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Multibody contact dynamics on mechanisms with deep groove ball bearing joints
Tingqiang Yao,Liguo Xian,Lihua Wang,Xiaobao Liu 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.9
The dynamics of ball bearings are important to fatigue breakage, dynamic performance and motion precision of mechanisms connected by ball bearings joints with multi-clearances. In this study, a new method is proposed for multibody dynamics analysis on mechanisms under the effects of radial internal clearances and impact of balls/cage pockets interactions of ball bearings. Including balls/rings interactions and balls/cage pockets interactions, the three dimensional dynamics models of the crank slider mechanism are established and calculated by generalized-α algorithms on the basis of Hertzian contact theory and penalty function method. The rules of eccentric trajectories of inner and outer ring center for one ball bearing joint are verified with the results calculated by XU’s references. The results of dynamic errors, motion trajectories, dynamic forces are achieved under different speeds, radial clearances and number of ball bearings. The speeds and radial clearances are critical to the dynamic performances and motion precision of mechanisms, especially the number of ball bearings. The number of ball bearings is important to impact force and motion stability of the mechanism.
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Chongwen Xu,Yuan Shao,Wanli Ren,Hao Dai,Fangli Yang,Xiang Li,Shaoqiang Zhang,Junsong Liu,Xiaobao Yao,Qian Zhao,Xin Sun,Zhiwei Zheng 한국분자세포생물학회 2023 Molecules and cells Vol.46 No.6
Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid carcinoma. Despite a good prognosis, approximately a quarter of PTC patients are likely to relapse. Previous reports suggest an association between S-phase kinase-associated protein 2 (SKP2) and the prognosis of thyroid cancer. SKP1 is related to apoptosis of PTC cells; however, its role in PTC remains largely elusive. This study aimed to understand the expression and molecular mechanism of SKP2 in PTC. SKP2 expression was upregulated in PTC tissues and closely associated with clinical diagnosis. In vitro and in vivo knockdown of SKP2 expression in PTC cells suppressed cell growth and proliferation and induced apoptosis. SKP2 depletion promoted cell autophagy under glucose deprivation. SKP2 interacted with PH domain leucine-rich repeat protein phosphatase-1 (PHLPP1), triggering its degradation by ubiquitination. Furthermore, SKP2 activates the AKT-related pathways via PHLPP1, which leads to the cytoplasmic translocation of SKP2, indicating a reciprocal regulation between SKP2 and AKT. In conclusion, the upregulation of SKP2 leads to PTC proliferation and survival, and the regulatory network among SKP2, PHLPP1, and AKT provides novel insight into the molecular basis of SKP2 in tumor progression.
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