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Xing Pei,Jiyoung Shin,김희정,Nana Wang,Chaewon Seo,Miyun Yoon,Xiongwen Chen,Jianqing Gao,Victor C. Yang,Huining He,Seungjin Lee 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-
Stem cell-based therapeutic approach provides a possible treatment for critical limb ischemia (CLI) byinducing revascularization and regenerating ischemic tissue. However, the clinical benefit is modestdue to low cell survival and limited efficacy after transplantation. Cardiac-derived stem cells (CSCs) mightbe a novel cell source for CLI treatment owing to their superb endothelial differentiation potential andangiogenic paracrine functions. In this study, the angiogenic ability of CSCs was maximized by geneticengineering with constitutively active form of hypoxia-inducible factor-1a (CA-HIF-1a), resistant tooxygen-dependent degradation. CSCs transfected with CA-HIF-1a (CA-HIF-CSCs) promoted supplementaryexpression of proangiogenic factors including VEGF, bFGF, Ang-1 and PDGF-B, along with enhancedangiogenic function including migratory effect, tube formation and endothelial differentiation potential. In the mouse CLI model, CA-HIF-CSCs transplanted into the ischemic region using fibrin gel as cell deliveryvehicle, improved blood perfusion and limb functional recovery with minimal incidence of foot necrosisand limb loss by promoting new vessel formation. Histological evidence further confirmed that CAHIF-CSC/gel treatment markedly alleviated muscle degeneration and fibrosis. CSCs genetically engineeredwith constitutively active HIF-1a provide a novel therapeutic modality in CLI combining stem cell andgene therapy.
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Research and Simulation on the Performance of Multi-User Detection for MC-CDMA System
Xingpei Wu,Qiong Wang,Xibiao Cai,Meng Li 보안공학연구지원센터 2015 International Journal of Future Generation Communi Vol.8 No.2
The paper makes a brief introduction of Multiple Carrier- Code Division Multiple Access (MC-CDMA) scheme based on the principles of Orthogonal Frequency Division Multiplexing (OFDM) and CDMA, and a mathematical model of the uplink is established in MC-CDMA system. The simulation research on different multi-user detection methods in MC-CDMA system is implemented by using MATLAB software, and it also compares the impacts to system performance by several different multi-user detection methods, such as De-Correlation (DEC) multi-user detection, Minimum Mean Square Error (MMSE) multi-user detection and Parallel Interference Cancellation (PIC) multi-user detection, based on understanding and analyzing the experimental results. In addition, the paper also focuses on the research of multi level PIC multi-user detection performance in different primary detection methods and different series detections.
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주지형,곽영근,Xingpei Hao,Chung S. Yang 한국영양학회 2012 Nutrition Research and Practice Vol.6 No.5
The aim of the study was to investigate the inhibitory effects of calcium against intestinal cancer in vitro and in vivo. We first investigated the effects of calcium treatment in HCT116 and HT29 human colon cancer cells. At the concentration range of 0.8-2.4 mM, calcium significantly inhibited cell growth (by 9-29%), attachment (by 12-26%), invasion (by 15-31%), and migration (by 19-61%). An immunofluorescence microscope analysis showed that the treatment with calcium (1.6 mM) for 24 h increased plasma membrane β-catenin but decreased nuclear β-catenin levels in HT29 cells. We then investigated the effect of dietary calcium on intestinal tumorigenesis in ApcMin/+ mice. Mice received dietary treatment starting at 6 weeks of age for the consecutive 8 weeks. The basal control diet contained high-fat (20% mixed lipids by weight) and low-calcium (1.4 mg/g diet) to mimic the average Western diet, while the treatment diet contained an enriched level of calcium (5.2 mg calcium/g diet). The dietary calcium treatment decreased the total number of small intestinal tumors (by 31.4%; P < 0.05). The largest decrease was in tumors which were ≥ 2 mm in diameter, showing a 75.6% inhibition in the small intestinal tumor multiplicity (P < 0.001). Immunohistochemical analysis showed significantly reduced nuclear staining of β-catenin (expressed as nuclear positivity), but increased plasma membrane staining of β-catenin, in the adenomas from the calcium-treated groups in comparison to those from the control group (P < 0.001). These results demonstrate intestinal cancer inhibitory effects of calcium both in human colon cancer cells and ApcMin/+ mice. The decreased β-catenin nuclear localization caused by the calcium treatment may contribute to the inhibitory action.
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Jihyeung Ju,Youngeun Kwak,Xingpei Hao,Chung S. Yang 한국영양학회 2012 Nutrition Research and Practice Vol.6 No.5
The aim of the study was to investigate the inhibitory effects of calcium against intestinal cancer in vitro and in vivo. We first investigated the effects of calcium treatment in HCT116 and HT29 human colon cancer cells. At the concentration range of 0.8-2.4 mM, calcium significantly inhibited cell growth (by 9-29%), attachment (by 12-26%), invasion (by 15-31%), and migration (by 19-61%). An immunofluorescence microscope analysis showed that the treatment with calcium (1.6 mM) for 24 h increased plasma membrane β-catenin but decreased nuclear β-catenin levels in HT29 cells. We then investigated the effect of dietary calcium on intestinal tumorigenesis in ApcMin/+ mice. Mice received dietary treatment starting at 6 weeks of age for the consecutive 8 weeks. The basal control diet contained high-fat (20% mixed lipids by weight) and low-calcium (1.4 ㎎/g diet) to mimic the average Western diet, while the treatment diet contained an enriched level of calcium (5.2 ㎎ calcium/g diet). The dietary calcium treatment decreased the total number of small intestinal tumors (by 31.4%; P < 0.05). The largest decrease was in tumors which were ≥ 2 ㎜ in diameter, showing a 75.6% inhibition in the small intestinal tumor multiplicity (P < 0.001). Immunohistochemical analysis showed significantly reduced nuclear staining of β-catenin (expressed as nuclear positivity), but increased plasma membrane staining of β-catenin, in the adenomas from the calcium-treated groups in comparison to those from the control group (P < 0.001). These results demonstrate intestinal cancer inhibitory effects of calcium both in human colon cancer cells and ApcMin/+ mice. The decreased β-catenin nuclear localization caused by the calcium treatment may contribute to the inhibitory action.
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