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Truong Van Tri,Al-Shakfa Fidaa,Roberge David,Masucci Giuseppina Laura,Tran Thi Phuoc Yen,Dib Rama,Yuh Sung-Joo,Wang Zhi 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.4
Study Design: Retrospective study.Purpose: The purpose of this study was to see how well the Tomita score, revised Tokuhashi score, modified Bauer score, Van der Linden score, classic Skeletal Oncology Research Group (SORG) algorithm, SORG nomogram, and New England Spinal Metastasis Score (NESMS) predicted 3-month, 6-month, and 1-year survival of non-surgical lung cancer spinal metastases.Overview of Literature: There has been no study assessing the performance of prognostic scores for non-surgical lung cancer spinal metastases.Methods: Data analysis was carried out to identify the variables that had a significant impact on survival. For all patients with spinal metastasis from lung cancer who received non-surgical treatment, the Tomita score, revised Tokuhashi score, modified Bauer score, Van der Linden score, classic SORG algorithm, SORG nomogram, and NESMS were calculated. The performance of the scoring systems was assessed by using receiver operating characteristic (ROC) curves at 3 months, 6 months, and 12 months. The predictive accuracy of the scoring systems was quantified using the area under the ROC curve (AUC).Results: A total of 127 patients are included in the present study. The median survival of the population study was 5.3 months (95% confidence interval [CI], 3.7–9.6 months). Low hemoglobin was associated with shorter survival (hazard ratio [HR], 1.49; 95% CI, 1.00–2.23; p =0.049), while targeted therapy after spinal metastasis was associated with longer survival (HR, 0.34; 95% CI, 0.21–0.51; p <0.001). In the multivariate analysis, targeted therapy was independently associated with longer survival (HR, 0.3; 95% CI, 0.17–0.5; p <0.001). The AUC of the time-dependent ROC curves for the above prognostic scores revealed all of them performed poorly (AUC <0.7).Conclusions: The seven scoring systems investigated are ineffective at predicting survival in patients with spinal metastasis from lung cancer who are treated non-surgically.
Hoan Minh Tran,Lan Ngoc Tan Phan,Thang Van Le,Thuy Thuy Truong,Tam Huu Nguyen,Khuong Tung Truong,Le-Thu T. Nguyen,Mai Thanh Phong,Ha Tran Nguyen 한국고분자학회 2019 폴리머 Vol.43 No.4
A novel organic photocatalyst, 4-(10H-phenothiazin-10-yl)-N,N-diphenylaniline (PDPA) has been successfully synthesized from triphenylamine and phenothiazine moiety via Buchwald-Hartwig C-N coupling. The chemical structure of catalyst was characterized via proton nuclear magnetic resonance (1H NMR) and the optical properties were investigated via UV-vis spectroscopy. The PDPA has been applied as an organic photocatalyst for metal free atom transfer radical polymerization (O-ATRP). The well-controlled molecular weights of polymethacrylates have been obtained with high yield of 95% and narrow polydispersity index (Đ).
High-Resolution Simulations for Vietnam - Methodology and Evaluation of Current Climate
Jack Katzfey,Kim Nguyen,John McGregor,Peter Hoffmann,Suppiah Ramasamy,Hiep Van Nguyen,Mai Van Khiem,Thang Van Nguyen,Kien Ba Truong,Thang Van Vu,Hien Thuan Nguyen,Tran Thuc,Doan Ha Phong,Bang Thanh Ng 한국기상학회 2016 Asia-Pacific Journal of Atmospheric Sciences Vol.52 No.2
To assist the government of Vietnam in its efforts to better understand the impacts of climate change and prioritise its adaptation measures, dynamically downscaled climate change projections were produced across Vietnam. Two Regional Climate Models (RCMs) were used: CSIRO’s variable-resolution Conformal-Cubic Atmospheric Model (CCAM) and the limited-area model Regional Climate Model system version 4.2 (RegCM4.2). First, global CCAM simulations were completed using bias- and variance-corrected sea surface temperatures as well as sea ice concentrations from six Coupled Model Intercomparison Project Phase 5 (CMIP5) global climate models. This approach is different from other downscaling approaches as it does not use any atmospheric fields from the GCMs. The global CCAM simulations were then further downscaled to 10 km using CCAM and to 20 km using RegCM4.2. Evaluations of temperature and precipitation for the current climate (1980-2000) were completed using station data as well as various gridded observational datasets. The RCMs were able to reproduce reasonably well most of the important characteristics of observed spatial patterns and annual cycles of temperature. Average and minimum temperatures were well simulated (biases generally less than 1oC), while maximum temperatures had biases of around 1oC. For precipitation, although the RCMs captured the annual cycle, RegCM4.2 was too dry in Oct.-Nov. (−60% bias), while CCAM was too wet in Dec.- Mar. (130% bias). Both models were too dry in summer and too wet in winter (especially in northern Vietnam). The ability of the ensemble simulations to capture current climate increases confidence in the simulations of future climate.
Orodispersible film incorporating nanoparticulate loratadine for an enhanced oral bioavailability
Van Nguyen Khanh,Dang Thu Kim,Vu Linh Thi Dieu,Ha Nhan Thi,Truong Hieu Duy,Tran Tuan Hiep 한국약제학회 2023 Journal of Pharmaceutical Investigation Vol.53 No.3
Purpose Loratadine (LOR), a commonly prescribed antihistamine, has low water solubility but high permeability. In this study, an orodispersible film incorporating the nanoparticulate loratadine was prepared to enhance the oral bioavailability of a poorly water-soluble drug. Methods Nanoparticulate loratadine was formulated using the antisolvent precipitation method and optimized by a singlefactor design based on the particle size and polydispersity index. The optimal formulation was spray-dried and characterized by powder X-ray diffraction and differential scanning calorimetry. Nanoparticulate loratadine was loaded into an orodispersible film using a solvent casting method. Results In the dissolution tests, the nanoparticulate loratadine-loaded orodispersible film exhibited a 6.5-fold higher dissolution rate than the pure loratadine-loaded film and a similar dissolution rate compared to the commercialized orodispersible tablet, Loratadine SPM. In pharmacokinetic studies conducted on rats, the maximum concentration (Cmax) and area under the curve of the plasma concentration–time profile from 0 to 24 h (AUC 0-24 h) of the nanoparticulate loratadine-loaded orodispersible film significantly increased 1.8-fold and 5.8-fold, respectively. The elimination half-life (t1//2) increased 5.1-fold compared to the loratadine-loaded counterpart. Conclusion These results suggest the potential of orodispersible films to improve the oral bioavailability of poorly watersoluble drugs and promote compliance in pediatric and geriatric patients.
China-ASEAN Trade Relations: A Study of Determinants and Potentials
TRAN, Hiep Xuan,HOANG, Nhan Thanh Thi,NGUYEN, Anh Thuy,TRUONG, Hoan Quang,DONG, Chung Van Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.9
The purpose of this study is to investigate the development and determinants of China-ASEAN trade relations over the period of 2000-2018. Employing both the qualitative and quantitative approaches, the results show that the trade relations between China and the Association of South East Asian Nations (ASEAN) have remarkably developed and rapidly grown over times, with a significantly important concentration on the segments of high technological and medium technological products. We also find that China's economic scale is crucially impacting on the China-ASEAN trade relations under both the aggregate and sub-sector level. It is interesting to notice that there is no evidence to support accession to the World Trade Organization (WTO) and officially forming of ASEAN-China Free Trade Agreement (ACFTA) to enhance trade relation between both sides. The findings also quantitatively indicate that there is much significant potential for the expansion of mutual trade between China and some members of ASEAN such as Brunei, Laos and Malaysia, while less potential is predicted for other members of ASEAN. It is strongly suggested that China and ASEAN should find a new proactive approach and make more efforts in improving the mutual political trusts to enhance trading activities in the coming years.
Tran Ha Thi Thanh,Dang Anh Kieu,Ly Duc Viet,Vu Hao Thi,Hoang Tuan Van,Nguyen Chinh Thi,Chu Nhu Thi,Nguyen Vinh The,Nguyen Huyen Thi,Truong Anh Duc,Pham Ngoc Thi,Dang Hoang Vu 아세아·태평양축산학회 2020 Animal Bioscience Vol.33 No.10
Objective: The rapid and reliable detection of the African swine fever virus (ASFV) plays an important role in emergency control and preventive measures of ASF. Some methods have been recommended by FAO/OIE to detect ASFV in clinical samples, including real-time polymerase chain reaction (PCR). However, mismatches in primer and probe binding regions may cause a false-negative result. Here, a slight modification in probe sequence has been conducted to improve the qualification of real-time PCR based on World Organization for Animal Health (OIE) protocol for accurate detection of ASFV in field samples in Vietnam. Methods: Seven positive confirmed samples (four samples have no mismatch, and three samples contained one mutation in probe binding sites) were used to establish novel real-time PCR with slightly modified probe (Y = C or T) in comparison with original probe recommended by OIE. Results: Both real-time PCRs using the OIE-recommended probe and novel modified probe can detect ASFV in clinical samples without mismatch in probe binding site. A high correlation of cycle quantification (Cq) values was observed in which Cq values obtained from both probes arranged from 22 to 25, suggesting that modified probe sequence does not impede the qualification of real-time PCR to detect ASFV in clinical samples. However, the samples with one mutation in probe binding sites were ASFV negative with OIE recommended probe but positive with our modified probe (Cq value ranked between 33.12-35.78). Conclusion: We demonstrated for the first time that a mismatch in probe binding regions caused a false negative result by OIE recommended real-time PCR, and a slightly modified probe is required to enhance the sensitivity and obtain an ASF accurate diagnosis in field samples in Vietnam.