-induced DNA damage repair. It localizes to photolesions and associates with DDB1 to promote the assembly and activity of the DDB2-DDB1-Cul4A-Roc1 (CRL4(DDB2)) ubiquitin ligase complex, leading to efficient XPC recruitment and global genomic NER. UVRAG depletion decreased substrate handover to XPC and conferred UV-damage hypersensitivity. We confirmed the importance of UVRAG for UV-damage tolerance using a Drosophila model. Furthermore, increased UV-signature mutations in melanoma correlate with reduced expression of UVRAG. Our results identify UVRAG as a regulator of CRL4(DDB2)-mediated NER and suggest that its expression levels may influence melanoma predisposition.</P>