Flexural behaviour of steel plate-masonry composite beams

Deng-Hu Jing,Shuang-Yin Cao,Lei Shi 국제구조공학회 2012 Steel and Composite Structures, An International J Vol.13 No.2

Steel plate-masonry composite structure is a newly-developed type of structural technique applicable to existing masonry buildings by which the load-bearing walls can be removed for large spaces. This kind of structure has been used in practice for its several advantages, but experimental investigation on its elements is nearly unavailable in existing literature. This paper presents an experimental study on the flexural behaviour of four steel plate-masonry composite beams loaded by four-point bending. Test results indicate that failure of the tested beams always starts from the local buckling of steel plate, and that the tested beams can satisfy the requirement of service limit state. In addition, the assumption of plane section is still remained for steel plate prior to local buckling or steel yielding. By comparative analyses, it was also verified that the working performance of the beam is influenced by the cross-section of steel plate, which can be efficiently enhanced by epoxy adhesive rather than cement mortar or nothing at all. Besides, it was also found that the contribution of the encased masonry to the flexural capacity of the composite beam cannot be ignored when the beam is injected with epoxy adhesive.

Experimental investigation of masonry walls supported by steel plate-masonry composite beams

Deng-Hu Jing,Jian-Fei Chen,Giuseppina Amato,Ting Wu,Shuang-Yin Cao 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.28 No.6

Masonry walls are sometimes removed in buildings to either make new passages or increase the usable space. This may change the loading paths in the structure, and require new beams to transfer the loads which are carried by the masonry walls that are to be removed. One possible method of creating such new beams is to attach steel plates onto part of the existing walls to form a steel plate-masonry composite (SPMC) beam, leading to a new structure with part of the masonry wall supported by a new SPMC beam. This paper presents an experimental investigation into the interaction between the SPMC beam and the masonry wall above. Five SPMC beams supporting a masonry wall were tested to study the influence of parameters including the height-to-span ratio of the masonry wall, height of the beam and thickness of the steel plates. The test results, including failure mode, load-carrying capacity, load-deflection curves and strain distribution, are presented and discussed. It is found that for developing better arching effect in the masonry wall the ratio of the in-plane flexural stiffness of the masonry wall to the flexural stiffness of the SPMC beam must be between 2.8 and 7.1.

MiR-214 inhibits apoptosis in thyroid epithelial follicular cells induced by amiodarone through the FASL/MAPK pathway

Wen Jing,Deng Chaonan,Shi Lixin,Zhou Shi,Zhang Miao,Hu Xiaoli,Wang Nianxue,Luo Lijuan 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.2

Background Hashimoto's thyroiditis (HT), also known as chronic lymphocytic thyroiditis, is one of the most common autoimmune disease (AITD) in clinical practice. It is urgent to explore the mechanism of amiodarone-induced thyroid dysfunction. Objective This study aims to assess the expression levels of miR-214 and FasL in amiodarone contact type of HT, and the effect of miR-214 on cell viability and apoptosis and potential mechanism. Results We found that miR-214 was low expressed in the tissues of amiodarone-treated thyroiditis patients. MiR-214 increased the survival rate of amiodarone-induced thyroid epithelial follicular cells and inhibited apoptosis. Mechanically, we found that miR-214 could bind to FASL and regulate MAPK signaling pathway through FASL. Conclusions Our results suggested that miR-214 could be a potential therapeutic target for Hashimoto's thyroiditis.

Research on the Construction of Evaluation Index System of Ideological and Political Teaching Ability of Professional Teachers in Colleges and Universities

邓晶(Jing Deng),张睦南(Munan Zhang),胡永娇(Yongjiao Hu),孙荣(Rong Sun) 아시아사회과학학회 2023 International Science Research Vol.3 No.2

摘要: 构建科学合理的高校专业课教师课程思政教学能力评价体系既是对高校专业课教师思政育人教学能力的全面检验,也是引导教师专业课课程思政能力提升的有效途径。本研究分析当前高校教师课程思政教学能力评价工作存在的突出问题,提出高校教师课程思政教学能力评价体系构建应建立在针对性原则、全局性原则、可操作性原则和发展性原则的基础上。从教学准备、教学实施、教学反思与交流三个维度,构建由 3 个一级指标,7 个二级指标,19 个三级指标组成的高校教师课程思政教学能力评价指标体系。 Constructing a scientific and reasonable evaluation system for professional course teachers' ideological and political teaching ability can not only test the teaching ability of professional course teachers, but also guide teachers to improve their ideological and political teaching ability.This study analyzes the outstanding problems existing in the evaluation of college curriculum ideological and political teaching ability, and proposes that the construction of the evaluation system of college teachers' curriculum ideological and political teaching ability should be based on the principle of pertinence, overall principle, operability principle and development principle.The evaluation is carried out from three dimensions: teaching preparation, teaching implementation, teaching reflection and communication.An evaluation index system of ideological and political teaching ability of college teachers is set up, which consists of 3 first-level indicators, 7 second-level indicators and 19 third-level indicators.

Application of High-speed Counter-current Chromatography for the Isolation of 5 Alkaloids from Lotus (Nelumbo nucifera Gaertn.) Leaves

Jiang-Ning Hu,Bin Shan,Ze-Yuan Deng,Jing Li,Ya-Wei Fan,Rong Liu,Zheng Ruan 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.6

A high-speed counter-current chromatography (HSCCC) method was developed for isolation of 5alkaloids from lotus (Nelumbo nucifera Gaertn.) leaves. The 2-phase solvent system of HSCCC composed of light petroleum-ethyl acetate-methanol-water was set up in 2-step separation process in the proportion of 3:5:3:5 for isolation of N-nornuciferine and armepavine, and in the proportion of 1:5:1:5 for that of anonaine, pronuciferine,and nuciferine. The purity of anonaine (14.6mg), pronuciferine (29.7 mg), N-nornuciferine (31.4 mg), nuciferine (22.1 mg),and armepavine (23.3 mg) isolated from 150 mg crude extract of lotus leaves were examined as 95.6, 88.2, 92.5,94.3, and 92.1%, respectively.

Methods on improvements of the poor oral bioavailability of ginsenosides: Pre-processing, structural modifi cation, drug combination, and micro- or nano- delivery system

Qi-rui Hu,Huan Hong,Zhi-hong Zhang,Hua Feng,Ting Luo,Jing Li,Ze-yuan Deng,Fang Chen 고려인삼학회 2023 Journal of Ginseng Research Vol.47 No.6

Panax ginseng Meyer is a traditional Chinese medicine that is widely used as tonic in Asia. The mainpharmacologically active components of ginseng are the dammarane-type ginsenosides, which havebeen shown to have anti-cancer, anti-inflammatory, immunoregulatory, neuroprotective, and metabolicregulatory activities. Moreover, some of ginsenosides (eg, Rh2 and Rg3) have been developed intonutraceuticals. However, the utilization of ginsenosides in clinic is restrictive due to poor permeability incells and low bioavailability in human body. Obviously, the dammarane skeleton and glycosyls of ginsenosidesare responsible for these limitations. Therefore, improving the oral bioavailability of ginsenosideshas become a pressing issue. Here, based on the structures of ginsenosides, we summarized theunderstanding of the factors affecting the oral bioavailability of ginsenosides, introduced the methods toenhance the oral bioavailability and proposed the future perspectives on improving the oral bioavailabilityof ginsenosides.

The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo.

Qi-rui Hu,Yao Pan,Han-cheng Wu,Zhen-zhen Dai,Qing-xin Huang,Ting Luo,Jing Li,Ze-yuan Deng,Fang Chen The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.2

Cancer is a global public health issue that becomes the second primary cause of death globally. Considering the side effects of radio- or chemo-therapy, natural phytochemicals are promising alternatives for therapeutic interventions to alleviate the side effects and complications. Ginsenoside Rh2 (GRh2) is the main phytochemical extracted from Panax ginseng C.A. Meyer with anticancer activity. GRh2 could induce apoptosis and autophagy of cancer cells and inhibit proliferation, metastasis, invasion, and angiogenesis in vitro and in vivo. In addition, GRh2 could be used as an adjuvant to chemotherapeutics to enhance the anticancer effect and reverse the adverse effects. Here we summarized the understanding of the molecular mechanisms underlying the anticancer effects of GRh2 and proposed future directions to promote the development and application of GRh2.

Reconstructed Adeno-Associated Virus with the Extracellular Domain of Murine PD-1 Induces Antitumor Immunity

Elhag, Osama A.O.,Hu, Xiao-Jing,Wen-Ying, Zhang,Li, Xiong,Yuan, Yong-Ze,Deng, Ling-Feng,Liu, De-Li,Liu, Ying-Le,Hui, Geng Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

Background: The negative signaling provided by interactions of the co-inhibitory molecule, programmed death-1 (PD-1), and its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2), is a critical mechanism contributing to tumor evasion; blockade of this pathway has been proven to enhance cytotoxic activity and mediate antitumor therapy. Here we evaluated the anti-tumor efficacy of AAV-mediated delivery of the extracellular domain of murine PD-1 (sPD-1) to a tumor site. Material and Methods: An rAAV vector was constructed in which the expression of sPD-1, a known negative regulator of TCR signals, is driven by human cytomegalovirus immediate early promoter (CMV-P), using a triple plasmid transfection system. Tumor-bearing mice were then treated with the AAV/sPD1 construct and expression of sPD-1 in tumor tissues was determined by semi quantitative RT-PCR, and tumor weights and cytotoxic activity of splenocytes were measured. Results: Analysis of tumor homogenates revealed sPD-1 mRNA to be significantly overexpressed in rAAV/sPD-1 treated mice as compared with control levels. Its use for local gene therapy at the inoculation site of H22 hepatoma cells could inhibit tumor growth, also enhancing lysis of tumor cells by lymphocytes stimulated specifically with an antigen. In addition, PD-1 was also found expressed on the surfaces of activated CD8+ T cells. Conclusion: This study confirmed that expression of the soluble extracellular domain of PD-1 molecule could reduce tumor microenvironment inhibitory effects on T cells and enhance cytotoxicity. This suggests that it might be a potential target for development of therapies to augment T-cell responses in patients with malignancies.

Staged Improvement in Awareness of Disease for Elderly Cancer Patients in Southern China

Li, Xing,Dong, Min,Wen, Jing-Yun,Wei, Li,Ma, Xiao-Kun,Xing, Yan-Fang,Deng, Yun,Chen, Zhan-Hong,Chen, Jie,Ruan, Dan-Yun,Lin, Ze-Xiao,Wang, Tian-Tian,Wu, Dong-Hao,Liu, Xu,Hu, Hai-Tao,Lin, Jia-Yu,Li, Zhu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

Background: In mainland China, awareness of disease of elderly cancer patients largely relies on the patients' families. We developed a staged procedure to improve their awareness of disease. Materials and Methods: Participants were 224 elderly cancer patients from 9 leading hospitals across Southern China. A questionnaire was given to the oncologists in charge of each patient to evaluate the interaction between family and patients, patient awareness of their disease and participation in medical decision-making. After first cycles of treatment, increased information of disease was given to patients with cooperation of the family. Then patient awareness of their disease and participation in medical decision-making was documented. Results: Among the 224 cancer elderly patients, 26 (11.6%) made decisions by themselves and 125 (55.8%) delegated their rights of decision-making to their family. Subordinate family members tended to play a passive role in decision-making significantly. Patients participating more in medical decision-making tended to know more about their disease. However, in contrast to the awareness of disease, patient awareness of violation of medical recommendations was reversely associated with their participation in medical decision-making. Improvement in awareness of diagnosis, stages and prognosis was achieved in about 20% elderly cancer patients. About 5% participated more actively in medical decision-making. Conclusions: Chinese elderly cancer patient awareness of disease and participation in medical decision-making is limited and relies on their family status. The staged procedure we developed to improve patient awareness of disease proved effective.