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Wei Li,Nathan C. Twaddle,Beverly Spray,Bernice Nounamo,Behjatolah Monzavi-Karbassi,Reza Hakkak 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.2
Soy's anti-inflammatory properties contribute to the health benefits of soy foods. This study was designed to investigate the bioavailability of soy isoflavones and whether the isoflavone content of soy protein concentrate diet would affect serum inflammatory proteins in an obese (fa/fa) Zucker rat model. Six-week-old male lean (L) and obese (O) Zucker rats were fed a casein control diet (C), soy protein concentrate with low isoflavones (SPC-LIF), or soy protein concentrate with high isoflavones (SPC-HIF) (7 rats/dietary group) before being killed at 9 and 18 weeks. Serum samples were analyzed for isoflavones and inflammatory proteins. At both time points, serum total (aglycone + conjugates) genistein, daidzein, and equol concentrations were significantly higher in L-SPC-HIF and O-SPC-HIF groups compared with L-SPC-LIF and O-SPC-LIF groups, respectively, and were not detectable in either L-C or O-C groups. At week 9, serum C-reactive protein (CRP) concentration was significantly lower in O-SPC-HIF group compared with O-C and O-SPC-LIF group, whereas proteins tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels did not differ between any groups. At week 18, serum CRP levels in both O-SPC-HIF and O-SPC-LIF groups were significantly lower compared with the O-C group. TNF-α level was higher in the O-SPC-LIF group compared with both O-C and O-SPC-HIF groups, whereas IL-6 levels were not different between any groups. Taken together, feeding Zucker rats SPC-LIF and SPC-HIF diets led to different serum isoflavone concentrations in both L and O Zucker rats and altered CRP and TNF-α levels in obese Zucker rats compared with controls.
Wei Li,Qian Liu,Guoyu Zhang,Xuedong Cheng,Yingfeng Wang,Zhenzhen Xu 한국섬유공학회 2022 Fibers and polymers Vol.23 No.8
This work aimed to evaluate the paste stability and desizability of new starch grafted copolymer [poly(sodium allylsulfonate)-g-starch-g-poly(ethyl acrylate)] (PSAS-g-starch-g-PEA) for providing an important supporting role in sizingapplication. The PSAS-g-starch-g-PEA samples were prepared by grafting reaction of acid-thinned starch (AHS) with SASand subsequent with EA in water phase. The PSAS-g-starch-g-PEA granules were characterized by Fourier transforminfrared spectroscopy and scanning electron microscopy. Also, paste stability was assessed and desizability was investigatedin terms of desizing efficiency, swelling ability of the film and time interval for the break of starch film in water. Comparedwith control AHS, the PSAS-g-starch-g-PEA had higher paste stability, desizing efficiency and swelling ability, and lowertime interval required, concluding that the PSAS and PEA branches could promote the paste stability and desizability ofstarch. Increasing the number of both branches facilitated the paste stability and desizability. PSAS-g-starch-g-PEA displayedpotential value in textile sizing field.
Wei Li,Haijun Shen 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.2
We present a finite element model of laminated composite cylindrical shells with piezoelectric layers by using layerwise theory. The formulation, which is based on Reddy’s layerwise displacement theory, involves the coupling between mechanical deformations and electric displacements. The full layerwise theory is used to represent the total displacement field and electric potential, and then a finite element model has been formulated based on the developed mechanics by employing Hamilton’s principle and variational method. This layerwise finite element model can give an accurate description of displacement field at the ply level and can model complex boundary conditions. Numerical example of a simply-supported laminated piezoelectric composite shell for static response and free vibration analysis was implemented to evaluate the efficiency and accuracy of the present method. Numerical results obtained with the present method are in excellent agreement with other similar solutions.
Efficient Metric Vector-Based Code Clone Detection Using Function-calling Tree
Wei Li,Dongmei Li,Chengjing Qiu,Jiajia Hou 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.11
Most traditional code clone detections have less accurate results because they ignore the structure of the program itself, and some of them really think about it by creating a complex syntax tree but leading to a high time complexity. Confronting such situation, this paper proposes an efficient metric vector-based code clone detection method using function-calling tree. Considering the two program code to be detected, feature vectors in all defined functions of the two different code are extracted first. Then, two function-calling trees are created according to the function-calling process and node matches each other between two trees, at the same time, the matching similarities are calculated. Finally, by using the bottom-up approach and combining similarity values of all child nodes, the detection can get the similarity of the two program code to be detected. Our experiment selects a set of typical code sample to measure and the results demonstrate that, compared the famous JPlag system, it shows better detection effect.
( Wei Li ),( Han Fan ),( Chao He ),( Xuecheng Zhang ),( Xiaotang Wang ),( Jing Yuan ),( Zemin Fang ),( Wei Fang ),( Yazhong Xiao ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.11
A novel α-glucoside hydrolase (named PspAG97A) from glycoside hydrolase family 97 (GH97) was cloned from the deep-sea bacterium Pseudoalteromonas sp. K8, which was screened from the sediment of Kongsfjorden. Sequence analysis showed that PspAG97A belonged to GH97, and shared 41% sequence identity with the characterized α-glucosidase BtGH97a. PspAG97A possessed three key catalytically related glutamate residues. Mutation of the glutamate residues indicated that PspAG97A belonged to the inverting subfamily of GH97. PspAG97A showed significant reversibility against changes in salt concentration. It exhibited halophilic ability and improved thermostability in NaCl solution, with maximal activity at 1.0 M NaCl/KCl, and retained more than 80% activity at NaCl concentrations ranging from 0.8 to 2.0 M for over 50 h. Furthermore, PspAG97A hydrolyzed not only α-1,4-glucosidic linkage, but also α-1,6- and α-1,2-glucosidic linkages. Interestingly, PspAG97A possessed high catalytic efficiency for long-chain substrates with α-1,6-linkage. These characteristics are clearly different from other known α-glucoside hydrolases in GH97, implying that PspAG97A is a unique α-glucoside hydrolase of GH97.
IoT Healthcare Communication System for IEEE 11073 PHD and IHE PCD-01 Integration Using CoAP
( Wei Li ),( Cheolwoo Jung ),( Jongtae Park ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.4
With the proliferation of the Internet of Things (IoT) healthcare devices, significant interoperability issue arises where devices use proprietary data transfer protocols. The IHE PCD-01 standard has been suggested for the exchange of healthcare data in ISO/IEEE 11073 PHD data model. However, the PCD-01 is not efficient to be used in the IoT environment. This is because the use of SOAP for PCD-01 may be too complex to be implemented in the resource-constrained IoT healthcare devices. In this paper, we have designed a communication system to implement ISO/IEEE 11073 and IHE PCD-01 integration using the IETF CoAP. More specifically, we have designed the architecture and procedures, using CoAP, to seamlessly transmit the bio-signal from the tiny resource-constrained IoT healthcare devices to the server in a standardized way. We have also built the agent, gateway, and PCD-01 interface at the server, all of which are using the CoAP as a communication protocol. In order to evaluate the performance of the proposed system, we have used the PCD data to be transmitted over CoAP, MQTT, and HTTP. The evaluation of the system performance shows that the use of CoAP results in faster transaction and lesser cost than other protocols, with less battery power consumption.
Wei Li,Xiangrong Zhang,Meng Ding,Yanfei Xin,Yaoxian Xuan,Yuqing Zhao 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.4
Background: Ginsenosides have been widely used clinically for many years and were regarded as very safe. However, a few researches on the toxicities of these kinds of agents showed that some ginsenosides may have side-effect on the rats or dogs. So it is extremely necessary to further clarify the potential toxicity of ginsenosides. This study was carried out to investigate long-term toxicity and genotoxicity of 25-methoxydammarane-3, 12, 20-triol (25-OCH₃-PPD), a new derivative of ginsenoside, in beagle dogs. Methods: Twenty-four beagle dogs were divided randomly into four treatment groups and repeatedly orally administered with 25-OCH₃-PPD capsule at 60, 120, and 240 mg/kg/day for 91 consecutive days. Ames, micronucleus, and chromosomal aberration tests were established to analyze the possible genotoxicity of 25-OCH₃-PPD. Results: There was no 25-OCH₃-PPD-induced systemic toxicity in beagle dogs at any doses. The level of 25-OCH₃-PPD at which no adverse effects were observed was found to be 240 mg/kg/day. The result of Ames test showed that there was no significant increase in the number of revertant colonies of 25-OCH₃- PPD administrated groups compared to the vehicle control group. There were also no significant differences between 25-OCH₃-PPD administrated groups at all dose levels and negative group in the micronucleus test and chromosomal aberration assay. Conclusion: The highest dose level of 25-OCH₃-PPD at which no adverse effects were observed was found to be 240 mg/kg per day, and it is not a genotoxic agent either in somatic cells or germs cells. 25-OCH₃-PPD is an extremely safe candidate compound for antitumor treatment.