Intravenous Flurbiprofen Axetil Enhances Analgesic Effect of Opioids in Patients with Refractory Cancer Pain by Increasing Plasma β-Endorphin

Wu, Ting-Ting,Wang, Zhi-Gang,Ou, Wu-Ling,Wang, Jun,Yao, Guo-Qing,Yang, Bo,Rao, Zhi-Guo,Gao, Jian-Fei,Zhang, Bi-Cheng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24

Background: The study aimed to investigate the analgesic effect of a combination of intravenous flurbiprofen axetil and opioids, and evaluate the relationship between refractory pain relief and plasma ${\beta}$-endorphin levels in cancer patients. Materials and Methods: A total of 120 cancer patients was randomly divided into two groups, 60 patients took orally morphine sulfate sustained-release tablets in group A, and another 60 patients receiving the combination treatment of intravenous flurbiprofen axetil and opioid drugs in group B. After 7 days, pain relief, quality of life improvement and side effects were evaluated. Furthermore, plasma ${\beta}$-endorphin levels were measured by radioimmunoassay. Results: With the combination treatment of intravenous intravenous flurbiprofen axetil and opioids, the total effective rate of pain relief rose to 91.4%, as compared to 82.1% when morphine sulfate sustained-release tablet was used alone. Compared with that of group A, the analgesic effect increased in group B (p=0.031). Moreover, satisfactory pain relief was associated with a significant increase in plasma ${\beta}$-endorphin levels. After the treatment, plasma ${\beta}$-endorphin level in group B was $62.4{\pm}13.5pg/ml$, which was higher than that in group A ($45.8{\pm}11.2pg/ml$) (p<0.05). Conclusions: Our results suggest the combination of intravenous flurbiprofen axetil and opioids can enhance the analgesic effect of opioid drugs by increasing plasma ${\beta}$-endorphin levels, which would offer a selected and reliable strategy for refractory cancer pain treatment.

Scavenging Effect of Extract from Perilla frutescens and Rosmarinic Acid from Free Radical and Lipid Peroxidation

Ting Ting Wu,Bo Ra Hwang,Eun Ju Cho 한국식품영양과학회 2011 Preventive Nutrition and Food Science Vol.16 No.3

The radical scavenging activity and inhibition effect from lipid peroxidation induced by peroxyl radical of methanol extract from Perilla frutescens and its active compound, rosmarinic acid (RA), were investigated in vitro. The treatment of extract and RA scavenged 1,1-diphenyl-2-picrylhydrazyl, hydroxyl radical (·OH) and nitric oxide in a concentration-dependent manner. In particular, the extract and RA showed strong radical scavenging activity against ·OH, the most toxic and reactive radical. In addition, Perilla frutescens and RA effectively inhibited lipid oxidation induced by sodium nitroprusside and 2, 2'-azobis(2-aminopropane) dihydrochloride, determined by the ferric thiocyanate method. The present results suggest that Perilla frutescens and RA play a protective role against oxidative stress induced by free radical and lipid peroxidation.

Scavenging Effect of Extract from Perilla frutescens and Rosmarinic Acid from Free Radical and Lipid Peroxidation

Wu, Ting Ting,Hwang, Bo-Ra,Cho, Eun-Ju The Korean Society of Food Science and Nutrition 2011 Preventive Nutrition and Food Science Vol.16 No.3

The radical scavenging activity and inhibition effect from lipid peroxidation induced by peroxyl radical of methanol extract from Perilla frutescens and its active compound, rosmarinic acid (RA), were investigated in vitro. The treatment of extract and RA scavenged 1,1-diphenyl-2-picrylhydrazyl, hydroxyl radical (${\cdot}OH$) and nitric oxide in a concentration-dependent manner. In particular, the extract and RA showed strong radical scavenging activity against ${\cdot}OH$, the most toxic and reactive radical. In addition, Perilla frutescens and RA effectively inhibited lipid oxidation induced by sodium nitroprusside and 2,2'-azobis(2-aminopropane) dihydrochloride, determined by the ferric thiocyanate method. The present results suggest that Perilla frutescens and RA play a protective role against oxidative stress induced by free radical and lipid peroxidation.

SIMPLE SYNTHESIS OF UNIFORM α-Fe2O3 MICROSPHERES WITH EXCELLENT PHOTOCATALYTIC PERFORMANCE USING POLY (N-VINYL-2-PYRROLIDONE)

TING-TING ZHANG,TING-TING GUO,ZHI-PING WU,SI-WEI YANG,ZHOU-FENG WANG,FANG LIAO 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2013 NANO Vol.8 No.5

In this paper, a new simple approach has been developed for the preparation of α-Fe2O3 microspheres by a facile hydrothermal method using PVP as a surfactant. Uniform α-Fe2O3 microspheres could be routinely synthesized through solvothermal approach by controlling the PVP/FeCl3⋅6H2O ratio. The as-obtained α-Fe2O3 microspheres exhibit high efficiency on the decolorization of RhB aqueous solution in the presence of H2O2 at room temperature.

Effects of STF and Fiber Characteristics on Quasi-Static Stab Resistant Properties of Shear Thickening Fluid (STF)-Impregnated UHMWPE/Kevlar Composite Fabrics

Ting-Ting Li,Wenna Dai,Liwei Wu,Hao-Kai Peng,Xiayun Zhang,Bing-Chiuan Shiu,Jia-Horng Lin,Ching-Wen Lou 한국섬유공학회 2019 Fibers and polymers Vol.20 No.2

In order to deeply explore the fiber characteristics influencing on stab resistance of shear thickening fluid (STF)-impregnated fabrics, two different weaving fabrics, ultra-high molecular weight polyethylene (UHMWPE) fabric and Kevlar fabrics are saturate the various concentrations and particle size of STFs. Result shows that, SiO2/PEG-200 blends demonstrate quick shear-thickening property, and the critical shear rate lowers to 1.2-45 s-1 with higher concentration of 75 nm SiO2. STF concentration and particle size significantly affect spike puncture resistance property, but the knife stab resistance mainly depends on fiber characteristics. Comparatively, STF-UHMWPE composite fabrics exhibit better knife stab resistance but weaker spike puncture resistance than STF-Kevlar fabrics. This study can provide an optimization for structure design of stab resistance armors in the future.

UHRF2 mRNA Expression is Low in Malignant Glioma but Silencing Inhibits the Growth of U251 Glioma Cells in vitro

Wu, Ting-Feng,Zhang, Wei,Su, Zuo-Peng,Chen, San-Song,Chen, Gui-Lin,Wei, Yong-Xin,Sun, Ting,Xie, Xue-Shun,Li, Bin,Zhou, You-Xin,Du, Zi-Wei Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10

UHRF2 is a member of the ubiquitin plant homeo domain RING finger family, which has been proven to be frequently up-regulated in colorectal cancer cells and play a role as an oncogene in breast cancer cells. However, the role of UHRF2 in glioma cells remains unclear. In this study, we performed real-time quantitative PCR on 32 pathologically confirmed glioma samples (grade I, 4 cases; grade II, 11 cases; grade III, 10 cases; and grade IV, 7 cases; according to the 2007 WHO classification system) and four glioma cell lines (A172, U251, U373, and U87). The expression of UHRF2 mRNA was significantly lower in the grade III and grade IV groups compared with the noncancerous brain tissue group, whereas its expression was high in A172, U251, and U373 glioma cell lines. An in vitro assay was performed to investigate the functions of UHRF2. Using a lentivirus-based RNA interference (RNAi) approach, we down-regulated UHRF2 expression in the U251 glioma cell line. This down-regulation led to the inhibition of cell proliferation, an increase in cell apoptosis, and a change of cell cycle distribution, in which S stage cells decreased and G2/M stage cells increased. Our results suggest that UHRF2 may be closely related to tumorigenesis and the development of gliomas.

Mitigating SYN flooding Attack and ARP Spoofing in SDN Data Plane

Ting-Yu Lin,Jhen-Ping Wu,Pei-Hsuan Hung,Ching-Hsuan Shao,Yu-Ting Wang,Yun-Zhan Cai,Meng-Hsun Tsai 한국통신학회 2020 한국통신학회 APNOMS Vol.2020 No.09

As the number of network devices increases rapidly, it becomes more and more difficult to defend network attacks. Large-scaled attacks, such as SYN flooding, may lead to heavy burden to the switches as well as the controller in a software defined network (SDN). In this paper, we investigate the SYN flooding and Address Resolution Protocol (ARP) spoofing attacks in SDN, and then propose mechanisms to address these two attacks. We also present a new scheme to detect SYN flooding by using only a few forwarding rules. Moreover, we utilize the Programming Protocol-independent Packet Processors (P4) technique to mitigate the burden of the controller.

Preparation and Mechanical Property Evaluations of Puncture-Resistant Insoles Composites Reinforced by High-Modulus Filament and Thermal Bonding

Ting-Ting Li,Fei Sun,Xing Liu,Hua-Ling Wu,Ching-Wen Lou,Jia-Horng Lin 한국섬유공학회 2018 Fibers and polymers Vol.19 No.6

High-modulus PET filaments and thermal bonding are used to reinforce the puncture resistance stability of the insole composite. This study aims to discuss the influences of the amount of low-melting-point polyester fibers (LMPET) and needle densities (ND) on tensile, bursting, and quasi-static puncture resistance properties. Besides, significance of LMPET amount and ND on puncture resistance against flat-head (A), spherical-head (B), and pointed-head (C) probes are in particular investigated to simulate the diversified application environments for insoles. Research result shows that, LMPET amount significantly affects the static puncture resistance against three probes; ND only significantly influences the puncture resistance against Probe A and C. Thermal bonding significantly improves the puncture strength against Probe B with various LMPET amounts of insoles, but evidently increases the puncture resistance against Probe A and C when being punched at various ND. The amount of LMPET fibers has a positive influence on the puncture strength of insoles, and 70 wt% of LMPET provide the average static puncture resistance up to 342.6 N. The high-modulus resultant insoles have advantages of flexibility, ease of process, and bendability with a higher and more stabilized puncture resistances.

Training-free neural architecture search: A review

Wu Meng-Ting,Tsai Chun-Wei 한국통신학회 2024 ICT Express Vol.10 No.1

The goal of neural architecture search (NAS) is to either downsize the neural architecture and model of a deep neural network (DNN), adjust a neural architecture to improve its end result, or even speed up the whole training process. Such improvements make it possible to generate or install the model of a DNN on a small device, such as a device of internet of things or wireless sensor network. Because most NAS algorithms are time-consuming, finding out a way to reduce their computation costs has now become a critical research issue. The training-free method (also called the zero-shot learning) provides an alternative way to estimate how good a neural architecture is more efficiently during the process of NAS by using a lightweight score function instead of a general training process to avoid incurring heavy costs. This paper starts with a brief discussion of DNN and NAS, followed by a brief review of both model-dependent and model-independent training-free score functions. A brief introduction to the search algorithms and benchmarks that were widely used in a training-free NAS will also be given in this paper. The changes, potential, open issues, and future trends of this research topic are then addressed in the end of this paper.

Fluorescence Characteristic Spectra of Domestic Fuel Products through Laser Induced Fluorescence Detection

Ting-Nien Wu,Shui-Ping Chang,Wen-Hsien Tsai,Cian-Yi Lin 한국지하수토양환경학회 2014 지하수토양환경 Vol.19 No.5

Traditional investigation procedures of soil and groundwater contamination are followed by soil gas sampling, soil sampling,groundwater sampling, establishment of monitoring wells, and groundwater monitoring. It often takes several weeks toobtain the analysis reports, and sometimes, it needs supplemental sampling and analysis to delineate the polluted area. Laserinduced fluorescence (LIF) system is designed for the detection of free-phase petroleum pollutants, and it is suitable for onsitereal-time site investigation when coupling with a direct push testing tool. Petroleum products always contain polycyclicaromatic hydrocarbon (PAH) compounds possessing fluorescence characteristics that make them detectable through LIFdetection. In this study, LIF spectroscopy of 5 major fuel products was conducted to establish the databank of LIFfluorescence characteristic spectra, including gasoline, diesel, jet fuel, marine fuel and low-sulfur fuel. Multivariate statisticaltools were also applied to distinguish LIF fluorescence characteristic spectra among the mixtures of selected fuel products. This study successfully demonstrated the feasibility of identifying fuel species based on LIF characteristic fluorescencespectra, also LIF seemed to be uncovered its powerful ability of tracing underground petroleum leakages.