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- 저자 : Xianzhi Zhao (검색결과 4 건)
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Hongxi Zhao,Zhifu Yang,Xiaohong Wang,Xianzhi Zhang,Meng Wang,Yukun Wang,Qibing Mei,Zhipeng Wang 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.11
Triptolide, a compound extracted from the traditional Chinese medicine preparation of Tripterygium wilfordii Hook F., has been reported to have anti-inflammatory and anti-cancer activities. However, its effect on ovarian cancer invasion is unknown. We observed that MMP7 and MMP19 expression increased in ovarian cancer tissue. Triptolide treatment inhibited the migration and invasion of ovarian cancer cells SKOV3 and A2780 at the concentration of 15 nM. We also observed that triptolide suppressed MMP7 and MMP19 promoter activity in a dose-dependent manner,down-regulating the expressions of these promoters on mRNA and protein level. Moreover, triptolide enhanced E-cadherin expression in ovarian cancer cells. In vivo, triptolide inhibited tumor formation and metastasis in nude mice, and suppressed MMP7 and MMP19 expression; it also enhanced E-cadherin expression in tumor in a dose-dependent manner. Over expression of MMP7 and MMP19, or suppression of E-cadherin expression partially abolished the inhibitory effect of triptolide on invasion of ovarian cancer cells. To summarize, triptolide significantly inhibited the migration and invasion of ovarian cancer cells by suppression of MMP7 and MMP19 and up-regulation of E-cadherin expression. This study shows that triptolide is a good candidate for the treatment of ovarian cancer and reduction of metastasis.
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Fugui He,Xianzhi Gao,Xianzheng Zhao,Huilai Wang,Dexiang Yang,Quan Wang 한국지질과학협의회 2017 Geosciences Journal Vol.21 No.4
The Bayindulan Sag situated in Erlian Basin, northeast China, is characterized by pervasive dolomitization in Upper A4 Member to Lower T1 Member of Bayanhua Group. These stratum in the Lower Cretaceous Bayanhua Group were deposited in a lacustrine environments. The main objective of this study is to identify the origin of dolomitization and distribution model of dolomitized rocks. Based on petrographic examination, mud-crystal dolomites (<0.03 mm), silt-crystal dolomites (0.03–0.1 mm) and fine-crystal dolomites (0.1– 0.25 mm) have been observed, and the former two types were predominant. Meanwhile, only one type of dolomite have been defined: replacive dolomite. A variety of dolomite textures have also been observed, the major ones of them are scattered, blocky, joined and annular textures. These dolomites have strongly depleted oxygen isotopic values from –17.48‰ to –6.96‰ with the average of –10.48‰ (PDB), carbon isotopic values from 0.24‰ to 8.37‰ with the average of 5.39‰ (PDB). The obvious depletion of oxygen isotopic was presented as a result of the increase in temperature with progressive burial, and the high carbon isotopic content of dolomites maybe result from the involvement of CO2 in the dolomitization process. These CO2 were generated by bio-methanation which commonly took place in moderately deep burial environments. The Sr values from 62.4 ppm to 262 ppm as well as the Sr/Ba ratios from 0.24 to 0.76 in Tengyi Formation mudstones indicate the freshwater lacustrine sedimentary environments. Taking the petrographic and geochemical data into consideration, the conclusion that the dolomites have formed in a freshwater environments during deep burial depths at temperatures of at least 60 °C can be drawn. Petrographic observations and mineralogy analyses indicate that dolomitization is closely associated with tuffaceous materials, the Mg needed for the dolomitization is provided by dissolution of tuffaceous materials and dolomitization is most probably driven by tuffaceous materials alteration at elevated temperatures.
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Xiaoyu Li,Xianzhi Zhao,Wen Song,Zibin Tian,Lin Yang,Qinghui Niu,Qi Zhang,Man Xie,Bin Zhou,Yonghong Xu,Jun Wu,Cuiping Zhang 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.1
Purpose: This study was aimed to investigate the effect of pseudolaric acid B (PAB) on proliferation, invasion and epithelial-to-mesenchymal transition (EMT) in pancreatic cancer cells and to explore the possible mechanism. Materials and Methods: The pancreatic cancer cell line SW1990 was cultured and treated with PAB dose- and time-dependent manners. Cell proliferation and invasion ability were measured by MTT assay and Matrigel/Transwell test, respectively. Semi-quantitative real-time polymerase chain reaction and Western blotting were conducted to detect the expression of EMT markers and the key molecules. Finally, nude mice subcutaneous transplantation tumor model was used to confirm the therapy efficacy of PAB. Results: PAB could inhibit SW1990 cell proliferation and invasion in time- and dose-dependent manners. Vimentin, fibronectin, N-cadherin, Snail, Slug, YAP, TEAD1, and Survivin were down-regulated (p<0.01), while E-cadherin, caspase-9, MST1, and pYAP were up-regulated (p<0.05). Combined PAB and gemcitabine treatment markedly restricted the tumor growth compared with gencitabin or PAB alone groups. Conclusion: PAB could inhibit the proliferation and invasion ability of pancreatic cancer cells through activating Hippo-YAP pathway and inhibiting the process of EMT.
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Jiangtao Fan,Jingyan Wang,Xianzhi Liu,Changping Zhao,Chaobing Zhou,Tasheen Saba,Jiaojiao Wu,Wenkai Hui,Wei Gong 한국원예학회 2022 원예과학기술지 Vol.40 No.3
Zanthoxylum armatum, known as green prickly ash, is a major condiment species planted on a large scale in southwest China. However, its limited cold tolerance has been a significant disadvantage for its cultivation in low-temperature regions. To better understand the antioxidant enzyme activities related to cold resistance, superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) activities as well as malondialdehyde (MDA) content were investigated under 16 fertilizer and soil moisture treatments to explore the cold resistance response mechanism in Z. armatum. The results showed that low temperatures could significantly affect antioxidant enzyme activities in the leaves of Z. armatum seedlings. The antioxidant enzyme activities of seedlings treated with soil moisture and fertilizer treatments were significantly higher than those without fertilizer. Furthermore, the comprehensive evaluation index (CEI) was positively correlated with SOD, POD, and CAT activities but negatively correlated with MDA content. Meanwhile, the treatment T12 (60% field water capacity + 300 kg·ha-1 nitrogen + 30 kg·ha-1 phosphoric anhydride) had the highest CEI value, whereas T1 (20% water capacity) had the lowest. Based on the regression equation for CEI improvement, the predicted optimal levels for field water capacity (FWC), nitrogen, phosphorus, and potassium were 59.6%–63.4% FWC (average 61.5%), 114.2–248.8 kg N/ha (average 181.5 kg N/ha), 40.1–108.5 kg P2O5/ha (average 74.3 kg P2O5/ha), and 200.2–254.4 kg K2O/ha (average 227.3 kg K2O/ha), respectively. The present study provides the optimal soil moisture and fertilizer concentration required to enhance protective enzyme activity and low-temperature tolerance, which is crucial for improving cold resistance in Z. armatum.
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