Biological and Medicinal Properties of Grapes and Their Bioactive Constituents: An Update

Yadav, Mukesh,Jain, Shalini,Bhardwaj, Aarti,Nagpal, Ravinder,Puniya, Monica,Tomar, Radha,Singh, Vinod,Parkash, Om,Prasad, G.B.K.S.,Marotta, Francesco,Yadav, Hariom The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.3

The grape is one of the most valued conventional fruits, worldwide. Although most of the parts of the grapevine are useful, primarily, the grape is considered as a source of unique natural products not only for the development of valuable medicines against a number of diseases, but also for manufacturing various industrial products. Over the last few decades, apart from the chemistry of grape compounds, considerable progress has been made towards exploring the biological activities of various grape-derived constituents. Today, it is well established that in addition to serving as food, the grape is a major source of several phytochemicals. The main biologically active and well-characterized constituent from the grape is resveratrol, which is known for various medicinal properties in human diseases. This review discusses the roles of various grape-derived phytochemicals in relation to various diseases.

RESEARCH : Open Access ; Effect of misting and wallowing cooling systems on milk yield, blood and physiological variables during heat stress in lactating Murrah buffalo

( Brijesh Yadav ),( Vijay Pandey ),( Sarvajeet Yadav ),( Yajuvendra Singh ),( Vinod Kumar ),( Rajneesh Sirohi ) 한국동물자원과학회(구 한국축산학회) 2016 한국축산학회지 Vol.58 No.1

Background: Heat stress adversely affects the physiological and metabolic status, and the productive performance of buffalo. Methods: The present study was conducted to explicate the effect of misting and wallowing cooling strategies during heat stress in lactating Murrah buffalo. The study was conducted for three months (May.July) of which first two months were hot dry and last month was hot humid. Eighteen lactating buffaloes, offered the same basal diet, were blocked by days in milk, milk yield and parity, and then randomly allocated to three treatments: negative control (no cooling), cooling by misting, and cooling by wallowing. Results: The results showed higher (P < 0.05) milk yield in buffaloes of misting and wallowing group compared to control during the experimental period however wallowing was found more (P < 0.05) effective during July (hot humid period). Both the treatments resulted into significant (P < 0.05) reduction in rectal temperature (RT) and respiratory rate (RR) compared to control animals during study period whereas wallowing was found to be effective on pulse rate (PR) only during July. Both treatments were resulted in mitigating the heat stress mediated decrease in packed cell volume (PCV), lymphocytopnoea and neutrophilia whereas decrease in total erythrocyte count (TEC) and monocytes was only mitigated by wallowing. Heat load induced alteration in serum creatinine and sodium concentration was significantly (P < 0.05) ameliorated by misting and wallowing whereas aspartate aminotransferase, alkaline phosphatase and superoxide dismutase activity, and reactive oxygen species concentration could be normalized neither by misting nor by wallowing. The significant (P < 0.05) increment in serum cortisol and prolactin levels observed in June and July period in control animals was significantly (P < 0.05) prevented by misting and wallowing. Conclusions: It can be concluded that misting and wallowing were equally effective in May and June (hot dry period) whereas wallowing was more effective during hot humid period in preventing a decline in milk production and maintaining physiological, metabolic, endocrine and redox homeostasis.

Biological and Medicinal Properties of Grapes and Their Bioactive Constituents: An Update

Mukesh Yadav,Shalini Jain,Aarti Bhardwaj,Ravinder Nagpal,Monica Puniya,Radha Tomar,Vinod Singh,Om Parkash,G.B.K.S. Prasad,Francesco Marotta,Hariom Yadav 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.3

The grape is one of the most valued conventional fruits, worldwide. Although most of the parts of the grapevine are useful, primarily, the grape is considered as a source of unique natural products not only for the development of valuable medicines against a number of diseases, but also for manufacturing various industrial products. Over the last few decades, apart from the chemistry of grape compounds, considerable progress has been made towards exploring the biological activities of various grape-derived constituents. Today, it is well established that in addition to serving as food, the grape is a major source of several phytochemicals. The main biologically active and well-characterized constituent from the grape is resveratrol, which is known for various medicinal properties in human diseases. This review discusses the roles of various grape-derived phytochemicals in relation to various diseases.

Stem Rot of Pearl Millet Prevalence, Symptomatology, Disease Cycle, Disease Rating Scale and Pathogen Characterization in Pearl Millet-Klebsiella Pathosystem

Vinod Kumar Malik,Pooja Sangwan,Manjeet Singh,Pavitra Kumari,Niharika Shoeran,Navjeet Ahalawat,Mukesh Kumar,Harsh Deep,Kamla Malik,Preety Verma,Pankaj Yadav,Sheetal Kumari,Aakash,Sambandh Dhal 한국식물병리학회 2024 Plant Pathology Journal Vol.40 No.1

The oldest and most extensively cultivated form of millet, known as pearl millet (<i>Pennisetum glaucum</i> (L.) R. Br. Syn. <i>Pennisetum americanum</i> (L.) Leeke), is raised over 312.00 lakh hectares in Asian and African countries. India is regarded as the significant hotspot for pearl millet diversity. In the Indian state of Haryana, where pearl millet is grown, a new and catastrophic bacterial disease known as stem rot of pearl millet spurred by the bacterium <i>Klebsiella aerogenes</i> (formerly <i>Enterobacter</i>) was first observed during fall 2018. The disease appears in form of small to long streaks on leaves, lesions on stem, and slimy rot appearance of stem. The associated bacterium showed close resemblance to <i>Klebsiella aerogenes</i> that was confirmed by a molecular evaluation based on 16S rDNA and gyrA gene nucleotide sequences. The isolates were also identified to be <i>Klebsiella aerogenes</i> based on biochemical assays, where Klebsiella isolates differed in D-trehalose and succinate alkalisation tests. During fall 2021-2023, the disease has spread all the pearl millet-growing districts of the state, extending up to 70% disease incidence in the affected fields. The disease is causing considering grain as well as fodder losses. The proposed scale, consisting of six levels (0-5), is developed where scores 0, 1, 2, 3, 4, and 5 have been categorized as highly resistant, resistant, moderately resistant, moderately susceptible, susceptible, and highly susceptible disease reaction, respectively. The disease cycle, survival of pathogen, and possible losses have also been studied to understand other features of the disease.

Efficacy of Newer Molecules, Bioagents and Botanicals against Maydis Leaf Blight and Banded Leaf and Sheath Blight of Maize

Vinod Kumar Malik,Manjeet Singh,Karambir Singh Hooda,Naresh Kumar Yadav,Prashant Kumar Chauhan 한국식물병리학회 2018 Plant Pathology Journal Vol.34 No.2

Maize (Zea mays L.; 2N=20) is major staple food crop grown worldwide adapted to several biotic and abiotic stresses. Maydis leaf blight (MLB) and banded leaf and sheath blight (BLSB) are serious foliar fungal diseases may cause up to 40% and 100% grain yield loss, respectively. The present studies were undertaken to work out the efficacy of chemicals, botanicals and bioagents for the management of MLB and BLSB under field condition for two seasons Kharif 2014 and 2015. Five molecules (propiconazole 25 EC, hexaconazole 25 EC, carbendazim 50 WP, mancozeb 75 WP and carbedazim 12 WP + mancozeb 63 WP), two bioagents i.e. Trichoderma harzianum and T. viridae and three botanicals namely azadirachtin, sarpagandha and bel pathar were tested for their efficacy against MLB. Eight newer fungicides viz., difenconazole 250 SC, hexaconazole 5 EC, carbendazim 50WP, validamycin 3 L, tebuconazole 250 EC, trifloxystrobin 50 WG + tebuconazole 50 WG, azoxystrobin 250 EC and pencycuron 250 SC were evaluated against BLSB. Analysis revealed significant effects of propiconazole at 0.1%, carbendazim 12 WP + mancozeb 63 WP at 0.125% and sarpagandha leaves at 10% against MLB pathogen, whereas validamycin at 0.1% and trifloxystrobin 25 WG + tebuconazole 50 WG at 0.05% were found effective against BLSB. The slow rate of disease control virtually by the bioagents might have not shown instant effect on plant response to the yield enhancing components. The identified sources of management can be used further in strengthening the plant protection in maize against MLB and BLSB.

Efficacy of Newer Molecules, Bioagents and Botanicals against Maydis Leaf Blight and Banded Leaf and Sheath Blight of Maize

Malik, Vinod Kumar,Singh, Manjeet,Hooda, Karambir Singh,Yadav, Naresh Kumar,Chauhan, Prashant Kumar The Korean Society of Plant Pathology 2018 Plant Pathology Journal Vol.34 No.2

Maize (Zea mays L.; 2N=20) is major staple food crop grown worldwide adapted to several biotic and abiotic stresses. Maydis leaf blight (MLB) and banded leaf and sheath blight (BLSB) are serious foliar fungal diseases may cause up to 40% and 100% grain yield loss, respectively. The present studies were undertaken to work out the efficacy of chemicals, botanicals and bioagents for the management of MLB and BLSB under field condition for two seasons Kharif 2014 and 2015. Five molecules (propiconazole 25 EC, hexaconazole 25 EC, carbendazim 50 WP, mancozeb 75 WP and carbedazim 12 WP + mancozeb 63 WP), two bioagents i.e. Trichoderma harzianum and T. viridae and three botanicals namely azadirachtin, sarpagandha and bel pathar were tested for their efficacy against MLB. Eight newer fungicides viz., difenconazole 250 SC, hexaconazole 5 EC, carbendazim 50WP, validamycin 3 L, tebuconazole 250 EC, trifloxystrobin 50 WG + tebuconazole 50 WG, azoxystrobin 250 EC and pencycuron 250 SC were evaluated against BLSB. Analysis revealed significant effects of propiconazole at 0.1%, carbendazim 12 WP + mancozeb 63 WP at 0.125% and sarpagandha leaves at 10% against MLB pathogen, whereas validamycin at 0.1% and trifloxystrobin 25 WG + tebuconazole 50 WG at 0.05% were found effective against BLSB. The slow rate of disease control virtually by the bioagents might have not shown instant effect on plant response to the yield enhancing components. The identified sources of management can be used further in strengthening the plant protection in maize against MLB and BLSB.

Experimental investigation of kerf characteristics through wire electrochemical spark cutting of alumina epoxy nanocomposite

Pallvita Yadav,Vinod Yadava,Audhesh Narayan 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.1

Alumina epoxy nanocomposite (AENC) is an emerging class of composites with a wide range of functionality and applicability; however, managing AENC using a machine is difficult because of its special mixed characteristics. The presence of extremely hard alumina particles in soft epoxy matrix enhances material properties. The present work investigates the kerf characteristics of a straight cut made in AENC through Wire electrochemical spark cutting (WECSC) process. The kerf characteristics, such as kerf deviation and taper, are used to measure the cut quality. The applied voltage, electrolyte concentration, wire velocity, pulse on-time and pulse off-time are varied, and their effects on the kerf characteristics are experimentally investigated in a developed setup. Influencing parameters for straight cutting of AENC are applied voltage, concentration of electrolyte and wire velocity.

Performance study of Electrical discharge diamond face surface grinding (EDDFSG) on hybrid metal matrix composite

Ram Singar Yadav,Vinod Yadava 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.1

Hybrid machining techniques are effective means for machining of difficult-to-cut, electrically conductive hard and brittle materials. In the present work, performance characteristics of newly developed Electrical discharge diamond face surface grinding were experimentally studied during machining flat surfaces of a difficult-to-cut hybrid metal matrix composite, which is a new configuration of electrical discharge diamond grinding. Gap current, on and off time are the spark related parameters as well as grinding related parameters such as abrasive grit size, RPM of wheel, and table speed are considered as input process parameters. The role of input process parameters was investigated in machining performance such as MRR and R a during electrical discharge diamond face surface grinding of Al/SiCp/B 4 Cp hybrid metal matrix composite. Scanning electron microscopy was also used to study the recast layers and surface texture of machined surface. Better surface finish with reduced recasts and higher MRR evince the potential applicability of the process.

Slotted-electrical discharge diamond cut-off grinding of Al/SiC/B4C hybrid metal matrix composite

Ravindra Nath Yadav,Vinod Yadava 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.1

Advanced manufacturing industries need materials with high strength and low weight in the fields of advanced engineering, such asautomobiles and aeronautics. Metal matrix composites (MMCs) are one of the advanced engineering materials that meet the above requirements. To enhance the properties of MMCs, researchers added an additional phase of reinforcements into single reinforced MMCs,such developed MMCs are known as hybrid MMCs. The additional phase of reinforcements enhances the properties of MMCs, but simultaneouslyleads to rapid tool wear and poor machinability. This study developed an innovative hybrid machining process (HMP)consisting of electrical discharge grinding and diamond grinding in such a way that both the processes occur alternately with equal intervalsdue to the rotation of a slotted abrasive grinding wheel. The performance of the hybrid process was tested on an Al/SiCp/B4Cp workpiecein cut-off grinding mode. The experiments were conducted on an electrical discharge machining machine, which consists of a separateattachment on a vertical column to rotate the wheel. Pulse current, pulse on-time, pulse off-time, wheel RPM, and abrasive grit numberwere taken as input parameters while material removal rate (MRR) and average surface roughness were taken as output parameters. Result were shown that the HMP gives higher MRR with better surface finish as compared to the constituent processes. Pulse currentranging from 3 A to 21 A, pulse on-time ranging from 30 μs to 200 μs, and pulse off-time ranging from 15 μs to 90 μs were also found tobe more suitable for higher MRR, and a wheel RPM at 1300 RPM was more suitable for higher MRR with better surface finish.

Application of non-dominated sorting genetic algorithm for multi-objective optimization of electrical discharge diamond face grinding process

Ravindra Nath Yadav,Vinod Yadava,G. K. Singh 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.6

Hybrid machining processes (HMPs), having potential for machining of difficult to machine materials but the complexity and highmanufacturing cost, always need to optimize the process parameters. Our objective was to optimize the process parameters of electricaldischarge diamond face grinding (EDDFG), considering the simultaneous effect of wheel speed, pulse current, pulse on-time and dutyfactor on material removal rate (MRR) and average surface roughness (Ra). The experiments were performed on a high speed steel(HSS) workpiece at a self developed face grinding setup on an EDM machine. All the experimental results were used to develop themathematical model using response surface methodology (RSM). The developed model was used to generate the initial population for agenetic algorithm (GA) during optimization, non-dominated sorting genetic algorithm (NSGA-II) was used to optimize the process parametersof EDDFG process. Finally, optimal solutions obtained from pareto front are presented and compared with experimental data.