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Improving Interfacial Interactions of CF/PEEK Composites with Sulfonated Polyether Sulfone
Tianning Ren,Guangming Zhu,Xiaoming Ren,Renjie Tian,Ben Li 한국섬유공학회 2021 Fibers and polymers Vol.22 No.1
Due to the limitation of surface inertness and wettability of carbon fibers (CF), the adhesion between Poly(etherether-ketone) (PEEK) resin matrix and CF is poor, which reduces the mechanical properties of CF/PEEK composites. Inorder to improve the interfacial performance between PEEK matrix and carbon fiber fabric, sulfonated-polyether-sulfone (s-PSF) was coated as a sizing agent on the surface of the carbon fiber to construct CF/PEEK composite interface. On one hand,the formation of hydrogen bonds between s-PSF and activated CF increases the adhesion between s-PSF and fibers. On theother hand, Good compatibility between S-PSF and PEEK, which improves the interface performance between PEEK andCF. The results showed that the mechanical properties and interface properties of CF/PEEK composite prepared by modifiedCF were improved to some extent. The flexural strength, flexural modulus, impact strength and interlaminar shear strength ofthe materials were increased by 57.5 %, 16.7 %, 44.2 % and 39.7 %, respectively. By introducing s-PSF as sizing agent intoCF/PEEK composite interface, the comprehensive properties of the material were effectively improved.
Tian Yang,Hong Li,Tianjun Chen,Hui Ren,Puyu Shi,Mingwei Chen 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.3
This study was aimed to explore if lncRNA MALAT1 would modify chemo-resistance of non-small cell lung cancer (NSCLC) cells by regulating miR-197-3p and p120 catenin (p120-ctn). Within this investigation, we totally recruited 326 lung cancer patients, and purchased 4 NSCLC cell lines of A549, H1299, SPC-A-1 and H460. Moreover, cisplatin, adriamycin, gefitinib and paclitaxel were arranged as chemotherapies, and half maximal inhibitory concentration (IC50) values were calculated to evaluate the chemo-resistance of the cells. Furthermore, mice models of NSCLC were also established to assess the impacts of MALAT1, miR-197-3p and p120-ctn on tumor growth. Our results indicated that MALAT1 and miR-197-3p were both over-expressed within NSCLC tissues and cells, when compared with normal tissues and cells (P < 0.05). The A549, H460, SPC-A-1 and SPC-A-1 displayed maximum resistances to cisplatin (IC50 = 15.70 μg/ml), adriamycin (IC50 = 5.58 μg/ml), gefitinib (96.82 μmol/L) and paclitaxel (141.97 nmol/L). Over-expression of MALAT1 and miR-197-3p, or under-expression of p120-ctn were associated with promoted viability and growth of the cancer cells (P < 0.05), and they could significantly strengthen the chemo-resistance of cancer cells (P < 0.05). MALAT1 Wt or p120-ctn Wt co-transfected with miR-197-3p mimic was observed with significantly reduced luciferase activity within NSCLC cells (P < 0.05). Finally, the NSCLC mice models were observed with larger tumor size and weight under circumstances of over-expressed MALAT1 and miR-197-3p, or under-expressed p120-ctn (P < 0.05). In conclusion, MALAT1 could alter chemo-resistance of NSCLC cells by targeting miR-197-3p and regulating p120-ctn expression, which might assist in improvement of chemo-therapies for NSCLC.
In vitro Free Radical Scavenging and Hepatoprotective Compound from Sanguisorbae Radix
Ren-Bo An,Yu-Hua Tian,Hyuncheol Oh,Youn-Chul Kim 한국생약학회 2005 Natural Product Sciences Vol.11 No.3
In the course of searching for hepatoprotective agents from natural products, four compounds wereisolated from the MeOH extract of Sanguisorbae Radix, as guided by their DPPH free radical scavenging activity.The structures were determined as 4,5-dimethoxy-3-hydroxybenzoic acid methyl ester (1), (+)-gallocatechin (2),methyl 6-O-galloyl-β-D-glucopyranoside (3), and pomolic acid 3-O-[α O-[β-D-gluco-pyranosyl] ester (ziyu-glycoside I) (4). Compounds 2 and 3 showed significant DPPH fre radical scavengingefects, exhibiting IC50 values of 1.4 and 13.0M, respectively. L-Ascorbic acid was used as a positive controland exhibited the IC50 value of 50.3M. In evaluation of the hepatoprotective activity of the isolated compoundson drug-induced cytotoxicity, compound 2 50 value of91.84 ± 11.0M on tacrine-induced cytotoxicity in Hep G2 cells, while silybin, a positive control, exhibited EC50value of 122.4 ± 12.5M.
Secalonic acid D; A Cytotoxic Constituent from Marine Lichen-derived Fungus Gliocladium sp. T31
Ren, Hong,Tian, Li,Gu, Qianqun,Zhu, Weiming The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.1
Secalonic acid D(SAD) was isolated as the major secondary metabolite of the marine lichen-derived fungus Gliocladium sp. T31. Its structure was established on the basic of physicochemical and spectroscopic data. This is the first report on the isolation of SAD from this fungus, as well as its inhibitory effect on K562 cell cycle and its cytotoxicity against several tumor cell lines in vitro.
Tian, Fang-Shuo,Shen, Li,Ren, Yang-Wu,Zhang, Yue,Yin, Zhi-Hua,Zhou, Bao-Sen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14
N-acetyltransferase 2 (NAT2) is a polymorphic enzyme that plays an important role in the metabolism of various potential carcinogens. In recent years, a number of studies have been carried out to investigate the relationship between the rs1799930 and rs1799931 polymorphism in NAT2 and cancer risk in multiple populations for different types of cancer. However, the results were not consistent. Therefore, we performed a meta-analysis to further explore the relationship between NAT2 polymorphism and the risk of cancer. A total of 21 studies involving 15, 450 subjects for rs1799930 and 13, 011 subjects for rs1799931 were included in this meta-analysis. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess strength of associations. We also evaluated the publication bias and performed a sensitivity analysis. Overall, our results showed an apparent significant association between the NAT2 rs1799930 polymorphism and cancer susceptibility in Asians (GA vs. GG: OR=1.22, 95% CI=1.03-1.45; dominant model: OR=1.22, 95% CI=1.03-1.43) and population-based controls (GA vs. GG: OR=1.10, 95% CI=1.01-1.19; dominant model: OR=1.09, 95% CI=1.01-1.18). In contrast, a significant association was observed between the NAT2 rs1799931 G>A polymorphism and decreased cancer susceptibility in overall meta-analysis (AA vs. GG: OR=0.55, 95% CI=0.33-0.93; GA vs. GG: OR=1.00, 95% CI=0.88-1.14; dominant model: OR=0.97, 95% CI=0.86-1.10; recessive model: OR=0.56, 95% CI=0.34-0.94) and the Asian group (AA vs. GG: OR=0.50, 95% CI=0.26-0.94; recessive model, OR=0.50, 95% CI=0.27-0.94). We found that the NAT2 rs1799930 may be a risk factor, while the NAT2 rs1799931 polymorphism is associated with a decreased risk of cancer and is likely a protective factor against cancer development.
( Tian Yi Yan ),( Qiang Li ),( Kun Ru Ren ),( Yu Lin Wang ),( Lu Zou Zhang ) 한국농업기계학회 2012 바이오시스템공학 Vol.37 No.3
Purpose: In order to improve road-friendliness of heavy vehicles, a fuzzy hybrid control strategy consisting of a hybrid control strategy and a fuzzy logic control module is proposed. The performance of the proposed strategy should be effectively evaluated using a hardware-in-the-loop (HIL) simulation model of a semi-active suspension system based on the fuzzy hybrid control strategy prior to real vehicle implementations. Methods: A hardware-in-the-loop (HIL) simulation system was synthesized by utilizing a self-developed electronic control unit (ECU), a PCI-1711 multi-functional data acquisition board as well as the previously developed quarter-car simulation model. Road-friendliness of a semi-active suspension system controlled by the proposed control strategy was simulated via the HIL system using Dynamic Load Coefficient (DLC) and Dynamic Load Stress Factor (DLSF) criteria. Results: Compared to a passive suspension, a semi-active suspension system based on the fuzzy hybrid control strategy reduced the DLC and DLSF values. Conclusions: The proposed control strategy of semi-active suspension systems can be employed to improve road-friendliness of road vehicles.
Absorption of SO<sub>2</sub> at High Temperatures by Ionic Liquids and the Absorption Mechanism
Tian, Shidong,Hou, Yucui,Wu, Weize,Ren, Shuhang,Qian, Jianguo Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.9
The capture of $SO_2$ at or close to the temperatures of real flue gas is much more attractive in application. In this work, two kinds of ionic liquids (ILs) based on lactate anion were used to absorb $SO_2$ at high temperatures from 100 to $120^{\circ}C$. The ILs show high absorption capacities of over one mol $SO_2$ per mol IL at $110^{\circ}C$. The absorption of $SO_2$ by the ILs based on lactate anion is reversible and the ILs can be reused for the capture of $SO_2$ at high temperatures with high absorption capacity and thermal stability. Furthermore, the absorption mechanism of $SO_2$ by the ILs was studied by FT-IR, $^1H$ NMR and $^{13}C$ NMR spectra. It has been found that there are strong chemical interactions between the ILs and $SO_2$. Also the absorption mechanism is different when there is water present in ILs compared to when there is not.