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Criteria for evaluating working fluids in loop gravity-assisted heat systems
Chen Jianxun,Liu Jinping,Xu Xiongwen,Liang Lingjiao,Yu Yinhao 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.9
A loop gravity-assisted heat pipe (LGHP) is characterized by passive heat dissipation and extensive application prospect. Dissimilar working fluids give rise to noticeable differences in their working performance (Critical heat flux (CHF)). Consequently, it is of great significance to evaluate the performance of LGHP working fluid for its design. In accordance with the basic theories of CHF and hydrodynamics, the pressure drop models of laminar, smooth turbulence, and completely rough turbulence flows were established, and an extensible two-phase composite property parameter was obtained. On this basis, the physical property parameter of transitional rough turbulent flow was also derived. Finally, as persuasively illustrated by the experimental results, there was almost a linear association between CHFs and the derived physical parameter. As a result, the physical parameters derived in this paper can be employed as favorable criteria for the selection of LGHP working fluid.
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Xing Pei,Jiyoung Shin,김희정,Nana Wang,Chaewon Seo,Miyun Yoon,Xiongwen Chen,Jianqing Gao,Victor C. Yang,Huining He,Seungjin Lee 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-
Stem cell-based therapeutic approach provides a possible treatment for critical limb ischemia (CLI) byinducing revascularization and regenerating ischemic tissue. However, the clinical benefit is modestdue to low cell survival and limited efficacy after transplantation. Cardiac-derived stem cells (CSCs) mightbe a novel cell source for CLI treatment owing to their superb endothelial differentiation potential andangiogenic paracrine functions. In this study, the angiogenic ability of CSCs was maximized by geneticengineering with constitutively active form of hypoxia-inducible factor-1a (CA-HIF-1a), resistant tooxygen-dependent degradation. CSCs transfected with CA-HIF-1a (CA-HIF-CSCs) promoted supplementaryexpression of proangiogenic factors including VEGF, bFGF, Ang-1 and PDGF-B, along with enhancedangiogenic function including migratory effect, tube formation and endothelial differentiation potential. In the mouse CLI model, CA-HIF-CSCs transplanted into the ischemic region using fibrin gel as cell deliveryvehicle, improved blood perfusion and limb functional recovery with minimal incidence of foot necrosisand limb loss by promoting new vessel formation. Histological evidence further confirmed that CAHIF-CSC/gel treatment markedly alleviated muscle degeneration and fibrosis. CSCs genetically engineeredwith constitutively active HIF-1a provide a novel therapeutic modality in CLI combining stem cell andgene therapy.
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