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Numerical Method with High Real-time Property Based on Shortest Path Algorithm for Optimal Control
Wei Liao,Xiaohui Wei,Jizhou Lai,Hao Sun 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.6
A numerical method consisting of an off-line part and an on-line part for optimal control problems is proposed in this paper. In the off-line part, the state space is discretized into a Cartesian grid structure and then define a graph over all grid points by connecting two points if the Euclidean norm between them is closer than a positive number called adjacent radius, the minimum cost between them is estimated using difference method and stored in a matrix. After that the matrix is updated by a shortest path algorithm and a matrix holding the information of the shortest paths between any two grid points is generated. In the on-line part, the optimal control vector at each time step can be generated by reading data from the matrix according to the current state and target state and doing some simple calculations. Since there is no need to do a lot of calculation in the on-line part, this method can satisfy the real-time requirements in some engineering control problems. We prove that the solution of the proposed method converge to the analytical solution when the adjacent radius and the grid size tend to zero and the grid size tend is a higher order infinitesimal of the adjacent radius. At the end of this paper, some numerical examples are taken to illustrate the effectiveness of the proposed method.
Wei, Qing,Liu, Sanzhen,Huang, Jianfeng,Mao, Xueying,Chu, Xiaohui,Wang, Yu,Qiu, Minyan,Mao, Yumin,Xie, Yi,Li, Yao Korean Society for Biochemistry and Molecular Biol 2004 Journal of biochemistry and molecular biology Vol.37 No.4
Double stranded targets on the cDNA microarray contain representatives of both the coding and noncoding strands, which will introduce hybridization competition with probes. Here, the effect of double and single strands of targets on the signal intensity and the ratios of Cy5/Cy3 within the same slide were compared. The results show that single stranded targets can increase the hybridization efficiency without changing the Cy5/Cy3 ratio. Based on these results, a new strategy was established by generating cDNA targets with asymmetric PCR, instead of conventional PCR, to increase the sensitivity of the cDNA microarray. Furthermore, the feasibility of this approach was validated. The results indicate that the cDNA microarray system based on asymmetric PCR is more sensitive, with no decrease in the reliability and reproducibility as compared with that based on conventional symmetric PCR.
Porcine parvovirus nonstructural protein NS1 activates NF-κB and it involves TLR2 signaling pathway
Xiaohui Jin,Yixin Yuan,Chi Zhang,Yong Zhou,Yue Song,Zhanyong Wei,Gaiping Zhang 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.3
Background: Porcine parvovirus (PPV) is a single-stranded DNA virus that causes porcine reproductive failure. It is of critical importance to study PPV pathogenesis for the prevention and control of the disease. NS1, a PPV non-structural protein, is participated in viral DNA replication, transcriptional regulation, and cytotoxicity. Our previous research showed that PPV can activate nuclear factor kappa B (NF-κB) signaling pathway and then up-regulate the expression of interleukin (IL)-6. Objectives: Herein, the purpose of this study is to determine whether the non-structural protein NS1 of PPV also has the same function. Methods: Real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR), enzyme-linked immunosorbent assay, western blot, immunofluorescence assay and small interfering RNA (siRNA) were used. Results: Our findings demonstrated that PPV NS1 protein can up-regulate the expression levels of IL-6 and tumor necrosis factor-alpha in a dose-dependent manner. Moreover, PPV NS1 protein was found to induce the phosphorylation of IκBα, then leading to the phosphorylation and nuclear translocation of NF-κB. In addition, the NS1 protein activated the upstream pathways of NF-κB. Meanwhile, TLR2-siRNA assay showed TLR2 plays an important role in the activation of NF-κB signaling pathway induced by PPV-NS1. Conclusions: These findings indicated that PPV NS1 protein induced the up-regulated of IL-6 expression through activating the TLR2 and NF-κB signaling pathways. In conclusion, these findings provide a new avenue to study the innate immune mechanism of PPV infection.
An improved kernel principal component analysis based on sparse representation for face recognition
( Wei Huang ),( Xiaohui Wang ),( Yinghui Zhu ),( Gengzhong Zheng ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.6
Representation based classification, kernel method and sparse representation have received much attention in the field of face recognition. In this paper, we proposed an improved kernel principal component analysis method based on sparse representation to improve the accuracy and robustness for face recognition. First, the distances between the test sample and all training samples in kernel space are estimated based on collaborative representation. Second, S training samples with the smallest distances are selected, and Kernel Principal Component Analysis (KPCA) is used to extract the features that are exploited for classification. The proposed method implements the sparse representation under ℓ<sub>2</sub> regularization and performs feature extraction twice to improve the robustness. Also, we investigate the relationship between the accuracy and the sparseness coefficient, the relationship between the accuracy and the dimensionality respectively. The comparative experiments are conducted on the ORL, the GT and the UMIST face database. The experimental results show that the proposed method is more effective and robust than several state-of-the-art methods including Sparse Representation based Classification (SRC), Collaborative Representation based Classification (CRC), KCRC and Two Phase Test samples Sparse Representation (TPTSR).
Electroconvulsive Therapy on Severe Obsessive-Compulsive Disorder Comorbid Depressive Symptoms
Xiaohui Liu,Xinhui Xie,Hong Cui,Qiang Wei,Ying Wang,Keyong Wang,Chen Wang,Chunyan Zhu 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.2
Electroconvulsive therapy (ECT) is not currently used as a first-line treatment for obsessive-compulsive disorder (OCD). However, several related case reports have demonstrated that ECT seems to be effective for severe OCD, especially when first-line therapies have failed. In this study, we describe the courses, detailed parameters, effects, and follow-up information relating to three patients with severe OCD who were treated by modified bifrontal ECT after their first-line anti-OCD treatments pharmacotherapy, behavioral therapy, and cognitive behavioral therapy failed. The number of ECT procedures administered in each case is as follows: Case 1, eight; Case 2, three; and Case 3, four. In all three cases, the patients’ depressive symptoms improved considerably after the ECT procedures. In addition, the condition of all three patients’ OCD significantly improved and remained stable at regular follow-ups. ECT may play an effective role in treating severe OCD.
Electroconvulsive Therapy on Severe Obsessive-Compulsive Disorder Comorbid Depressive Symptoms
Xiaohui Liu,Hong Cui,Qiang Wei,Ying Wang,Keyong Wang,Chen Wang,Chunyan Zhu,Xinhui Xie 대한신경정신의학회 2004 PSYCHIATRY INVESTIGATION Vol.1 No.2
Electroconvulsive therapy (ECT) is not currently used as a first-line treatment for obsessive-compulsive disorder (OCD). However, several related case reports have demonstrated that ECT seems to be effective for severe OCD, especially when first-line therapies have failed. In this study, we describe the courses, detailed parameters, effects, and follow-up information relating to three patients with severe OCD who were treated by modified bifrontal ECT after their first-line anti-OCD treatments pharmacotherapy, behavioral therapy, and cognitive behavioral therapy failed. The number of ECT procedures administered in each case is as follows: Case 1, eight; Case 2, three; and Case 3, four. In all three cases, the patients’ depressive symptoms improved considerably after the ECT procedures. In addition, the condition of all three patients’ OCD significantly improved and remained stable at regular follow-ups. ECT may play an effective role in treating severe OCD.
Yi, Wei-Min,Wang, Feige,Wu, Xue-Bing,Yang, Jinyi,Bai, Jin-Ming,Fan, Xiaohui,Brandt, William N.,Ho, Luis C.,Zuo, Wenwen,Kim, Minjin,Wang, Ran,Yang, Qian,Zhang, Ju-jia,Wang, Fang,Wang, Jian-Guo,Ai, Yanl IOP Publishing 2014 ASTROPHYSICAL JOURNAL LETTERS - Vol.795 No.2
<P>Very few of the z > 5 quasars discovered to date have been radio-loud, with radio-to-optical flux ratios (radio-loudness parameters) higher than 10. Here we report the discovery of an optically luminous radio-loud quasar, SDSS J013127.34-032100.1 (J0131-0321 in short), at z = 5.18 +/- 0.01 using the Lijiang 2.4 m and Magellan telescopes. J0131-0321 has a spectral energy distribution consistent with that of radio-loud quasars. With an i-band magnitude of 18.47 and a radio flux density of 33 mJy, its radio-loudness parameter is similar to 100. The optical and near-infrared spectra taken by Magellan enable us to estimate its bolometric luminosity to be L-bol similar to 1.1 x 10(48) erg s(-1), approximately 4.5 times greater than that of the most distant quasar known to date. The black hole mass of J0131-0321 is estimated to be 2.7 x 10(9) M-circle dot, with an uncertainty up to 0.4 dex. Detailed physical properties of this high-redshift, radio-loud, potentially super-Eddington quasar can be probed in the future with more dedicated and intensive follow-up observations using multi-wavelength facilities.</P>