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Tao Tong,고두옥,김보섭,함경식,강성국 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.6
Effect of extracts from Capsosiphon fulvescens, Hizikia fusiforme, and Undaria pinnatifida blades on development of oxidative stress and insulin resistance in rats fed a high-fat diet (HFD) were studied. Sprague-Dawley rats were fed a normal diet, HFD, and HFD-supplemented with C. fulvescens, H. fusiforme, or U. pinnatifida blades for 8 weeks. Supplementation with C. fulvescens and H. fusiforme extracts significantly (p<0.05) elevated the plasma HDL-cholesterol concentration in HFD-fed rats, compared with controls. The plasma thiobarbituric acid reactive substance level was significantly (p<0.05) lower in H. fusiforme and U. pinnatifida blade group rats than in HFD group rats. C. fulvescens, H. fusiforme, and U. pinnatifida blade extracts significantly (p<0.05) attenuated the effects of the HFD on plasma total antioxidant and superoxide dismutase activities, and on development of insulin resistance. Consumption of seaweed extracts increased antioxidant effects and improved insulin resistance in HFD-fed rats.
Tao Tong,Jinglei Li,고두옥,김보섭,Chengmei Zhang,함경식,강성국 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.6
Hizikia fusiforme, Capsosiphon fulvescens,Undaria pinnatifida sporophyll, and Undaria pinnatifidablade extracts were evaluated for in vitro antioxidant andantihyperglycemic activities. Seaweed extracts containedhigh levels of phenolic compounds (12.44 to 39.01 mg ofgallic acid equivalents/g of extract) and exhibited multipleantioxidant activities. Extracts showed weak inhibition ofα-amylase. However, all extracts showed pronouncedinhibition of α-glucosidase with EC50 values from 2.56 to18.81 mg/mL. U. pinnatifida sporophyll and U. pinnatifidablade extracts both contained protocatechuic and syringicacids. p-Coumaric and ferulic acids were detected only inthe H. fusiforme extract. Caffeic acid and epicatechin werethe dominant phenoilc acids found in C. fulvescensextracts. A basis for further research is provided to establishthe capability of seaweed extracts as hypoglycemic agentsor functional food ingredients.
Significance of Caveolin-1 Regulators in Pancreatic Cancer
Chen, Tao,Liu, Liang,Xu, Hua-Xiang,Wang, Wen-Quan,Wu, Chun-Tao,Yao, Wan-Tong,Yu, Xian-Jun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8
Caveolin-1 is a scaffold protein on the cell membrane. As the main component of caveolae, caveolin-1 is involved in many biological processes that include substance uptake and transmembrane signaling. Many of these processes and thus caveolin-1 contribute to cell transformation, tumorigenesis, and metastasis. Of particular interest are the dual rolesof tumor suppressor and oncogene that caveolin-1 appear to play in different malignancies, including pancreatic cancer. Therefore, analyzing caveolin-1 regulators and understanding their mechanisms of actionis key to identifying novel diagnostic and therapeutic tools for pancreatic cancer. This review details the mechanisms of action of caveolin-1 regulators and the potential significance for pancreatic cancer treatment.
Tao Fei,Darren Jarboe,Tong Wang 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.57 No.-
A soybean oil-based carnauba substitute was developed, and structure–function relationships wereestablished. Amide derivatives of saturated fatty acid showed higher hardness and melting point thanester derivatives having the same chain length. Increasing chain length using diacids increased hardness. The cinnamic ring was confirmed to contribute to surface shininess and smoothness. The addition oflong-chain fatty alcohols increased the hardness of a C52 (carbon chain length of 52) diester. Overall, amaterial consisted of C52 polyamide (76.3 wt%), C38 diamide (11.3 wt%), and C29 diamide with a ringstructure (12.4 wt%) showed comparable hardness and surface properties as carnauba wax.
Tong Wang,Tao He,Hongjing Li 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.59 No.6
Elastic constraints are usually simplified as “spring forces” exerted on beam ends without considering the “spring deformation”. The partial differential equation governing the free vibrations of a cantilever Bernoulli-Euler beam considering the deformation of elastic constraints is firstly established, and is nondimensionalized to obtain two dimensionless factors, κv and κr, describing the effects of elastically vertical and rotational end constraints, respectively. Then the frequency equation for the above Bernoulli- Euler beam model is derived using the method of separation of variables. A numerical analysis method is proposed to solve the transcendental frequency equation for the continuous change of the frequency with κv and κr. Then the mode shape functions are given. Finally, effects of κv and κr on free vibration characteristics of the beam with different slenderness ratios are calculated and analyzed. The results indicate that the effects of κv are larger on higher-order free vibration characteristics than on lower-order ones, and the impact strength decreases with slenderness ratio. Under a relatively larger slenderness ratio, the effects of κv can be neglected for the fundamental frequency characteristics, while cannot for higher-order ones. However, the effects of κr are large on both higher- and lower-order free vibration characteristics, and cannot be neglected no matter the slenderness ratio is large or small.