The effect of the spinning conditions on the structure of mesophase pitch-based carbon fibers by Taguchi method

Zhao Jiang,Ting Ouyang,Xiangdong Yao,Youqing Fei 한국탄소학회 2016 Carbon Letters Vol.19 No.-

Taguchi’s experimental design was employed in the melt spinning of molten mesophase pitch to produce carbon fibers. The textures of the obtained carbon fibers were radial with varied crack angles, as observed by scanning electron microscopy and polarized optical imaging. The diameter, crack angle, preferred orientation, and tensile modulus of the produced samples were examined to investigate the influence of four spinning variables. The relative importance of the variables has been emphasized for each characteristic. The results show that thicker carbon fiber can be obtained with a smaller entry angle, a higher spinning temperature, a reduced winding speed, and an increased extrusion pressure. The winding speed was found to be the most significant factor in relation to the fiber diameter. While it was observed that thicker carbon fiber generally shows improved preferred orientation, the most important variable affecting the preferred orientation was found to be the entry angle. As the entry angle decreased from 120° to 60°, the shear flow was enhanced to induce more ordered radial alignment of crystallite planes so as to obtain carbon fibers with a higher degree of preferred orientation. As a consequence, the crack angle was increased, and the tensile modulus was improved.

microRNA-506-3p suppresses the proliferation of triple negative breast cancer cells via targeting SNAI2

Zhao Xuye,Bai Xiangdong,Li Weina,Gao Xuezhen,Wang Xiaoli,Li Bin 대한독성 유전단백체 학회 2021 Molecular & cellular toxicology Vol.17 No.4

Background The lacking of estrogen, progesterone and ERBB2 receptor makes the therapy of Triple negative breast cancer (TNBC) is particularly challenging. Accumulating evidences has demonstrated the dysfunction and critical roles of microRNAs (miRNAs) in TNBC. Objective Explore the role of miR-506-3p in TNBC and evaluate the clinical significance of miR-506-3p. Results miR-506-3p expression was significantly decreased in TNBC and correlated with the worst status of TNBC patients. miR-506-3p overexpression repressed the proliferation, migration and induced cell cycle arrest as well as apoptosis of TNBC cells. Mechanistically, SNAI2 was identified as a target of miR-506-3p in TNBC cells. Consistently, SNAI2 was overexpressed in TNBC and inversely correlated with miR-506-3p level. Transfection of SNAI2 abolished the inhibitory role of miR-506-3p in regulating the malignant phenotypes of TNBC cells. Conclusions These results demonstrated the suppressive function of miR-506-3p in TNBC via targeting SNAI2, indicating the possible application of miR-506-3p in TNBC treatment. Background The lacking of estrogen, progesterone and ERBB2 receptor makes the therapy of Triple negative breast cancer (TNBC) is particularly challenging. Accumulating evidences has demonstrated the dysfunction and critical roles of microRNAs (miRNAs) in TNBC. Objective Explore the role of miR-506-3p in TNBC and evaluate the clinical significance of miR-506-3p. Results miR-506-3p expression was significantly decreased in TNBC and correlated with the worst status of TNBC patients. miR-506-3p overexpression repressed the proliferation, migration and induced cell cycle arrest as well as apoptosis of TNBC cells. Mechanistically, SNAI2 was identified as a target of miR-506-3p in TNBC cells. Consistently, SNAI2 was overexpressed in TNBC and inversely correlated with miR-506-3p level. Transfection of SNAI2 abolished the inhibitory role of miR-506-3p in regulating the malignant phenotypes of TNBC cells. Conclusions These results demonstrated the suppressive function of miR-506-3p in TNBC via targeting SNAI2, indicating the possible application of miR-506-3p in TNBC treatment.

Prevalence of Allergic Rhinitis Among Adults in Urban and Rural Areas of China: A Population-Based Cross-Sectional Survey

Ming Zheng,Xiangdong Wang,Mingyu Bo,Kuiji Wang,Yan Zhao,Fei He,Feifei Cao,Luo Zhang,Claus Bachert 대한천식알레르기학회 2015 Allergy, Asthma & Immunology Research Vol.7 No.2

Purpose: The aim of the present study was to compare the prevalence of self-reported and confirmable allergic rhinitis (AR) with positive skin pricktest (SPT) results among adults living in urban and rural areas of China. Methods: Adults from a community in Beijing and a village in Baoding wereselected as representative urban and rural dwellers, respectively. All eligible residents were enrolled from the population register and received aface-to-face interview using modified validated questionnaires. Equal sets of randomly selected self-reporting AR-positive and AR-negative participantswho responded to the questionnaires were also investigated using skin prick tests. Results: A total of 803 participants in the rural area and atotal of 1,499 participants in the urban area completed the questionnaires, with response rates being 75.9% and 81.5% respectively. The prevalenceof self-reported AR of the rural area (19.1%) was significantly higher than that of the urban area (13.5%). The elementary school of educational levelincreased the risk of having AR (adjusted OR=2.198, 95% CI=1.072-2.236) .The positive SPT rates among subjects with self-reported AR in therural and urban areas were 32.5% and 53.3%, respectively; the confirmable AR prevalence of 6.2% and 7.2% among the rural and urban adults, respectively. Conclusions: The prevalence of confirmable AR is similar between rural and urban areas in China, although there is a higher prevalenceof self-reported AR in the former. Purpose: The aim of the present study was to compare the prevalence of self-reported and confirmable allergic rhinitis (AR) with positive skin prick test (SPT) results among adults living in urban and rural areas of China. Methods: Adults from a community in Beijing and a village in Baoding were selected as representative urban and rural dwellers, respectively. All eligible residents were enrolled from the population register and received a face-to-face interview using modified validated questionnaires. Equal sets of randomly selected self-reporting AR-positive and AR-negative participants who responded to the questionnaires were also investigated using skin prick tests. Results: A total of 803 participants in the rural area and a total of 1,499 participants in the urban area completed the questionnaires, with response rates being 75.9% and 81.5% respectively. The prevalence of self-reported AR of the rural area (19.1%) was significantly higher than that of the urban area (13.5%). The elementary school of educational level increased the risk of having AR (adjusted OR=2.198, 95% CI=1.072-2.236) .The positive SPT rates among subjects with self-reported AR in the rural and urban areas were 32.5% and 53.3%, respectively; the confirmable AR prevalence of 6.2% and 7.2% among the rural and urban adults, respectively. Conclusions: The prevalence of confirmable AR is similar between rural and urban areas in China, although there is a higher prevalence of self-reported AR in the former.

The Dynamic Compliance and Its Compensation Control Research of the Highly Integrated Valve-controlled Cylinder Position Control System

Kaixian Ba,Bin Yu,Xiangdong Kong,Hua-Long Zhao,Jin-Song Zhao,Qi-Xin Zhu,Chun-He Li 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.4

The highly integrated valve-controlled cylinder (HIVC) is the joint driver in the hydraulic drive leggedrobot motion process, with the inner-loop-control-based outer loop dynamic compliance control method of the hydraulicsystem adopted. Yet the dynamic compliance of the HIVC position inner loop control has effects on theaccuracy of the outer loop dynamic compliance control. Therefore, the dynamic compliance parallel compositiontheory of the HIVC position inner loop control is presented and its dynamic compliance is analyzed in this paper,based on the HIVC position control nonlinear mathematical model. Moreover, the multiple parallel branch dynamiccompliance compound compensation control method is also designed and the dynamic compliance parallel compositionis rearranged. The experimental results indicate that adopting the compensation control method can decreasethe dynamic compliance of the HIVC position control system dramatically, which would provide the inner loopdynamic compliance compensation control method of the robot with high accuracy and high robustness.

Characterization of the effect of He⁺ irradiation on nanoporous-isotropic graphite for molten salt reactors

Zhang, Heyao,He, Zhao,Song, Jinliang,Liu, Zhanjun,Tang, Zhongfeng,Liu, Min,Wang, Yong,Liu, Xiangdong Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.6

Irradiation-induced damage of binderless nanoporous-isotropic graphite (NPIG) prepared by isostatic pressing of mesophase carbon microspheres for molten salt reactor was investigated by 3.0 MeV He⁺ irradiation at room temperature and high temperature of 600 ℃, and IG-110 was used as the comparation. SEM, TEM, X-ray diffraction and Raman spectrum are used to characterize the irradiation effect and the influence of temperature on graphite radiation damage. After irradiation at room temperature, the surface morphology is rougher, the increase of defect clusters makes atom flour bend, the layer spacing increases, and the catalytic graphitization phenomenon of NPIG is observed. However, the density of defects in high temperature environment decreases and other changes are not obvious. Mechanical properties also change due to changes in defects. In addition, SEM and Raman spectra of the cross section show that cracks appear in the depth range of the maximum irradiation dose, and the defect density increases with the increase of irradiation dose.

The Pyongnam basin: A local basin witnessed global tectonics

Peng Peng,Mingguo Zhai,Jinghui Guo,Yanbin Zhang,Bo Hu,Lei Zhao,Fengbo Sun,Xiangdong Su,Xiaohui Zhang,Qiuli Li,Chang-Whan Oh,Xu Liu 대한지질학회 2022 대한지질학회 학술대회 Vol.2022 No.10

Auditory Deficits in Patients With Mild and Moderate Obstructive Sleep Apnea Syndrome: A Speech Syllable Evoked Auditory Brainstem Response Study

Qiuyang Fu,Tao Wang,Yong Liang,Yong Lin,Xiangdong Zhao,Jian Wa,Suxiao Fa 대한이비인후과학회 2019 Clinical and Experimental Otorhinolaryngology Vol.12 No.1

Objectives. The energy consumption process of cochlea and neural signal transduction along the auditory pathway are highly dependent on blood oxygen supply. At present, it is under debate on whether the obstructive sleep apnea syndrome (OSAS) would affect the auditory function since the patients suffer from low oxygen saturation. Moreover, it is difficult to detect the functional state of auditory in less severe stage of OSAS. Recently, speech-evoked auditory brainstem response (speech-ABR) has been reported to be a new electrophysiological tool in characterizing the auditory dysfunction. The aim of the present study is to evaluate the auditory processes in adult patients with mild and moderate OSAS by speech-ABR. Methods. An experimental group of 31 patients with mild to moderate OSAS, and a control group without OSAS diagnosed by apnea hypopnea index in polysomnogram were recruited. All participants underwent otologic examinations and tests of pure-tone audiogram, distortion product otoacoustic emissions, click-evoked auditory brainstem response (click-ABR) and speech-ABR, respectively. Results. The results of pure-tone audiogram, distortion product otoacoustic emissions, and click-ABR in OSAS group showed no significant differences compared with the control group (P>0.05). Speech-ABRs for OSAS participants and controls showed similar morphological waveforms and typical peak structures. There were significant group differences for the onset and offset transient peaks (P<0.05), where OSAS group had longer latencies for peak V (6.69±0.33 ms vs. 6.39±0.23 ms), peak C (13.48±0.30 ms vs. 13.31±0.23 ms), and peak O (48.27±0.39 ms vs. 47.60±0.40 ms) compared to the control group. The latency of these peaks showed significant correlations with apnea hypopnea index for peak V (r=0.37, P=0.040), peak C (r=0.36, P=0.045), as well as peak O (r=0.55, P=0.001). Conclusion. These findings indicate that some auditory dysfunctions may be present in patients with mild and moderate OSAS, and the damages were aggravated with the severity of OSAS, whi

Dual Attention Based Image Pyramid Network for Object Detection

( Xiang Dong ),( Feng Li ),( Huihui Bai ),( Yao Zhao ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.12

Compared with two-stage object detection algorithms, one-stage algorithms provide a better trade-off between real-time performance and accuracy. However, these methods treat the intermediate features equally, which lacks the flexibility to emphasize meaningful information for classification and location. Besides, they ignore the interaction of contextual information from different scales, which is important for medium and small objects detection. To tackle these problems, we propose an image pyramid network based on dual attention mechanism (DAIPNet), which builds an image pyramid to enrich the spatial information while emphasizing multi-scale informative features based on dual attention mechanisms for one-stage object detection. Our framework utilizes a pre-trained backbone as standard detection network, where the designed image pyramid network (IPN) is used as auxiliary network to provide complementary information. Here, the dual attention mechanism is composed of the adaptive feature fusion module (AFFM) and the progressive attention fusion module (PAFM). AFFM is designed to automatically pay attention to the feature maps with different importance from the backbone and auxiliary network, while PAFM is utilized to adaptively learn the channel attentive information in the context transfer process. Furthermore, in the IPN, we build an image pyramid to extract scale-wise features from downsampled images of different scales, where the features are further fused at different states to enrich scale-wise information and learn more comprehensive feature representations. Experimental results are shown on MS COCO dataset. Our proposed detector with a 300×300 input achieves superior performance of 32.6% mAP on the MS COCO test-dev compared with state-of-the-art methods.