放射線 撮影에 의한 命門과 "與臍平"의 比較 觀察

金炳洙,權五燮,黃祐準 한국전통의학연구소 1998 한국전통의학지 Vol.8 No.2

This research was studied whether umbilicus level of belly is to same Gv4(命門) level of back or not. we know that Gv4(命門) is located at L2-L3. The survey was done on 50 case of low back pain with L-spine X-ray. The resurts obtained here were as follows: 1. Umbilicus level of belly is to same L4 body level of back.(52%) 2. Umbilicus level of belly is to same L4-L5 level of back.(30%) 3. Umbilicus level of belly is to same L3-L4 level of back.(10%) 4. Umbilicus level of belly is to same L5 body back.(8%) As you see on the above results, umbilicus level of belly is not to same Gv4(命門) level of back.

인장시험 시 불안정과 네킹 거동의 유한요소해석

김형섭,김성호,류우석 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.8

A tensile test is the most widely used mechanical property testing method to measure inherent material behaviour including full flow curves as well as Young's modulus, yield strength, tensile strength and elongation. In the present study, tensile deformation and necking behaviour was investigated using the finite element method code MSC.MARC and the plasticity instability theory. It is shown that the finite element analysis for the tensile test of cylindrical samples can reproduce necking instability by applying a radial constraint at the loading points without assuming initial imperfections. The predicted finite element results compared to the Hart's instability criterion shows that the Hart's analytical solution overestimates necking strains a little in strain hardening materials. The finite element analysis of tensile tests with the geometric constraint is useful for interpreting deformation and developing new materials in that it can successfully reproduce not only uniform elongation and necking initiation but also post necking behaviour.

체육교사의 지도행동 유형에 관한 선호도 분석

이창섭,김우년 忠南大學校體育科學硏究所 2002 體育科學硏究誌 Vol.20 No.1

The purpose of this study is to examine the Physical education teachers preferred type of teaching behavior. The population of this study was middle school students, physical education teachers, other teachers, and administration officials, such as principals and vice-principals, studying and serving in Taejeon megalopolis. Using random sampling, 674 subjects were asked to respond the survey. The survey had 22 questionnaires about physical education teachers teaching behavior. The survey divided teaching behavior into 5 types, which is Teaching & Instruction Behavior. democratic behavior, Social Support Behavior, and Positive Feedback Behavior. To analyze the data collected for this study factor analysis, t-test, paired t-test, and one-way ANOVA were used. Conclusions from the results of this study are as follows: First, the students preferred democratic behavior among the 5 types of behavior. Second was positive feedback, third was teaching & instruction, fourth was social support, and last was autocratic behavior. Second, the teachers and administration officials preferred positive feedback behavior among 5 types of behavior. Second was social support, third was teaching & instruction, fourth was democratic, and last was autocratic behavior. Third, students preferred behavior considering class satisfaction was democratic behavior. And teachers preferred behavior considering class accomplishment and result was positive feedback behavior. Fourth, administrator groups preference of teaching & instruction, positive feedback, and social support behavior were highest among 4 subject groups (physical education teacher, teacher, administrator, and student group). And students group preference of autocratic behavior and democratic behavior were the highest among 4 subject groups (physical education teacher, teacher, administrator, and student group).

沖積粘土의 各種 土質定數間의 相關性에 關한 硏究

전우섭,김진훈 대구대학교 과학기술연구소 1995 科學技術硏究 Vol.2 No.2

This study was made to find several significant relations among various soil parameter of physical and mechanical properties including N--values. The soil sample ware taken at district of ulsan area, Kyungsangnamdo, where the structures would be placed on the alluvial clay foundation. It was the statistical analysis through computer programs, Minitab statistics package, were carried out using the results of laboratory and field tests of 71 soil samples. The obtain results from this study are summarized as follows: 1. Judging form Casagrande's plasticity chart, it is considered that almost all soil samples belong to inorganic clay with medium or high plasticity. 2. It is certain that the foundation is weak because the natural moisture contents are much higher then the the liquid limits. 3. The relationship between various physical and mechanical properties for the alluvial clay samples are presented as follow: 1) ω₁ = 1.210 ( Cy + 25.62 ) 2) e_(0)= 0.0271 ( ω_(n) + 0.987 ) 3) ω₁ = 0.874 ( ω_(n) + 12.59 ) 4) γ_(t) = 0.0066 ( 313.55 - ω_(n) ) 5) Cc = 0.0117 ( ω_(n) - 11.62 ) 6) Cc = 0.499 ( e_(0) - 0.477 ) 7) Cc = -0.318 + 0.0275 ω₁ - 0.470 e_(0) 8) c=0.380( q_(u)+0.096) 9) c=0.00684(ξ +5.63) 10) c = 0.0258 + 0.375 q_(u) + 0.001 ξ 11) q_(u) = 2.290 ( γ_(t) - 1.480 )

말기신부전 환자의 혈색소 순환 : 투석 방식에 따른 양상 비교 및 관련 인자들에 대한 고찰

최재혁,김준섭,원기범,박준형,탁우택,이정호 동국대학교 의학연구소 2009 東國醫學 Vol.15 No.2

혈색소 순환은 말기신부전 환자에서 인체 재조합 적혈구 조혈 인자를 투여하여 빈혈을 치료하는 동안 빈번히 관찰되며 이는 환자의 입원과 사망률과 관계가 있다고 알려져 있다. 이에 저자는 투석중인 말기 신부전 환자를 대상으로 혈색소 순환 양상과 이와 연관된 인자들을 알아보고자 하였다. 혈색소 순환의 관련 인자들을 알아보기 위하여 투석 치료를 받고 있는 환자 40명 (혈액투석 환자군: 20형, 복막투석 환자군: 20명)을 대상으로 투석 시작부터 1년 동안의 환자의 나이와 성별, 투석시작 1년간의 평균 Hb, 수혈 횟수, 총입원 횟수, 감염으로 인한 입원 횟수, 혈청 ferritin 농도, 혈청 transferrin saturation (TSAT), 철분제제 복용 유무, 일주일 동안 투여된 rHuEPO 양, rHuEPO의 변화량, 알부민, C-reactive protein (CRP) 및 입원 원인 등을 후향적으로 조사하였다. 전체 환자 40명 중 33명 (82.5%)에서 혈색소 순환이 관찰되었다. 혈액투석 환자군에 비해 복막투석 환자군에서 혈색소 순환 첫수가 유의하게 높았다 (p=0.037).혈색소 순환 발생군과 혈색소 순환 미발생군의 관련인자들을 비교하였을 경우 혈색소 순환 발생군에서 총 입원 첫수 (p=0.01), 감염으로 인한 입원 횟수 (p=0.036)가 유의하게 많았으며, 혈중 알부민 수치는 유의하게 낮았다 (p=0.003).그러나 두 군간의 나이, 성별, 수혈 횟수, 혈청 ferritin농도, 혈청 transferrin saturation (TSAT) 및 혈청 철분 농도는 유의한 차이가 없었다. 혈색소 순환의 빈도는 일주일 동안 투여된 r-HuEPO변화량과 양의 상관관계를 보였고 (p=0.003),혈중 알부민 수치와 음의 상관관계를 보였다 (p=0.013). 복막투석 환자군에서 혈액투석 환자군에 비해 혈색소 순환이 유의하게 높게 발생하였다. 일주일 동안 투여된 r-HuEPO 변화량, 입원 및 혈청 알부민 수치는 투석 시작부터 1년 동안의 혈색소 순환과 관련이 있었다. Hemoglobin cycling is frequently observed during treatment of anemia with recombinant human erythropoietin (r-HuEPO) in patients with end stage renal disease (ESRD) it is also reported to be associated with hospitalization and morbidity. We analyzed hemoglobin cycling and potential associated factors in patients on dialysis. Forty new dialysis patients (20 hemodialysis, HD and 20 peritoneal dialysis, PD) were recruited during their first year. Age, gender, mean hemoglobin level, frequency of transfusion, frequency of hospital admission, frequency of admission due to infection, serum ferritin, transferrine saturation, iron levels, rHuEPO dose per week, serum albumin, and c-reactive protein were retrospectively evaluated in order to examine the possible correlations with hemoglobin cycling. Thirty-three patients (82.5%) were identified in the hemoglobin cycling group. The PD group had a higher frequency of hemoglobin cycling than did the HD group (p=0.037). The hemoglobin cycling group showed a significantly higher frequency of hospital admission (P=0.001), admission due to infection (p=0.036) and a lower serum albumin level (p=0.003) than the other group, but there was no significant difference between the groups for age, gender, frequency of transfusion, serum ferritin, transferrine saturation, and iron levels. The frequency of hemoglobin cycling showed a positive correlation with the i-HuEPO dose variation per week (p=0.003) and a negative correlation with serum albumin level (p=0.013). The PD group had a higher frequency of hemoglobin cycling than the HD group, and the change of rHuEPO dose per week, hospitalization and serum albumin were associated with the hemoglobin cycling during the first year of dialysis.

Thioacetamide에 의한 BALB/c 마우스 간의 시간별 약물대사효소 억제 양상 : A Time-Course Study

이정운,고우석,김갑호,배연경,하현정,한상섭,천영진,정태천 영남대학교 약품개발연구소 2001 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-

Thioacetamide is a potent hepatotoxicant which requires metabolic activation by cytochrome P450s (P450s) for toxicity. In the present study, the elevation kinetic of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities by thioacetamide treatment was investigated in male BALB/c mice. Inaddition, the inhibitory effects of thioacetamide on liver microsomal P450 enzymes were further investigated. Thioacetamide at 100 mg/kg/ was treated intraperitoneally for 6, 12, 24, 36, 48 and 72 hr. The blood was collected at the designated time for assaying the serum enzyme activities. To determine the P450 isozyme-specific activities. ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD), and benzyloxyresorufin O-debenzylase (BROD) activities were determined for P450 1A1, 1A2 and 2B1, respectively, in liver microsomal fractions. The activities of ALT and AST were started to be elevated 6 hr after thioacetamide treatment andreached the maximun at 36 hr after the treatment. The elevated activities were dramatically recovered at 72 hr. The microscopic exmination of the liver specimen also showed a similar profile of hepatotoxicity. All P450-associated enzyme activities were time-dependently inhibited by the treatiment with thioacetamide. The maximum inhibition of P450 enzymes was observed 36 hr after the treatment. Because the inhibition of P450 enzymes by thioacetamide was time-dependent, our present results suggest that thioacetamide might inhibit P450 enzymes in mechanism-based inactivation.

Fournier’s Gangrene: A 10-Year Clinical Experience at a Tertiary Academic Medical Center

Woo Seop Seong,Byeong Jin Kang,A Reum Kim,Kyung Hwan Kim,Hong Koo Ha 대한요로생식기감염학회 2023 Urogenital Tract Infection Vol.18 No.2

Purpose: This retrospective study examined the factors influencing clinical outcomes and mortality in patients with Fournier's Gangrene (FG). The medical history, diagnostic procedures, treatment approaches, complications, and mortality factors associated with FG were analyzed. Materials and Methods: This study retrospectively analyzed the medical records of 40 patients with FG treated over 10 years. The collected data included the patient demographics, comorbidities, vital signs, laboratory tests, Fournier’s Gangrene Severity Index (FGSI) scores, wound swab culture results, treatment approaches, and length of hospitalization. Results: Among the patients with FG, diabetes mellitus and hypertension were the most common comorbidities. The hemodialysis dependence has been identified as a significant risk factor of mortality. In addition, septic shock and an FGSI >9 were associated with increased mortality. Escherichia coli was the most prevalent bacterium in wound swab cultures, and the presence of antibiotic-resistant bacteria was significantly higher in the non-survivors. Treatment involved broad-spectrum antibiotics, emergency surgical debridement, and subsequent adjustments based on culture results. Conclusions: Early diagnosis and prompt initiation of treatment are essential for improving the outcomes of patients with FG. Hemodialysis dependency, septic shock, FGSI scores, and the presence of antibiotic-resistant bacteria are important factors associated with mortality in patients with FG. Further research will be needed to validate these findings and explore adjunctive therapies to enhance the patient outcomes and improve FG management.

The Current Status of Evaluation Technologies for the Function of Human Olfaction

Kim, Woo Seop,Jang, Dong Pyo,Kim, In Young Hanyang University College of Medicine (KAMJE) 2014 Hanyang medical reviews Vol.34 No.3

Gene Expression Analysis in a Transgenic Mice Expressing NSE-controlled Tau for Alzheimer’s Disease Model

Woo, Jong-Min,Park, So Jung,Kim, Chuel kyu,Kang, Ho-Il,Shim, Sun Bo,Lee, Su Hae,Sin, Ji Soon,Bae, Chang Joon,Kim, Sang Seop,Jang, Mee Kyung,Kim, Byoung-Guk 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.4

Alzheimer’s disease is a progressive brain disorder cytopathologically characterized by beta amyloid plaques consisting of β-amyloid peptides and neurofibrillary tangles consisting of hyperphosphorylated tau proteins. Transgenic mice expressing NSE/htau23 human wild tau exhibit behavior deficits and the modulated phosphorylations of tau, GSK3β, and β-catenin. The aim of the present study was to identify differentially expressed genes during tau pathology in the transgenic mice. These mice display Alzheimer’s disease features of neurodegeneration and tau hyperphosphorylation. Using Illumina gene expression beadchips, we compared hippocampal mRNA levels between 6 month-old transgenic mice and 12 month-old transgenic mice. We identified total 28 genes that were expressed greater than 2-fold higher or lower with a p value <0.05. Of these, 17 genes were up-regulated and 11 genes were downregulated. Theses gene profiles, therefore, provide novel targets for future molecular and genetic information on Alzheimer’s disease.

Observational relationships between aerosol and snow/ice melt over the Himalayas and Tibetan Plateau

Woo-Seop Lee,Maeng-Ki Kim,Kyu-Myong Kim,William K. M. Lau 한국기상학회 2010 한국기상학회 학술대회 논문집 Vol.2010 No.4