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Katsurano, M,Niwa, T,Yasui, Y,Shigematsu, Y,Yamashita, S,Takeshima, H,Lee, M S,Kim, Y-J,Tanaka, T,Ushijima, T Macmillan Publishers Limited 2012 Oncogene Vol.31 No.3
Epigenetic fields for cancerization are involved in development of human cancers, especially those associated with inflammation and multiple occurrences. However, it is still unclear when such field defects are formed and what component of inflammation is involved in induction of aberrant DNA methylation. Here, in a mouse colitis model induced by dextran sulfate sodium (DSS), we identified three CpG islands specifically methylated in colonic epithelial cells exposed to colitis. Their methylation levels started to increase as early as 8 weeks after DSS treatment and continued to increase until colon cancers developed at 15 weeks. In contrast to the temporal profile of DNA methylation levels, infiltration of inflammatory cells spiked immediately after the DSS treatment and then gradually decreased. Exposure of cultured colonic epithelial cells to DSS did not induce DNA methylation and it was indicated that inflammation triggered by the DSS treatment was responsible for methylation induction. To clarify components of inflammation involved, severe combined immunodeficiency (SCID) mice that lack functional T- and B-cells were similarly treated. Even in SCID mice, DNA methylation, along with colon tumors, were induced at the same levels as in their background strain of mice (C.B17). Comparative analysis of inflammation-related genes showed that Ifng, Il1b and Nos2 had expression concordant with methylation induction whereas Il2, Il6, Il10, Tnf did not. These results showed that an epigenetic field defect is formed at early stages of colitis-associated carcinogenesis and that functional T and B cells are non-essential for the formation.
TT Virus Infection Among Blood Donors and Patients with non-B, Non-C Liver Diseases in Korea
T, Nakano,Park, Young-Min,Mizokami,Choi, Jong-Young,E, Orito,T, Ohno,T, Kato,Y, Kondo,Y, Tanaka,H, Kato,T, Kato,Kim, Boo-Sung 가톨릭대학교 2000 Bulletin of The Catholic Research Institutes of Me Vol.28 No.-
Background/Aims : A novel virus, designated the TT virus (TTV), was isolated from the serum of a patient with posttransfusion hepatitis of unknown etiology, in Japan. Subsequently, TTV was suggested to be a causative agent in a proportion of cases with cryptogenic hepatitis in Japan. This study aimed to elucidate the significance of TTV infection in cases with cryptogenic liver disease in Korea, a neighbor of Japan. Methods : The prevalence of TTV infection was studied in 120 patients with liver diseases, including 85 patients diagnosed as having non-B, non-C liver diseases. As controls, 220 blood donors were also examined. TTV DNA was detected by polymerase chain reaction, and the sequence was analyzed by phylogenetic analysis. Results : Fourteen (14.0%) of 100 accepted blood donors, 23 (19.2%) of 120 rejected blood donors, and 15 (17.6%) of 85 patients with non-B, non-C liver diseases were positive for TTV DNA. The prevalences of TTV infection among these groups were not significantly different. Phylogenetic analysis suggested the existence of four major genotypes of TTV The proportions of each genotype among patients with non-B, non-C liver diseases were not different from those among accepted blood donors. Conclusions : TTV exists in Korea, but the prevalence among patients with non-B, non-C liver diseases was almost the same as that among blood donors. TTV may not be the main causative agent of cryptogenic liver disease in Korea. The relationship between non-B, non-C liver diseases and TTV genotype remains unclear, although TTV can be classified into four genotypes. (The Journal of Hepatology 30(3):389-93, 1999)
Tanaka, T.,Abe, K.,Hayato, Y.,Iida, T.,Kameda, J.,Koshio, Y.,Kouzuma, Y.,Miura, M.,Moriyama, S.,Nakahata, M.,Nakayama, S.,Obayashi, Y.,Sekiya, H.,Shiozawa, M.,Suzuki, Y.,Takeda, A.,Takenaga, Y.,Ueno, IOP Publishing 2011 The Astrophysical journal Vol.742 No.2
<P>We present the result of an indirect search for high energy neutrinos from Weakly Interacting Massive Particle (WIMP) annihilation in the Sun using upward-going muon (upmu) events at Super-Kamiokande. Data sets from SKI-SKIII (3109.6 days) were used for the analysis. We looked for an excess of neutrino signal from the Sun as compared with the expected atmospheric neutrino background in three upmu categories: stopping, non-showering, and showering. No significant excess was observed. The 90% C. L. upper limits of upmu flux induced by WIMPs of 100 GeV c(-2) were 6.4 x 10(-15) cm(-2) s(-1) and 4.0 x 10(-15) cm(-2) s(-1) for the soft and hard annihilation channels, respectively. These limits correspond to upper limits of 4.5 x 10(-39) cm(-2) and 2.7 x 10(-40) cm(-2) for spin-dependent WIMP-nucleon scattering cross sections in the soft and hard annihilation channels, respectively.</P>
High-$T_c$ SQUID Application for Roll to Roll Metallic Contaminant Detector
Tanaka, S.,Kitamura, Y.,Uchida, Y.,Hatsukade, Y.,Ohtani, T.,Suzuki, S. The Korean Superconductivity Society 2012 Progress in superconductivity Vol.14 No.2
A sensitive eight-channel high-Tc Superconducting Interference Device (SQUID) detection system for magnetic contaminant in a lithium ion battery anode was developed. Finding ultra-small metallic foreign matter is an important issue for a manufacturer because metallic contaminants carry the risk of an internal short. When contamination occurs, the manufacturer of the product suffers a great loss from recalling the tainted product. Metallic particles with outer dimensions smaller than 100 microns cannot be detected using a conventional X-ray imaging system. Therefore, a highly sensitive detection system for small foreign matter is required. We have already developed a detection system based on a single-channel SQUID gradiometer and horizontal magnetization. For practical use, the detection width of the system should be increased to at least 65 mm by employing multiple sensors. In this paper, we present an 8-ch high-Tc SQUID roll-to-roll system for inspecting a lithium-ion battery anode with a width of 65 mm. A special microscopic type of a cryostat was developed upon which eight SQUID gradiometers were mounted. As a result, small iron particles of 35 microns on a real lithium-ion battery anode with a width of 70 mm were successfully detected. This system is practical for the detection of contaminants in a lithium ion battery anode sheet.
Tanaka, K.,Nagaoka, K.,Murakami, S.,Takahashi, H.,Osakabe, M.,Yokoyama, M.,Seki, R.,Michael, C.A.,Yamaguchi, H.,Suzuki, C.,Shimizu, A.,Tokuzawa, T.,Yoshinuma, M.,Akiyama, T.,Ida, K.,Yamada, I.,Yasuhar IOP 2017 Nuclear fusion Vol.57 No.11
<P>Surveys of the ion and electron heat transports of neutral beam (NB) heating plasma were carried out by power balance analysis in He and H rich plasma at LHD. Collisionality was scanned by changing density and heating power. The characteristics of the transport vary depending on collisionality. In low collisionality, with low density and high heating power, an ion internal transport barrier (ITB) was formed. The ion heat conductivity (<I>χ</I> <SUB>i</SUB>) is lower than electron heat conductivity (<I>χ</I> <SUB>e</SUB>) in the core region at <I>ρ</I> < 0.7. On the other hand, in high collisionality, with high density and low heating power, <I>χ</I> <SUB>i</SUB> is higher than <I>χ</I> <SUB>e</SUB> across the entire range of plasma. These different confinement regimes are associated with different fluctuation characteristics. In ion ITB, fluctuation has a peak at <I>ρ</I> = 0.7, and in normal confinement, fluctuation has a peak at <I>ρ</I> = 1.0. The two confinement modes change gradually depending on the collisionality. Scans of concentration ratio between He and H were also performed. The ion confinement improvements were investigated using gyro-Bohm normalization, taking account of the effective mass and charge. The concentration ratio affected the normalized <I>χ</I> <SUB>i</SUB> only in the edge region (<I>ρ</I> ~ 1.0). This indicates ion species effects vary depending on collisionality. Turbulence was modulated by the fast ion loss instability. The modulation of turbulence is higher in H rich than in He rich plasma.</P>