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6-shogaol suppresses oxidative damage in L6 muscle cells
Hur Jinyoung,Lee Yeonmi,Lee Chang Jun,Park Ho-Young,Choi Sang Yoon 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.5
Ginger (Zingiber Officinale Roscoe) has been known reduce muscle pain after exercise, and 6-shogaol {(E)-1-(4- Hydroxy-3-methoxyphenyl)dec-4-en-3-one)} is the major essential oil contained in ginger. In this study, the protective effect of 6-shogaol on L6 muscle cells against oxidative damage was measured. 6-shagol inhibited the damage of L6 cell induced by H2O2, and allowed the increase in mRNA and protein expression levels of intracellular HO-1 and NRF2. 6-shogaol also reduced the production of intracellular ROS. These results suggested that 6-shagol effectively inhibits oxidative damage of skeletal muscle cell.
Gliotoxin ameliorates TNBS-induced colitis through regulation of NF-kB, and up-regulation of HO-1
김상욱 ( Kim Sang Ug ),( Jay Min Oh ),( Yeon Hwa Kim ),( Jung Moo Hur ),( Kyo Sang Yoo ),( Yong Sung Kim ),( Joo Jin Yeom ),( Tae Hyeon Kim ),( Suck Chei Choi ),( Chang Duk Jun ),( Yong Ho Nah ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<Background & aims> During inflammation in colon, cells of the gut mucosa produce or express various inflammatory mediators, including IL-8, TNF-a and IL-1b, and intercellular adhesion molecule 1 (ICAM-1). These cytokines and chemokines have recently been
Kim, Se-Jin,Ho Hur, Joon,Park, Channy,Kim, Hyung-Jin,Oh, Gi-Su,Lee, Joon No,Yoo, Su-Jin,Choe, Seong-Kyu,So, Hong-Seob,Lim, David J,Moon, Sung K,Park, Raekil Nature Publishing Group 2015 Experimental and molecular medicine Vol.47 No.2
<P>Bucillamine is used for the treatment of rheumatoid arthritis. This study investigated the protective effects of bucillamine against cisplatin-induced damage in auditory cells, the organ of Corti from postnatal rats (P2) and adult Balb/C mice. Cisplatin increases the catalytic activity of caspase-3 and caspase-8 proteases and the production of free radicals, which were significantly suppressed by pretreatment with bucillamine. Bucillamine induces the intranuclear translocation of Nrf2 and thereby increases the expression of γ-glutamylcysteine synthetase (γ-GCS) and glutathione synthetase (GSS), which further induces intracellular antioxidant glutathione (GSH), heme oxygenase 1 (HO-1) and superoxide dismutase 2 (SOD2). However, knockdown studies of HO-1 and SOD2 suggest that the protective effect of bucillamine against cisplatin is independent of the enzymatic activity of HO-1 and SOD. Furthermore, pretreatment with bucillamine protects sensory hair cells on organ of Corti explants from cisplatin-induced cytotoxicity concomitantly with inhibition of caspase-3 activation. The auditory-brainstem-evoked response of cisplatin-injected mice shows marked increases in hearing threshold shifts, which was markedly suppressed by pretreatment with bucillamine <I>in vivo</I>. Taken together, bucillamine protects sensory hair cells from cisplatin through a scavenging effect on itself, as well as the induction of intracellular GSH.</P>
Comparison of Outcomes between STEMI and NSTEMI patients with Totally Occluded IRA (초)
( Sang Woong Choi ),( Yun Kyeong Cho ),( Jae Pil Lee ),( Ji Hyun Sohn ),( Hyun Ok Cho ),( Hyoung Seob Park ),( Hyuck Jun Yoon ),( Hyung Seop Kim ),( Chang Wook Nam ),( Seung Ho Hur ),( Yoon Nyun Kim ) 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1
( Sung Joon Park ),( Jin Hur ),( Won Ho Son ) 한국체육학회 2015 국제스포츠과학 학술대회 Vol.2015 No.1
Purpose: Whether a professional sport game can succeed is determined by what factors it has to attract various sports consumers to the arena. A sport or a game that fails to attract sports consumers will eventually be forgotten by the audiences. In other words, how to attract sports consumers determines whether or not a professional sport game will succeed. As personal and social interests in various professional sports increase, however, the behavior of sports consumers is also diversifying. The increasingly fierce competition and the nearly saturated sports market mean that retaining consumers is of primary importance. In order to ensure continuous survival and growth of professional soccer, it is crucial to conduct a marketing campaign, based on the characteristics and behavior of consumers, that enhances consumers` after purchases to soccer by appealing to their needs, desires, and values. Professional soccer teams and leagues must focus their efforts on creating strategy designed to attract as many consumers to the stadiums as possible. The analysis of servicescape of professional soccer will enhance customers` positive feelings and satisfaction, thereby solidifying continuous relationship between the audience and professional soccer and increasing the number of consumers returning to stadiums. This study was conducted in order to identify and verify the correlations between servicescape of professional soccer, customers` feelings and satisfaction, and after purchases to the sport. Method: 307 samples were collected through random sampling from the audiences of the four teams that competed at 2014 Professional soccer. Those unqualified for the study were excluded from the collected samples. The remaining effective samples were given explorative factor analysis, reliability analysis, and correlation analysis using SPSSWIN Ver. 18.0. Then a confirmative factor analysis was run using AMOS 18.0. Result: The overall findings were: χ2 = 415.041; GFI = .902; AGFI = .911; RMR = .043; NFI = .917; and TLI = .924, meaning the samples suited the purpose of the study. The findings of the structural equation model analysis were: χ2 = 418.214; GFI = .911; AGFI = .901; NFI = .921; and TLI = .932 Based on these findings and procedure, the following findings were obtained. Conclusion: First, servicescape had significant influence on affect. Second, servicescape had significant influence on customer satisfaction. Third, affect had significant influence on customer satisfaction and after purchases. Fourth, customer satisfaction had significant influence after purchases.
Hur, Woon-Yung,Roh, Eun-Jung,Oh, Chang-Sik,Han, Man-Wi,Lee, Seung-Don,Kim, Doo-Ho,Heu, Sung-Gi The Korean Society of Plant Pathology 2009 Plant Pathology Journal Vol.25 No.3
The stability of three different kinds of pUC-derived plasmids, pDsRed, pZsYellow, and pGFPuv, was investigated in Pectobacterium strains to utilize those plasmids as tracers. All three plasmids pDsRed, pZsYellow and pGFPuv showed their specific colors in Pectobacterium strains. Especially, the plasmid pDsRed conferred bright pink colonies on the Pectobacterium strains. When the bacteria lost the plasmid pDsRed, the colonies turned white, suggesting that the plasmid could be a good marker system for Pectobacterium strains on different environmental conditions. The effect of the antibiotic pressure on the stability of the plasmid was different depending on the host bacteria. P. carotovorum subsp. betavasculorum was more sensitive to the antibiotic pressure than P. carotovorum subsp. carotovorum Pcc21. However, temperature change significantly affected plasmid stability on both Pectobacterium strains. Almost all strains lost the plasmids with the shift in temperature from $28^{\circ}C$ to $37^{\circ}C$. Presence of the plasmids did not affect bacterial pathogenicity on their own host plants. Among three plasmids, pZsYellow was not useful as a marker because the yellow fluorescent proteins from pZs Yellow were interfered with the yellow natural fluorescence of the plant tissues induced by the defense system. Since the red color of DsRed can be seen with naked eyes, plasmid pDsRed was applicable as a marker. However, the color change was slow so that additional manipulation to increase the expression speed was necessary. Plasmid pGFPuv could serve as a perfect marker without any problem, tracing the reproduction and spread of the plant pathogens perfectly.