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Chongwen Xu,Yuan Shao,Wanli Ren,Hao Dai,Fangli Yang,Xiang Li,Shaoqiang Zhang,Junsong Liu,Xiaobao Yao,Qian Zhao,Xin Sun,Zhiwei Zheng 한국분자세포생물학회 2023 Molecules and cells Vol.46 No.6
Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid carcinoma. Despite a good prognosis, approximately a quarter of PTC patients are likely to relapse. Previous reports suggest an association between S-phase kinase-associated protein 2 (SKP2) and the prognosis of thyroid cancer. SKP1 is related to apoptosis of PTC cells; however, its role in PTC remains largely elusive. This study aimed to understand the expression and molecular mechanism of SKP2 in PTC. SKP2 expression was upregulated in PTC tissues and closely associated with clinical diagnosis. In vitro and in vivo knockdown of SKP2 expression in PTC cells suppressed cell growth and proliferation and induced apoptosis. SKP2 depletion promoted cell autophagy under glucose deprivation. SKP2 interacted with PH domain leucine-rich repeat protein phosphatase-1 (PHLPP1), triggering its degradation by ubiquitination. Furthermore, SKP2 activates the AKT-related pathways via PHLPP1, which leads to the cytoplasmic translocation of SKP2, indicating a reciprocal regulation between SKP2 and AKT. In conclusion, the upregulation of SKP2 leads to PTC proliferation and survival, and the regulatory network among SKP2, PHLPP1, and AKT provides novel insight into the molecular basis of SKP2 in tumor progression.
Yina Ren,Xiaobao Xu,Qianlan Zhang,Yongzhuang Lu,Ximin Li,Lin Zhang,Jingkui Tian 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.2
One new oleanolic acid triterpenoid saponin,3-O-b-D-glucopyranosyl olean-11, 13(18)-diene-23,28-dioicacid, (hereafter referred to as DS-1) was isolated from thetraditional Chinese medicinal plant Dianthus superbus (D. superbus). DS-1 plays an important role in the bioactivity ofD. superbus. Thus, a sensitive, reliable and accuratereversed-phased liquid chromatography with tandem massspectrometry (LC–MS/MS) in negative ion mode wasdeveloped and validated for the quantification and pharmacokineticstudy of DS-1 in rats plasma. The pharmacokineticprofile showed that DS-1 was rapidly absorbed and eliminatedin plasma, indicating that significant accumulation ofthe compound in biological specimen is unlikely. In addition,poor absorption into systemic circulation was observed afteroral administration of DS-1, resulting in low absolute bioavailability(0.92 %).
GETACHEW ALEMU,MINGKUI WANG,BINGYAN ZHANG,JUNPENG LI,XIAOBAO XU,JIN CUI,YAN SHEN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.5
The power conversion e±ciency of p-type dye-sensitized solar cells (DSSC) is determined by thekinetics of hole injection and dye-regeneration reaction at the dye/electrolyte interface. In thiswork, the photochemical regeneration kinetics of dye adsorbed on CuCrO 2 mesoporous ¯lm wasinvestigated by using scanning electrochemical microscopy with feedback mode. Organic P1 andC343 sensitizers in combination with iodide-based and thiolate-based electrolytes were selected tounderstand the e®ect of sensitizers and redox shuttles on dye-regeneration process. A fast re-generation kinetic rate constant was con¯rmed in thiolate-based sample compared with iodide-based electrolyte, indicating that the organic redox shuttle was an e±cient mediator to optimizethe performance of p-type DSSC.