<i>CYP2A6</i> and <i>ERCC1</i> polymorphisms correlate with efficacy of S-1 plus cisplatin in metastatic gastric cancer patients

Park, S R,Kong, S-Y,Nam, B-H,Choi, I J,Kim, C G,Lee, J Y,Cho, S J,Kim, Y W,Ryu, K W,Lee, J H,Rhee, J,Park, Y-I,Kim, N K Nature Publishing Group 2011 The British journal of cancer Vol.104 No.7

<P><B>Background:</B></P><P>We evaluated the association between polymorphisms of cytochrome P450 2A6 (<I>CYP2A6</I>)/excision repair cross-complementation group 1 (<I>ERCC1</I>)/X-ray repair cross-complementing group 1(<I>XRCC1</I>) and treatment outcomes of metastatic gastric cancer (MGC) patients treated with S-1/cisplatin.</P><P><B>Methods:</B></P><P>Among MGC patients (<I>n</I>=108), who received S-1 (40 mg m<SUP>−2</SUP> b.i.d., days 1–14) and cisplatin (60 mg m<SUP>−2</SUP>, day 1) every 3 weeks, we analysed the wild-type allele (<I>W</I>) and variants (<I>V</I>) of <I>CYP2A6</I> (<I>*4</I>, <I>*7, *9, *10</I>), and the polymorphisms of <I>ERCC1</I> (rs11615, rs3212986) and <I>XRCC1</I> (rs25487).</P><P><B>Results:</B></P><P>Patients having fewer <I>CYP2A6</I> variants had better response rates (<I>W</I>/<I>W vs W</I>/<I>V</I> other than <I>*1/*4 vs V</I>/<I>V</I> or <I>*1/*4</I>=66.7 <I>vs</I> 58.3 <I>vs</I> 32.3% <I>P</I>=0.008), time to progression (TTP) (7.2 <I>vs</I> 6.1 <I>vs</I> 3.5 months, <I>P</I>=0.021), and overall survival (23.2 <I>vs</I> 15.4 <I>vs</I> 12.0 months, <I>P</I>=0.004). <I>ERCC1 19442C</I>><I>A</I> (rs3212986) was also associated with response rate (<I>C/C</I>, 46.7% <I>vs C/A</I>, 55.3% <I>vs A/A</I>, 87.5%) (<I>P</I>=0.048) and TTP (4.4 <I>vs</I> 7.6 <I>vs</I> 7.9 months) (<I>P</I>=0.012). Patients carrying both risk genotypes of <I>CYP2A6</I> (<I>V</I>/<I>V</I> or <I>1/*4</I>) and <I>ERCC1 19442C</I>><I>A</I> (<I>C/C</I>) <I>vs</I> those carrying none showed an adjusted odds ratio of 0.113 (<I>P</I>=0.004) for response, and adjusted hazard ratios of 3.748 (<I>P</I>=0.0001) for TTP and 2.961 (<I>P</I>=0.006) for death.</P><P><B>Conclusion:</B></P><P>Polymorphisms of <I>CYP2A6</I> and <I>ERCC1 19442C</I>><I>A</I> correlated with the efficacy of S-1/cisplatin.</P>

단세포군 항체를 이용한 Shigella serotyping serum 개발(Ⅱ) : S. flexneri type Ⅰ,Ⅱ & type Ⅰ:6, group 6

정의범,이영희,김순남,박강수,이명숙,성원근,김종욱,홍승의,박정우 국립보건연구원 1994 국립보건원보 Vol.31 No.1

Antibiotic susceptibility and resistance of Streptococcus iniae and Streptococcus parauberis isolated from olive flounder (Paralichthys olivaceus)

Park, Y.K.,Nho, S.W.,Shin, G.W.,Park, S.B.,Jang, H.B.,Cha, I.S.,Ha, M.A.,Kim, Y.R.,Dalvi, R.S.,Kang, B.J.,Jung, T.S. Elsevier Scientific Pub. Co 2009 Veterinary microbiology Vol.136 No.1

The rates of antibiotic susceptibility and resistance were investigated in Streptococcus iniae and Streptococcus parauberis isolates obtained from diseased olive flounders (Paralichthys olivaceus) collected from fish farms in Jeju Island, Korea. Isolates of S. iniae (n=65) were susceptible to cefotaxime, erythromycin, ofloxacin, penicillin, tetracycline and vancomycin, as demonstrated by the minimum inhibitory concentration (MIC) test. Isolates of S. parauberis (n=86) were highly resistant to erythromycin (58% of the 86 isolates tested) and tetracycline (63% of the 86 isolates tested). Fifty-four isolates of tetracycline-resistant S. parauberis contained the tet(M/O/S) genes, of which 39 and 12 isolates contained the tet(M) and tet(S) genes, respectively, whereas 3 isolates contained both the tet(M) and tet(S) genes. Among the erythromycin-resistant isolates of S. parauberis (n=50) only 14 contained the erm(B) gene. These results suggest that the tet(S) and erm(B) genes of S. parauberis are involved in the acquisition of high-level resistance to erythromycin and tetracycline. Our findings reveal a high rate of antibiotic resistance among strains of S. parauberis and emphasize the need to develop an appropriate vaccine to reduce the use of antibiotics.

Application of genetically engineered Salmonella typhimurium for interferon-gamma-induced therapy against melanoma

Yoon, W.,Park, Y.C.,Kim, J.,Chae, Y.S.,Byeon, J.H.,Min, S.H.,Park, S.,Yoo, Y.,Park, Y.K.,Kim, B.M. Pergamon Press 2017 European journal of cancer Vol.70 No.-

Salmonella have been experimentally used as anti-cancer agents, because they show selective growth in tumours. In this study, we genetically modified attenuated Salmonella typhimurium to express and secrete interferon-gamma (IFN-γ) as a tumouricidal agent to enhance the therapeutic efficacy of Salmonella. IFN-γ was fused to the N-terminal region (residues 1-160) of SipB (SipB160) for secretion from bacterial cells. Attenuated S. typhimurium expressing recombinant IFN-γ (S. typhimurium (IFN-γ)) invaded the melanoma cells and induced cytotoxicity. Subcutaneous administration of S. typhimurium (IFN-γ) also efficiently inhibited tumour growth and prolonged the survival of C57BL/6 mice bearing B16F10 melanoma compared with administration of phosphate-buffered saline (PBS), unmodified S. typhimurium or S. typhimurium expressing empty vector (S. typhimurium [Vec]) in a natural killer (NK) cell-dependent manner. Moreover, genetically modified Salmonella, including S. typhimurium (IFN-γ), showed little toxicity to normal tissues with no observable adverse effects. However, S. typhimurium (IFN-γ)-mediated tumour suppression was attributed to direct killing of tumour cells rather than to stable anti-tumour immunity. Collectively, these results suggest that tumour-targeted therapy using S. typhimurium (IFN-γ) has potential for melanoma treatment.

선택적 촉매 산화 반응에 의한 황화 수소의 제거 Ⅱ . TiO2 / SiO2 촉매 상에서 황화 수소의 선택적 산화 반응

천승우,박대원,우희철,홍성수,정종식 ( S . W . Chun,D . W . Park,H . C . Woo,S . S . Hong,J . S . Chung ) 한국공업화학회 1996 공업화학 Vol.7 No.4

본 연구는 H₂S를 TiO₂/SiO₂촉매상에서 산소와의 직접 산화 반응을 통해 원소 황의 형태로 제거하는 반응에 관한 것이다. 순수한 TiS₂Ti(SO₄)_2를 사용한 반응 실험과 순수한 TiO₂에 대한 주기적 온도 조작 실험 결과로부터 TiO₂는 황 회수 공정에서 사용되는 촉매의 비활성화의 주원인으로 알려진 sulfation이나 salfidation에 대해 매우 안정한 것으로 나타났다. TiO₂/SiO₂촉매에서 TiO₂의 담지량이 증가함에 따라 H₂S 전화율이 증가하였고, 원소 황의 선택도는 아주 소폭으로 감소하였다. 반응 실험결과 O₂/H₂S의 비가 증가할수록 원소 황의 선택도는 크게 감소하였다. 10 wt.% TiO₂/SiO₂ 촉매는 화학 양론비의 조성(H₂S=5 vol.% O₂=2.5 vol.%)의 반응물에 10 vol.%의 수증기를 첨가한 경우 활성과 선택도가 감소하였으나 여전히 80% 이상의 원소 황 수율을 유지하고 있었다. Selective catalytic oxidation of H₂S to elemental sulfur using TiO₂/SiO₂ catalysts was investigated in this study. The reaction test with pure TiS₂and Ti(SO₄)₂and cyclic temperature operation revealed that TiO₂had a good resistance to sulfation and sulfidation, which are known as the main cause of catalytic deactivation in sulfur recovery process. With the increase of TiO₂loading amount in Tio₂/SiO₂catalysts, the conversion of H₂S increased and the selectivity of elemental sulfur was very slightly decreased. As the ratio of O₂/H₂S increased, the selectivity to elemental sulfur was drastically decreased. In the presence of 10 vol.% water vapor to a stoichiometric mixture of H₂S and O₂(H₂S =5 vol.% O=2.5 vol.%), both activity and selectivity of 10 wt.% TiO₂/SiO₂catalyst are decreased, but it still showed more than 80% of sulfur yield.

1987년 한국에서 발생한 렙토스피라병의 혈청역학적 조사

이증훈,박영수,이우곤,김석용,정선식,우준희,박성광,박경희,송영욱,김선영,기정일,최두혁,강성귀,김주완,최강원,김우열,최명식,최인학,장우현,윤성열 대한감염학회 1988 감염 Vol.20 No.3

Human leptospirosis was an unfamiliar disease in Korea until 1984 that outbreak of leptospirosis occurred among farmers and soldiers after field works for harvesting rice. During that time, Lee and Jo confirmed the first Korean cases of leptospirosis by serological test, isolation of causative agent and autopy findings. Afterward several outbreaks occurred also during autumn especially after flood in every years and some characterisitcs of leptospirosis in Korea such as clinical manifestations, serotypes and seroepidemiological features has been revealed by many investigators. Because of the major mode of transmission between rodents and human is by direct contact with leptospiral urine of rodents or contaminated soil by the urine, leptospirosis in Korea has been primarily a disease of person in occupations heavily exposed to contaminated soil or infected urine such as farmer, army and etc. Therefore it seems that leptospirosis is one of the main communicable diseases to be controlled urgently in Korea, for an agricultural people account for almost half of total Korean people. For clarifying the seroepidemiological patterns of human leptospirosis in Korea by sex, month region and main reacting serovars of L. interrogans among acute febrile disease occurred in 1987, 1,773 patient's sers with acute febrile episodes were tested by microagglutination test using 19 representative strains of leptospiral serogroup as antigen. All of those sera were collected from 10 collaborative clinics located in Kyunggi, Kangwon, Chungbuk, Chungnam, Chonbuk, Chonnam province and Seoul. The results wee summerized as follows. 1) Among 1,773 sera of patients with acute febrile episodes, 219 (12.4%) were seropositive to L. interrogans, 487(27.5%) to R. tsutsugamushi, 241(13.6%) to R.typhi and 160(90.0%) to Hantaan virus. 2) Among seropositives to L.interrogans, the male outnumbered the female, 65% and 35%. 3) For age distribution, 26.9% of seropositives to L.interrogans were fifties, 19.6% were forties, 9.1% were sixties, 5.9% were thirties and 4.1% were twenties. 4) Eighty three percent of seropositives had occurred between September and October in 1987 with a peak in September. 5) Main leptospiral serovars reactive to patient's sera were Icterohaemorrhagiae(54.3%), Canicola(31.0%), CH-48(13.2%), Tarassovi(0.9%)and Cynopteri(0.5%). 6) For regional distribution, 65.8% of seropositives to L.interrogans were residents from Chonbuk, 12.3% were Chonnam, 7.3% were Chungnam, 5.5% were Kyunggi and 1.4% were Kangwon.

Magnetic Properties of <tex> $ [\hbox{Ni}_{97{\rm at.}\%}$</tex>-W<tex> $_{3{\rm at.}\%}]_{{100}-{x}}$</tex>-Cu<tex> $_x$</tex> Textured Substrates for Coated Conductors

Song, K.J.,Ko, R.K.,Kim, H.S.,Ha, H.S.,Ha, D.W.,Oh, S.S.,Park, C.,Yoo, S.-I.,Kim, M.W.,Kim, C.J.,Joo, J.H. Institute of Electrical and Electronics Engineers 2007 IEEE transactions on applied superconductivity Vol.17 No.2

<P>The degree of ferromagnetism of Ni-W<SUB>y</SUB> alloys decreases as W-content y increases. Both the saturation magnetization <I>M</I> <SUB>sat</SUB> and Curie temperature <I>T</I> <SUB>c</SUB> decrease linearly with W-content y, and both <I>M</I> <SUB>sat</SUB> and <I>T</I> <SUB>c</SUB> go to zero at critical concentration of y<SUB>c</SUB> ~9.50 at.% W. To compare with Ni-W alloys, the magnetic properties of a series of both as-rolled (non-textured) and annealed (biaxially textured) [Ni<SUB>97at.%</SUB>-W<SUB>3at.%</SUB>]<SUB>100-x</SUB>-Cu<SUB>x</SUB> alloy tapes with compositions x = 0, 1, 3, 5, and 7 at.%, were studied. Characterization methods included XRD analyses to investigate the biaxial texturing of the annealed [Ni-W]-Cu alloy tapes and studies of the magnetization for both as-rolled and annealed [Ni-W]-Cu alloy tapes. Both the isothermal mass magnetizations <I>M</I>(<I>H</I>) of a series of samples at different fixed temperatures and <I>M</I>(<I>T</I>) in fixed field, were measured. The effect of Cu addition on both the saturation magnetization and Curie temperature T<SUB>c</SUB> of the Ni<SUB>97at.%</SUB>-W<SUB>3at.%</SUB> alloy was investigated.</P>

공작기계용 개방형 HMI Platform 기반 사용자 라이브러리 운용, 관리 모듈 설계

손진호(J. Sohn),조정훈(J. H. Cho),이학철(H. C. Lee),정태근(T. K. Jung),이경태(K. T. Lee),박진욱(J. W. Park),나수인(S. I. Na) Korean Society for Precision Engineering 2021 한국정밀공학회 학술발표대회 논문집 Vol.2021 No.11월

공작기계용 개방형 HMI Platform 은 하나의 단일 S/W Application 으로 구성되는 기존의 일반적인 HMI 시스템과 달리, 새로운 S/W Application 을 설치하거나, 기존 Application 이나 기능 혹은 모듈을 삭제할 수 있어 개별 생산 제조 현장에 최적화된 공작기계 사용 환경을 구성할 수 있다. 또한, 단위 기능이나 모듈을 라이브러리 형태로 만들고 이를 설치하여 다른 App 들이 공용으로 사용할 수 있는 기능을 제공할 수 있도록 지원한다. 이를 위해 공작기계용 개방형 HMI Platform 은 사용자 라이브러리를 설치 및 삭제할 수 있는 기능을 제공하며, 일관된 인터페이스와 데이터 교환 모델을 통해 손쉽게 주요 정보를 교환하고 이를 처리한 결과를 수용할 수 있도록 지원한다. 이 뿐만 아니라, 라이선스 관리 기능을 함께 제공하여 라이브러리에 대한 접근 권한 관리 기능도 지원한다. S/W Application 을 자유롭게 설치. 삭제할 수 있도록 함으로써 HMI 사용환경을 최적화할 수 있는 것과 마찬가지로 라이브러리를 설치 삭제함으로써 단위 App 의 기능을 확장하거나 최적화할 수 있게 지원하여 공작기계 HMI 환경을 좀 더 세밀하게 최적화 할 수 있는 수단을 제공한다 또한 각종 App 들이 공통으로 사용할 수 있는 필수 기능들을 라이브러리 형태로 제공함에 따라 공작기계용 S/W Application 개발을 활성화할 수 있으며, 라이선스 관리 기능 지원을 통해 라이브러리를 통한 과금 정책 운영의 수단을 제공함으로써 개방형 HMI 플랫폼 기반 소프트웨어 생태계 조성의 기반을 갖추게 된다.

DBM을 활용한 EMR 기반의 스트로크환자의 재활프로토콜 추천 시스템

이선우(S. W. Lee),박경남(K. N. Park),김세진(S. J. Kim),원인수(I. S. Won),권장우(J. W. Kwon) 한국재활복지공학회 2017 한국재활복지공학회 학술대회논문집 Vol.2017 No.4

Most existing stroke rehabilitation training systems were determined by empirical treatment methods of doctors. Standard treatment guidelines for stroke rehabilitation have been introduced to address these problems. However, these guidelines are determined by the doctor"s objective judgment, and sometimes the doctor suggests different treatments for the same patient. In addition, there are cases where only the patient"s exercise function is presented and the individual"s risk management factor is missing during rehabilitation treatment. To solve these problems, this paper proposes a training method suitable for the patient using DBN (Deep Belief Network). In this method, a part of the patient"s EMR(Electronic Medical Records) data and a risk management factor are inputted and a method of presenting a suitable exercise to the patient is derived.

Progress Report on the Search for Globular Clusters in M33

W. -K. Park,M. G. Lee,S. C. Kim,H. S. Park,J. H. Park,S. G. Lee,S. J. Oh,Y. W. Lee,Y. J. Sohn,S. C. Rey,I. S. Yuk,H. I. Kim,W. Han 한국천문학회 2003 天文學會報 Vol.28 No.1