뇌파의 비선형적 분석을 위한 Tool 개발

최윤정,한운섭,최경규 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2

연구목적 : 본 연구는 비선형 동역학 이론을 이용하여 뇌파를 시공간적으로 분석해 내고 이를 지능형 시스템에 도입함으로써 새로운 진단시스템을 개발하는 것을 목적으로 한다. 방법: 최대 64 채널가지의 모든 뇌파에 대해 적용이 가능한 시스템을 구성하여 가장 기본적인 형태의 뇌파 샘플을 적용, 측정된 뇌파를 불러오고 전처리 과정을 통해 신호를 분석에 용이하게 가공하고 분석법의 특성에 따라 알맞은 분석법을 선택하여 분석하고 분석된 데이터는 후처리과정을 통해 그 패턴을 분류하는 단계의 프로그램을 만들고 비선형 동역학 이론을 이용하여 단계별 프로그램을 구성하였다. 결과: 컴퓨터 시스템에 사용하는 프로그램을 다음과 같은 다양한 요소로 구성하였다. 신호 발생부에는 Lorenz sys-tem과 Rossler system을 포함하였다. 신호 전처리 부에는 정량화, 밴드 패스 필터링, 잡음 추가, 미분, sutto-gating 과정을 포함하였다. 신호 분석 부에는 스펙트럼분석, 위상공간 분석, 상관 분석, 모드 분석을 포함하였다. 신호 후처리 부에는 setting layer, Learning procce-ssing and Making weight file, Classifier start with Test file을 포함하였다. 부가기능으로서 Copy&paste, Print, Save 기능을 포함하였고 운영 환경은 Windows 95/98/2000 또는 Windows NT를 사용하고 데이터 형식은 뇌파 채널 최대 64채널까지 가능(Neural Network Processing의 경우 8채널) 하며 아스키 파일로 열(co-lumn)의 수는 채널을 의미하고 행(row)은 샘플링되어 저장된 데이터를 의미하는 것으로 하였다. 결론: 뇌에서 발생하는 전기학적 신호를 실시간으로 손쉽게 분석하여 실제 진단에 이용할 수 있는 기본적인 컴퓨터 프로그램을 개발하였으며 이를 토대로 더욱 정교하고 객관적인 뇌파 분석 결과를 얻을 수 있는 상용 프로그램의 개발에 이용할 수 있을 것으로 생각한다. Objectives : EEG is a record of electronic signals of brain. If there are effective methods for analysis of EEG signal it can be used as a diagnostic tool for diseases related to brain function. We developed a new a basic computer program which was designed to analysis of pattern of EEG. For nalysis of pattern, EEG signal was processed by variable experimental analytical methods and grouped by common pattern. Results : Program was composed of multiple systems. Signal generating system was composed of Lorenz signal generation and Rossler signal generation parts. EEG processing system was com-posed of Normalization, Band pass filtering, First Second difference, Add random noise and Sur-rogate making parts. EEG analyses system was composed of Spectral analyses, Phase space analyses, Correlation analyses and Mode analyses parts. Pattern recognition and grouping system was com-posed of data format, Power spectrum, Neural network process and Classification parts. Conclusion : We developed a basic computer program for systemic analysis of EEG by Nonlinear analysis methods.

Antifungal Activity of Streptomyces pad anus isolate TH04 against Monilinia fructicola, Brown rot Fungus on Stone-fruits

임태헌,최용화,이동운,한상섭,차병진,Lim, Tae-Heon,Choi, Yong-Hwa,Lee, Dong-Woon,Han, Sang-Sub,Cha, Byeong-Jin The Korean Society of Pesticide Science 2008 농약과학회지 Vol.12 No.3

복숭아 미이라 과일로부터 복숭아 잿빛무늬병 Monilinia fructicola에 대하여 강한 항균활성을 보이는 방선균 Streptomyces padanus TH04를 분리하였다. TH04 균주의 배양 추출물 1%를 함유한 배지에서의 균사생육 및 포자발아는 시험한 M. fructicola의 strain에 따라 각각 $79.8{\sim}81%$와 $73.9{\sim}75.8%$ 억제되었다. 병원균과 TH04 균주 초기접종 밀도를 0.01%, 0.1% 및 1%로 달리하여 동시배양 한 결과, 항균활성은 선발 방선균의 밀도에 따라 $7.5%{\sim}94%$로 나타났다. 사과(품종; 후지)를 이용한 조추출물의 항균활성은 0.1% 처리구 85.9%, 1%처리구 100%로 나타났다. 항균활성 물질 생산, 안정성 및 제형화에 관한 연구가 이루어질 경우 선발한 Streptomyces padanus TH04는 생물학적 방제제로의 개발 가능성 있을 것으로 생각된다. The Streptomyces padanus isolate TH04, isolated from mummified peaches, showed strong antifungal activity to Monilinia fructicola. The inhibition activity of the isolate TH04 to mycelial growth and spore germination at 1% concentration of sub-antifungal powder made from culture suspension (CS) was ranged from 79.8% to 81.0% and from 73.9% to 75.8% to M. fructicola four strains, respectively. In the test of antifungal activity in mixed culture of the isolate and M. fructicola, inhibition rate was 7.5%, 86.8% and 94.0% in 0.01, 0.1, and 1% concentration of CS containing bacterial cell of the isolate, respectively. On apples (cultivar; Fuji), the control values of the isolate TH04 crude filtrates (0.1 and 1%) were 85.9% and 100%, respectively. The results suggest that the isolate TH04 indicate development possibility as biocontrol agent of brown rot caused by M. fructicola with the study on delivery method and fermentation condition to produce an antifungal compound.

Hydrodeoxygenation of oleic acid over Ce<SUB>(1-x)</SUB>Zr<SUB>(x)</SUB>O<SUB>2</SUB> solid solution

Jae-Oh Shim,Dae-Woon Jeong,Won-Jun Jang,Kyung-Won Jeon,Won-Bi Han,Hyun-Suk Na,Hak-Min Kim,Hyun-Seog Roh,Jeong-Geol Na,You-Kwan Oh,Chang Hyun Ko,Sang Sub Han 한국신재생에너지학회 2013 한국신재생에너지학회 학술대회논문집 Vol.2013 No.05

난소 및 충수돌기의 원발성 경계성 점액성 종양이 병발된 복막 위점액종 1 예

한운섭,김승철,김연정,김희옥,정경아,이민진 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.11

Pseudomyxoma peritonei is a poorly understood condition characterized by mucinous ascites and multifocal peritoneal mucinous tumors. Pseudomyxoma peritonei is most commonly associated with mucinous tumors of the ovary and appendix. When two lesions are morphologically similar, it is difficult to determine whether one reflects a metastasis or whether the tumors are independent. Many studies concluded that most cases in which both the appendix and ovary were involved were primary appendiceal tumor with secondary involvement of the ovary, but we have experienced one case of pseudomyxoma peritonei originated from independent primary borderline mucinous tumors of the ovary and appendix. So we report this case with the brief review of literatures

Nematicidal activity of Phellodendron amurense rhizome-derived materials toward root-knot nematode (Meloidogyne Spp.)

Chang-sub Moon,Kyung-whan Yoon,Tae-kyun Hong,Byung-soo Han,Sung chul Moon,Young-ho Kim,Li-Wei,Dong Woon Lee 한국응용곤충학회 2011 한국응용곤충학회 학술대회논문집 Vol.2011 No.10

The nematicidal activity of Phellodendron amurense rhizome-derived materials (methanol extract) toward Meloidogyne Spp. second-stage juveniles (J2) and these effects on Cucumis sativus and Cucumis melo. Results were compared with these of fosthiazate. J2 was examined using 24-well plate tests, pot bioassays (C. sativa and C. melo) and Field trials (C. melo). In 24-well plate test with J2, methanol extract of P. amurense exhibited 98.7% and 69.8% mortality at 0.25 and 0.125 mg/ml toward J2, respectively, whereas Fosthiazate showed 100% mortality at 1 mg/ml. In pot bioassays with J2, P. amurense rhizome methanol extract gave 79.5% and 57.4% mortality at 2ℓ/m2(1,000x) and 2ℓ/m2(2,000x)/3kg soil from C. sativa and 73.7% and 53.3% mortality at 2ℓ/m2(1,000x) and 2ℓ/m2(2,000x)/3kg soil from C. melo, respectively. In Field test at C. melo in greenhouse showed 55.1% and 26.9% mortality at 2ℓ/m2(1,000x) and 2ℓ/m2(2,000x) applied soil. P. amurense rhizome-derived materials, merit further study as potential root-knot nematode control agents because of their nematicidal activity.

Digital Relay 자동성능평가 시스템 개발

민병운(Byoung-Woon Min),박동호(Dong-Ho Park),김정한(Jung-Han Kim),최항섭(Hang-Sub Choi),이승재(Seung-Jae Lee) 대한전기학회 2005 대한전기학회 학술대회 논문집 Vol.2005 No.7

Biocompatible PEG Grafting on DLC-coated Nitinol Alloy for Vascular Stents

Shin, Hong-Sub,Park, Kwideok,Ji Heung Kim,,Kim, Jae-Jin,Dong Keun Han,,Moon, Myoung-Woon,Lee, Kwang-Ryeol,Ji Hoon Shin, SAGE Publications 2009 Journal of bioactive and compatible polymers Vol.24 No.4

<P>The surfaces of Nitinol (TiNi), a popular metal alloy for arterial stents were thin-coated with diamond-like carbon (DLC) and then grafted with poly(ethylene glycol) (PEG) to increase biocompatibility. The TiNi control, DLC-coated TiNi (TiNi—DLC), and the PEG-grafted TiNi—DLC (TiNi—DLC—PEG) surface characteristics and biocompatibility were evaluated. The hydrophilicity of the TiNi—DLC—PEG significantly increased and the amount of both oxygen and nitrogen on the TiNi—DLC—PEG also increased compared to the TiNi control and TiNi—DLC due to the grafted PEG. The ratio between albumin and fibrinogen was higher on the PEG-grafted surface than the other surfaces when tested with human blood components; the platelet adhesion decreased the most on the TiNi—DLC—PEG surface, indicating improved blood compatibility. For in vivo tests using a rat model, the samples that were implanted for 6 weeks formed fibrous tissue; the tissue layer was much thinner on the PEG-grafted sample than the other two groups. The present results indicate that PEG-grafted TiNi—DLC surface may be effective in enhancing biocompatibility of blood-contacting biomaterials including vascular stents.</P>

Damage and Seasonal Occurrence of Arboridia spp. in Grapevine Export Complexes in Korea

Chae Min Lee,Dong Woon Lee,Suk Jun Lee,Jin Sun Song,Tae Heon Lim,Sang Sub Han,Sang Myeong Lee,Hyeong Hwan Kim,Myoung Rae Cho 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.04

This report is a part of research on pests occurring in grapevine orchards in export complexes (Hwangsung in Gyeonggi, Sangju and Yeongcheon in Gyeongbuk, Namwon in Junbuk and Yeongdong in Chungbuk) from 2010 to 2012. This research was conducted to evaluate the distribution and difference in damage rates depending on management types of grapevine orchards (domestic sale farm vs. export farm). Damage by Arbordia spp. occurred only in 2010 and differed depending on localities and individual farms in the same area. Numbers of orchards damaged by Arbordia spp. were one, two and four in Hwasung, Namwon and Sangju, respectively, and the damage rate was below 6.2%. There was no damage in the orchards in 2011 and 2012, however, Arbordia spp. were collected on sticky traps in the orchards. A. nigrigena and A. kakogawana were the dominant species in Yeongcheon and Yeongdong, respectively, in 2011. A. kakogawana, A. maculifrons and A. nigrigena were collected on sticky traps in 2012. Collected numbers of Arbordia spp. were different depending on localities and management types of the orchards (domestic sale vs. export). A. kakogawana was the dominant species in all the survey sites and the densities were higher in the domestic sale farms than in the export farms.

IPv6로의 전환을 위한 DNS 적용방안

한민규(Min Kyu Han),안진섭(Jin Sub Ahn),백일우(Il Woo Paik),홍진표(Jin Pyo Hong),김용운(Yong Woon Kim) 한국통신학회 2004 한국통신학회 학술대회 및 강연회 Vol.2004 No.12

開放性動脈管 : 31例手術報告 Report of 31 Cases

徐景弼,申漢壽,沈台燮,洪彰義,朱東雲,李寧均 최신의학사 1967 最新醫學 Vol.10 No.5

Thirty one cases, 18 females and 13 males, were operated on for patent ductus arteriosus. There were three adult cases. Patent ductus arteriosus alone was present in 27, while in 4 there were significant associated cardiovascular anomalies. No deaths occurred in 24 patients isolated patent ductus a' eriosus without and with mild to moderate pulmonary hypertension. Severe pulmonary hypertension was present in 4 patients with an isolated patent ductus. An operative death occurred in the 2 patients in this group. One of them died as result of the tearing of the ductus during surgery. The remaining case died 3 days postoperatively., Patent ductus arteriosus with congenital cardiovascular anomalies was present in 4 patients. Single operative death occurred 7 days postoperatively because of bronchopneumonia of right lung and atelectasis of the left lung. There was an increased mortality when patent ductus arteriosus was associated with severe pulmonary hypertension. All survival patients showed very satisfactory postoperative results.