만화 과제를 이용한 정신분열병 환자의 사회인지 능력의 측정

오정은,나명현,하태현,신용욱,노규식,홍순범,이경진,신민섭,이영호,권준수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.3

Objectives : This study is to investigate the hypothesis that schizophrenic patients have difficulty in inferring mental state of others. Methods : Twenty schizophrenic patients and twenty normal subjects were administered to the Cartoon Task required inferring the character's intention in a given context. Results : The schizophrenic patients showed a statistically significant impairment in the Cartoon Task. Both groups chose the card depicting a frequent everyday action significantly more rather than the similar card to the last picture in each story for wrong answers. Conclusion : These preliminary results suggest that schizophrenia is associated with a specific deficit of the cognitive ability referred to as social cognition, and this deficit can be detected not only in the acute phase as found in previous research studies, but also in remission. Also when subjects fail to appreciate what is going on in the minds of other people, they seem to rely on a socially familiar experience.

White matter alterations in male patients with obsessive–compulsive disorder

Ha, Tae Hyon,Kang, Do-Hyung,Park, Jun Sung,Jang, Joon Hwan,Jung, Wi Hoon,Choi, Jung-Seok,Park, Ji-Young,Jung, Myung Hun,Choi, Chi-Hoon,Lee, Jong-Min,Ha, Kyooseob,Kwon, Jun Soo Lippincott Williams Wilkins, Inc. 2009 NEUROREPORT - Vol.20 No.7

To investigate white matter abnormalities in patients with obsessive–compulsive disorder and to clarify the relationship between discrete white matter alterations and obsessive–compulsive symptom dimensions, the fractional anisotropy obtained from 25 male patients and 25 matched normal controls were analyzed. The patients had a significantly lower fractional anisotropy in the left anterior cingulate white matter than the controls. When stratified by clinical symptom dimensions, patients with a predominant aggressive/checking symptom dimension exhibited a significantly lower fractional anisotropy in the left anterior cingulate white matter, whereas patients with a predominant contamination/cleaning symptom dimension showed a significantly higher fractional anisotropy in the bilateral prefrontal white matter. Our findings provide evidence that obsessive–compulsive disorder may be a heterogeneous disease with distinct white matter changes.

양극성장애와 성격장애의 경계

하태현(Tae Hyon Ha) 대한신경정신의학회 2018 신경정신의학 Vol.57 No.4

The concept of bipolar spectrum disorder (BSD) has developed to include affective temperaments such as cyclothymia and hyperthymia. This has greatly helped clinicians to differentiate depressed patients, who would potentially benefit from mood stabilizing treatment, from those with unipolar depression. Cyclothymia, however, has significant similarities with personality disorders, especially with borderline personality disorder (BPD). All the diagnostic items for BPD are frequently found in patients with BSD as well, which presents diagnostic challenges. There are no clear guidelines on how to differentiate BSD from BPD. Featuring borderline pathology for clinical purposes, it may be useful to rely on psychodynamic approaches to identify primitive defense mechanisms of splitting and projective identification suggesting borderline personality organization. Based on new findings on common features between BSD and BPD, some authors have proposed a renewal of the classification system of mental disorders. The dichotomy of bipolar and unipolar depression has gestated a new concept of BSD. Currently, the BSD concept forced us to formulate the border of BSD and personality disorders.

Effect of Home-based Self-administered Transcranial Direct Stimulation in Patients with Mild to Moderate Major Depressive Disorder: A Single-arm, Multicentral Trial

Jihoon Oh(Jihoon Oh),Sekye Jeon(Sekye Jeon),Tae Hyon Ha(Tae Hyon Ha),Woojae Myung(Woojae Myung),Seung-Hwan Lee(Seung-Hwan Lee),Young-Hoon Ko(Young-Hoon Ko),Do Hoon Kim(Do Hoon Kim),Hwa-Young Lee(Hwa-Y 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2

Objective: Although the effects and safety of transcranial direct current stimulation (tDCS) treatment in depressive patients are largely investigated, whether the self-administration of tDCS treatment at patient’s home is comparable to clinic-based treatment is still unknown. Methods: In this single-arm, multi-center clinical trial, 61 patients with mild to moderate major depressive disorder were enrolled. tDCS treatment was delivered at the patient’s home once a day, 5 to 7 times a week for 6 weeks, and each session lasted for 30 minutes. The primary outcome was a total Beck-Depression Inventory-II score, and no concurrent antidepressants were used. Results: The remission rates in both Full-Analysis (FA) (n = 61) and Per-Protocol (PP) (n = 43) groups were statistically significant (FA: 57.4% [0.44−0.70], PP: 62.8% [0.47−0.77]; percent [95% confidence interval]). The degree of depression- related symptoms was also significantly improved in 2, 4, and 6 weeks after the treatment when compared with baseline. There was no significant association between treatment compliance and remission rate in both FA and PP groups. Conclusion: These results suggest that acute treatment of patient-administered tDCS might be effective in improving the subjective feeling of depressive symptoms in mild to moderate major depressive disorder patients.

간이지능평가 도구로서의 전산화 Standard Progressive Matrices의 타당도 검증 및 임상적용에 관한 연구

하태현,유한익,윤화영,송정연,홍경수,정도언,김중술,하규섭 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.6

연구목적 : 신경정신장애를 가진 환자들을 대상으로 간이지능평가 도구로서 전산화 Standard Progressive Ma-trices(이하 SPM)의 타당도를 검증하고. 표준화가 필요한 대상군을 파악하며 임상적-유용성을 확인하고자 본 연구를 수행하였다. 방 법: 신경정신장애를 가진 166명의 환자를 대상으로 비엔나 총집 중 SPM으로 평가하여 추정한 지능지수와 한국판-웩슬러 성인용지능검사(이하 KWAIS)로 평가한 지능지수간의 일치하는 정도와 상관관계를 전체대상군. 성별. 연령별, 학력별, 그리고 진단별로 검증하였다. 또한 중다회귀분석을 이용하여 SPM기초점수로부터 지능지수를 산출해내는 수식을 얻었다. 결 과: 전체 대상군에서 SPM으로 추정한 지능지수와 KWAI을로 평가한 지능지수 사이의 Pearson 상관계수는 0.704로서 높은 상관관계를 보였다. 전체 대상군의 54.8%에서 양 지능지수간 차의 절대치가 10 이하 였다. 연령과 교육정도는 양 지능지수간의 일치 정도에 영향을 미쳤다 연령과 교육정도가 낮은 경우에는 SPM 추정 지능지수가 KWAIS 지능지수보다 높았고. 연령과 교육정도가 높은 경우에는 SPM 추정지능지수가 KWAIS 지능지수보다 낮아지는 경향이 있었다. BPM 기초점수, 연령, 그리고 학력으로부터 중다회귀분석을 통해 얻어낸 수식으로 KWAIS 지능지수를 보다 더 정확하게 예측할 수 있었다. 결 론: 전산화 SPM은 신경정신과 환자들의 간이지능평가 도구로서 유용하게 사용될 수 있다. 전산화 SPM이 보다 더 유용하게 사용되기 위해서는 16세에서 25세 사이, 중졸 이하의 26세에서 35세 사이를 대상으로한 표준화 연구가 시급하다. 0bjective : We examined the difference between IQ(Intelligence Quotient) estimated from computerized Standard Pogressive Matrices(SPM) score(SPM IQ) and Korean-Wechsler Adult Intelligence Scale(KWAIS) IQ(KWAIS IQ) in Korean patients with mental disorders in order to test the validity of SPM as a brief nonverbal intelligence test, and to find the groups that need standardization. And, we studied the method to predict KWAIS IQ more precisely from SPM test. Methods : SPM test in Vienna test system was administered to 166 Korean patients with mental disorders. The degree of consistency and Pearson's correlation coefficient between SPM IQ and KWAIS IQ in total subjects and groups by sex, age, education, and clinical diagnosis were investigated. And, we obtained a recession equation to predict KWAIS IQ from SPM score. Results : In total subjects, Pearson's correlation coefficient between SPM IQ and KWAIS IQ was as high as 0.704, and the percent of patients whose absolute value of difference between SPM IQ and KWAIS IQ is equal to or less than 10 was 54.8%. The degree of consistency between SPM IQ and KWAIS IQ was influenced by age and educational level. SPM IQ were higher than KWAIS IQ in younger age and lower education group. SPM IQ were lower than KWAIS IQ in older age and higher education group. The regression equation from SPM score, age, and education years predicted KWAIS IQ more correctly. Conclusion The Computerized Standard Progressive Matrices test is validated and can be used usefully as a brief nonverbal intelligence test in patients with mental disorders. In order to provide more precise evaluation, standardized data should be prepared for age group 16 to 25 and age group 26 to 35 with lower educational level.

강박장애의 증상차원과 공존 인격병리의 관련성에 관한 연구

하태현,윤탁,노규식,김명선,권준수 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.1

Internal Energy Distributions of OH Products in the Reaction of O(3PJ) with HSiCl3

Hyon Tae Kwak,Seung Chul Ha,Sungwoo Jang,Hong Lae Kim,Chan Ryang Park 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.2

The OH(X2Π, υ"=0, 1) internal state distributions from the reaction of electronically ground state oxygen atoms with HSiCl3 were measured using laser-induced fluorescence. The ground-state O(3PJ) atoms with kinetic energies above the reaction barrier were produced by photolysis of NO2 at 355 nm. The OH product revealed strong vibrational population inversion, P(υ"=1)/P(υ"=0) = 4.0 ± 0.6, and rotational distributions in both vibrational states exhibit substantial rotational excitations to the limit of total available energy. However, no preferential populations in either of the two Λ doublet states were observed from the micropopulations, which supports a mechanism involving a direct abstraction of hydrogen by the atomic oxygen. It was also found that the collision energy between O and HSiCl3 is effectively coupled into the excitation of the internal degrees of freedom of the OH product (<fvib> = 0.62, and < frot> = 0.20). The dynamics appear consistent with expectations for the kinematically constrained reaction which supports the reaction type, heavy + light-heavy → heavy-light + heavy (H + LH′ → HL + H′). The dynamics of oxygen atom collision with HSiCl3 are discussed in comparison to those with SiH4.

전자정부 책임성 구현을 위한 대안적 접근: 맥락적 정의와 공유된 인지모형

최태현 ( Tae Hyon Choi ),김덕수 ( Deok Soo Kim ),하정연 ( Jung Yun Ha ) 한국행정학회 2015 韓國行政學報 Vol.49 No.4

전자정부는 정부업무의 효율성과 민주성의 제고를 위해 공공부문에 적극적으로 도입되었다. 그러나 전자정부기반 기술의 발전이 가져오는 변화는 책임성의 개념적 이해 및 책임성 확보의 실천에 중대한 도전을 안겨주었다. 이 논문은 교육행정정보시스템(NEIS) 사례 분석을 통해 전자정부를 위한 맥락적 행정책임성 개념틀을 제시하고 책임성 확보 방안으로서 공유된 인지모형의 구축을 제안한다. 먼저 개념의 측면에서 맥락적 행정책임성 개념틀은 전자정부 체계가 다루는 정보의 속성, 정보통신기술의 속성, 정책집단을 고려하면서 합법성, 효율성, 민주성 간 균형을 책임성의 핵심으로 본다. 이러한 책임성을 실현함에 있어서는 다양한 가치들의 균형을 위해 전자정부 체계 요소들의 사회적 의미에 대한 공유된 인지모형의 구성을 통해 이루어져야 한다고 주장한다. 마지막으로 이러한 접근의 실천적 함의에 대해 논의한다. The implementation of electronic government systems has brought serious challenges to accountability, particularly with regard to how to understand and ensure accountability while pursuing both efficiency and democracy. This article proposes a conceptual framework of contextual accountability for electronic government by analyzing the case of the National Education Information System. A contextual accountability framework is composed of the contextuality tier including the characteristics of information, information technology, and policy groups, and the value tier including legal accountability, efficiency, and democracy. We argue that more attention should be paid to the role of a shared mental model of a specific electronic government system among policy groups than to the traditional internal/external control mechanisms. The process of developing a shared mental model should begin at an earlier stage of system adoption along with a high level of stakeholder inclusiveness to ensure contextual accountability.

Banding-Artifact Reduction Using an Improved Threshold Scaling Function in Multitoning with Stochastic Screen

Park, Tae-Yong,Park, Kee-Hyon,Jang, In-Su,Kwon, Oh-Seol,Ha, Yeong-Ho Society for Imaging Science and Technology 2007 The Journal of Imaging Science and Technology Vol. No.

Isolation and characterization of polymorphic microsatellite DNA markers in the sea squirt <i>Halocynthia roretzi</i>

HAN, HYON-SOB,NAM, BO-HYE,KANG, JUNG-HA,CHOI, TAE-JIN,KIM, WOO-JIN,HUR, YOUNG-BAEK,YOON, MOONGEUN Blackwell Publishing Ltd 2009 Molecular ecology resources Vol.9 No.2

<P>Abstract</P><P>The sea squirt <I>Halocynthia roretzi</I> is an important marine food resource species that is found in the waters around Korea. We describe the isolation and characterization of 13 new polymorphic microsatellite loci in 96 sea squirt samples that were collected from the marine environment of Samcheok on the east coast of Korea. The number of alleles that were observed for each locus ranged from six to 32, and the value of expected and observed heterozygosities was 0.504–0.922 and 0.396–0.813, respectively. These markers will be useful tools for future population studies.</P>