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      • 폐결핵 환자 혈청에서 수용성 Interleukin 2 수용체 및 Adenosine Deaminase 활성도에 관한 연구

        고정희,박성규,백상현,박찬권,박병수,안진영,최우석,박정규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

        Interleukin-2 (IL-2) induces T cell proliferation in an autocrine manner and provides a means by which antigen triggered T cells can be clonally expanded in vitro. During the following activation, the activity of IL-2 is mediated by specific high affinity IL-2 binding membrane receptors which are expressed shortly after activation. In this process, a 42 KD-fragment (soluble IL-2R) is continuously cleaved off and circulates as a soluble marker of T lymphocyte activation. Elevated level of soluble IL-2R has been identified in the serum of patients with malignant autoimmune and allergic disorders, systemic parasitic infection, undergoing graft versus host disease, acute or chronic lymphocytic leukemia and HIV-infection. ADA (adenosine deaminase) completes the process of differentiation of T cell and is essential for progression of T cell maturation. Therefore level of ADA is to correlated with magnitude of T cell immune response. The fact that expression of sIL-2R and ADA activity increases in peripheral blood T-lymphocytes of patients with active pulmonary tuberculosis suggests that T cell activation might have a major role in the pathogenesis of pulmonary tuberculosis. In order to evaluate the T cell immune response in pulmonary tuberculosis, we measured the serum concentration of sIL-2R and ADA activity in 17 patients with current pulmonary tuberculosis, 10 chronic inactive pulmonary tuberculosis, 10 as normal controls. (1) Current pulmonary tuberculosis had significantly higher levels of sIL-2R (237.24±95.47)when compared with those of inactive tuberculosis (78.6±11.06). and the control (68.17±15.4) group. (2) ADA activity in current pulmonary tuberculosis was significantly increased (34.41±20.63) when compared with those of inactive tuberculosis (24.7±14.36) and control (17.65± 5.94) group. (3) There was good correlation between sIL-2R concentration and ADA activity in serum in current pulmonary tuberculosis group. (4) sIL-2R concentration and ADA activity was decreased significantly 6 months after anti-tuberculosis drug medication. In conclusion, sIL-2R concentration and ADA activity in serum in current pulmonary tuberculosis group was increased when compared with those of inactive pulmonary tuberculosis and the control group. By the way, T cell mediated immune response was enhanced in current pulmonary tuberculosis, but in inactive chronic pulmonary tuberculosis who had treated by antituberculosis drug medication, the concentration of sIL-2R and ADA activity was nearly normal.

      • KCI등재후보

        LabVIEW를 이용한 소형 유도전동기의 권선고장 자동진단

        宋明現(Myung-Hyun Song),朴奎南(Kyu-Nam Park),韓東奇(Dong-Gi Han),禹奕在(Hyeok-Jae Woo) 대한전기학회 2006 전기학회논문지 P Vol.55 No.4

        In this paper, an auto detection method of stator winding fault of small induction motor is suggested. The Park's vector pattern which is obtained from 3-phase current signal by d-q transforming, is very good to detect winding fault. Comparing the Park's vector pattern of testing motor with its of healthy motor, the Park's vector pattern of fault motor is became an ellipse and the asymmetry is increased by the winding fault serios. So for detecting the dis-symmetry, id-filtered function, Min-value, and Max-value are suggested for auto detecting. Using LabVIEW programing, 3-phase healthy motor and several kind of winding fault motors are tested and the test results are shown that the suggested method can gives us a possibility of an auto detecting winding fault.

      • 한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

        양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

        The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

      • MIC 빔 Steering 안테나 특성에 관한 연구

        朴漢奎,宋宇永 연세대학교 대학원 1981 延世論叢 Vol.18 No.1

        In this paper, a MIC beam steering antenna is designed by using the microstrip substrate whose dielectric constant is 2.45 and height is 0.10875cm. In order to match the impedance of the antenna with free space, dimensions of the antenna are determined from the C.A.D. and Hammerstad formulae are used for calculating the width of microstrip and the rat-race hybrid ring phase shifter is used for the phase shift between antennas. From this experiment, the antenna has ±200MHz bandwidth with the center frequency of 10.5GHz. The main beam of the antenna could be steeled by about 30 degrees by taking the distance of antenna 1 and 2 by □λ and the phase shift between them by zero and □λ radians. These experimental results were in good agreement with the theoretical values.

      • KCI등재
      • Camping實習에 따른 自己槪念의 變化

        朴宇奎 慶北大學校 師範大學 體育學硏究會 1984 體育學會誌 Vol.11 No.-

        The major purpose of the present study is to find out how the life in camping has effected the camper's self-concept and also to study the effect of camping. The subjects were 102 students, male and female, participating in the 1983 Kyung-Pook University Camping and 63 students to comparise with them. From this study, the instrument was an inventory Nakasima's "Self-Differential Form A" consisted of a 47-item adjective scale, which was translated into Korean in consideration of our real condition. The main findings of this study are summarized as follows: 1. Prior to and after the camping, I have found out the significant changes of 10 items among 47 items. But a monthe later of camping, the situation has returned to the begining before the camping. 2. These items which have shown significant changes, for example, lazy→dilligent, unfaithful→faithful and etc., were toward desirable attitude in general. 3. In the changes of self-concept in camping, I have found out that the significant changes were linked with factor of firmness, Namely, campers' attitude have changed toward "vigorous and strong attitude direction" rather than reliable, passive or only strong one.

      • 정상 인체 멜라닌세포에서 endothelin-1 receptor antagonist가 melanin생성에 미치는 영향에 관한 연구

        박진우,이종석,황규왕,김정하 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

        In the normal skin, melanocytes maintain their constant population and their melanogenic activity in steady state, but respond to several stimulus such as UV radiation and chemical irritation, to accentuate proliferation and differentiation, leading to hyperpigmentation of the skin. Human Keratinocytes produce and secrete endothelin-1, which can be strong mitogens for human melanocytes. The paracrine linkage of endothelin-1 between keratinocytes and melanocytes suggested that endothelin-1 is intrinsic mediators for human melanocytes in UVB-induced pigmentation. The purpose of this study is to investigate the new whitening agent, which improve the hyperpigmentation by inhibiting the ET-1. So, we add ET-1 and five kinds of ETRA into the cultured normal human melanocyte and then three days later, each ETRA on ET-1 was measured melanocyte number and inhibitory effect of melanin synthesis, respectively. In this study, ETRA has a inhibitory effect on ET-1 induced melanocyte proliferation and melanogenesis. ETRA I has a strong inhibitory effect on melanocyte proliferation and ETRA Ⅱ has a strong inhibitory effect melanogenesis. western blotting results shows negative. It may be due to the processing error of protein denaturing or low antigen -antibody affinity. But, we also confirm that ETRA Ⅱ has a inhibitory effect of tyrosinae synthesis by RT-PCR

      • 전사억제인자 Small Hetrodimer Partner-Interacting Leucine Zipper(SMILE)의 당대사와 지질대사 조절

        박우람,최병윤,사다시밤 난티니,김돈규 전남대학교 농업과학기술연구소 2022 농업생명과학연구동향 Vol.60 No.-

        Small heterodimer partner-interacting leucine zipper (SMILE) is a member of the cAMP response element-binding protein / activator transcription factor (CREB/ATF) family of basic leucine zipper (bZIP) transcription factors. Structurally, it exists in small and long isoforms resulting from alternative usage of the initiation codon. Though structurally similar to bZIP proteins, SMILE cannot bind to DNA but can homodimerize like them. SMILE acts as a corepressor for nuclear receptors related transcriptional activity and other transc- ription factors. SMILE plays a crucial role in metabolic signaling pathways by inhibiting DNA binding, competing with coactivators, and directly repressing transcription. This review focuses on the role of SMILE in hepatic glucose and lipid metabolism. Regulation of SMILE improves pathological conditions such as hepatitis, diabetes and fatty liver disease. Therefore, understanding the role of SMILE in metabolism and signaling pathways paves the way to consider SMILE as a potential target in treating liver metabolic diseases.

      • 스포츠 현장에서 사고 분쟁해결을 위한 법적 구조 및 그 효용성 분석

        박형상,육조영,김우규,이재봉,유관호,이무연,박태민,이신언 한국스포츠리서치 2005 한국 스포츠 리서치 Vol.16 No.2

        1. The purpose of this study is to reflect reality of sports to legal structure. This author classified types of sports related accidents as match accidents, school accidents, leisure and living sports accidents. Out of such accidents common factors such as 'the provider of virtue' and 'user' could be deduced and this author reviewed what kinds of obligations must be shouldered by these people respectively. In particular this author stressed the fact that disproportionate emphasis is placed on malfeasance in disposition of dispute over the sports accidents. Malfeasance is a method for seeking relief through money after the accident. However default in an obligation enables supplementary completion when it is not performed or imperfectly performed. Thus if object which must be performed is providing safety then it is possible to secure safety prior to accident. Furthermore at such time mistake of the debtor can not become a factor. For this reason this line of thinking has the following merits: (1) In comparison with constitution of malfeasance default of an obligation has long prescription. It seems that such fact was a motivation for saving obligation for safety consideration by making it fall under the principle of faith. (2) Default of an obligation is not an obligation for ordinary attention which is cause of malfeasance but it takes up issue with obligation for attention required for performance. Game organization, sponsor and spectators etc. shares certain sense of identity and are demanded to have manners. As method for evaluation of such relationship of faith it may be possible to impose a special kind of obligation for attention and it will be close to constitution of default of an obligation. (3) Imposing obligation for provision clarifies that such responsibility belongs to game organizations promoting sports to which anyone can participates or to national or public organizations, sponsor, schools which induced such sports as a part of its educational programs, installer who made people use it as leisure facility or person in charge for its management. (4) It is also applicable to umpires, players or spectators who use field of sports. It is possible to reflect reality whereby these people specifically relate themselves to sports. In consequence it will be possible to make people feel the necessity of expanding the principals of sports from 'doers' to 'watchers.' (5) The obligation of provision is an obligation under the principle of faith therefore mutual negotiation may be expected to clarify such fact. It may be also evaluated by effectuation of users' self-determining right. 2. If the above mentioned structure is provided then, although it is limited to sports, students who are subjects of instruction, seminar attendants, and furthermore players who finished games may be obligated to bear responsibility for safety consideration under the principle of faith. Accordingly level of relief for considerable number of victims may be increased as cases of treating even borrowed materials as default of obligation being expanded. 3. As scope of responsibility becomes more clearer it will be possible to prevent disputes while securing more safety as rules and regulations become more clearly enacted or new contract is signed or existing contract is revised.

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