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      • Determining the Predictors of Postpartum Depression in Vietnamese Women: Mediating Effect of Maternal Role Strain

        NGUYEN THI PHUONG THAO Garduate school, Inje university, Korea 2021 국내박사

        RANK : 247692

        Postpartum depression is a significant public health issue which has not only negative effects on maternal postpartum health but also on family relationship and infant growth and development. In Vietnam, postpartum depression is not usually cared in the community as well as in the health care system because it is insufficiently screened or diagnosed and followed up during the postpartum period. Moreover, there is very little research analyzing, predicting factors of postpartum depression. Especially there is less study of the mediating effects of maternal role strain among self-efficacy, social support, infant temperament, and postpartum depression in Vietnam. Moreover, the support of the theoretical model in which self-efficacy, social support, and infant temperament were linked to postpartum depression symptoms through their effects on maternal role strain is important both contribute to conceptual understanding of these processes and to seek effective interventions for postpartum depression in Vietnamese women. Thus, the purposes of this study are to identify the predictors for postpartum depression and determine the mediating effects of the maternal role strain on the relationship among the degree of self-efficacy, infant temperament, social support, and postpartum depression. Methods: The focus of correlational descriptive research design was performed on 190 mothers who were the first birth from four weeks to six months and be enrolled to give vaccination in 12 community health centers of Hue city in Vietnam. Data gathering tools included the “Perceived Self-Efficacy Scale”, “Maternal Social Support Scale”, “Difficult Infant Temperament Scale”, “Maternal Role Strain Scale”, and “Edinburgh Postnatal Depression Scale (EPDS)”. Data analysis was done by using the SPSS software, which was based on descriptive statistics and statistical independent t-test or one-way ANOVA test, mediation. These were tested by a series of multiple regressions by using Baron and Kenny methods. The Sobel test was used to test the significance of the mediating effects. Results: The prevalence of probable postpartum depression which had the EPDS score at or greater cut-off of 13 points was 18.9%. There were a significant differences between postpartum depression and mother’s occupation (t=-2.86, p=.005), relationship with her husband (F=5.91, p=.003), stressful life events (t=2.94, p=.004), paid maternity leave (F=6.83, p=.001), and gestational age (t=3.32, p=.001), history of mental health (t=3.86, p<.001), self-efficacy (r=-.15, p=.030), and social support (r=-.38, p<.001), infant temperament (r=.40, p<.001), and maternal role strain (r=.59, p<.001). Furthermore, there was identified paid maternity leave (β=-.16, p=.004), gestational age (β=.15, p=.005), history of mental health (β=-.19, p=.002), self-efficacy (β=.12, p=.031), and the maternal role strain (β=.47, p<.001) as the prediction of postpartum depression. The regression model with significant predictors explains 46% of the variance. As the mediating effects, maternal role strain had a full mediating effect on the relationship between self-efficacy and postpartum depression. Besides, maternal role strain was also a partial mediating effect on the relationship between maternal social support, infant temperament and postpartum depression among postpartum women. Conclusion: The findings of this study contribute to nursing science by identifying the mediating effects of maternal role strain on postpartum depression in Vietnam. Future research suggests solutions for professional experts of community mental health to develop effective intervention strategies which aims at the reduction of maternal role strain to decrease the impact of self-efficacy, social support, infant temperament on postpartum depression.

      • 베트남 초 중급 한국어 학습자의 관형사형 어미 오류 양상 및 교육 방안 연구 : ‘-(으)ㄴ, -는, -(으)ㄹ, -던’을 중심으로

        Thao, Pham Nguyen Yhanh 성균관대학교 일반대학원 2022 국내석사

        RANK : 247615

        베트남어에는 관형사형 어미가 존재하지 않으므로 모어가 베트남어인 한국어 학습자는 복문을 구성하는 데에 많은 어려움을 겪으며 오류가 빈번하게 발생하기도 한다. 그러므로 본고에서는 한국어의 관형사형 어미 ‘-(으)ㄴ, -는, -(으)ㄹ, -던’은 어떤 의미기능을 지니는지 고찰하였다. 일반적으로 관형사형 어미는 시제 범주로 해석되는데, 시제 측면에서 절대 시제 및 상대 시제로 분류할 수 있다. 더불어, 관형사형 어미가 상, 양태와 같은 문법 범주에서 해석될 수도 있기에 각 문법 범주에 따른 관형사형 어미의 의미기능이 달라지기도 하며, 이는 발화자의 의도에 의해 사용된다. 그리하여 한국어 학습자가 관형사형 어미를 정확하게 활용하기 위해 다면적 측면에서 관형사형 어미의 의미기능을 구체적이고 상세하게 학습할 필요가 있다. 우선 베트남인 초-중급 한국어 학습자가 작성한 작문을 수집하여 분석한 이후 관형사형 어미 ‘-(으)ㄴ, -는, -(으)ㄹ, -던’과 관련된 오류 양상을 밝혔다. 초급 학습자 및 중급 학습자가 가장 많이 범한 오류는 대치 오류에 관한 것이다. 이는 학습자가 각 관형사형 어미의 의미기능을 분명하게 파악하지 못해 잘못 사용한 것으로 보인다. 한국어에 미숙한 초급 학습자에서 대치 오류 외에 누락 오류, 첨가 오류 등과 같은 기타 오류가 많이 발생하였으나 중급 학습자에서는 이러한 오류가 일부분에서 미세하게 나타났다. 한국어 교재에 제시된 관형사형 어미는 그 내용이 보편적으로 시제나 상 범주에서 다뤄지고 있다. 그러나 양태 범주에 관한 의미기능을 제시하는 교재는 그 수가 많지 않았다. 또, 대다수의 교재에 주어진 관형사형 어미에 대한 예문들이 상대 시제로 해석되는 경우가 나타나는데, 이와 관련된 설명 내용이 기술되어 있지 않다. 이는 한국어 학습자가 관형사형 어미를 심층적으로 이해하는 데 저해하는 요인이 될 수 있다. 베트남인 한국어 학습자의 관형사형 어미에 관한 오류를 분석한 결과 및 네 종류의 한국어 교재에 제시된 관형사형 어미에 대한 교육 내용을 탐구한 결과를 바탕으로 관형사형 어미에 대한 교육 방안을 모색하는 동시에 지도 방안을 제시하였다. 초급 한국어 학습자의 경우 관형사형 어미에 대한 인식이 부족하고 한국어 교재에 내용이 제시되지 않으므로 관형사형 어미의 불규칙성 및 제약과 관련된 오류가 많이 발생하였기 때문에 이에 대한 교육 방안을 모색하였다. 관형사형 어미 ‘-(으)ㄴ’에 관한 오류가 가장 많이 발생하였기에 이에 대한 교안을 제시하기도 하였다. 중급 한국어 학습자가 빈번하게 범한 오류는 관형사형 어미 ‘-(으)ㄴ, -던, -었던’을 명백하게 구별하지 못해 나타난 것으로 분석되었다. 따라서 ‘-(으)ㄴ, -던, -었던’의 의미기능에 대한 차이를 교육하는 방안 및 교안을 제시하였다. 아울러, 한국어 교재에 나타난 예문에서 상대 시제로 보는 경우가 적지 않으므로 관형사형 어미와 관련된 상대 시제를 교육하는 것이 필요하다고 생각되어 이에 대한 교육방안 및 교안을 제시하기도 하였다. 뿐만 아니라 중급 후반에서 고급으로 올라갈 학습자가 관형사형 어미 상적-양태적 의미기능을 터득해야 오류를 예방할 수 있으며 상황 맥락과 적절하고 정연한 복합 문장도 완성할 수 있을 것이므로 상 및 양태 범주에서 관형사형 어미에 대한 교육 방안과 교안도 제시하였다. Since Vietnamese does not have an adjective ending, Korean learners whose mother tongue is Vietnamese have a lot of difficulty in constructing complex sentences, and errors frequently occur. Therefore, in this paper, the meanings and functions of the Korean adjective endings ‘-n, -neun, -l, -deon’ were examined. In general, adjective endings are interpreted as tense categories, and in terms of tense, they can be classified into absolute and relative tenses. In addition, in that it is possible that the adjective endings can be interpreted in grammatical categories such as images and modes, these mantic function of the adjective endings varies according to each grammatical category, so it is used according to the intention of the speaker. Therefore, it is necessary for Korean learners to learn the semantic functions of the adjective endings in detail in a multifaceted way in order to use the adjective endings accurately.   First of all, after collecting and analyzing compositions written by Vietnamese elementary-intermediate Korean learners, errors related to the adjective endings ‘-n, -neun, -l, -deon’ were revealed. The most common errors made by beginner and intermediate learners are substitution errors. In other words, it seems that the learner did not clearly grasp the semantic function of each adjective ending and used it incorrectly. In addition to substitution errors, other errors such as omission errors and addition errors occurred in beginner learners who are not fluent in Korean, but intermediate learners showed minor errors in some parts.   The contents of the adjective endings presented in Korean textbooks are generally dealt with in the tense or figurative category, but there are only a few textbooks that suggest the semantic function of the modal category. Also, there are cases where the example sentences for the adjective ending given in most textbooks are interpreted in the relative tense, but the related explanations are not described. This may be a factor that hinders Korean learners from comprehending in-depth knowledge about adjective endings.   Based on the results of analyzing the errors of Vietnamese Korean learners regarding the adjective endings and the educational contents of the adjective endings presented in four types of Korean textbooks, the educational plan for the adjective endings was sought and guidance methods were suggested.   In the case of beginner Korean learners, there were a lot of errors related to irregular endings and restrictions due to the lack of awareness of the adjective endings and the contents not presented in Korean textbooks. Because the most common errors related to the adjective ending ‘-n’ occurred, so a guidance plan was suggested as well.   The semantic function of ‘-n, -deon, -atdeon’ in that the error frequently made by intermediate Korean learners is the misuse of the adjective endings ‘-n, -deon, -atdeon’ 'because they could not clearly distinguish them. Methods and teaching plans for educating the differences in In addition, since there are not many cases of using the relative tense in the example sentences shown in Korean textbooks, it was thought that it was necessary to educate the relative tense related to the adjective ending. In addition, since learners who will advance from the intermediate to advanced level must master the tubular suffix-modal semantic function, errors can be prevented, and they will be able to complete complex sentences appropriate and orderly with the context of the situation. and teaching instructions were also presented.

      • Rural Development Policy in Korea Lessons for Vietnam

        Tru Phuong Thao 강원대학교 대학원 2008 국내석사

        RANK : 247373

        The main objective of the study is to understand the Korean experience in fostering rural development policy for the development of rural society in Vietnam. Based on the theoretical background of integrated development system comprising the top-down and bottom-up approach, the characteristics of Korean rural development policy has been built. The bottom-up approach in rural Korea is highlighted through the Rural Community Based Development (RCBD). The current rural situation in Korea, the changes, the basic trend as well as evaluation and future directions of rural development policy in Korea will be studied to make clear of the characteristics of integrated development approach. Case studies will be given by the two very popular rural development models namely Saemaul Undong (New Village Movement) and Rural Community Renewal Campaign (RCRC). Problem of rural development policy as well as the practice of Saemaul Undong in Vietnam will also be discussed. Eventually, the study will come up with solutions for Vietnam’s rural development policy, they are: The combination of supports from the Government and the self-help incentive of rural people by mobilizing their own resources. Rural infrastructure is also an initial must in rural development projects, and last but not least is the importance of rural human resource in creating a sustainable rural society.

      • Accelerating the evolution of bacteriophages targeting Acinetobacter baumannii in host range expansion and determination of its background genetic mechanisms

        Vu Thao Nguyen Graduate School, Yonsei University 2024 국내박사

        RANK : 247359

        Prior to the discovery and widespread use of antibiotics, bacteriophages (phages) were a potential solution for preventing and treating bacterial infections (1, 2). With the emergence of antimicrobial resistance, there has been a renewed interest in phages (3). However, a major limitation to using phage as therapy is their narrow host range, limiting their effectiveness to specific bacterial strains of the same species (4). To address this limitation, phage training, such as Appelmans protocol, has been proposed as a strategy for expanding the host range of phages (5). Despite its potential, there are currently no reports of the protocol being applied to phages targeting Acinetobacter baumannii, an opportunistic pathogen responsible for a variety of hospitalacquired infections with high mortality rate (6). The aims of my dissertation were to apply the Appelmans protocol for expanding the host range of a phage cocktail targeting A. baumannii and evaluate the therapeutic potential of the expanded host range phages generated from the protocol. Additionally, the genetic mechanism underlying the protocol was also investigated to gain insights into its effectiveness. Chapter I provides a brief overview of Acinetobacter baumannii and highlights the significant global concern surrounding carbapenem-resistant A. baumannii (CRAB) strains. Furthermore, it introduces the fundamental background on bacteriophages and phage therapy, along with their limitations and discusses various approaches to overcome these challenges. Chapter II describes the application of the Appelmans protocol as a host range expansion method to broaden the host range of a phage cocktail targeting CRAB. The assessment of the host range expansion covered both the output cocktail and individual phage clones generated from the method. While the protocol consistently demonstrated the capability to expand the host range of the cocktail, it faced challenges when dealing with CRAB strains. Chapter III delves into the screening and characterization process used to identify potential therapeutic phages. The focus was on evaluating individual phage clones generated from the Appelmans protocol for therapeutic applications. Throughout the evaluation, key factors such as host range stability,lytic growth, transduction potential, and the absence of toxin genes were rigorously examined. However, it is noteworthy that the expanded host range phages obtained from this protocol exhibited limited stability, raising concerns about their suitability for therapeutic purposes. Chapter IV discusses the genetic insights into the Appelmans protocol’s mechanism, not only based on previous studies involving phages targeting different bacterial species but also when applied to the phage cocktail targeting CRAB. A bioinformatics workflow was established to analyze the ancestral of the expanded host range generated from the protocol and the finding revealed that they were recombinant derivatives of prophages induced from encountered bacterial strains. Favorable conditions and explanations for prophage induction during this protocol were proposed to support this genetic mechanism. In conclusion, this dissertation focused on the potential and challenges of a phage training method, especially, the Appelmans protocol in expanding the host range of phages for therapeutic applications. The findings emphasize the importance of understanding the genetic mechanisms underlying phage-host interactions to optimize phage therapy strategies for combating antibioticresistant bacterial infections. Parts of this dissertation are adapted from Vu TN, Clark JR, Jang E, D'Souza R, Nguyen LP, Pinto NA, et al. Appelmans protocol - A directed in vitro evolution enables induction and recombination of prophages with expanded host range. Virus Res. 2023;339:199272.

      • MOMENTUM AND CONTRARIAN STRATEGIES EVIDENCE IN VIETNAM STOCK MARKET : 베트남 주식시장의 계속투자전략 및 반전투자전략의 성과

        THAO, NGUYEN THI PHUONG 안동대학교 대학원 2009 국내석사

        RANK : 247359

        The past return-based investment strategies have been employed for many decades ago by many practitioners and scholars, such as contrarian and momentum strategies so these strategies have been investigated extensively by academics and scholars all over the world in recent years. They showed that average stock returns are concerned to past performance and stock returns are predictable based on past returns. A number of scholars reported that past losers (lowest return-stocks) outperform past winners (highest return-stocks) or vice versa. This study mainly investigates the investment performance of momentum strategy and contrarian strategy in Vietnam stock market from January, 2004 to March, 2008 by using the same empirical methodology in Jegadeesh and Titman (1993). In this paper, I examine whether the momentum strategy and contrarian strategy can create significant return. Additionally, I investigate whether holding period influences the momentum and contrarian profits. Finally, I examine the relationship between trading volume and momentum profits. The empirical results show that during the period January, 2004 to March, 2008 momentum strategy works effectively over the horizon of 1, 5, 10, 20, 60 and 90 days, meanwhile, no contrarian strategy can make significant profit during the same horizon, which is quite different from other developed stock markets. Moreover, the results suggest that in Vietnam stock market it is better to limit the holding period in short term because momentum profit will decrease rapidly when holding period is longer and the best choice is limiting the trading and holding period to 5 days. Additionally, I find that buying high-volume winners and selling high-volume losers is more profitable than buying low-volume winners and selling low-volume losers. 계속투자전략 및 반전투자전략과 같은 과거성과에 기초한 투자전략은 오랫동안 많은 학계 및 실무계에서 연구되어 왔다. 연구 결과, 평균주식수익률이 과거성과와 관계가 있으며, 과거수익률에 기초하여 주식수익률을 예측할 수 있는 것으로 나타나고 있다. 몇몇 연구들은 과거 패자(최저수익률을 갖는 주식)가 과거 승자(최고수익률을 갖는 주식)보다 더 나은 성과를 올리거나 과거 승자가 과거 패자보다 더 나은 성과를 올린다고 제시하였다. 본 연구는 2004년 1월부터 2008년 3월까지 베트남 주식시장에서 Jegadeesh and Titman (1993)의 분석방법을 사용하여 계속투자전략과 반대투자전략의 투자성과를 분석한다. 본 연구에서 계속투자전략 및 반전투자전략이 유의한 수익률을 올리는가를 살펴본다. 또한 보유기간이 계속투자전략 및 반전투자전략의 이익에 영향을 미치는가를 분석한다. 마지막으로 거래량과 계속투자이익간의 관계를 분석한다. 실증분석 결과, 표본기간 동안 계속거래전략은 1, 5, 10, 20, 60 및 90일의 포트폴리오 구성 및 보유기간 동안 유의한 성과를 올리는 반면에 반전거래전략은 동일한 기간 동안 유의한 성과를 올리지 못하는 것으로 나타났다. 이러한 결과는 다른 선진국 시장을 대상으로 한 연구결과와는 차이가 있다. 게다가, 이런 결과는 베트남주식시장에서 보유기간이 길어짐에 따라 계속거래전략의 이익이 급격하게 감소하므로 보유기간을 제한하는 것이 더 바람직하며, 최선의 선택은 보유기간을 5일 이내로 제한하는 것임을 제시한다 거래량이 많은 주식으로 구성되는 승자포트폴리오를 매입하고 그렇지 않은 주식으로 구성되는 패자포트폴리오를 매도하는 것이 승자포트폴리오를 매도하고 패자포트폴리오를 매입하는 것보다 더 큰 이익을 창출하는 것을 발견하였다.

      • Functional and topological modularity of disease genes explain comorbidity of human genetic diseases

        Thao, Bui Phuong Pohang University of Science and Technology 2014 국내석사

        RANK : 247359

        Molecular connection is primary mechanism for comorbidity of distinct diseases in population. However, molecular connection allows only partial explanation of disease comorbidity, for two main reasons. First, disease is consequence of perturbation in group of genes rather than in single gene. Secondly, single gene may contribute to multiple cellular functions whose perturbations lead to unrelated diseases. While the role of various molecular connections in disease comorbidity is well studied, the contribution of modularity of disease genes has remained unclear. Here, we report that the modularity of disease causing genes impacts comorbidity of associated disease pairs. Modularity is the cause of low comorbidity among molecular connected disease pairs and high comorbidity among molecular disconnected disease pairs. Modularity of genes successfully increases the coverage of comorbid disease pairs explained. Furthermore, it improves prediction performance for significant comorbidity of human genetic diseases. Our study highlights the role of modularity of disease genes in understanding the manifestation of related diseases in human population and its implication toward bridging the gap in molecular and phenotypic connections.

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