Glutamine-Supplemented Parenteral Nutrition and Probiotics in Four Adult Autoimmune Enteropathy Patients

( Ren Ying Xu ),( Yan Ping Wan ),( Yi Quan Zhou ),( Li Ping Lu ),( Zhi Qi Chen ),( Ying Jie Wu ),( Wei Cai ) 대한소화기학회 2014 Gut and Liver Vol.8 No.3

To evaluate the effects of glutamine-supplemented parenteral nutrition (PN) and probiotics in adult autoimmune enteropathy (AIE) patients. Four adult AIE patients were identified from April 2006 to January 2012. Clinical and nutritional data were obtained from the patients’ medical records. Glutamine-supplemented PN started immediately when the AIE diagnosis was confirmed. The total PN duration was 351 days. According to the PN prescription, the average caloric intake ranged from 20 to 25 kcal/kg/day, and the protein intake ranged from 1.2 to 1.5 g/kg/day. Alanyl-glutamine (20 g/day) was administered to AIE patients for 4 weeks followed by a 2-week break, and this treatment schedule was repeated when PN lasted for more than 6 weeks. Body weight gain and an increased serum albumin level were achieved after PN, and defecation frequency and quality also improved. Each patient received oral supplements, 250 mL of Ensure and two probiotics capsules (each capsule containing 0.5×108 colonies) three times a day when enteral nutrition started. Three AIE patients were successfully weaned off PN, and one patient died of pneumonia. Glutamine-supplemented PN and probiotics show promise in managing patients with AIE and related malnutrition.

P53 Arg72Pro and MDM2 SNP309 Polymorphisms Cooperate to Increase Lung Adenocarcinoma Risk in Chinese Female Non-smokers: A Case Control Study

Ren, Yang-Wu,Yin, Zhi-Hua,Wan, Yan,Guan, Peng,Wu, Wei,Li, Xue-Lian,Zhou, Bao-Sen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

Background: Cell cycle deregulation is a major component of carcinogenesis. The p53 tumor suppressor gene plays an important role in regulating cell cycle arrest, and mouse double minute 2 (MDM2) is a key regulator of p53 activity and degradation. Abnormal expression of p53 and MDM2 occurs in various cancers including lung cancer. Methods: We investigated the distribution of the p53 Arg72Pro (rs1042522) and MDM2 SNP309 (rs2279744) genotypes in patients and healthy control subjects to assess whether these single nucleotide polymorphisms (SNPs) are associated with an increased risk of lung adenocarcinomas in Chinese female non-smokers. Genotypes of 764 patients and 983 healthy controls were determined using the TaqMan SNP genotyping assay. Results: The p53 Pro/Pro genotype (adjusted OR = 1.55, 95% CI = 1.17-2.06) significantly correlated with an increased risk of lung adenocarcinoma, compared with the Arg/Arg genotype. An increased risk was also noted for MDM2 GG genotype (adjusted OR = 1.68, 95% CI = 1.27-2.21) compared with the TT genotype. Combined p53 Pro/Pro and MDM2 GG genotypes (adjusted OR = 2.66, 95% CI = 1.54-4.60) had a supermultiplicative interaction with respect to lung adenocarcinoma risk. We also found that cooking oil fumes, fuel smoke, and passive smoking may increase the risk of lung adenocarcinomas in Chinese female non-smokers who carry p53 or MDM2 mutant alleles. Conclusions: P53 Arg72Pro and MDM2 SNP309 polymorphisms, either alone or in combination, are associated with an increased lung adenocarcinoma risk in Chinese female non-smokers.

DH-LRU: Dynamic Hybrid LRU Caching Scheme for PRAM/DRAM Hybrid Main Memory

Yongjian Ren,Hongtianchen Xie,Gangyong Jia,Jilin Zhang,Yuyu Yin,Jian Wan 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.11

Both performance and capacity of the main memory are the key to the computer systems in current architecture. DRAM, which is the most used main memory, can’t extend in capacity for its high energy consumption and repeatedly refresh. Fortunately, some new memory mediums, such as phase-change memory (PRAM), are used to replace traditional DRAM memory. These new memories have many advantages, like low energy consumption, without repeatedly refresh, high density storage, and so on. Therefore, these memories are promising. However, their low read/write performance and limited life are restricted the replacement process. In current time, hybrid memory, which consists of both PRAM and DRAM, is a good choice. In this way, the memory capacity can be extended. So, the most challenge for the hybrid memory is the performance. In this paper, we propose a dynamic hybrid LRU caching scheme (DH-LRU) for the last level cache in PRAM/DRAM hybrid main memory to improve the main memory performance. Compared with traditional cache policies, like LRU, FIFO, RANDOM, CFLRU, our DH-LRU improves performance by 4.6%. Moreover, energy consumption of write and read operation can be reduced up to 88.2%.

Performance Evaluation and Modeling Method Research Based on IaaS Cloud Platform

Jian Wan,Xianghong Yang,Zujie Ren,Zheng Ye 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.10

With the widespread use of cloud platforms, their performance evaluation tools also have become the research hot spot of academic circle. So far, many performance evaluation tools of the cloud platform have been designed in their corresponding application scenarios, which have brought much convenience on the performance evaluation and management of the cloud platform. In order to predict the maximum number of virtual machines that can be opened by the cloud platform, this paper integrates the current tools of performance evaluation and proposes a performance evaluation tool based on IaaS cloud platform. The key of the performance evaluation tool is that it not only can evaluate the performance of the cloud platform, but also can predict the maximum number of virtual machines that can be opened by the cloud platform when the configuration of the virtual machine and the workload of each virtual machine have been known. This special performance evaluation tool has not been put forward now. And, the prediction model has been introduced into this tool in this paper that is the most important and core part. Lastly, to test the effectiveness of cloud platform performance evaluation tool proposed in this paper, some tests have been done on the IaaS cloud platform. According to the contrast results of the forecast error among models, establishing support vector machine and neural network as single forecasting model. The results show combined model can be chosen as the prediction model of cloud platform performance evaluation tool.

Screening, Characterization, and Cloning of a Solvent-Tolerant Protease from Serratia marcescens MH6

( Mao Hua Wan ),( Wu Bin ),( Wei Ren ),( Bing Fang He ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.5

Robust thermal boundary conditions applicable to a wall along which temperature varies in lattice-gas cellular automata.

Shim, Jae Wan,Gatignol, René,e Published by the American Physical Society through 2010 Physical review. E, Statistical, nonlinear, and so Vol.81 No.4

<P>We show that the heat exchange between fluid particles and boundary walls can be achieved by controlling the velocity change rate following the particles' collision with a wall in discrete kinetic theory, such as the lattice-gas cellular automata and the lattice Boltzmann method. We derive a relation between the velocity change rate and temperature so that we can control the velocity change rate according to a given temperature boundary condition. This relation enables us to deal with the thermal boundary whose temperature varies along a wall in contrast to the previous works of the lattice-gas cellular automata. In addition, we present simulation results to compare our method to the existing and give an example in a microchannel with a high temperature gradient boundary condition by the lattice-gas cellular automata.</P>

Electrospun PS/PAN Nanofiber Membranes Formed from Doped Carbon Nanotubes with a Fluffy and Multi-scale Construction for Air-Filtration Materials

Weili Shao,Wanli Yue,Gaihuan Ren,Chen Cui,Junpeng Xiong,Ling Wang,Tong Lu,Wanjun Bu,Fan Liu,Jianxin He 한국섬유공학회 2022 Fibers and polymers Vol.23 No.5

Electrospun nanofibers are widely used in air-filtration materials because of their fine fiber diameter, small poresize, and high porosity. However, nanofiber membranes exhibit a dense structure, such that they present a large resistance toany air flow. In this study, we set out to design and develop composite nanofiber materials with fluffy structures, as well asblended structures of coarse and fine fibers, through electrospinning technology. These materials could be used in airfiltration applications, given that they offer high efficiency and low resistance. The results show that, compared with purePAN nanofibers, the diameter of PAN nanofibers doped with CNT decreased from 192.36 to 124.37 nm; when the spinningratio of PS coarse fiber (1053 nm) and PAN/CNT fine fiber is 3:1, the resulting nanofiber membrane materials has an obviousthree-dimensional structure, with a specific surface area of 103.16 m2/g, a pore size of 2.25 μm, and a quality factor of0.0947 Pa-1. Under test conditions featuring an air flow of 32 L/min, and 0.3 μm NaCl aerosol particles, the filtrationefficiency was 99.37 % and the resistance was 35 Pa. Furthermore, the dust-holding capacity of the nanofiber air-filter paperwas found to be almost the same as that of melt-blown air-filter papers. Even after being water-soaked 50 times, the filteringefficiency of the nanofiber air-filter paper was still higher. Interestingly, the nanofiber membrane materials doped with CNTalso exhibited excellent sound-absorption abilities. Thus, the composite nanofiber material could potentially be applied toareas with serious air pollution and high noise pollution.

Trends in Nasopharyngeal Carcinoma Mortality in China, 1973-2005

Huang, Tian-Ren,Zhang, Si-Wei,Chen, Wan-Qing,Deng, Wei,Zhang, Chun-Yan,Zhou, Xin-Juan,Zhai, Ri-Hong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

Nasopharyngeal carcinoma (NPC) is a disease with distinct ethnic and geographic distribution. The incidence of NPC in Chinese residing in Asia has declined over the last few decades, but NPC mortality trends in the entire Chinese population over time have not been systematically evaluated. In this study, we examined NPC mortality at the national level in China between 1973-2005. Mortality rates were derived from the databases of national retrospective surveys on cancer mortality conducted in the periods of 1973-1975, 1990-1992, and 2004-2005, respectively. NPC was classified according to the International classification of diseases. Age-adjusted mortality rates were calculated by direct standardization according to the world standard population. Trends in rates were evaluated by age, gender, geographic areas, and socioeconomic status. From 1973 to 2005, there was a general trend of decrease in NPC mortality in China, with higher rates in the south on a downward trend in the north. The age-standardized NPC mortality rates were 2.60 per 100,000 in 1973-1975, 1.94 per 100,000 in 1990-1992, and 1.30 per 100,000 in 2004-2005, respectively. The trend was similar in both men and women, in both urban and rural areas, but the declining rates in females were more remarkable than in males. The mortality rates were higher for the age groups above 50 years than those less than 50 years of age, both showing downward trend over 30-year period. In summary, the overall NPC mortality has consistently decreased in China over the past three decades, particularly in women and in old adults.

Design and Characteristic Measurement of 8000 mm Large Aperture Integrating Sphere

Zhao Zhang,Zhi Wan,Xiansheng Li,Hongxing Liu,Jingxu Sun,Zexun Liu,Yamin Wang,Jianwei Ren,Jianyue Ren 한국광학회 2016 Current Optics and Photonics Vol.20 No.4

Integrating spheres play a central role in the radiometric calibration of remote sensors. With thedevelopment of the wide field of view (FOV) remote sensors, aperture diameters of remote sensors arebecoming larger and larger. To satisfy the radiometric calibration requirements of full FOV and fullaperture, an 8000mm diameter large aperture integrating sphere uniform source with a variable exit portwas designed and manufactured. This integrating sphere will be used for pre-launch test and radiometriccalibration of remote satellites. In this paper, optical theories were used to design the output spectralradiance. The LightTools software based on ray-tracing simulation method was used to determine the bestcombination and distribution of inner light sources. A spectral experiment was made to verify the spectralradiance design. To reduce the influence of longtime power-on, a new characteristic measurement methodwas developed to obtain the radiation characteristic of the integrating sphere, which could greatly improvethe measuring efficiency. This method could also be applied to measure other large aperture uniformsources. The obtained results indicate that the spatial uniformity is 98.35%, and the angular uniformityat center position is 98.78%.

Self-assembled magnetic lamellar hydroxyapatite as an efficient nanovector for gene delivery

Guangyao Xiong,Yizao Wan,Guifu Zuo,Kaijing Ren,Honglin Luo 한국물리학회 2015 Current Applied Physics Vol.15 No.7

Magnetic lamellar hydroxyapatite (ML-HA) nanoparticles were synthesized by a template-assisted selfassembly process. The as-prepared ML-HA nanoparticles self-assembled under different conditions were characterized by XRD, TEM, cytotoxicity assessment, and DNA-loading and transfection efficiency measurements. We found that the structure and morphology of ML-HA were controlled by self-assembly conditions. The ML-HA synthesized in this work exhibited good biocompatibility. The DNA-loading capacity and z-potential of ML-HA were much lower in comparison to bare lamellar HA (L-HA) without magnetic nanoparticles. Despite that, the ML-HA with good lamellar structure showed 47% higher transfection efficiency than L-HA. Results suggested that the ordered lamellar structure is a key factor in controlling transfection efficiency and magnetization is an effective way of improving the transfection efficiency of lamellar HA. Mechanisms were proposed to interpret these experimental results. It is demonstrated that the ML-HA may be a promising gene vector to deliver DNA into the cells effectively and safely.