Productivity Loss of Rheumatoid Arthritis Patients according to the Their Stages of the Disease Activity Score

( Sang-Cheol Bae ),( Jin-Hye Cha ),( Jung-Yoon Choe ),( Sung Jae Choi ),( Soo-Kyung Cho ),( Won-Tae Chung ),( Chung-Il Joung ),( Young-Ok Jung ),( Young Mo Kang ),( Dong-Wook Kim ),( Jinseok Kim ),( Y 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.2

Objective. Productivity loss was compared by 3-stage of disease activity and associations between higher disease activity and high productivity loss were identified. Methods. Data were extracted from Rheumatoid Arthritis (RA) Patient-reported Outcomes Research, which enrolled 2,000 RA patients (>20-year) on disease-modifying-antirheumatic-drugs (DMARDs) (≥ 6-month) from December 2012 to June 2013. This included 1,457 RA patients with the disease activity score (DAS-28-ESR) in their medical charts. Productivity loss in time and indirect cost was estimated using The World Health Organization Health and Work Performance Questionnaire (HPQ). Baseline characteristics and productivity loss outcomes were compared according to DAS-28-ESR groups. Results. 84.4% were females, 54.2% had low DAS-28-ESR (<3.2), and 38.2% and 7.6% had moderate (3.2∼5.1) and high DAS-28-ESR (>5.1). Patients with moderate to high DAS-28-ESR had higher lost productivity time (LPT) and monthly costs of LPT than those with low DAS-28-ESR (time in hours: 110.0±58.4 vs. 132.4±57.2 vs. 71.5±52.0, p<0.0001; monthly costs of LPT in 1,000 Korean won: 1,097±607 vs. 1,302±554 vs. 741±531, p<0.0001). Multiple regression analyses revealed significant associations with high LPT in high (adjusted odds ratio [OR]=3.87, 95% confidence interval [CI]: 2.18∼6.87) and moderate DAS-28-ESR (adjusted OR=1.88, 95% CI: 1.41∼2.52) compared to low DAS-28-ESR. In addition, positive associations with high monthly costs of LPT were observed in high (adjusted OR=3.45, 95% CI: 1.98∼5.99) and moderate DAS-28-ESR (adjusted OR=1.93, 95% CI: 1.43∼2.54) compared to low DAS-28-ESR. Conclusion. Timely therapeutic strategies should be taken into consideration given that the RA patients with moderate to high DAS-28-ESR showed strong associations with high productivity loss for effective management of RA. (J Rheum Dis 2018;25:122-130)

온수배관을 이용한 온실의 난방성능

윤용철(Yong Cheol Yoon),신익수(Yik Soo Shin),김현태(Hyeon Tae Kim),배승범(Seoung Beom Bae),최진식(Jin Sik Choi),서원명(Won Myung Suh) (사)한국생물환경조절학회 2012 생물환경조절학회지 Vol.21 No.2

본 연구는 온실의 난방 에너지 절감을 목적으로 온실 내부에 알루미늄 온수배관을 설치하여 난방효과에 대한 기초자료를 구축하고자 수행되었다. 그 연구결과를 요약하면 다음과 같다. 전체 실험을 포함하여 온실내의 높이별 온도편차는 4.0~7.0℃ 정도의 범위로서 그 차이가 크게 나타났다. 팬코일유니트(FCU)를 작동시킨 경우가 작동시키지 않은 경우에 비해 유출입수의 온도차가 3.3℃ 정도 크고, 소비전력량은 36.2~40.1% 정도 증가하였으며, 시간당 방열량은 44.6~52.0% 정도 증가하는 것으로 나타났다. 실험기간동안 순환유량은 0.48~0.49L · s<SUP>?1</SUP> 정도의 범위에 있었고, 평균유속은 1.53~1.56m · s<SUP>?1</SUP> 정도였다. 유출입수의 평균 온도차는 6.24~11.50℃이었다. 최저 외기온 ?14.0~?0.6℃ 범위에서 설정온도별 방열량은 135,930~307,150㎉ 정도의 범위로서 시간당 9,610~19,630㎉ · h<SUP>?1</SUP> 정도의 범위에 있었다. 이것은 최대난방부하의 약 23~53% 정도의 난방에너지를 공급할 수 있을 것으로 나타났다. 전체 방열량과 소비전력량은 각각 2,548,306㎉ 및 3,075.7㎾h이다. 화석연료인 경유로 난방할 경우, 소요되는 경유의 총 소비량은 281.6L 정도이고 비용은 321,000won인 것으로 나타났다. 농가용 전력요금을 적용하면 전력사용에 대한 총비용은 110,730won 정도로서 경유 소비 비용의 33.5% 정도로 나타났다. 실험구의 온도가 대조구보다 약 8.3~14.6℃ 정도 높게 나타났다. This research was conducted to obtain basic data with regard to the heating performance that would be produced by installing an aluminum hot water pipe inside the greenhouse with the goal of reducing the heating energy in greenhouse. The research results are summarized as follows. The degree of difference in relation to the temperature by height within the greenhouse during the entire experiment was significant - within the range of 4.0~7.0℃. The temperature difference between incoming and outgoing water was about 3.3℃ greater when FCU was activated compared to when it was not activated. Meanwhile, the amount of energy consumed increased about 36.2~40.1%. The amount of pyrexia per hour also increased by 44.6~52.0%. During the experiment period, circulated flux was within the range of 0.48~0.49 L · s<SUP>?1</SUP> while average fluid speed was 1.53~1.56 m · s<SUP>?1</SUP>. The average temperature difference between incoming and outgoing water was 6.24~11.50℃. The amount of heating value by each set temperature within the minimum outdoor temperature range of ?14.0~?0.6℃ was 135,930~307,150 ㎉, and the range was within the 9,610~19,630 ㎉ · h<SUP>?1</SUP> per hour. This demonstrated that about 23~53% heating energy of the maximum heating load could be supplied. Total radiating value and amount of energy consumed were 2,548,306 ㎉ and 3,075.7 ㎾h, respectively. When heating takes place using oil, which is a fossil fuel, the total amount of light oil consumed was 281.6 L while the cost was 321,000 won. When the electricity cost for farms is applied, the total cost was about 110,730 won, which is about 33.5% of the cost required compared to oil consumption. The temperature at in the experiment area was about 8.3~14.6℃ higher compared to that of the control area.

Development and in vitro/in vivo evaluation of loxoprofen extended release tablets

KIM Tae Hwan,SEO Won Sik,CHOI Jin Ho,SHIN Jeong Cheol1. KIM Min Gi. YOO Sun Dong. SHIN Beom Soo 대한약학회 2012 大韓藥學會 總會 및 學術大會 Vol.2012 No.1

S-224 : The Early Repolarization Pattern EKG in patients with Acute Coronary Syndrome: IVUS study

( Cheol Won Hyeon ),( Young Hwan Choi ),( Jun Hwan Cho ),( Kyung Joon Kim ),( Sharath Kumar ),( Seong Hyeop Hyeon ),( Jee Eun Kwon ),( Eun Young Kim ),( Seung Yong Shin ),( Wang Soo Lee ),( Kwang Je L 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Background: Early repolarization pattern (ERP) has been considered as benign condition in great majority of cases. Recently, the presence of ERP can be an index of poor prognosis in various heart diseases. Method: We analyzed 59 consecutive patients with acute coronary syndrome underwent primary coronary intervention and virtual histology intravascular ultrasonography (VH-IVUS). Thin cap fibroatheroma (TCFA) was defined as necrotic core (NC) >10% of plaque area with a plaque burden of >40% and NC in contact with the lumen for >3 image slices. Positive remodeling was a remodeling index (lesion/reference vessel area) >1.05. The diagnostic criterion of ERP was defined when there is J-point elevation of ≥0.1 mV in two adjacent leads. Results: The presence of ERP was observed in 27 patients (45.8%). Although there was no significant difference in lesion length and remodeling index at minimal lumen area between the 2 groups, reference diameter and minimal luminal area were significantly smaller in patients with ERP (p=0.033, p=0.048, respectively). The lesion characteristics of patients with ERP demonstrated (1) more necrotic core (p<0.001), (2) lesser calcium component (p=0.028). Although the incidence of plaque rupture failed to demonstrate significant differences, TCFA was more frequently observed in patients with ERP (p=0.038). Conclusion: We report, for the first time, that the ERP in ACS might distinguish patients with more vulnerable plaque.

Lack of Additional Benefit of Intracoronary Transplantation of Autologous Peripheral Blood Stem Cell in Patients With Acute Myocardial Infarction

Choi, Jin-Ho,Choi, Jinoh,Lee, Wang-Soo,Rhee, Il,Lee, Sang-Chol,Gwon, Hyeon-Cheol,Lee, Sang Hoon,Choe, Yeon Hyeon,Kim, Dae Won,Suh, Wonhee,Kim, Duk-Kyung,Jeon, Eun-Seok Japanese Circulation Society. 2007 Circulation journal Vol.71 No.4

<P><B>Background</B> Recently the potential of myocardial repair by transplantation of autologous bone marrow stem cells has been suggested. Whether the additional intracoronary transplantation of autologous peripheral blood stem cells (PBSC), which were mobilized by granulocyte-colony-stimulating factor (G-CSF), could safely improve myocardial function in patients with acute myocardial infarction (AMI) was investigated. <B>Methods and Results</B> Seventy-three patients with AMI who had successfully undergone percutaneous coronary intervention (PCI) were enrolled in the present prospective nonrandomized open-labeled study. Ten patients with elective PCI received G-CSF for 4 days followed by intracoronary PBSC transplantation. Thirty-two patients with primary PCI and 31 patients with recent AMI and elective PCI served as controls. The left ventricular (LV) function was evaluated using echocardiography and magnetic resonance imaging. G-CSF and intracoronary transplantation of PBSC did not incur any periprocedural myocardial damage. After 6 months, the LV ejection fraction was significantly improved in the cell therapy group. For 2 years of the follow-up period, there was no adverse clinical events, except one asymptomatic in-stent restenosis. However, comparable improvement of the LV ejection fraction was also identified in the primary PCI and elective PCI control groups. <B>Conclusions</B> In the present study, additional intracoronary infusion of PBSC was safe and feasible for the patients with AMI who had undergone PCI, but did not lead to a significant improvement in LV function compared to standard reperfusion treatment. (<I>Circ J</I> 2007; <B>71:</B> 486 - 494)</P>

Modeling and Applications of Electrochemical Impedance Spectroscopy (EIS) for Lithium-ion Batteries

Choi, Woosung,Shin, Heon-Cheol,Kim, Ji Man,Choi, Jae-Young,Yoon, Won-Sub The Korean Electrochemical Society 2020 Journal of electrochemical science and technology Vol.11 No.1

As research on secondary batteries becomes important, interest in analytical methods to examine the condition of secondary batteries is also increasing. Among these methods, the electrochemical impedance spectroscopy (EIS) method is one of the most attractive diagnostic techniques due to its convenience, quickness, accuracy, and low cost. However, since the obtained spectra are complicated signals representing several impedance elements, it is necessary to understand the whole electrochemical environment for a meaningful analysis. Based on the understanding of the whole system, the circuit elements constituting the cell can be obtained through construction of a physically sound circuit model. Therefore, this mini-review will explain how to construct a physically sound circuit model according to the characteristics of the battery cell system and then introduce the relationship between the obtained resistances of the bulk (R_b), charge transfer reaction (R_ct), interface layer (R_SEI), diffusion process (W) and battery characteristics, such as the state of charge (SOC), temperature, and state of health (SOH).

Nipple Reconstruction Using a Scar-Based Modified C-V Flap

Won Chul Choi,최현곤,Jee Nam Kim,Myung Chul Lee,신동혁,김순흠,Cheol Keun Kim,조동인 대한미용성형외과학회 2016 Archives of Aesthetic Plastic Surgery Vol.22 No.3

Background Numerous techniques have emerged for nipple-areolar complex (NAC) over the years. Scar-based modified C-V flap technique is a new method for creating NAC, surgeons can accomplish nipple reconstruction and scar revision simultaneously. This article described the modified C-V flap technique for nipple reconstruction. This modified method is simple and reliable with good outcome. Methods To evaluate the effectiveness of our technique, we reviewed 21 patients who underwent nipple reconstruction using the scar-based modified C-V flap technique. For scar-based modified C-V flap, a C flap was designed to match the contralateral nipple in width while a V flap including scar after mastectomy was designed. The flap pedicle was centrally located. The V flap was then fixed surrounding the central part with a proper shape and volume considering the distal part of the flap that had poor vascularization. Results The average age of the 21 patients was 48.4 years. The average length of follow up was 7.4 months. Complication rate was 19.0% including projection loss in 2 cases, tip necrosis in 1 case, postoperative infection in 1 case, and wound dehiscence in 1 case. Re-operations were performed for 2 cases of projection loss, 1 case of partial flap necrosis, and 1 case of wound dehiscence. Conclusions The scar-based modified C-V flap technique is a simple and reliable method for nipple reconstruction with aesthetic outcome. Patients who have undergone this surgical technique tend to have great satisfaction with the results.

Application of Genomic Information for Genetics and Breeding in Apple Tree

Cheol Choi,Seung Hyun Ban,Won Ho Yun,Gi Hoon Kim 한국원예학회 2014 한국원예학회 학술발표요지 Vol.2014 No.5

Effect of in-Plane Magnetic Field on Rashba Spin-Orbit Interaction

Won Young Choi,Jae Hyun Kwon,Joonyeon Chang,Suk Hee Han,Hyun Cheol Koo 한국진공학회 2013 한국진공학회 학술발표회초록집 Vol.2013 No.2

S-211 : Biventricular tachycardia induced by herbal medicine containing ephedra sinica

( Cheol Won Hyeon ),( Young Hwan Choi ),( Jun Hwan Cho ),( Kyung Joon Kim ),( Sharath Kumar ),( Seong Hyeop Hyeon ),( Jee Eun Kwon ),( Eun Young Kim ),( Seung Yong Shin ),( Wang Soo Lee ),( Kwang Je L 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Ephedra is a potent sympathomimetic agent with cardiovascular effects including tachyardia, positive inotropy, arterial vasoconstriction and hypertension. We report 1 case of biventricular tachycardia after taking herbal medicine containing ephedra sinica. A 77-year-old male with a 30-year-history of COPD prsented with acute onset chest discomfort and dyspnea. He was precribed herbal medicines containing ephedra sinica for abdominal discomfort 2 days ago. Initial electrocardiography (ECG, Fig. A) showed hemodynamically unstable monomorphic ventricular tachycardia with RBBB pattern in percordial leads, which was terminated by electrical cardioversion. ECG after cardioversion, atrial fibrillation was observed (Fig. B). About 1 hour later, hemodynamically unstable fast monomorphic ventricular tachycardia with LBBB pattern was spontaneously induced (Fig. C). Because of hemodynamic instability, additional electrical cardioversion was performed and sinus rhythm was restored (Fig.D). Electrolytes and arterial blood gas analyses were normal. To rule out structural heart disease, echocardiography was done and it revealed normal ejection fraction and no significant abnormalities. Coronary angiography showed a 80% stenosis in the proximal circumflex coronary artery and a 70% stenosis in the posterior descending artery. Percutanous coronary intervention was done to left circumflex artery. The patient was discharged on clopidogrel, warfarin, ACE inhibitor, beta-blocker, statin. His follow up was uneventful.