Integral-event-triggered H∞ Blood Glucose Control of Type 1 Diabetes via Artificial Pancreas

Shen Yan,Yue Cai 제어·로봇·시스템학회 2024 International Journal of Control, Automation, and Vol.22 No.4

This technical note is concerned with the event-triggered H∞ blood glucose regulation issue of type 1 diabetes by using networked artificial pancreas (AP). In order to improve the service life of AP, an integral-eventtriggered scheme (IETS) is presented to reduce the releasing rate of control signal and the updating times of insulin pump. Compared with the normal event-triggered scheme (ETS), the proposed scheme can generate a larger interevent time by utilizing the integration of the triggering condition in normal ETS. To maintain the blood glucose concentration (BGC) within standard range, the co-design conditions of triggering parameter and H∞ controller are derived by linear matrix inequalities (LMIs). Finally, the validity of the developed strategy is verified through some simulation results.

Current treatment outcomes of bile duct cancer: Are we improving?

Yan-Shen SHAN 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.-

Vibration Energy Transfer Characteristics of Panels with Multiple Coupling Forms in Satellites

Yan Shen,Yang Xu,Xiaowei Sheng,Song Wan,Xianbo Yin 한국항공우주학회 2023 International Journal of Aeronautical and Space Sc Vol.24 No.5

Micro-vibrations on-board a satellite have degrading effects on the performance of certain payloads like observation cameras. There are numerous sources and extremely complicated transfer paths for micro-vibration in satellites. The vibration energy transfer characteristics of panels with multiple coupling forms in satellites were analyzed, which can guide the vibration isolation measures of satellites. First, the satellite was divided into honeycomb panel subsystems with multiple coupling forms. In the next phase, based on the energy finite element analysis (EFEA), the energy finite element equation of the honeycomb subsystem and the connection matrix at the coupling boundary was established to determine the energy distribution and energy flow characteristics of the multiform coupled honeycomb panels under different excitation frequencies. Finally, the finite difference approximation based on the response obtained from the measurement point array was employed to obtain the energy density. By comparing the results of the experiment and EFEA simulation under different frequency excitations, the average error of the energy density was less than 4 dB, which proved the accuracy of EFEA in the transfer characteristics analysis of the vibration energy of the satellite. The experiment method of vibration transfer based on the finite difference approximation can directly obtain the energy density of the structure.

Current epidemiology and management of bile duct cancer

Yan-Shen SHAN 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.-

MicroRNA-196b enhances the radiosensitivity of SNU-638 gastric cancer cells by targeting RAD23B

Shen, Yan Nan,Bae, In-Seon,Park, Gil Hong,Choi, Hwa Sik,Lee, Kee-Ho,Kim, Sang Hoon Elsevier 2018 BIOMEDICINE AND PHARMACOTHERAPY Vol.105 No.-

<P><B>Abstract</B></P> <P>Gastric cancer is characterized by resistance to ionizing radiation. The development of resistance to radiotherapy in gastric cancer patients is one of the obstacles to effective radiotherapy. MicroRNAs are small well-conserved non-coding RNA species that regulate post-transcriptional activation. Our study aimed to investigate the role of miR-196b in radiation-induced gastric cancer. In the present study, we found that miR-196b expression was significantly reduced following radiation. The ectopic miR-196b expression sensitized SNU-638 gastric cancer cells and increased γ-H2AX foci upon radiation treatment. Bioinformatics analysis suggested that the DNA repair protein RAD23B was a putative target gene of miR-196b. Overexpression of miR-196b suppressed RAD23B expression in SNU-638 cells. Reporter assays further showed that miR-196b inhibited RAD23B 3′-UTR luciferase activity. Knockdown of RAD23B by small interfering RNA transfection closely mimicked the outcomes of miR-196b transfection, leading to impaired DNA damage repair in gastric cancer cells. Our results show that miR-196b improved radiosensitivity of SNU-638 cells by targeting RAD23B. Our data indicate that miR-196b is a potential target to enhance the effect of radiation treatment on gastric cancer cells. These findings will provide evidence for a new therapeutic target in radiotherapy.</P>

A Study on the Relationship between Production Country Image and Attitude toward the Product: An Estimaion of Switching Costs in Korean Wave

Yan Shen,Ro-Sung Kwak 한국무역학회 2019 한국무역학회 국제학술대회 Vol.2019 No.08

In international markets, research on consumers’ attitude toward international pro ducts is crucial to the expansion of international trades, which is a common practice nowadays. In the relationship between consumers and products, country image is associated with its products by consumers. Product attitude and product attachment affect the formation of relationship between products and consumers. Switching costs can prevent consumers from switching to other suppliers. This study examined the mediation effect of switching costs (economic risk costs and set-up-costs) on the relations hips of country image with product attitude and with product attachment. The Korean wave switching costs effects were investigated using the country image of Korea as the proxy variable for Korean wave. The Korean wave switching costs effects have not garnered sufficient academic attention. This study examined the economic effects of Korean waves and the negative effect of Terminal High Altitude Area Defense (THAAD) on such economic effects. This study used partial least squares structural equation modeling (PLS-SEM) to analyze proposed hypotheses. The PLS-SEM results revealed that most hypotheses were supported. Switching costs had mediation effects on the relationships of country image with product attitude and with product attachment. The Korean wave switching costs effects were verified. However, the economic image and culture image of Korea both did not have significant effects on the economic risk costs. The economic image of Korea also had no significant effect on the set-up costs. This study expanded the understanding of the relationships among switching costs, country image, product attitude, and product attachment and the knowledge of relevant theories. The results provided theoretical contributions to research relevant to Korean wave switching costs effects. The results verified the negative effect of THAAD on Korean wave economic effects. In the rapidly developing international environment, the research results could serve as useful and theory-driven reference guidelines for suppliers in developing marketing strategies.

Asocial: Adaptive Task Re-Allocation in Distributed Computing Systems with Node Failures

Yanli Shen,Taoshun Xiao,Weiwei Zheng 한국통신학회 2020 한국통신학회 APNOMS Vol.2020 No.09

Task allocation-the problem of efficiently allocating a set of M tasks to a set of N nodes-is a fundamental issue in distributed computing systems (DCSs). The problem is particularly challenging in the presence of fail-prone nodes. In this work, we design an adaptive task (re-)allocation mechanism, named Asocial. The Asocial allows us to optimize the utilization of system resources (including computing resources and network resources) while increasing service-level fault tolerance as well as failure resilience. In addition, we propose a cooperative game model based task (re-)allocation approach for cooperation among Physical Nodes (PNs). We consider both the performance states and reliability levels of candidate PNs when deploying tasks. Specifically, we exploit failure prediction techniques to evaluate PNs’ reliability levels. As a result, we can utilize the resources efficiently and thus improve the service reliability (i.e., the probability of serving all the tasks before their delivery time). We show by means of numerical evaluations that the proposed Asocial can significantly improve service reliability, system availability as well as resource utilization. In particular, by using failure prediction result (F-measure is around 0.8), the application completion rate (ACR), the task completion rate (TCR) and the computing resource utilization (CRU) reach 85.20%, 85.67% and 78.34%, respectively. Compared with 67.30%, 70.07% and 65.79% of the initial allocation scheme, the performance achieves a significant improvement (26.60%, 22.26% and 19.08%, respectively).

Phase II Study of Docetaxel (Aisu^Ⓡ) Combined with Three-dimensional Conformal External Beam Radiotherapy in Treating Patients with Inoperable Esophageal Cancer

Shen, Kang,Huang, Xin-En,Lu, Yan-Yan,Wu, Xue-Yan,Liu, Jin,Xiang, Jin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Objective: This study was designed to investigate treatment efficacy and side effects of concomitant Aisu$^{(R)}$ (docetaxel) with three-dimensional conformal external beam radiotherapy for the treatment of inoperable patients with esophageal cancer. Methods: Inoperable patients were treated with three-dimensional conformal external beam radiotherapy (5/week, 2 GY/day, and total dose 60GY) plus docetaxel ($30-45mg/m^2$, iv, d1, 8). Results: Twenty eight patients met the study eligibility criteria and the response rate was evaluated according to RICIST guidelines. Among 28 patients, 2 achieved CR, 22 PR, 3 SD and 1 patient was documented PD. Mild gastrointestinal reaction and bone marrow suppression were also documented. All treatment related side effects were tolerable. Conclusion: Three-dimensional conformal external beam radiotherapy combined with docetaxel is an active and safe regimen for inoperable patients with esophageal cancer.

The Space Debris Problem

( Shen Yan Chen ) 경남대학교 극동문제연구소 2011 ASIAN PERSPECTIVE Vol.35 No.4

Near-Earth orbits are becoming congested as a result of an increase in the number of objects in space-operational satellites as well as orbital space debris. The risk of collisions between satellites and space debris is also growing. Controlling the production of debris is crucial to the sustainable use of space. This article presents background information on space debris, including number, size, spatial distribution, source, and the threat to satellites. It also discusses international efforts to control the debris population, including the development of debris mitigation measurements, active removal of space debris, and space traffic management.

Subdivision and Correlation of Eocene Fossil Hill Formation from King George Island, West Antarctica

Yan-Bin Shen 한국해양과학기술원 1999 KOREAN JOURNAL of Polar Research Vol.10 No.2