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Hur, Haeng Jeon,Lee, Ae Sin Korean Society of Cancer Prevention 2017 Journal of cancer prevention Vol.22 No.4
<P><B>Background</B></P><P>Endothelial adhesion molecule expression induced by pro-inflammatory cytokine plays an important role in vascular endothelial cell injury, leading to vascular disease. <I>Allium tuberosum</I> (AT), which is used as a functional food, has a thrombolytic effect. It contains vitamin A, vitamin C, carbohydrate, calcium, iron, and phosphorus. There are many carotenes that turn into vitamin A in the body. Also, it helps blood circulation and stimulates metabolism. The purpose of the this study was to estimate the anti-inflammatory effects of the AT extract.</P><P><B>Methods</B></P><P>Human vascular endothelial cells were pre-treated with 100 μg/mL AT extract for 30 minutes and subsequently co-treated with TNF-α (10 ng/mL) and AT extract (100 μg/mL) for 1, 4, and 6 hours. After treatment, the cells were lysed and used for quantitative reverse transcription PCR, Western blot analysis, and monocyte adhesion assay.</P><P><B>Results</B></P><P>We examined the effect of the AT extract on inflammatory gene expression in TNF-α-induced human umbilical vein endothelial cells (HUVECs). The extract reduced the expression levels of mRNA and protein of intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in TNF-α-stimulated HUVECs. It also inhibited the TNF-α-induced phosphorylation of the NF-κB p65 subunit and degradation of IκBα. Furthermore, the AT extract prevented the increased adhesion capacity of monocyte to TNF-α-stimulated vascular endothelial cells by reducing ICAM-1 and VCAM-1 expression.</P><P><B>Conclusions</B></P><P>The AT extract has preventive and anti-inflammatory effect against vascular disease and has potential for supporting prevention against the early process of atherosclerosis.</P>
고지방 식이로 유도된 비만 쥐에서 실리빈 (Silybin)이 체중 및 내당 능에 미치는 영향
허행전(Haeng Jeon Hur),황진택(Jin Taek Hwang) 한국생물공학회 2011 KSBB Journal Vol.26 No.1
In this study, we investigated the effects of silybin on body weight and glucose tolerance in mice fed high fat diet mice. We found that body weight, plasma TG contents, fat size, glycerol, 3-hydroxybutyrate and total cholesterol were significantly decreased in silybin (500 mg/kg) supplemented groups compared to high fat diet group. Whereas, total food intake was not changed between high fat diet group and high fat diet plus silybin group. Futhermore, supplement of high fat elevated the glucose intolerance and was improved in silybin supplement group. Finally, we examined the effect of silybin on circulating adipocytokine level to explore the possible mechanism by which silybin improves high fat diet-induced obesity and diabetes. The silybin supplement significantly reduced the level of adipocytokine, such as leptin, resistin, IL-6, and MCP-1 induced by high fat diet. These results suggest that silybin can be used to improve obesity and diabetes.
Jeon, Soon-Hyeok,Lee, Eun-Hee,Hur, Do Haeng Elsevier 2017 Journal of nuclear materials Vol.485 No.-
<P><B>Abstract</B></P> <P>The effect of dissolved hydrogen (DH) on the general corrosion behavior and oxide films of Alloy 690TT is investigated in simulated primary water at 330 °C. With increasing DH, the structure of oxide film significantly changed and the corrosion rate decreased. At DH = 5 cm<SUP>3</SUP>/kg H<SUB>2</SUB>O, the oxide layer was thick, and consisted of outer Ni oxide layer and inner Cr<SUB>2</SUB>O<SUB>3</SUB> layer. Under the conditions of DH = 35 and 100 cm<SUP>3</SUP>/kg H<SUB>2</SUB>O, the oxide films grew thinner and composed of outer polyhedral spinel oxide particles such as NiCr<SUB>2</SUB>O<SUB>4</SUB> or NiCrFeO<SUB>4</SUB> and an intermediate metallic Ni-rich layer, with inner Cr<SUB>2</SUB>O<SUB>3</SUB> layer. The general corrosion rate significantly decreased by about 72% as DH concentration increased from 5 to 35 cm<SUP>3</SUP>/kg H<SUB>2</SUB>O. In the range of 35–65 cm<SUP>3</SUP>/kg H<SUB>2</SUB>O, the corrosion rate slightly decreased with increasing DH concentration. However, no further changes were observed in the range of 65–100 cm<SUP>3</SUP>/kg H<SUB>2</SUB>O.</P> <P><B>Highlights</B></P> <P> <UL> <LI> DH effect on the general corrosion rate of Alloy 690TT is provided. </LI> <LI> At low DH condition, the filament-like and planer Ni oxide layers were formed. </LI> <LI> At high DH condition, the polyhedral spinel oxide particles were formed. </LI> <LI> The thickness of oxide films decreased with increasing the DH concentration. </LI> <LI> General corrosion rate decreased with an increase in the DH concentration. </LI> </UL> </P>
Mechanistic insights into lead-accelerated stress corrosion cracking of Alloy 600
Hur, Do Haeng,Choi, Won-Ik,Song, Geun Dong,Jeon, Soon-Hyeok,Lim, Sangyeob Elsevier 2018 Corrosion science Vol.145 No.-
<P><B>Abstract</B></P> <P>The purpose of this work is to provide insights into the lead-accelerated stress corrosion cracking mechanisms of Alloy 600 from the perspective of the electrochemical role of lead. Lead-species were electrochemically reduced at the oxide/matrix interface, which increased the dissolution rate of the alloy elements (preferentially Cr) from and oxidation of the matrix. These electrochemical processes resulted in the fast formation of defective thick oxides with a relatively lower Cr content, which provide paths for the migration of lead-species toward the interface. Finally, the mechanistic model of fast cracking by lead contamination is described.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pb-species is electrochemically reduced to metallic Pb at the oxide/matrix interface. </LI> <LI> The fraction of metallic Pb incorporated in oxides increases toward the interface. </LI> <LI> The dissolution of the matrix is stimulated by the reduction to metallic Pb. </LI> <LI> The accelerated corrosion process induces the formation of defective thick oxides. </LI> </UL> </P>
Characteristics of steam generator tube deposits in an operating pressurized water reactor
Jeon, Soon-Hyeok,Hong, Seokmin,Kwon, Hyuk-Chul,Hur, Do Haeng Elsevier 2018 Journal of nuclear materials Vol.507 No.-
<P><B>Abstract</B></P> <P>The objective of this study is to characterize steam generator tube deposits collected from an operating pressurized water reactor. The deposits were mostly composed of magnetite and contained small amounts of trevorite, jacobsite, and metallic copper. The concentration of impurities within the pores of the deposits was estimated to be 2 × 10<SUP>6</SUP>–3 × 10<SUP>7</SUP> for copper and 2 × 10<SUP>5</SUP>–5 × 10<SUP>5</SUP> for sodium, chloride, and sulfur. The deposit density was estimated to be approximately 2.72 g/cm<SUP>3</SUP>. The porosity and mean pore diameter of the deposits measured by mercury intrusion porosimetry were approximately 9.82% and 196.20 nm, respectively.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Steam generator tube deposits were mostly composed of magnetite. </LI> <LI> Density of the deposits was estimated to be approximately 2.72 g/cm<SUP>3</SUP>. </LI> <LI> Porosity of the deposits were about 10% by using mercury intrusion porosimetry. </LI> <LI> Aggressive chemical impurities were detected within the pores of the deposits. </LI> <LI> Useful information for chemical cleaning and corrosion problems was obtained. </LI> </UL> </P>
Jeon, Soon-Hyeok,Song, Geun-Dong,Hur, Do Haeng Hindawi Limited 2016 Advances In Materials Science And Engineering Vol.2016 No.1
<P>The purpose of this work is to investigate the effect of electrochemical deposition potential on the morphology and structure of iron-based films on the carbon steel in an alkaline Fe(III)-triethanolamine solution. The deposition potentials were controlled in the range from −1.05 to −1.23 <SUB>VSCE</SUB>for 1800 s at 80°C. Total amount of electric charge for electrodeposition process was increased with increasing deposition potential in negative direction. Pure magnetite films with a columnar and defect-free structure were deposited in the potential range from −1.05 <SUB>VSCE</SUB>to −1.11 <SUB>VSCE</SUB>. However, petal-like magnetite film containing ferrihydrite and iron was formed at −1.17 <SUB>VSCE</SUB>. At more negative potential of −1.23 <SUB>VSCE</SUB>, two distinct layers were observed: a porous outer layer containing ferrihydrite and goethite and a compact inner layer consisting of columnar metallic iron. In the potential range from −1.05 to −1.11 <SUB>VSCE</SUB>, the pure magnetite films gradually increased the thickness and decreased the surface roughness with an increase of the overpotential. The magnetite film deposited at −1.11 <SUB>VSCE</SUB>showed the most thick layer and smooth surface state.</P>