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우상우(S.W. Woo),김현태(H.T. Kim),이진형(J.H. Lee),이기학(K.H. Lee),박종포(J.P. Park) 한국전산유체공학회 2011 한국전산유체공학회 학술대회논문집 Vol.2011 No.5
Wind power system is generally divided into the onshore wind turbine and the offshore wind turbine according to site locations. The offshore wind turbine is manufactured as a closed nacelle cooling system including a heat exchanger to prevent corrosion, but the onshore wind turbine is manufactured as open nacelle cooling system dependent on only the outdoor air without a heat exchanger. The indoor of a nacelle which is composed of a generator, full power converters and a gearbox with a lot of heat is very narrow and airtight. This aim of the study is to demonstrate the temperature effect depending on positions of air-supply and exhaust ports. And this study discusses the flow field and removal efficiency of heat caused by components.
프로골프선수의 슬관절 등속성 근력에 관한 굴곡근과 신전근의 비교연구
박성태,정성태,정덕조,정영수,엄우섭,전태원,우재홍,박익렬 한국운동과학회 2000 운동과학 Vol.9 No.1
프로골프선수의 슬관절 등속성 근력에 관한 굴곡근과 신전근의 비교연구. 운동과학, 제 9권 제 1호. (201)-(209), 2000. 본 연구는 장기간의 골프운동이 슬관절의 단축성 굴근력과 신근력의 발달에 미치는 영향을 규명하여 경기력 향상을 위한 트레이닝 방법의 기초자료를 제공하고자 수행 되었다. 연구의 대상은 24명의 프로골프선수들(29.60±3.8세)로 골프경력은 12±1.7년으로 대상자 전원이 오른손을 주로 사용(우타)하였다. 측정은 등속성근력계(Cybex 770)를 이용하여 각속도 60°/sec와 180°/sec에서 3회씩 좌·우 교대로 측정하였다. 측정변인은 peak torque, peak torque 발현각, 평균파워, 총운동량 등이었다. 자료분석은 SPSS통계프로그램을 이용하여 실시하였으며 다음과 같은 결론을 얻었다.; 슬관절 굴곡근과 신장근의 좌·우 근력 비교에서 각속도 180°/sec로 굴곡성 운동시 총 운동량(total work)에서 좌·우측간에 유의한 차이가 있는 것으로 나타났으나(p<.05), 나머지 측정변인에서는 굴곡근과 신전근 모두 부하각속도에서 통계적으로 유의하지 않았다. 굴곡력의 경우 우측하지가 좌측하지에 비하여 높았으나 신전력의 경우 좌측하지가 다소 높은 경향을 보였다. 각 변인의 평균치에 대한 60°/sec와 180°/sec간의 비교에서는 모든 변인에서 통계적으로 유의한 차이를 나타내었다(p<.05). 슬관절 굴곡근의 신전근에 대한 비율(Flexor/Extensor Ratio)은 60°/sec에서 60%보다 낮게 나타났으나 좌·우측간 유의하지는 않았다. 결론적으로 다년간의 골프운동은 하지의 슬관절 근기능을 발달시키며 우측하지에 비해 좌측하지의 신전근에 더 많은 발달을 가져온다고 할 수 있다. A study on isokinetic concentric torque of kee extensor and flexor in golf players. Exercise Science, 9(1): 201-209, 2000. The purpose of this stydy was to investigate the effect of long therm golf exercise on isokinetic concentric torque of kee extensor and flexor. The subjects of this study were 24 men progolf players(29.60±3.8yrs) who have experience of 12±1.7yrs golf exercise and use mainly a right hand. The measurement was performed by use of Cybex 770 in angular velocity 60˚ /sec, 180˚ /sec and 3 repetitions. The variable of measure were peak torque, angle of peak torque, average power, total work and so on. The result of this study were as follow: There only was statistical difference between both low limb in Total work of knee flexor in angular velocity 180°/sec(p<.05) but not in other variables in both angular valocity. Right low limb was little stronger than reft low limb in flexor but there was opposite result in extensors. There was statistical difference between 60°/sec and 180°/sec in all varible. Knee flexors and extensors ratio was lower than 60% in angular velocity 60°/sec but there was no statistical difference between right and left low limb. It might be concluded from the test that long term golf exercise strengthen muscle function of knee flexors and extensor and left knee extensors more strengthen than right knee extensors.
( C Breitbach ),( M Cho ),( T H Hwang ),( C W Kim ),( U B Jeon,),( H Y Woo ),( K T Yoon ),( J W Lee ),( J Burke ),( T Hickman ),( K Duboi ),( L Longpre ),( R Patt ),( D H Kirn ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: JX-594 is a targeted oncolytic vaccinia virus designed to selectively replicate in and destroy cancer cells with epidermal growth factor receptor (EGFR)/ ras pathway activation. Direct oncolysis plus granulocyte macrophage?colony stimulating factor (GM-CSF) expression is accompanied by tumor vascular disruption and anti-tumoral immunity (Reviewed in Nat Rev Cancer 2009). JX-594 was well-tolerated intravenously (IV) (Nature 2011) and intratumorally (IT) (Lancet Oncol 2008). Complementary anti-tumor effects are predicted with JX-594 followed by sorafenib due to acute vascular disruption effects with JX-594 and anti-angiogenic effects with sorafenib. Objectives: The primary objective of the study was to determine the safety of JX-594 followed by sorafenib in patients with advanced HCC. Secondary objectives include disease control rate (DCR) based on mRECIST and/or Choi response criteria at Day 6 (optional), Day 25 (after JX-594 only), 6 and 12 weeks. Methods: Treatment-refractory HCC patients received JX-594 for three weeks (Day 1 IV, Day 8 IT and Day 22 IT) followed by sorafenib. An IT boost dose of JX-594 at Week 12 was optional. Results: Twenty-five (25) patients were treated in this study; twenty (20) were refractory to sorafenib. Enrollment has been completed. The sequential treatment regimen was well-tolerated. Transient flu-like symptoms (Grade 1-2) and transient leukopenia (lymphopenia, neutropenia) were the most common adverse events following JX-594 therapy. Sorafenib toxicities were consistent with the expected toxicity profile. After JX-594 alone at Day 25, 56% of patients exhibited Choi tumor responses (range 19-48% reduced enhancement). Following subsequent sorafenib therapy, 76% had Choi responses at Week 6-12, including 83% sorafenib-failure patients. The disease control rate was 80% with JX-594 alone and 38% following initiation of sorafenib. Conclusions: JX-594 was well-tolerated and associated with Choi tumor responses following IV and IT injections in patients with advanced HCC. Subsequent sorafenib was associated with the expected toxicity profile. Further trials of JX-594 in HCC patients are warranted.